Researchers at Uppsala University have discovered lymph node-like structures close to the tumour in brain cancer patients, where immune cells can be activated to attack the tumour. They also found that immunotherapy enhanced the formation of these structures in a mouse model. This discovery suggests new opportunities to regulate the anti-tumour response of the immune system. Glioma is a deadly brain tumour with a dismal prognosis. One reason why brain tumours are very hard to treat is that our immune system, which is designed to detect and destroy foreign ...

Although most Canadians die from predictable causes and have health needs that can be met at home, only 20% of people receive a physician home visit in their last year of life. To help understand the changing care needs of older adults as they age and when they might be nearing the end of their lives, a team of researchers developed the Risk Evaluation for Support: Predictions for Elder-Life in the Community Tool (RESPECT). The calculator, which predicts death within 6 months, is based on data from more than 491 000 community-dwelling older adults who used home care in the 6-year period between 2007 and 2013. "The RESPECT calculator allows families and their loved ...

Oncotarget published "Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth" which reported that the authors investigated whether EMT can confer endothelial attributes upon carcinoma cells, augmenting tumor growth and vascularization. Hypoxic regions, demarcated by HIF-1α staining, exhibited focal areas of E-cadherin loss and elevated levels of vimentin and the EMT-mediator FOXC2. Implantation of MCF-7 cells, co-mixed with human mammary epithelial cells overexpressing the EMT-inducer Snail, markedly ...

Oncotarget published "Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery" which reported that little is known about the impact of anesthesia on the plasma metabolome, although many metabolites have been shown to modulate the function of various immune cells, making it particularly interesting in the context of oncological surgery. In this study longitudinal dynamics in the plasma metabolome during general anesthesia in patients undergoing pancreatic surgery were analyzed. Prospective, observational study with 10 patients diagnosed with pancreatic malignancy and subjected to elective resection surgery under general anesthesia. Plasma metabolites were quantified at ...

Oncotarget published "Genome wide DNA methylation landscape reveals glioblastoma's influence on epigenetic changes in tumor infiltrating CD4+ T cells" which reported that whole-genome bisulfite sequencing of tumor infiltrating and blood CD4 T-cell from GBM patients showed 13571 differentially methylated regions and a distinct methylation pattern of methylation of tumor infiltrating CD4 T-cells with significant inter-patient variability. The methylation changes also resulted in transcriptomic changes with 341 differentially expressed genes in CD4 tumor infiltrating T-cells compared to blood. Analysis of specific genes involved in CD4 differentiation and function revealed differential methylation status of TBX21, GATA3, RORC, FOXP3, IL10 and ...

Inadequate exposure to UVB light from the sun may be associated with an increased risk of colorectal cancer, particularly in older age groups, according to a study using data on 186 countries, published in the open access journal BMC Public Health. Researchers at the University of California San Diego, USA investigated possible associations between global levels of UVB light in 2017 and rates of colorectal cancer for different countries and age groups in 2018. The authors found that lower UVB exposure was significantly correlated with higher rates of colorectal cancer across all ...

Why are gold deposits found at all? Gold is famously unreactive, and there seems to be little reason why gold should be concentrated, rather than uniformly scattered throughout the Earth's crust. Now an international group of geochemists have discovered why gold is concentrated alongside arsenic, explaining the formation of most gold deposits. This may also explain why many gold miners and others have been at risk from arsenic poisoning. This work is presented at the Goldschmidt conference, after recent publication*. Gold has been prized for millennia, for its purity and stability. It's also rare enough to retain its value - the World Gold Council estimates that all the gold ever mined in the world would fit into a 20x20x20-meter cube. It is valued for its beauty, but also because it ...

Scientists have reconstructed the Eastern Mediterranean silver trade, over a period including the traditional dates of the Trojan War, the founding of Rome, and the destruction of Solomon's Temple in Jerusalem. The team of French, Israeli and Australian scientists and numismatists found geochemical evidence for pre-coinage silver trade continuing throughout the Mediterranean during the Late Bronze and Iron Age periods, with the supply slowing only occasionally. Silver was sourced from the whole north-eastern Mediterranean, and as far away as the Iberian ...

