About The Study: Among adults with prediabetes and overweight or obesity, referral to a fully automated AI-led Diabetes Prevention Program (DPP) was noninferior to referral to a human-led DPP in achieving a composite outcome based on weight reduction, physical activity, and HbA1c. Corresponding Author: To contact the corresponding author, Nestoras Mathioudakis, MD, MHS, email nmathio1@jh.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.19563) Editor’s Note: Please see the article for additional information, ...

Researchers from Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health report that an AI-powered lifestyle intervention app for prediabetes reduced the risk of diabetes similarly to traditional, human-led programs in adults.  Funded by the National Institutes of Health and published in JAMA Oct. 27, the study is believed to be the first phase III randomized controlled clinical trial to demonstrate that an AI-powered diabetes prevention program (DPP) app helps patients meet diabetes risk-reduction benchmarks established by the Centers for Disease Control and Prevention (CDC) at rates comparable to those in human-led programs.  An estimated 97.6 ...

A major new study, which has recently begun recruiting, is hoped to lead to earlier detection of lung cancers. People living in Leeds, Bath, Hull and Stoke-on-Trent will be among those approached to take part. The study is funded by National Institute for Health and Care Research (NIHR). At the moment, chest X-ray is the test GPs are advised to use in almost for almost all symptoms to rule out or confirm a cancer. Symptoms can include a cough that persists for several weeks. Worryingly, however, chest X-rays are not always conclusive. ...

About The Study: This study characterizes stillbirth rates between 2016 and 2022 across clinical risk factors and geographic-based measures of access, income, and race in a large U.S. commercially insured population. Corresponding Author: To contact the corresponding author, Jessica L. Cohen, PhD, email cohenj@hsph.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.17392) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest ...

From tiger stripes to leopard spots, the animal world is full of distinctive and intricate patterns.  In a new study, CU Boulder scientists refined their previous theory of how animal patterns form and successfully recreated imperfections in natural designs, like irregular spots on a leopard. The new mechanism, described October 27 in Matter, could lead to materials that can respond to their environment, such as fabrics that change color on demand for camouflage.  “Imperfections are everywhere in nature,” said Ankur Gupta, the study’s lead researcher in the ...

Embargoed for release: Monday, October 27, 2025, 11:00 AM ET Key points: Stillbirth burden in the U.S. is higher than previously reported, with over 1 in 150 births ending in stillbirth. The rate is even higher—1 in 112—in low-income areas. Over 70% of stillbirths occurred in pregnancies with at least one identified clinical risk factor (e.g. chronic hypertension), but a substantial share—especially those occurring at 40+ weeks gestation—had none. According to the researchers, the findings point to a need to improve ...

About The Study: The updated 2024-2025 COVID-19 vaccines provided effective protection, particularly against severe disease, although their effectiveness waned over time. Effectiveness against different subvariants was similar.  Corresponding Author: To contact the corresponding author, Dan-Yu Lin, PhD, email lin@bios.unc.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2025.5465) Editor’s Note: Please ...

About The Study: This randomized clinical trial found that this unsupervised multimodal online tai chi intervention improved knee pain and function compared with the control at 12 weeks. This free-to-access web-based intervention offers an effective, safe, accessible, and scalable option for guideline-recommended osteoarthritis exercise.  Corresponding Author: To contact the corresponding author, Kim L. Bennell, PhD, email k.bennell@unimelb.edu.au. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2025.5723) Editor’s ...

New research from the Champalimaud Foundation (CF) reveals how missing just one essential amino acid can change gene expression and the brain’s sensory systems, prompting animals to seek out protein-rich yeast and gut bacteria that help them restore nutritional balance and survive in times of need. Fermented clues Cheese and chocolate might not tempt a fruit fly’s palate, but to a hungry fly short on nutrients, their smell carries a hidden signal. When deprived of certain amino acids – the building blocks of protein – these tiny insects develop a surprisingly refined ...

“These findings uncover a previously unknown role of TRF1 in regulating metabolism.” BUFFALO, NY — October 27, 2025 — A new research paper was published in Volume 17, Issue 9 of Aging-US on September 17, 2025, titled “Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles.” In this study led by first author Jessica Louzame Ruano and corresponding author Maria A. Blasco from the Spanish National Cancer Centre (CNIO), researchers ...

(Toronto, October 27, 2025) JMIR Publications invites submissions to a new theme issue in its premier open access journal JMIR Medical Education titled "Bias, Diversity, Inclusion, and Cultural Competence in Medical Education." The open access journal is indexed in MEDLINE, PubMed, PubMed Central, Scopus, DOAJ, and the Emerging Sources Citation Index (Clarivate) and received a Journal Impact Factor of 12.5 according to the latest release of the Journal Citation Reports from Clarivate, 2025. Biases, both conscious and unconscious, significantly impact judgment, decision-making, and ultimately patient care. This call for papers seeks ...

SAN ANTONIO — October 27, 2025 — Southwest Research Institute (SwRI) has received a seven-year, $9.9 million contract from the U.S. Air Force to predict the life of landing gear components for the F-16 Fighting Falcon fleet. SwRI will leverage its aging aircraft expertise to predict when parts need replacement, determine the root causes of failure and recommend improvements to maintenance practices. The contract falls under the Comprehensive Landing Gear Integrity Program, a 20-year, $300 million Indefinite Delivery ...

