Just over 200,000 Americans suffer from systemic lupus erythematosus, or SLE, a condition in which the body's immune system mistakenly attacks its own healthy tissues, especially joints and skin, a new study shows. Led by a researcher at NYU Grossman School of the Medicine, the study provides the first national estimate of how widespread the autoimmune disease is since the U.S. Centers for Disease Control and Prevention (CDC) set up a half dozen state registries to track the illness more than a decade ago. SLE affects mostly women, can be fatal, and often involves debilitating flare-ups of fatigue and pain that keep nearly ...

PHILADELPHIA--Patients with inactive cancer and not currently undergoing treatments also face a significantly higher risk of severe illness from COVID-19, a new study from Penn Medicine published online today in JNCI Cancer Spectrum shows. Past reports have established an increased risk of severe disease and death for sick or hospitalized cancer patients with COVID-19 compared to patients without cancer, but less is known about patients in the general population. The findings underscore the importance of COVID-19 mitigation, like social distancing and mask wearing, and vaccinations for all patients, not just those recently diagnosed or with active disease. "Patients who have cancer need to be careful ...

New research has shown that people are more likely to follow Covid-19 restrictions based on what their friends do, rather than their own principles. Research led by the University of Nottingham carried out in partnership with experts in collective behaviour from British, French, German and American universities shows how social influence affects people's adherance to government restrictions. The researchers found that the best predictor of people's compliance to the rules was how much their close circle complied with the rules, which had an even stronger effect than people's own approval of the rules. The research published in British Journal of Psychology highlights a blindspot in policy responses ...

The US prevalence of the autoimmune disease lupus is 72.8 cases per 100,000 individuals, according to an analysis of population-based registries. The analysis, which is published in END ...

Where people die can affect the quality of their deaths and the end-of-life care that they receive. A study published in the END ...

Pharmacists play an important role in managing medication-based therapies for older community-dwelling patients, according to a study published in the END ...

Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on *PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pains. *Prostate-Specific Antigen (PSA): a prostate-specific antigen (a cancer factor) used as an index for the screening of prostate cancer. The Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique ...

Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers. According to the World Health Organisation, antibiotic resistance is one of the greatest threats to global health, food safety and development. It already causes over 33,000 deaths a year in Europe alone. Completely ...

Since 1997 (Reno vs. American Civil Liberties Union), the Supreme Court has used the metaphor of the free market of ideas to define the Internet, thus addressing the regulation of the net as a matter of freedom of speech. In law, metaphors have a constitutive value and, once established, affect the debate and the decisions of the Courts for a long time. In the paper 'Judicial Frames and Fundamental Right in Cyberspace', published in the American Journal of Comparative Law, Oreste Pollicino (Bocconi University) and Alessandro Morelli (Università Magna Graecia, Catanzaro) apply to judicial reasoning reflections on metaphors and go so far as to criticize, on the one hand, the US Supreme Court's orientations on (non-)regulation of the Internet and, on the other, to invoke changes ...

In the first systematic large-scale evaluation of the UK National Early Warning Risk Score (NEWS) 2 as a scoring system for predicting severe COVID-19 outcomes in patients, researchers at King's College London have found poor-to-moderate accuracy for identifying patients at risk of being transferred to intensive care units (ICUs) or dying after 14 days of hospitalisation. Accuracy of predictions in short term (three days) showed moderate success. For people who are hospitalised with severe COVID-19, it is vital to quickly identify which patients may deteriorate and require transfer to an intensive care unit (ICU) for organ support or may die. NEWS2 is an ...

Researchers from the University of Cambridge have discovered a fossil of the earliest starfish-like animal, which helps us understand the origins of the nimble-armed creature. The prototype starfish, which has features in common with both sea lilies and modern-day starfish, is a missing link for scientists trying to piece together its early evolutionary history. The exceptionally preserved fossil, named Cantabrigiaster fezouataensis, was discovered in Morroco's Anti-Atlas mountain range. Its intricate design - with feathery arms akin to a lacework - has been frozen in time for roughly 480 million years. The new species is unusual because it doesn't have many of the key features of its contemporary relatives, lacking roughly 60% of ...

Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm. Back pain and knee osteoarthritis affect millions of people globally and are leading causes of disability. When first-line pain medications such as paracetamol and ibuprofen fail to improve symptoms, many people are prescribed antidepressants for their pain. Most clinical practice guidelines recommend antidepressants for long term (chronic) back pain and hip and knee osteoarthritis, yet evidence supporting their use is uncertain. Published today in the BMJ the ...

Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence published by The BMJ today. The findings, based on moderate certainty evidence, show that for people with back pain the effects were too small to be worthwhile, but for osteoarthritis a small beneficial effect cannot be ruled out. Most clinical practice guidelines recommend antidepressants for long term (chronic) back pain and hip and knee osteoarthritis, yet evidence supporting their use is uncertain. To address this knowledge gap, researchers led by Giovanni Ferreira at the ...

Adding the arthritis drug tocilizumab to standard care for patients in hospital with severe or critical covid-19 is no better than standard care alone in improving clinical outcomes at 15 days, finds a new trial published by The BMJ today. There was an increased number of deaths at 15 days in patients receiving tocilizumab, resulting in the trial being stopped early. Today's results contradict earlier observational studies suggesting a benefit of tocilizumab. However, observational effects are limited by a high risk that they may be due to other unknown (confounding) factors - and some studies have not yet been peer ...

