Quantitative real-time polymerase chain reaction (qPCR) is the most widely used diagnostic method to detect RNA viruses such as SARS-CoV-2. However, it requires expensive laboratory equipment and global shortages of reagents for RNA purification has increased the need to find simple but reliable alternatives. One alternative to the qPCR technology is RT-LAMP (reverse transcription loop-mediated isothermal amplification). This test amplifies the desired target sequences of the virus at a constant temperature, using minimal equipment compared to qPCR. In 2020, it was adapted to the detection of SARS-CoV-2. It was also shown that instead of a swab, which many people find unpleasant, it can be performed on gargle lavage samples. First author Lukas Bokelmann and colleagues have now ...

Researchers from the Pan African Programme: The Cultured Chimpanzee (PanAf) at the Max Planck Institute for Evolutionary Anthropology (MPI-EVA) and a team of international researchers, collected over 5000 fecal samples from 55 sites in 18 countries across the chimpanzee range over 8 years. This is by far the most complete sampling of the species to date, with a known location of origin for every sample, thus addressing the sampling limitations of previous studies. "Collecting these samples was often a daunting task for our amazing field teams. The chimpanzees were almost all unhabituated to human presence, so it took a lot of patience, skill and luck to find chimpanzee dung at each of the sites," explains ...

Researchers have developed a new quantum version of a 150-year-old thermodynamical thought experiment that could pave the way for the development of quantum heat engines. Mathematicians from the University of Nottingham have applied new quantum theory to the Gibbs paradox and demonstrated a fundamental difference in the roles of information and control between classical and quantum thermodynamics. Their research has been published today in Nature Communications. The classical Gibbs paradox led to crucial insights for the development of early thermodynamics and emphasises the need to consider an experimenter's ...

DUBLIN, Friday, 5 March 2021: RCSI researchers have discovered a new way to 'put the brakes' on excessive inflammation by regulating a type of white blood cell that is critical for our immune system. The discovery has the potential to protect the body from unchecked damage caused by inflammatory diseases. The paper, led by researchers at RCSI University of Medicine and Health Sciences, is published in Nature Communications. When immune cells (white blood cells) in our body called macrophages are exposed to potent infectious agents, powerful inflammatory proteins ...

New York, NY (March 5, 2021) - Overweight children who were exposed to lead in utero and during their first weeks of life have the potential for poorer kidney function in adulthood, according to an Icahn School of Medicine at Mount Sinai study published in Environment International in March. The study found that children with high body mass indexes who had been exposed to lead had lower estimated glomerular filtration rate (eGFR), a measure of how well the kidneys are filtering or cleaning the blood. The researchers measured blood levels during mothers' pregnancy and later measured eGFR levels in the children when they were between 8 and 12 years old. Decreased ...

Researchers have succeeded in making an AI understand our subjective notions of what makes faces attractive. The device demonstrated this knowledge by its ability to create new portraits on its own that were tailored to be found personally attractive to individuals. The results can be utilised, for example, in modelling preferences and decision-making as well as potentially identifying unconscious attitudes. Researchers at the University of Helsinki and University of Copenhagen investigated whether a computer would be able to identify the facial features we consider attractive and, based on this, create new images matching our criteria. The researchers used artificial intelligence to interpret brain signals and combined the resulting brain-computer interface with a ...

Researchers from University of Houston and University of Bochum published a new paper in the Journal of Marketing that examines how variable compensation plans for salespeople can lead to lower health. The study, forthcoming in the Journal of Marketing, is titled "Variable Compensation and Salesperson Health" and is authored by Johannes Habel, Sascha Alavi, and Kim Linsenmayer. Sales compensation plans typically comprise a variable component. Variable compensation is issued on top of a base salary and the amount is contingent on performance. For example, a salesperson with an annual target salary ...

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) shows that regular physical activity is a safe diabetes prevention strategy for people residing in relatively polluted regions. The study, which is the first to investigate the combined effects of physical activity and pollution exposure on type 2 diabetes risk, is by Dr Cui Guo and Professor Lao Xiang Qian, Faculty of Medicine at the Chinese University of Hong Kong, Hong Kong SAR, China, and Dr Hsiao Ting Yang, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands, and colleagues. An increasing body of evidence has shown that air pollution ...

