While it has been reported that opioid overdose deaths have increased during the COVID-19 pandemic, a new study looking at data in Philadelphia showed that this hardship has been overwhelmingly suffered by Black individuals. Researchers from the Perelman School of Medicine at the University of Pennsylvania analyzed the period of time after the city's stay-at-home order was announced in 2020 and showed that, compared to the year before, the number of fatal overdoses suffered by Black individuals spiked by more than 50 percent. At the same time, the rate for white individuals actually fell by 31 percent over the same period. This research ...

PORTLAND, OR - A first-of-its-kind randomized clinical trial found that patients with pancreatic cancer didn't live any longer than expected after receiving pre-operative chemotherapy from either of the two standard regimens, according to trial results published in JAMA Oncology. While the trial findings did not show a direct patient benefit, they do show that it's possible to safely administer chemotherapy prior to pancreatic cancer surgery. They also pave the way for better treatment testing for this notorious killer. With no symptoms in the early stages, and few effective therapies, pancreatic cancer is the fourth-most deadly cancer type in the United ...

What The Study Did: This study monitored suicide-related internet search rates during the early stages of the COVID-19 pandemic in the United States and researchers report searches for suicide decreased during that time. Although this study cannot independently confirm that changes in search rates were caused by changes in population-level suicide rates, it showed that COVID-19 may have been inversely associated with population suicide trends between March and July 2020. Authors: John W. Ayers, Ph.D., M.A., of theUniversity of California San Diego, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.34261) Editor's ...

What The Study Did: Evidence of SARS-CoV-2 RNA in human corneas was examined in this study. Authors: Maria Casagrande, M.D., of the University Medical Center Hamburg-Eppendorf in Hamburg, Germany, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaophthalmol.2020.6339) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full article is linked to this news release. Embed ...

What The Study Did: Researchers assembled suicide death data for people 10 and older from January 2015 through May 2020 in this observational study and they report stable rates of suicide deaths during the COVID-19 stay-at-home advisory in Massachusetts, a finding that paralleles others following ecological disasters. Authors: Jeremy Samuel Faust, M.D., M.S., of Brigham and Women's Hospital and Harvard Medical School in Boston, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.34273) Editor's ...

What The Study Did: This study estimated the frequency of reported forgone medical care because of the COVID-19 pandemic from March to mid-July 2020, including missed doses of prescription medications, forgone preventive and other general medical care, mental health care and elective surgeries, as well as reasons for forgoing care. Authors: Kelly E. Anderson, M.P.P., of the Johns Hopkins Bloomberg School of Public Health in Baltimore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.34882) Editor's Note: The article includes conflict of interest and funding/support ...

What The Study Did: Associations of the COVID-19 pandemic with overdoses among racial/ethnic groups in Philadelphia are described in this observational study. Authors: Utsha G. Khatri, M.D., of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.34878) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full ...

What The Study Did: An increase in pediatric cases of alcohol-based hand sanitizer eye exposure was assessed in this study, which also described the severity of ocular lesions and their management. Authors: Gilles C. Martin, M.D., M.Sc., of theRothschild Foundation Hospital in Paris, is the corresponding author. To access the embargoed study:  Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaophthalmol.2020.6346) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and ...

What The Study Did: The cases of two children with eye injuries after unintentional contact between alcohol-based hand rubs and the eye are described in this observation. Authors: Sonam Yangzes, M.S., of the Grewal Eye Institute in Chandigarh, India, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaophthalmol.2020.6351) Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media ...

What The Study Did: Researchers demonstrate a technique of tracheostomy that minimizes aerosolization risks while creating a tight seal around the tracheostomy tube. Authors: Oluwafunmilola T. Okuyemi, M.D., M.S.C.I., of the University of Nevada, Las Vegas School of Medicine, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaoto.2020.4432) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...

