SAN ANTONIO (March 23, 2021) -- More than half of all health care workers worldwide are experiencing burnout that, if not addressed, could cause many to leave their fields in favor of less-stressful occupations or choose early retirement. And the COVID-19 pandemic has only made it worse. That's the warning of a surgeon from The University of Texas Health Science Center at San Antonio in a letter and a call for global action published March 22 in the Lancet journal EClinicalMedicine. "A recent survey done in Medscape of nearly 7,500 physicians globally showed that burnout has reached a very high rate," said END ...

By targeting an enzyme that plays a key role in head and neck cancer cells, researchers from the UCLA School of Dentistry were able to significantly slow the growth and spread of tumors in mice and enhance the effectiveness of an immunotherapy to which these types of cancers often become resistant. Their findings, END ...

Researchers have succeeded in revealing the arsenal used by protozoans of the genus Leishmania in human cells to make leishmaniasis more severe, especially in cases of the mucocutaneous variety of the disease, which can cause deformations in patients. The discovery points the way to a search for novel treatments for the disease as well as casting light on a key mechanism involved in other diseases. The mechanism involves Leishmania, macrophages and a virus that lives endosymbiotically in the parasite and is known as the Leishmania RNA virus (LRV). According to a study published in the journal iScience, the parasite inhibits activation of caspase-11 via LRV-induced autophagy. Caspases are a family of enzymes that ...

A pilot study from North Carolina State University and the University of North Carolina at Chapel Hill has found evidence of Bartonella infection in the blood of people with schizophrenia and schizoaffective disorder. "Researchers have been looking at the connection between bacterial infection and neuropsychiatric disease for some time," says Dr. Erin Lashnits, a former veterinary internist at NC State, current faculty member at the University of Wisconsin and first author of the study. "Specifically, there has been research suggesting that cat ownership is associated with schizophrenia ...

Concern over attractiveness to the opposite sex affects the masculine image of physics and mathematics only in England, while having a negative view of intellectual women is correlated with a masculine image of mathematics as a field only in Japan, according to a survey conducted in the two countries by a Japanese research group. This comparative study shows that programs to increase women's representation in these fields must take into account each country's social context surrounding gender roles. Why do so few women choose to study and work in STEM (science, technology, ...

Obsessive compulsive disorder (OCD) among those who have recently given birth is more common than previously thought, and much of this can be attributed to thoughts of harm related to the baby, new UBC research has found. The researchers also learned that OCD can go undetected when new parents aren't asked specifically about infant-related harm. OCD is an anxiety-related condition characterized by the recurrence of unwanted, intrusive and distressing thoughts. If left untreated, it can interfere with parenting, relationships and daily living. The study estimates that eight per cent of postpartum women report symptoms ...

ANN ARBOR, Mich., (March 23, 2021) Researchers are urging consumers to avoid using weight loss or sports supplements that list deterenol as an ingredient. Scientists at NSF International (NSF), Harvard Medical School and Cambridge Health Alliance recently tested 17 brands of supplements listing deterenol as an ingredient and found nine potentially harmful, experimental stimulants in the products. Researchers at the Netherlands' National Institute for Public Health and the Environment (RIVM) and Belgium's Sciensano also participated in the study. Supplements containing deterenol have not been approved for use in humans in the United States and have been linked to reports of adverse events, including nausea, vomiting, sweating, agitation, ...

Cold Spring Harbor Laboratory (CSHL) President and CEO Bruce Stillman has been dissecting DNA replication, a critical step in cell division, since the 1980s. His lab studies how Origin Recognition Complexes--ORCs--coordinate DNA duplication. They discovered how our cells assemble and disassemble ORCs during the cell division cycle. One ORC protein is sequestered into small liquid droplets, keeping it apart until the right time to recruit other proteins and initiate DNA replication. The ORC recognizes where to initiate replication at numerous locations along the long, linear stretches of DNA ...

Philadelphia, March 23, 2021 - During the COVID-19 pandemic, Joseph S. Alpert, MD, Editor-in-Chief of The American Journal of Medicine, published by Elsevier, has observed that although non-COVID inpatients suffered from the usual mix of conditions such as heart failure and chronic obstructive pulmonary disease exacerbations, the Internal Medicine inpatient population was distinctly different from what he had seen over the past decades. They were considerably sicker and closer to dying than in the past. Dr. Alpert has been working on the Internal Medicine, Cardiac Care Unit, and Cardiology consult services. "At ...

