Using an innovative method, EPFL scientists show that the brain is not as compact as we have thought all along. To study the fine structure of the brain, including its connections between neurons, the synapses, scientists must use electron microscopes. However, the tissue must first be fixed to prepare it for this high magnification imaging method. This process causes the brain to shrink; as a result, microscope images can be distorted, e.g. showing neurons to be much closer than they actually are. EPFL scientists have now solved the problem by using a technique that ...

1. Clinical scoring system suggests possibility of more precise colon cancer screening Free abstract: http://www.annals.org/article.aspx?doi=10.7326/M14-1720 Editorial: http://www.annals.org/article.aspx?doi=10.7326/M15-1677 URLs go live when embargo lifts A clinical scoring system for colon cancer risk could help physicians identify which average-risk patients could potentially skip a colonoscopy and instead be screened with a less-invasive method. The researchers suggest that this approach could increase the uptake and efficiency of colorectal cancer (CRC) ...

Hamilton, ON (Aug. 10, 2015) -McMaster University research, published online today by the Annals of Internal Medicine, has demonstrated the benefits of corticosteroid therapy for one of the most common serious medical conditions. "Our study should lead to an important change in treatment for pneumonia," said lead author, Dr. Reed Siemieniuk, a physician and a graduate student at McMaster University. "Corticosteroids are inexpensive and readily available around the world. Millions of patients will benefit from this new evidence." Lower respiratory infections are the ...

DALLAS, Aug. 10, 2015 -- If your dinner plate often includes fried chicken, gravy-smothered liver, buttered rolls and sweet tea -- your heart may not find it so tasty. Eating a Southern-style diet is associated with an increased risk of heart disease, according to research published in Circulation, an American Heart Association journal. In a large-scale study that explored the relationship between dietary patterns and heart disease risk, researchers found that people who regularly ate traditional Southern fare -- which they characterized as fried foods, fatty foods, eggs, ...

DALLAS, Aug. 10, 2015 -- For the first time, experts urge early monitoring for heart and blood vessel disease among teens with major depression or bipolar disorder, according to an American Heart Association scientific statement. "Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease" is published in Circulation, a journal of the American Heart Association. This statement makes recommendations to consider these mood disorders as independent, moderate risk factors for cardiovascular diseases ...

An international team of astronomers studying 200,000 galaxies has measured the energy generated within a large portion of space more precisely than ever before, discovering that it's only half what it was 2 billion years ago and fading - the Universe is slowly dying. Researchers from the International Centre for Radio Astronomy Research (ICRAR) in Western Australia used seven of the world's most powerful telescopes to observe galaxies at 21 different wavelengths from the far ultraviolet to the far infrared. Initial observations were conducted using the Anglo-Australian ...

An international team of astronomers studying more than 200 000 galaxies has measured the energy generated within a large portion of space more precisely than ever before. This represents the most comprehensive assessment of the energy output of the nearby Universe. They confirm that the energy produced in a section of the Universe today is only about half what it was two billion years ago and find that this fading is occurring across all wavelengths from the ultraviolet to the far infrared. The Universe is slowly dying. The study involves many of the world's most powerful ...

Through identification of increased toxin production by epidemic forms of group A streptococcus (the "flesh-eating" bacterium), for the first time scientists are able to pinpoint the molecular events that contribute to large intercontinental epidemics of disease. The study was based on sequencing almost 5,000 group A streptococcus genomes collected over decades. Researchers from Houston Methodist Research Institute, Houston Methodist Hospital, institutions in Finland and Iceland, and the U.S. National Institute of Allergy and Infectious Diseases report their discoveries ...

Fast Facts: Study reveals simple things hospitals can do to improve a patient's experience, including ongoing rounds by nurses and hospital leadership. Study findings outline the following core practices that high-ranking hospitals employ: a devotion to consistency, personal and focused interactions with patients, and a culture that demands involvement of all levels of caregivers and services. Based on responses to questionnaires and letters sent to CEOs and medical personnel from a nationwide sample of 53 hospitals, Johns Hopkins investigators have identified ...

Athens, Ga. - The time since the introduction of a non-native marine species best explains its global range, according to new research by an international team of scientists led by University of Georgia ecologist James E. Byers. The study, published in the open access journal Nature Scientific Reports, also contains a warning: The vast majority of marine invaders have not yet finished spreading. Invasion by non-native species is a worldwide problem that causes billions of dollars of damage annually--more than $120 billion in the U.S. alone, according to a 2005 study ...

Berkeley -- The effort to improve food safety by clearing wild vegetation surrounding crops is not helping, and in some cases may even backfire, according to a new study led by researchers at the University of California, Berkeley. The findings, to be reported Monday, Aug. 10, in the journal Proceedings of the National Academy of Sciences, call into question the effectiveness of removing non-crop vegetation as a way to reduce field contamination of fresh produce by disease-causing pathogens. This practice led to extensive loss of habitat in a region that is globally ...

Human memory is the result of different mental processes, such as learning, remembering and forgetting. However, these distinct processes cannot be observed directly. Researchers at the University of Basel now succeeded at describing them using computational models. The scientists were thus for the first time able to identify gene sets responsible for steering specific memory processes. Their results have been published in the current issue of the journal PNAS. Thanks to our memory we are able to learn foreign languages, solve exams and remember beautiful moments from ...

Scientists have found that a newly identified and highly infectious tadpole disease is found in a diverse range of frog populations across the world. The discovery sheds new light on some of the threats facing fragile frog populations, which are in decline worldwide. The study, published in the Proceedings of the National Academy of Sciences journal, led by the University of Exeter and the Natural History Museum, describes the molecular methods used to test frog tadpoles for a newly identified infectious agent. Tadpoles from six countries across three continents were ...