Scientists have found an unexplained cache of fossilised shark teeth in an area where there should be none - in a 2900 year old site in the City of David in Jerusalem. This is at least 80 km from where these fossils would be expected to be found. There is no conclusive proof of why the cache was assembled, but it may be that the 80 million-year-old teeth were part of a collection, dating from just after the death of King Solomon*. The same team has now unearthed similar unexplained finds in other parts of ancient Judea. Presenting the work at the Goldschmidt Conference, lead researcher, Dr. Thomas Tuetken (University of Mainz, Institute of Geosciences) said: "These fossils are not in their original setting, so they have been moved. They were probably valuable to someone; ...

Tokyo, Japan - Researchers from Tokyo Metropolitan University have used high power impulse magnetron scattering (HiPIMS) to create thin films of tungsten with unprecedentedly low levels of film stress. By optimizing the timing of a "substrate bias pulse" with microsecond precision, they minimized impurities and defects to form crystalline films with stresses as low as 0.03 GPa, similar to those achieved through annealing. Their work promises efficient pathways for creating metallic films for the electronics industry. Modern electronics relies on the intricate, nanoscale deposition of thin metallic films onto surfaces. This is easier said than done; unless done right, "film stresses" arising from the microscopic internal structure of the film ...

In recent years, immunotherapy has revolutionised the field of cancer treatment. However, inflammatory reactions in healthy tissues frequently trigger side effects that can be serious and lead to the permanent discontinuation of treatment. This toxicity is still poorly understood and is a major obstacle to the use of immunotherapy. Scientists from the University of Geneva (UNIGE), Switzerland, and Harvard Medical School, United States, have succeeded in establishing the differences between deleterious immune reactions and those targeting tumour cells that are sought after. It appears that while the immune mechanisms are similar, the cell ...

It is the membrane of cancer cells that is at the focus of the new research now showing a completely new way in which cancer cells can repair the damage that can otherwise kill them. In both normal cells and cancer cells, the cell membrane acts as the skin of the cells. And damage to the membrane can be life threatening. The interior of cells is fluid, and if a hole is made in the membrane, the cell simply floats out and dies - a bit like a hole in a water balloon. Therefore, damage to the cell membrane must be repaired quickly, and now research from a team of Danish researchers shows that cancer cells use a ...

Fast facts: Nanobodies have been shown to inhibit the dysfunction of key proteins involved with various diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, B-cell lymphoma, and breast cancer Understanding the structure of a nanobody helps to better understand its disease-fighting potential Typically, the protein structure is determined from solid samples. Researchers at NYUAD used a liquid state technique to determine protein structure. Abu Dhabi, UAE: For the first time in the UAE, researchers at NYU Abu Dhabi have used ...

For decades, people have wondered why pelagic red crabs--also called tuna crabs--sometimes wash ashore in the millions on the West Coast of the United States. New research shows that atypical currents, rather than abnormal temperatures, likely bring them up from their home range off Baja California. Alongside the discovery, the scientists also created a seawater flow index that could help researchers and managers detect abnormal current years. The new study, published July 1 in Limnology and Oceanography, began after lead author Megan Cimino biked past a pelagic red crab stranding on her way to her office in Monterey ...

East Hanover, NJ. July 2, 2021. Among wheelchair users with spinal cord injury 42 percent reported adverse consequences related to needing wheelchair repair, according to a team of experts in spinal cord injury rehabilitation. The research team, comprised of investigators from the Spinal Cord Injury Model System, determined that this ongoing problem requires action such as higher standards of wheelchair performance, access to faster repair service, and enhanced user training on wheelchair maintenance and repair. The article, "Factors Influencing Incidence of Wheelchair Repairs and Consequences Among Individuals with Spinal Cord Injury" (doi: 10.1016/j.apmr.2021.01.094) was published online in ...

BOSTON -- Gaurav Gaiha, MD, DPhil, a member of the Ragon Institute of MGH, MIT and Harvard, studies HIV, one of the fastest-mutating viruses known to humankind. But HIV's ability to mutate isn't unique among RNA viruses -- most viruses develop mutations, or changes in their genetic code, over time. If a virus is disease-causing, the right mutation can allow the virus to escape the immune response by changing the viral pieces the immune system uses to recognize the virus as a threat, pieces scientists call epitopes. To combat HIV's high rate of mutation, Gaiha and Elizabeth Rossin, MD, PhD, a Retina Fellow at Massachusetts Eye and Ear, a member of Mass General ...

