Following a competitive review process, the National Institutes of Health (NIH) funding for Pennington Biomedical’s Metabolic Basis of Disease Center of Biomedical Research Excellence (COBRE) was renewed for an additional five years. This Phase II renewal builds on the momentum achieved since the center’s establishment in 2020, enabling continued support for young scientists who are focused on the mechanisms through which nutrition and metabolism contribute to health. “The renewal of this center grant provides Pennington Biomedical with the opportunity to continue a metabolic ...

New research from Rice University suggests that the giant planet Jupiter reshaped the early solar system in dramatic ways, carving out rings and gaps that ultimately explain one of the longest-standing puzzles in planetary science: why many primitive meteorites formed millions of years after the first solid bodies. The study, which combined hydrodynamic models of Jupiter’s growth with simulations of dust evolution and planet formation, was recently published in Science Advances. Through state-of-the-art computer simulations, planetary scientists André Izidoro and Baibhav Srivastava found that Jupiter’s rapid ...

Cancer remains one of the greatest health concerns in the U.S., but University of Louisville cancer researchers and UofL Health – Brown Cancer Center oncologists are improving outcomes for patients in Kentucky and beyond. UofL’s Center for Cancer Immunology and Immunotherapy (CCII), established in 2020, has been at the forefront of exciting developments in immunotherapy, using the patients’ own immune system to defeat cancer. That work will continue and expand at UofL thanks to $11.5 million in new funding from the National Institutes of Health. The funding ...

A new study from University of California San Diego has found that, while a third of Californians use cannabis regularly, there are significant gaps in knowledge around cannabis use and driving. The researchers found that even six years after the legalization of recreational cannabis use, adults in California demonstrate mixed awareness and knowledge of driving-related laws and regulations. The study results, published in BMC Public Health, come from a large-scale survey of cannabis use in California, titled Impact 64, which was funded by the California ...

EMBARGOED FOR RELEASE UNTIL 4:00 P.M. ET, WEDNESDAY, OCTOBER 22, 2025 Highlights: A new study finds that having both gum disease and cavities is linked to an 86% increased risk of stroke compared to having a healthy mouth. Poor oral health was tied to a 36% higher risk of heart attacks and other cardiovascular events. People with regular dental visits were 81% less likely to have both gum disease and cavities. Researchers say improving oral health could be an important — and often overlooked — way to help reduce stroke risk. MINNEAPOLIS – People with both cavities and gum disease may face a higher risk of ischemic stroke, according to a study ...

EMBARGOED FOR RELEASE UNTIL 4:00 P.M. ET, WEDNESDAY, OCTOBER 22, 2025. MINNEAPOLIS – Adults with gum disease may be more likely to have signs of damage to the brain’s white matter, called white matter hyperintensities, than people without gum disease, according to a new study published on October 22, 2025, in Neurology® Open Access, an official journal of the American Academy of Neurology. White matter refers to nerve fibers that help different parts of the brain communicate. Damage to this tissue can affect memory, thinking, balance and coordination and has been linked to higher stroke risk. White matter hyperintensities are bright spots that appear on ...

Brian Cleary is an assistant professor in the Faculty of Computing & Data Sciences (CDS) and a core faculty member in the Bioinformatics Program. Brian also holds appointments in the Biology and Biomedical Engineering departments, and the Biological Design Center (BDC) at the Rajen Kilachand Center for Integrated Life Sciences & Engineering.  Cleary is the sole principal investigator (PI) on the five-year project, “Measuring and modeling gene expression trajectories: new computational-experimental approaches.”   The research aims to deepen understanding of how gene expression changes ...

DNA within dried feces dating from more than 1,000 years ago provides valuable insights into the pathogens that plagued ancient Mexican peoples, according to a study published October 22, 2025 in the open-access journal PLOS One by Drew Capone of Indiana University, U.S., and colleagues. Ancient feces are a valuable source of information on the intestinal parasites of past populations. Microbial DNA is known to survive in stool samples, but analysis of ancient feces has historically been limited ...

