N6-methyladenosine methylation emerges as a key target for treating acute lung injury
Acute lung injury (ALI) is a critical clinical condition characterized by diffuse inflammation of the lung parenchyma and intractable hypoxemia, typically caused by factors, such as trauma, pneumonia, shock, and sepsis. Clinical symptoms of ALI include pulmonary edema, impaired gas exchange, and hypoxemia.
m6A methylation regulates gene expression by influencing RNA translation, splicing, stability, and export. This process is dynamically controlled by m6A writers, such as methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14), which install the m6A mark; m6A erasers such as fat mass and ...