Have you ever wondered why you are able to hear a sentence and understand its meaning - given that the same words in a different order would have an entirely different meaning? New research involving neuroimaging and A.I., describes the complex network within the brain that comprehends the meaning of a spoken sentence. "It has been unclear whether the integration of this meaning is represented in a particular site in the brain, such as the anterior temporal lobes, or reflects a more network level operation that engages multiple brain regions," ...

Domestication has a consistent effect on the gut microbiota of animals and is similar to the effects of industrialisation in human populations, with ecological differences such as diet having a strong influence. These findings, published today in eLife, highlight how the flexibility of the gut microbiota can help animals respond to ecological change and could help identify ways of manipulating gut microbial communities in the service of health. Animals typically have complex communities of microbes living in their gut that can strongly influence functions such as immunity and metabolism. These communities ...

A new study co-authored by a Tulane University geoscientist shows that human efforts to tame the Mississippi River may have had an unintended positive effect: more rapid transport of carbon to the ocean. The paper, published in AGU Advances, describes the work of a team of researchers who set out to learn more about the fate of organic carbon that is transported in large quantities by the Mississippi River. Organic carbon is mainly derived from plant remains, soils, and rocks, throughout the drainage basin of the Mississippi River that covers about 40% of the United States. "We estimate that over the past century, the amount of organic carbon lost to the atmosphere during Mississippi River transport to the Gulf of Mexico ...

"Several countries, including the United Kingdom and Canada have stated that they will delay second doses of COVID-19 vaccines in response to supply shortages, but also in an attempt to rapidly increase the number of people immunized," explains Chadi Saad-Roy, a graduate student in the Departments of Ecology and Evolutionary Biology (EEB) and Quantitative and Computational Biology in the Lewis-Sigler Institute at Princeton and the lead author of the study. "The original clinical trials of the vaccines, plus subsequent epidemiology, are quite optimistic regarding the efficacy of the first dose. However, ...

Featured on the cover of the Soil Science Society of America Journal, researchers at the University of Maryland (UMD) and the Spanish National Research Council partnered to create a new camera allowing for the imaging of wetland soil activity in real time. This camera gives the classic IRIS (indicator of reduction in soils) technology a big upgrade. IRIS is used universally by researchers and soil assessors to determine if soils are behaving like wetland soils and should therefore be classified as such. However, before this new camera, soil assessors couldn't quantify the rate of iron reduction in saturated wetland soils, and ...

BOSTON - An analysis of sex differences in the genetics of schizophrenia, bipolar disorder and major depressive disorders indicates that while there is substantial genetic overlap between males and females, there are noticeable sex-dependent differences in how genes related to the central nervous system, immune system, and blood vessels affect people with these disorders. The findings, from a multinational consortium of psychiatric researchers including investigators and a senior author at Massachusetts General Hospital (MGH), could spur better treatments for major psychiatric disorders. They are published in the journal Biological Psychiatry. The findings were made possible only through the cooperation of more than 100 investigators and research groups, ...

A new technique that can trace which tissues and organs the DNA in our blood comes from has been reported today in the open-access eLife journal. The method, called GETMap, could be used in prenatal screening, to monitor organ transplant rejection, or test for cancers that are concealed in the body. "Analysis of circulating free DNA has been shown to be useful for screening for early asymptomatic cancers," explains first author Wanxia Gai, Postdoctoral Fellow at the Chinese University of Hong Kong, Hong Kong SAR, China. "As cancer-associated DNA changes are present in ...

In a letter to The New England Journal of Medicine, published online March 23, 2021, a group of investigators from University of California San Diego School of Medicine and the David Geffen School of Medicine at UCLA report COVID-19 infection rates for a cohort of health care workers previously vaccinated for the novel coronavirus. "Because of the compulsory daily symptom screening of health care personnel, patients, and visitors, and the high testing capacity at both UC San Diego Health and UCLA Health, we were able to identify symptomatic and asymptomatic infections among health care workers at our institutions," said co-author ...