Nearly one-third of people with type 2 diabetes (T2D) in an Indian cohort achieved remission through an intensive lifestyle intervention program, according to a new study publishing October 22, 2025, in the open-access journal PLOS One by Pramod Tripathi of Freedom from Diabetes Clinic & Diabetes Research Foundation, India, and colleagues. Type 2 diabetes affects more than 72 million people in India. While lifestyle interventions have shown promise for diabetes management in Western populations, limited data exists on their effectiveness in India, where genetic and lifestyle factors place the population at higher risk. In the new study, researchers analyzed data ...

Idiopathic hypersomnia is a rare disease of excessive sleepiness, with patients revealing they never feel rested or awake no matter how much sleep they get, in analysis of online posts Article URL: http://plos.io/3KIF6W5 Article title: The experience and impact of living with idiopathic hypersomnia: A qualitative study of patient perspectives shared in online media Author countries: U.S., Germany, Canada Funding: This study was funded by Takeda Pharmaceuticals USA. END ...

Backyard birders in South Africa may continue to enjoy biodiversity in visiting birds under climate change scenarios, while climate change and declining biodiversity may decrease birding in protected public parks. Article URL: https://plos.io/4ol2UxW Article Title: Climate change impacts the non-market value of nature: A case study of birding cultural ecosystem services in South Africa Author Countries: United States Funding: This work was supported by the Ridge to Reef NSF Research Traineeship, Award DGE-1735040 to ...

Researchers led by investigators at Mass General Brigham and Massachusetts Institute of Technology have validated an ingestible capsule in preclinical models for the diagnosis of acute mesenteric ischemia, a condition caused by blocked or reduced blood flow to the intestines. The research is published in Science Robotics. Acute mesenteric ischemia accounts for less than 1.5% of emergency department visits for abdominal pain but has a mortality rate of 55%, due in part to how difficult it can be to diagnose the condition early. “Acute mesenteric ischemia is a potentially deadly but often underdiagnosed ...

Study found which abnormal cells talk to each other in harmful ways and perpetuate lung damage Scientists are already exploring therapeutic strategies based on this study’s discoveries Treatments also could help patients with other lung-scarring diseases (COPD, COVID-19, etc.) CHICAGO --- More than 50% of lung-transplant recipients experience a rejection of their new lung within five years of receiving it, yet the reason why this is such a prevalent complication has remained a medical mystery.  Now, a new Northwestern Medicine study has found that, following transplant and in chronic disease states, abnormal cells emerge and “conversations” ...

Very early on in our universe, when it was a seething hot cauldron of energy, particles made of matter and antimatter bubbled into existence in equal proportions. For example, negatively charged electrons were created in the same numbers as their antimatter siblings, positively charged positrons. When the two particles combined, they canceled each other out.  Billions of years later, our world is dominated by matter. Somehow matter "won out" over antimatter, but scientists still do not know how. Now, two of the largest experiments attempting to find answers—projects that focus on subatomic particles called neutrinos—have joined forces.  In a ...

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS—approximately 2,600—also have congenital heart defects (CHDs). What is not known is exactly why the genes on too many copies of chromosome 21 wreak such devastating effects. In a new paper published in the journal Nature, a team of scientists, including first and co-corresponding author  Sanjeev S. Ranade, PhD, assistant professor in the Center for Cardiovascular and Muscular Diseases and Center for Data Science and Artificial Intelligence at Sanford Burnham Prebys, identify a nuclear ...

About The Study: In this cohort study of more than 1,900 patients in randomized clinical trials (RCTs) for advanced epithelial ovarian cancer, Black and Asian patients were underrepresented compared with the general population estimates in the U.S., and Black patients had worse survival outcomes compared with white and Asian patients, despite having similar progression-free survival. Equitable enrollment in clinical trials ensures access to cutting-edge treatments and can lead to outcomes comparable to those of white counterparts. Sustained efforts to improve RCT diversity remain essential to long-term equity in cancer care and survival.  Corresponding ...

About The Study: In this large national cohort, all adverse pregnancy outcomes except small for gestational age were associated with increased risk for atrial fibrillation up to 46 years later. Women with adverse pregnancy outcomes need early preventive actions and long-term clinical follow-up for timely detection and treatment of cardiovascular disorders related to the development of atrial fibrillation. Corresponding Author: To contact the corresponding author, Casey Crump, MD, PhD, email casey.crump@uth.tmc.edu. To access ...