MINNEAPOLIS - A new study has found a brain pressure disorder called idiopathic intracranial hypertension is on the rise, and the increase corresponds with rising obesity rates. The study is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that for women, socioeconomic factors like income, education and housing may play a role in their risk. Idiopathic intracranial hypertension is when the pressure in the fluid surrounding the brain rises. It can mimic the symptoms of a ...

MINNEAPOLIS - A new study shows that intense immunosuppression followed by a hematopoietic stem cell transplant may prevent disability associated with multiple sclerosis (MS) from getting worse in 71% of people with relapsing-remitting MS for up to 10 years after the treatment. The research is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that in some people their disability improved over 10 years after treatment. Additionally, more than half of the people with the secondary progressive form of MS experienced no worsening of their symptoms 10 years after a transplant. While most people with MS are first diagnosed with relapsing-remitting MS, marked by symptom ...

The new tech elite share distinct views setting them apart from other segments of the world's elite more generally, according to a study published January 20, 2020 in the open-access journal PLOS ONE by Hilke Brockmann from Jacobs University Bremen, Germany, and colleagues. The global economic landscape over the last half-century is marked by a shift to a high-tech economy, dominated by the "Big Nine" (Amazon, Apple, Facebook, Google, IBM, Microsoft, Alibaba, Baidu, Huawei, and Tencent), computer hardware and software manufacturers, and most recently, app companies. In this study, Brockmann and colleagues investigate the worldviews of the 100 richest people in the tech world (as defined by Forbes). Though the authors initially approached all 100 of their subjects for a face-to-face ...

In the Early Bronze Age of Europe, ancient people used bronze objects as an early form of money, even going so far as to standardize the shape and weight of their currency, according to a study published January 20, 2020 in the open-access journal PLOS ONE by Maikel H. G. Kuijpers and C?t?lin N. Popa of Leiden University, Netherlands. Money is an important feature of modern human society. One key feature of money is standardization, but this can be difficult to identify in the archaeological record since ancient people had inexact forms of measurement compared with today. In this study, the authors assessed possible money from the Early Bronze Age of Central Europe, comparing the objects based on their perceived - if not ...

The onset date of the yearly rainy season reliably predicts if seasonal drought will occur in parts of Sub-Saharan Africa that are particularly vulnerable to food insecurity, and could help to mitigate its effects. Shraddhanand Shukla and colleagues at the University of California, Santa Barbara's Climate Hazards Center, present these findings in the open-access journal PLOS ONE on January 20, 2021. Climate-driven seasonal drought can impact crop yields and is among major contributors to food insecurity, which can threaten people's lives and livelihoods. In the last ...

There may be over 34,000 street cattle in the Indian city of Raipur (one for every 54 human residents), with implications for road accidents and human-cattle conflict. INFORMATION: Article Title: A population estimation study reveals a staggeringly high number of cattle on the streets of urban Raipur in India Funding: The author(s) did not receive any specific funding for this work. However, this work is a part of the Doctor of Philosophy thesis of one of the authors, BKS, who is getting a Junior Research Fellowship under the scheme CSIR-UGC NET for JRF [Sr. No. 2121530765. ...

Fixed dose combinations of antibiotics are consumed in huge quantities globally, but 80 percent of combinations are not on the WHO Essential Medicines List, and 92 percent are not FDA-approved, - with inappropriate combinations risking inefficacy, toxicity, and selection for antimicrobial resistance INFORMATION: Article Title: High global consumption of potentially inappropriate fixed dose combination antibiotics: Analysis of data from 75 countries Funding: We received no specific funding for this work. Competing Interests: The authors have declared that no competing interests exist. Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0241899 ...

Daddies' girls? Female Bengalese finches prefer their father's song to that of other birds throughout their lives - while sons lose this preference as they grow up. INFORMATION: Article Title: Sex differences in the development and expression of a preference for familiar vocal signals in songbirds Funding: This work was supported by MEXT/JSPS KAKENHI Grant, Numbers 17H06380 to KO & 17J07023 to TGF. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (https://www.jsps.go.jp/index.html) Competing Interests: The authors have declared ...

Boston, Mass. -- Renal cell carcinoma (RCC) is the most common form of cancer of the kidney. In 2018, there were an estimated 403,000 new cases of RCC and 175,000 deaths due to kidney cancer worldwide. Currently, the 5-year survival rate for patients with metastatic RCC is only about 12 percent. Current treatments include inhibitors of the VEGF and PD-1 pathways. However, resistance to therapy occurs in most patients and new combination treatments are still needed to enhance the efficacy of these current approaches. Now, investigators have demonstrated that ACE2 expression is a good prognostic factor in RCC, that loss ...

Catnip and silver vine have been known as cat attractant plants. Cat lovers use dry leaves of these plants and toys stuffed with the leaves to give joy to their pet cats. But how does this work? What is the biological significance of the responsive behavior? A research group at Iwate University, Nagoya University, Kyoto University, and University of Liverpool found that the behavior had more practical reasons than getting euphoria. "The first appearance of silver vine ("Matatabi" in Japanese) as a cat attractant in literature in Japan dates back to more than 300 years ago. A folklore Ukiyo-e drawn in 1859 shows a group of mice trying to tempt some ...

Scientists at the University of Southampton and University of Edinburgh have developed a flexible underwater robot that can propel itself through water in the same style as nature's most efficient swimmer - the Aurelia aurita jellyfish. The findings, published in Science Robotics, demonstrate that the new underwater robot can swim as quickly and efficiently as the squid and jellyfish which inspired its design, potentially unlocking new possibilities for underwater exploration with its lightweight design and soft exterior. Co-author Dr Francesco Giorgio-Serchi, ...