BUFFALO, N.Y. -- A year after University at Buffalo scientists demonstrated that it was possible to produce millions of mature human cells in a mouse embryo, they have published a detailed description of the method so that other laboratories can do it, too. The ability to produce millions of mature human cells in a living organism, called a chimera, which contains the cells of two species, is critical if the ultimate promise of stem cells to treat or cure human disease is to be realized. But to produce those mature cells, human primed stem cells must be converted back into an earlier, less developed naive state so ...

When environmental physicist Kira Rehfeld, from Heidelberg University, visited Antarctica for her research, she was struck by the intense light there. "It's always light in summer. This solar radiation could actually be used to supply the research infrastructure with energy", she observes. However, generators, engines, and heaters in these remote regions have mostly been powered until now by fossil fuels delivered by ship, such as petroleum or petrol, which cause global warming. Besides the high associated economic costs, pollution from even the smallest spills is also a major problem threatening the especially sensitive ...

July 2, 2021 - For health care organizations looking to improve performance and patient experiences, implementing data-driven solutions can be effective when focusing on addressing health equity and reducing patient length of stay. These topics are explored in selected member-submitted abstracts from the 2020 Vizient® Connections Education Summit that appear in a special supplement to the July/August 2021 issue of the American Journal of Medical Quality, the official journal of the American College of Medical Quality (ACMQ). Interventions for addressing health equity To help health care organizations address ...

GAINESVILLE, Fla. --- Archaeologists have unearthed a END ...

MANHATTAN, KANSAS -- Research led by Kansas State University's Suprem Das, assistant professor of industrial and manufacturing systems engineering, in collaboration with Christopher Sorensen, university distinguished professor of physics, shows potential ways to manufacture graphene-based nano-inks for additive manufacturing of supercapacitors in the form of flexible and printable electronics. As researchers around the world study the potential replacement of batteries by supercapacitors, an energy device that can charge and discharge very fast -- within few tens of seconds -- the team led by Das has an alternate prediction. The team's work could be adapted to integrate them to overcome ...

A huge global network of researchers is working together to take the pulse of our global tropical forests. ForestPlots.net, which is co-ordinated from the University of Leeds, brings together more than 2,500 scientists who have examined millions of trees to explore the effect of climate change on forests and biodiversity. A new research paper published in Biological Conservation explains the origins of the network, and how the power of collaboration is transforming forest research in Africa, South America and Asia. The paper includes 551 researchers and outlines 25 years of discovery in the carbon, biodiversity and dynamics of tropical forests. Professor Oliver Phillips, of Leeds' School of Geography, said "Our new paper shows how we are linking students, botanists, ...

MANHATTAN, KANSAS -- A recent study by Kansas State University virologists demonstrates successful postinfection treatment for SARS-CoV-2, the virus that causes COVID-19. College of Veterinary Medicine researchers Yunjeong Kim and Kyeong-Ok "KC" Chang published the study in the prestigious journal Proceedings of the National Academy of Sciences of the United States of America, or PNAS. They found that animal models infected with SARS-CoV-2 and treated with a deuterated protease inhibitor had significantly increased survival and decreased lung viral load. The results suggest that postinfection treatment with inhibitors of proteases that are essential for viral replication may be an effective treatment against SARS-CoV-2. ...

How on Earth? It has puzzled scientists for years whether and how bacteria, that live from dissolved organic matter in marine waters, can carry out N2 fixation. It was assumed that the high levels of oxygen combined with the low amount of dissolved organic matter in the marine water column would prevent the anaerobic and energy consuming N2 fixation. Already in the 1980s it was suggested that aggregates, so-called "marine snow particles", could possibly be suitable sites for N2 fixation, but this was never proven. Until now.. In a new study, researchers from the University of Copenhagen demonstrate, by use of mathematical models, ...

During the large second wave of the COVID-19 pandemic in fall 2020, pulmonologist and critical care provider Juan C. Rojas, MD, reflected on how disproportionately members of minority populations were being affected by the disease. After hearing similar thoughts from colleagues in New Orleans and New York City, Rojas began to wonder how, if at all, state governments planned to ensure these disparities would be addressed when COVID-19 vaccines were rolled out to the public. In a new study published July 2 in JAMA Network Open, Rojas and his team were surprised ...