Contracts written by employers and landlords often result in second parties—employees and tenants—facing unfair terms because these documents contain unreasonable or ambiguous clauses, leaving the second parties vulnerable to unjust expenses or constraints. For example, “Tenant must provide written notice of intent to vacate at a reasonable time”—commonly used phrasing in leases—is ambiguous because “reasonable” is undefined. Also, “Employee agrees not to work for any business in the United States for two years following termination,” often included in employee contracts, is unenforceable because many ...

Self-affirmations – brief exercises in which people reflect on their core values, identity and positive traits – can increase people’s general well-being and make them happier in small but significant ways, according to research published by the American Psychological Association. “Even brief, low-cost self-affirmation exercises can yield significant psychological benefits in terms of enhancing personal and social well-being,” said study author Minhong (Maggie) Wang, PhD, of The University of Hong Kong. “More importantly, these benefits are both immediate and long-lasting.” The ...

DALLAS, October 27, 2025 — The rapidly expanding availability of remote telehealth cardiac health care poses a growing challenge for health care providers to learn how to use new digital tools and resources safely and effectively to treat people living with chronic health conditions. The American Heart Association (Association), a global force changing the future of health for all, just launched its latest professional certification program to help bridge the gap between traditional practice and remote patient monitoring and care, while promoting privacy and compatibility with ...

Earthquakes in the American state of Utah, the Soultz-sous-Forêts region of France or in the Dutch province of Groningen should not be able to occur even if the subsurface has been exploited for decades. This is because the shallow subsurface behaves in such a way that faults there become stronger as soon as they start moving. At least that is what geology textbooks teach us. And so, in theory, it should not be possible for earthquakes to occur. So why do they still occur in such nominally stable subsurfaces? ...

ATLANTA, Oct. 28, 2025 — A groundbreaking study published in the peer-reviewed journal Music and Medicine demonstrates that intraoperative music therapy significantly reduces the amount of propofol and fentanyl required during laparoscopic cholecystectomy performed under general anesthesia. Patients exposed to therapeutic music also experienced smoother awakenings and lower physiological stress, as measured by decreased perioperative cortisol levels. “These findings show that this is more than just simple background music, rather an integration of a novel intervention into anesthetic ...

In a new study, researchers found high levels of ultrashort-chain per- and polyfluoroalkyl substances (PFAS) in blood samples taken from Wilmington, N.C. residents between 2010-2016. Two ultrashort-chain PFAS – perfluoromethoxyacetic acid (PFMOAA) and trifluoracetic acid (TFA) – were detected at high levels in almost every sample. In contrast, GenX – the chemical that jumpstarted public concern about PFAS in the Cape Fear River Basin – was detected in 20% of the samples. The work adds to the body of evidence that short-chain PFAS can accumulate in the ...

COLUMBUS, Ohio – A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.   Previous research has shown the relationship between connectivity and brain function for just one or a few functions, such as perception or social interactions.   But this study goes further by providing a “bird’s eye view” of the whole brain and its many functions, said Kelly Hiersche, lead author of the study ...

Air pollution is widely recognized as a public health hazard, but its role in workplace safety is often underestimated. A new study reveals that polluted air can make industrial accidents both more likely and more severe, adding a hidden layer to their human and economic costs. The research—led by Dr. Ning Zhang of Yonsei University in South Korea, in collaboration with Dr. Zaikun Hou of Shandong University and Dr. Huan Chen of the University of Cambridge—was published in Energy Economics on September 18, 2025. Using two decades ...

ALS, also known as Lou Gehrig’s disease, is among the most challenging neurological disorders: relentlessly progressive, universally fatal, and without a cure even after more than a century and a half of research. Despite many advances, a key unanswered question remains—why do motor neurons, the cells that control body movement, degenerate while others are spared? In their new study, Kazuhide Asakawa and colleagues used single-cell–resolution imaging in transparent zebrafish to show that large spinal motor neurons — which generate strong body movements and are most vulnerable in ALS — operate under a constant, intrinsic burden of protein and organelle degradation. ...

Is your ultra-high-definition television really worth it? Do you need a 4K or an 8K screen to get the best viewing experience at home? According to researchers at the University of Cambridge and Meta Reality Labs, the human eye has a resolution limit: in other words, there are only so many pixels the eye can see. Above this limit, a screen is giving our eyes more information than they can detect. To calculate the resolution limit, the researchers conducted a study that measured participants’ ability to detect specific ...

Kyoto, Japan -- Down here on Earth we don't usually notice, but the Sun is frequently ejecting huge masses of plasma into space. These are called coronal mass ejections (CMEs). They often occur together with sudden brightenings called flares, and sometimes extend far enough to disturb Earth's magnetosphere, generating space weather phenomena including auroras or geomagnetic storms, and even damaging power grids on occasion. Scientists believe that when the Sun and the Earth were young, the Sun was so active that these CMEs may have even affected the emergence and evolution of ...

Toyoake, Japan —October 27, 2025— In a groundbreaking study, researchers at Fujita Health University and the Tokyo Metropolitan Institute of Medical Science have uncovered a previously overlooked form of brain abnormality linked to anxiety: excessive maturation and aging in the hippocampus, a state they term "hyper-maturity." Published in Neuropsychopharmacology, the study systematically screened publicly available omics datasets and identified gene expression signatures of hippocampal ...

In the Egyptian Western Desert, where red sandstones and green shales rise above the arid plains of Kharga Oasis, paleontologists have uncovered a fossil that fundamentally reshapes our understanding of crocodile evolution. The new discovery, published in The Zoological Journal of the Linnean Society, was led by a team of Egyptian paleontologists. The newly described species, Wadisuchus kassabi, lived about 80 million years ago and is now recognized as the earliest known member of Dyrosauridae—a group of ancient crocodiles ...