When harmful bacteria that cause food poisoning, such as E. coli, invade through the digestive tract, gut cells usually fight back by pushing infected cells out of the body to stop the infection from spreading. In a new study published today in Nature, scientists from Genentech, a member of the Roche Group, in collaboration with researchers from Oregon Health & Science University, discovered that a dangerous strain of E. coli — known for causing bloody diarrhea — can block gut this defense, allowing ...

Findings from a randomised and blinded clinical trial investigating repeated ketamine infusions for treating depression have revealed no extra benefit for ketamine when added onto standard care for people admitted to hospital for depression. The paper is published in the journal JAMA Psychiatry today [Wednesday 22ndOctober 2025]. The KARMA-Dep (2) Trial involved researchers from St Patrick’s Mental Health Services, Trinity College Dublin, and Queens University Belfast, Ireland. It was led by Declan McLoughlin, Research Professor of Psychiatry at Trinity College Dublin and Consultant Psychiatrist at St Patrick’s Mental Health Services. Depression ...

Ants have evolved an acute sense of smell, which requires each sensory neuron to choose one scent receptor out of hundreds. In a new study published in Nature, researchers at New York University have discovered what ants use to solve this biological puzzle: a self-regulating system in which choosing one gene physically silences all its neighbors. A high-stakes sense of smell Ants communicate via pheromones to hunt, detect outsiders, and determine their role within a colony. Without precise control of olfactory receptors, ant society would unravel. When ants cannot smell, “they stop performing their duties, which leads to anarchy,” explained ...

SAN FRANCISCO—October 22, 2025—Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that require surgery in the first months of life. For decades, scientists have known that having an extra copy of chromosome 21—the genetic cause of Down syndrome—was responsible, but they couldn’t pin down which of its hundreds of genes were key for causing the heart problems. Now, scientists at Gladstone Institutes have an answer. In a study published in Nature, the researchers leveraged stem cell science and ...

The University of California San Diego School of Medicine’s Centers for Integrative Health has received a five-year, $6.2 million grant from the National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health (NIH) to establish the REACH Center for Translational Science on Whole Person Health. The three principal investigators are Cassandra Vieten, Ph.D.,  clinical professor in the Department of Family Medicine at UC San Diego School of Medicine, Gene “Rusty” Kallenberg, ...

PORTOLA VALLEY, Calif., October 22, 2025 - Bay Area Lyme Foundation, a leading sponsor of Lyme disease research in the US, today announced its call for applicants from academia and the private sector for the 2026 Emerging Leader Awards (ELA). These annual awards recognize innovative researchers advancing novel approaches in tick-borne disease diagnostics and treatments, while embodying the future of research leadership in this critical field.    In 2026, Bay Area Lyme Foundation will award two $150,000 ELA grants:  Lyme ...

In International Journal of Extreme Manufacturing, researchers have developed a dual post-processing method to make 3D-printed metals much stronger and tougher, addressing one of the field's most persistent challenges. By combining deep cryogenic treatment and laser shock peening, researchers find a new way to transform the microscopic structure of 3D-printed metals, relieving internal stresses and enhancing their mechanical resilience. Their method offers a practical route to producing stronger and more damage-tolerant components for industrial-grade metal additive manufacturing in aerospace, automotive, energy, and defense sectors. The Hidden Problem in Metal ...

(Toronto, October 22, 2025) JMIR Publications invites submissions to a new theme issue titled “Navigating AI-Enabled Uncertainty – Strategic Implications for Digital Health Management” in its open access journal Journal of Medical Internet Research. The premier, peer-reviewed journal is indexed in in all major literature indices including National Library of Medicine(NLM)/MEDLINE, PubMed, PMC, Scopus, DOAJ, Clarivate (which includes Web of Science (WoS)/ESCI/SCIE), and others. Health care administrators are increasingly facing ambiguous decisions as artificial intelligence (AI) permeates reimbursement, documentation, workforce planning, and vendor ecosystems. ...