A new study led by bioengineers at the University of California, San Diego defines the core set of genes and functions that a bacterial cell needs to sustain life. The research, which answers the fundamental question of what minimum set of functions bacterial cells require to survive, could lead to new cell engineering approaches for E. coli and other microorganisms, the researchers said. The findings are published online in the early edition of Proceedings of the National Academy of Sciences the week of August 10, 2015. This core set of genes is "the smallest common ...

Astronomers at the 29th International Astronomical Union General Assembly will announce on August 14 the discovery of a new transiting "circumbinary" planet, bringing the number of such known planets into double digits. A circumbinary planet orbits two stars, and like the fictional planet "Tatooine" from Star Wars, this planet has two suns in its sky. The discovery marks an important milestone and comes only four years after the first Kepler circumbinary planet was detected. Once thought to be rare or even impossible, these ten discoveries confirm that such planets are ...

COLUMBIA, Mo. - Remarriages often combine two families into one stepfamily unit. When that stepfamily unit dissolves after a divorce, little is known about the relationships between former stepparents and stepchildren. Now, researchers in the University of Missouri College of Human Environmental Sciences found stepchildren's views of former stepparents depended on emotional reactions to the divorce, patterns of support or resource exchanges, and parental encouragement or discouragement to continue step-relationships. Whether stepchildren maintained relationships with their ...

COLUMBUS, Ohio - Researchers who have revealed a highly efficient way that bacteria use toxins to interrupt the immune response say that until now, the trickery of these toxins has been underappreciated in science. Bacteria harm the body by releasing toxins - proteins that are exceptionally effective poisons. Always targeting essential molecules, toxins typically go after molecules that are either scarce or whose role is to send important signals. In both cases, only a small number of toxins is required to cause damage. In contrast, some toxins appear to deviate from ...

Alexandria, Va., USA - Today, the International and American Associations for Dental Research (IADR/AADR) published two reports including a critical review titled "Diet and Dental Caries - the Pivotal Role of Free Sugars Reemphasized." In this study, authors Aubrey Sheiham, University College London, England; and W. Philip James, London School of Hygiene and Tropical Medicine, England, demonstrate the sensitivity of cariogenesis (the development of caries) to even very low sugars intakes. In this critical review, the authors reviewed the literature on the role of sucrose ...

Scientists at the Johns Hopkins Kimmel Cancer Center have identified a molecular partnership in pancreatic cancer cells that might help to explain how the disease spreads -- metastasizes -- in some cases. Their findings reveal urgently needed new targets to treat pancreatic cancer, which strikes nearly 50,000 people in the U.S. each year and has only a 5 percent survival rate five years after diagnosis. One of the molecular partners is annexin A2, a protein that scientists say was already linked to poor survival rates in these cancers. In a report published in the Aug. ...

(Broadcast-quality video and infographics available with this story) ANN ARBOR, Mich. -- With more kids online and using cell phones at increasingly younger ages, two issues have quickly climbed higher on the public's list of major health concerns for children across the U.S: sexting and Internet safety. Compared with 2014, Internet safety rose from the eighth to the fourth biggest problem, ahead of school violence and smoking, in the 2015 annual survey of top children's health concerns conducted by the C.S. Mott Children's Hospital National Poll on Children's ...

OAK RIDGE, Tenn., Aug. 10, 2015 - A microscope being developed at the Department of Energy's Oak Ridge National Laboratory will allow scientists studying biological and synthetic materials to simultaneously observe chemical and physical properties on and beneath the surface. The Hybrid Photonic Mode-Synthesizing Atomic Force Microscope is unique, according to principal investigator Ali Passian of ORNL's Quantum Information System group. As a hybrid, the instrument, described in a paper published in Nature Nanotechnology, combines the disciplines of nanospectroscopy and ...

In emerging economies, where real estate is expensive and space is limited, there has been a boom in multiplex movie theater construction fueled by the conviction that small screens with many show times will increase ticket sales. But new research from the University of Chicago Booth School of Business finds that the strategy doesn't always work. In the paper Quality vs. Variety: Trading Larger Screens for More Shows in the Era of Digital Cinema by Chicago Booth Assistant Professor of Marketing Anita Rao and Stanford University Professor Wesley R. Hartmann, researchers ...

A drug candidate that overstimulates proteins crucial for tumor growth shows promise as a new strategy to treat a wide range of cancers. The demands of rapid cell division put a strain on cancer cells, and the approach works by tipping cell stress over the edge. In the August 10 issue of Cancer Cell, American researchers show that the drug candidate inhibits tumor growth in a mouse model of breast cancer and efficiently kills a broad range of human cancer cells. "No prior drug has been previously developed or proposed that actually stimulates an oncogene to promote therapy," ...

Low-income people who struggle to put food on the table also use the health care system more, which means higher health care costs, according to new research published in CMAJ (Canadian Medical Association Journal). "We know that people who have trouble affording the food they need have poorer health in general as well as more chronic disease," states Dr. Valerie Tarasuk, Department of Nutritional Sciences, University of Toronto, Toronto, Ontario. The term "food insecurity" describes inadequate or insecure access to food because of financial constraints. In Canada in ...

As California wildfires burn tree canopies and the forest floors they support, the plants that are replacing the understory are increasingly those found in more southern areas of the West, according to a study from the University of California, Davis. "The plants we're finding underneath our forests are becoming more like those seen in Mexico and Southern California," said lead author Jens Stevens, a postdoctoral scholar with the UC Davis John Muir Institute of the Environment. "Under climate change, we're seeing species from drier, warmer areas increasingly taking over. ...