A series of weekend workshops that integrate strategies for both reducing risky alcohol use and preventing sexually transmitted infections (STIs) led to an increase in safe sex and decrease in drinking among young Black women, according to a new study published in the American Journal of Preventive Medicine. "By designing an intervention that didn't treat sex and alcohol use as two separate risk factors, young women were empowered to make healthier decisions and better communicate with their partners," said Ralph DiClemente, professor and chair of the Department of Social and Behavioral Sciences at NYU School of Global Public Health and the study's lead author. "This groundbreaking study illustrates ...

Columbia researchers engineer first technique to exploit the tunable symmetry of 2D materials for nonlinear optical applications, including laser, optical spectroscopy, imaging, and metrology systems, as well as next-generation optical quantum information processing and computing. New York, NY--March 4, 2021--Nonlinear optics, a study of how light interacts with matter, is critical to many photonic applications, from the green laser pointers we're all familiar with to intense broadband (white) light sources for quantum photonics that enable optical quantum computing, super-resolution imaging, optical sensing and ranging, and more. Through nonlinear optics, researchers are discovering new ways to use light, from getting a closer look at ultrafast processes in physics, ...

A new study reveals that a precarious, unstable initiation by young people to working life is associated with poorer future mental health. The study was conducted by researchers from the Center for Research in Occupational Health (CISAL, a joint group of UPF and the Hospital del Mar Medical Research Institute) in Barcelona, Spain. Amaya Ayala-Garcia, Laura Serra and Mònica Ubalde-López are the authors of the study, which has been published in the journal BMJ Open. Since the 1990s, Spain has been among the European countries with the lowest employment rates, which are accentuated in the young active population. Moreover, in 2017, Spain ...

March 4, 2021 -- Pandemic-related anxiety, boredom, and irregular routines were cited as major drivers of increased nicotine and tobacco use during the initial COVID-19 "lockdown," according to research just released by Columbia University's Mailman School of Public Health. The study highlights ways that public health interventions and policies can better support quit attempts and harm reduction, both during the COVID-19 pandemic and beyond. The findings are published in the International Journal of Drug Policy. Between April-May 2020, the researchers conducted ...

CLEVELAND (March 5, 2021)--An international team of bioethicists and scientists, led by a researcher at Case Western Reserve University, contends it may be justified to go beyond the standing 14-day limit that restricts how long researchers can study human embryos in a dish. Going beyond this policy limit could lead to potential health and fertility benefits, and the authors provide a process for doing so. In an article published March 5 in Science, Insoo Hyun, a bioethics professor at the Case Western Reserve University School of Medicine and the paper's lead author, and colleagues urge policymakers and the International Society for Stem Cell Research (ISSCR) to consider "a cautious, stepwise approach" to scientific exploration beyond the 14-day limit. "But first," ...

Did you daydream as a kid, maybe even get in trouble for it? If you find it harder to be pleasantly lost in your thoughts these days, you're not alone. "This is part of our cognitive toolkit that's underdeveloped, and it's kind of sad," said Erin Westgate, Ph.D., a University of Florida psychology professor. The ability to think for pleasure is important, and you can get better at it, Westgate says. The first step is recognizing that while it might look easy, daydreaming is surprisingly demanding. "You have to be the actor, director, screenwriter and audience of a mental performance," she said. "Even though it looks like you're doing nothing, it's cognitively ...

ITHACA, N.Y. - Close friends are important drivers of adolescent behavior, including college attendance, according to Steven Alvarado, assistant professor of sociology in the College of Arts and Sciences. In new research published March 4 in American Educational Research Journal, Alvarado reports that having college-bound friends increases the likelihood that a student will enroll in college. However, the effect of having college-bound friends is diminished for Black and Latino students compared with white and Asian students, especially for males and especially for selective and highly selective colleges, due to structural ...

Ever get stuck trying to solve a puzzle? You look for a pattern, or a rule, and you just can't spot it. So you back up and start over. That's your brain recognizing that your current strategy isn't working, and that you need a new way to solve the problem, according to new research from the University of Washington. With the help of about 200 puzzle-takers, a computer model and functional MRI (fMRI) images, researchers have learned more about the processes of reasoning and decision-making, pinpointing the brain pathway that springs into action when problem-solving ...

A newly discovered planet could be our best chance yet of studying rocky planet atmospheres outside the solar system, a new international study involving UNSW Sydney shows. The planet, called Gliese 486b (pronounced Glee-seh), is a 'super-Earth': that is, a rocky planet bigger than Earth but smaller than ice giants like Neptune and Uranus. It orbits a red dwarf star around 26 light-years away, making it a close neighbour - galactically speaking. With a piping-hot surface temperature of 430 degrees Celsius, Gliese 486b is too hot to support ...