Boulder, Colo., USA: When geobiology graduate student Katie Maloney trekked into the mountains of Canada's remote Yukon territory, she was hoping to find microscopic fossils of early life. Even with detailed field plans, the odds of finding just the right rocks were low. Far from leaving empty-handed, though, she hiked back out with some of the most significant fossils for the time period. Eukaryotic life (cells with a DNA-containing nucleus) evolved over two billion years ago, with photosynthetic algae dominating the playing field for hundreds of millions of years as oxygen accumulated in the Earth's atmosphere. Geobiologists think that algae evolved first in freshwater environments ...

Over the past decades, the increased use of chemicals in many areas led to environmental pollution - of water, soil and also wildlife. In addition to plant protection substances and human and veterinary medical drugs, rodenticides have had toxic effects on wildlife. A new scientific investigation from scientists of the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW), the Julius Kühn Institute (JKI) and the German Environment Agency (Umweltbundesamt - UBA) demonstrate that these substances are widely found in liver tissues of birds of prey from Germany. Anticoagulant rodenticides, commonly used to kill rodents in agriculture and forestry, were frequently detected, particularly in birds of prey close to or in urban environments. ...

DALLAS - March 23, 2021 - Vaccinating health care workers resulted in an immediate and notable reduction of positive COVID-19 cases among employees, reducing the number of required isolations and quarantines by more than 90 percent, according to data at UT Southwestern Medical Center published in the New England Journal of Medicine. Health care workers were among the first groups to be eligible for vaccination. "Real-world experience with SARS-CoV-2 vaccination at UT Southwestern demonstrated a marked reduction in the incidence of infections among our employees, preserving the workforce when it was most needed," notes Daniel K. Podolsky, M.D., president of UT Southwestern and senior author. During ...

ITHACA, N.Y. - New research from Mildred Warner, professor of city and regional planning at Cornell University, shows that state laws designed to hinder union activity and indulge corporate entities do not enhance economic productivity. "We find that where state policy is captured by corporate interests, this undermines inclusive growth," Warner said. "These interests see union and city power as a threat, which is why there are groups like the American Legislative Exchange Council, for example, focused on crafting state laws that erode labor protections and enhance corporate interests." The ...

California's restrictions on vehicle emissions have been so effective that in at least one urban area, Los Angeles, the most concerning source of dangerous aerosol pollution may well be trees and other green plants, according to a new study by University of California, Berkeley, chemists. Aerosols -- particles of hydrocarbons referred to as PM2.5 because they are smaller than 2.5 microns in diameter and easily lodge in the lungs -- are proven to cause cardiovascular and respiratory problems. As a result of strict vehicle emissions laws, organic aerosol levels have been significantly reduced throughout the United States, but the drop has been particularly dramatic ...

Understanding the evolution of the polar sea ice is not enough to study the effects of the climate change on marine ecosystems in Antarctic seafloors. It is also necessary to determine the intensity of phytoplankton local production during the Antarctic summer, as stated in a new study by a research team of the Faculty of Biology and the Biodiversity Research Institute (IRBio) of the University of Barcelona, published in the journal Marine Environmental Research. When the sea freezes in Antarctica Extremely low temperatures, strong ocean currents and the broad seasonal coverage of marine ice are factors that determine the features of the Antarctic marine ecosystems. IN particular, the seasonality ...

The rate of sea-level rise in the 20th century along much of the U.S. Atlantic coast was the fastest in 2,000 years, and southern New Jersey had the fastest rates, according to a Rutgers-led study. The global rise in sea-level from melting ice and warming oceans from 1900 to 2000 led to a rate that's more than twice the average for the years 0 to 1800 - the most significant change, according to the study in the journal Nature Communications. The study for the first time looked at the phenomena that contributed to sea-level change over 2,000 years at six sites along the coast (in Connecticut, New York City, New Jersey and North Carolina), using a sea-level budget. A budget enhances ...

Researchers at North Carolina State University have designed and demonstrated a new system that allows them to remotely monitor the behavior of freshwater mussels. The system could be used to alert researchers to the presence of toxic substances in aquatic ecosystems. "When mussels feed, they open their shells; but if there's something noxious in the water, they may immediately close their shells, all at once," says Jay Levine, co-author of a paper on the work and a professor of epidemiology at NC State. "Folks have been trying to find ways to measure how widely mussels or oysters open their shells off and on since the 1950s, but there have been a wide variety ...