What The Study Did: A large health insurance database in Taiwan was used to investigate whether obstructive sleep apnea is a risk factor in male infertility and if treatment for sleep apnea is associated with risk. Authors: Ping-Ying Chang, M.D., Ph.D., and Wu-Chien Chien, Ph.D., of the National Defense Medical Center in Taipei, Taiwan, are the corresponding authors. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.31846) Editor's Note: The article includes funding/support disclosures. Please see the article for additional ...

HOUSTON - (Jan. 21, 2021) - Where did Earth's nitrogen come from? Rice University scientists show one primordial source of the indispensable building block for life was close to home. The isotopic signatures of nitrogen in iron meteorites reveal that Earth likely gathered its nitrogen not only from the region beyond Jupiter's orbit but also from the dust in the inner protoplanetary disk. Nitrogen is a volatile element that, like carbon, hydrogen and oxygen, makes life on Earth possible. Knowing its source offers clues to not only how rocky planets formed in the inner part of ...

What The Study Did: This randomized clinical trial compares the effects of three doses of bamlanivimab monotherapy (700 vs 2,800 vs 7,000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus 2 viral load in patients with mild to moderate COVID-19. Authors: Daniel M. Skovronsky, M.D., Ph.D., of Eli Lilly and Company in Indianapolis, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.0202) Editor's Note: The articles includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, ...

A research team from the Institut national de la recherche scientifique (INRS) has joined forces with French researchers from the Institute of Chemistry and Processes for Energy, Environment and Health (ICPEES), a CNRS-University of Strasbourg joint research lab, to pave the way towards the production of green hydrogen. This international team has developed new sunlight-photosensitive-nanostructured electrodes. The results of their research were published in the November 2020 issue of the journal of Solar Energy Materials and Solar Cells. An Energy Transition Vector Hydrogen is being considered by several countries of the Organisation for Economic Co-operation and Development (OECD) as a key player in the transition towards decarbonized ...

CHICAGO (January 21, 2021): A multimodal pain regimen (MMPR) designed to minimize opioid exposure and relieve acute pain associated with traumatic injury kept patient self-reported pain scores low while also reducing the daily and total amount of opioid drugs given to trauma patients. Results from the first study of its kind to evaluate an MMPR in a rigorous, randomized controlled trial are published online as an "article in press" by the Journal of the American College of Surgeons in advance of print. "Opioids should not be considered the pillar of treatment for acute pain after injury," said lead study author John A. Harvin, MD, FACS, an associate professor for the department of surgery, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth) ...

What The Study Did: This JAMA Insights review provides clinical details of anaphylactic reactions reported to and verified by the Centers for Disease Control and Prevention in the first week of use of the Pfizer-BioNTech COVID-19 vaccine in the United States. Authors: Tom Shimabukuro, M.D., M.P.H., M.B.A., of the CDC in Atlanta, is the corresponding author. To access the embargoed study:  Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.0600) Editor's Note: Please see the article for additional information, including other authors, author ...

A new study from the Institut de Ciències del Mar (ICM-CSIC, Spain) and the National Oceanography Centre brings unprecedented insights into the environmental constraints and climatic events that controlled the formation of these reefs. The results of this research will help understand how cold-water coral reefs can react to the effects caused by the present-day climate change. Similar to tropical coral reefs, cold-water coral reefs are incredible hotspots of biodiversity, with the difference that they do not rely on symbiosis with microscopic algae, and therefore can be found in the dark and deep waters of our oceans. Despite their uniqueness and key functional role in the ocean, they are still partially ...

Breast cancer investigators in the Lambe Institute at NUI Galway have collaborated on a pivotal international study into breast cancer risk which was published in the New England Journal of Medicine today (Wednesday, 20 January). The results of the study have identified that there are nine specific genes associated with breast cancer risk. Contributing authors Professor Michael Kerin, Chair of Surgery at NUI Galway, Director of the Cancer Managed Clinical Academic Network for Saolta University Health Care Group, along with Dr Nicola Miller, Lecturer in NUI Galway's School of Medicine, have directed the Breast Cancer in Galway Genetics Study (BIGGS) since 2008. DNA samples, which have been collected from 2,000 Irish ...