COLUMBUS, Ohio - For Black girls in the juvenile justice system, attention from a caregiver might amount to too much of a bad thing, a recent study suggests. Though parental attentiveness would generally be considered beneficial to troubled youths, the finding hints at the possibility that a history of trauma in a household's adults may filter down to younger generations, researchers say. The study, examining how family and peer social support influenced post-traumatic stress disorder (PTSD) symptoms in Black girls who were in detention, found that lower self-esteem, less optimism about the future and higher negative behaviors by peers were associated with greater PTSD symptoms in these girls. But one more factor also correlated with those symptoms: a higher level of caregiver support. "This ...

ARLINGTON HEIGHTS, IL (March 4, 2021) - Many new mothers with infants want very much to breastfeed as it is the gold standard for early nutrition. What to do when you find out your young child has a food allergy, and you are breastfeeding? A new study in Annals of Allergy, Asthma and Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI), found that more than 28% of the women were given no guidance on whether they could eat the same food their breastfeeding child was allergic to. "We found that guidance from healthcare practitioners for breastfeeding mothers in this situation ...

AMES, Iowa - Wind turbine blades spinning through cold, wet conditions can collect ice nearly a foot thick on the yard-wide tips of their blades. That disrupts blade aerodynamics. That disrupts the balance of the entire turbine. And that can disrupt energy production by up to 80 percent, according to a recently published field study led by Hui Hu, Iowa State University's Martin C. Jischke Professor in Aerospace Engineering and director of the university's Aircraft Icing Physics and Anti-/De-icing Technology Laboratory. Hu has been doing laboratory studies of turbine-blade icing for about 10 years, including performing experiments ...

HOUSTON - (March 4, 2021) - Federal and state governments auction leases to oil and gas companies to extract natural resources from public land. A revamp of the auction system -- utilizing a new model developed by a Rice University economist -- could lead to more competitive bids and, ultimately, more money for governments. Yunmi Kong, an assistant professor of economics at Rice and the study's author, discussed her model in "Sequential Auctions with Synergy and Affiliation Across Auctions." The article appeared in the January 2021 edition of the Journal of Political Economy. "Much of the oil- and gas-producing ...

Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy. All bacterial cells contain topoisomerases, an important group of enzymes that help deal with spatial difficulties stemming from bacterial cell division associated with circular DNA replication. Topoisomerases can be of two types, I and II, depending on breaks they produce in DNA (one strand or double strand). Type II often acts as a target for antibiotics, including fluoroquinolones (FQ), a common group of antibiotics that comprises levofloxacin, ciprofloxacin, and others. Unfortunately, bacteria easily acquire resistance to ...

Managing single risk factors like blood pressure rather than looking at overall risk may be wasting scarce resources in countries where cardiovascular disease (CVD) is on the rise, according to a new study. Researchers looked at country-specific levels of cardiovascular risk, associations with socio-demographic factors and whether WHO guidelines on the use of blood pressure medication were being followed across 45 low-income and middle-income countries (LMICs). They found a higher risk of CVD in lower educated and non-employed people, an overuse of medicines in people at lower levels of CVD risk and an underuse of medicines in people at higher risk across ...

Western butterfly populations are declining at an estimated rate of 1.6% per year, according to a new report to be published this week in Science. The report looks at more than 450 butterfly species, including the western monarch, whose latest population count revealed a 99.9% decline since the 1980s. "The monarch population that winters along the West Coast plummeted from several hundred thousand just a few years ago to fewer than 2,000 this past year," said Katy Prudic, an assistant professor of citizen and data science in the University of Arizona School of Natural Resources and the Environment and a co-author of the report. "Essentially, the western monarch is on the brink of extinction, but what's most unsettling is they are situated in the middle of the pack, so to speak, ...

How best to evaluate the performance of a group testing strategy for the SARS-CoV-2 virus, which involves pooling samples from multiple individuals in order to conduct a single RT-PCR test on the whole group? To do precisely that, scientists from the CNRS, l'université Grenoble Alpes, and l'université Sorbonne Paris Nord1 have developed a model that evaluates the efficiency of such tests. Their theoretical study accounts for both dilution effect and the detection limits of the RT-PCR test, in an effort to assess the number of potential false negatives based on pooled sample size, to optimize group size thereby minimizing epidemic risk, and finally to more accurately determine ...