Genetic inheritance affects the likelihood of developing breast cancer. Some genes are already known to increase cancer risk; other genes are suspected to be involved, but not to what extent. It is crucial to clarify this issue to improve prevention since it opens the way to more personalised follow-up and screening programs. A large international consortium, which includes the Spanish National Cancer Research Centre (CNIO), has studied 34 putative susceptibility genes on samples from 113,000 female breast cancer cases and controls, and its results confirm the importance ...

When university campuses sent students, staff and faculty members home in March, Padmini Rangamani, a professor at the University of California San Diego, suddenly found herself running her research lab remotely, teaching her classes online, and supervising her two children, ages 10 and 13, who are also learning online. To deal with the stress the situation created, Rangamani turned to a support network of fellow female faculty members around the United States. They chatted and texted and eventually decided to write a scholarly article with recommendations for all other female principal investigators in academia. The article, "Ten simple rules for women principal investigators during a pandemic," ...

Generating membranes using electrochemical polymerization, or electropolymerization, could provide a simple and cost-effective route to help various industries meet increasingly strict environmental regulations and reduce energy consumption. Researchers from KAUST have produced membranes with well-defined microscopic pores by electrochemically depositing organic conjugated polymers onto highly porous electrodes. These microporous membranes have numerous applications, ranging from organic solvent nanofiltration to selective molecular transport technologies. High-performance separation depends on membranes that are robust with well-ordered and dense microporous structures, such as zeolites and ...

Scientists from an international collaboration have found evidence of alpha particles at the surface of neutron-rich heavy nuclei, providing new insights into the structure of neutron stars, as well as the process of alpha decay. Neutron stars are amongst the most mysterious objects in our universe. They contain extremely dense matter that is radically different from the ordinary matter surrounding us--being composed almost entirely of neutrons rather than atoms. However, in the nucleus at the center of normal atoms, matter exists at similar densities. "Understanding the nature of matter at such extremes is important for our understanding of neutron stars, as well as the beginning, ...

COVID-19 has been spreading rapidly over the past several months, and the U.S. death toll has now reached 400,000. As evident from the age distribution of those fatalities, COVID-19 is dangerous not only for the elderly but for middle-aged adults, according to a Dartmouth-led study published in the European Journal of Epidemiology. "For a person who is middle-aged, the risk of dying from COVID-19 is about 100 times greater than dying from an automobile accident," explains lead author Andrew Levin, a professor of economics at Dartmouth College. "Generally speaking, very few children and young adults die of COVID-19. However, the risk is progressively greater for middle-aged and older adults. The odds that ...

The bipolar membrane, a type of ion exchange membrane, is considered the pivotal material for zero emission technology. It is composed of an anode and cathode membrane layer, and an intermediate hydrolysis layer. Under reverse bias, the water molecules in the intermediate layer produce OH- and H+ by polarization. Large-scale production of the membrane is hindered by the different expansion coefficients of the anode and cathode layers, causing the two layers easy to delaminate. Besides, the mostly used intermediate catalysts are small molecules or transition, which are instable and inefficient. In a study published on Nature Communications, a team led by ...

BOSTON - Regular aspirin use has clear benefits in reducing colorectal cancer incidence among middle-aged adults, but also comes with some risk, such as gastrointestinal bleeding. And when should adults start taking regular aspirin and for how long? There is substantial evidence that a daily aspirin can reduce risk of colorectal cancer in adults up to age 70. But until now there was little evidence about whether older adults should start taking aspirin. A team of scientists set out to study this question. They were led by Andrew T. Chan MD, MPH, a gastroenterologist and chief of the Clinical and Translational Epidemiology Unit at Massachusetts General Hospital (MGH). Their report appears in JAMA Oncology. The researchers ...