SAN FRANCISCO – OCTOBER 26, 2025 – Results from the first randomized clinical trial in the United States to compare a sirolimus-eluting balloon (DEB) to control group consisting of drug-eluting stent (DES) and balloon angioplasty (BA) for the treatment of bare-metal and DES in-stent restenosis (ISR) deemed DEB to be noninferior to conventional therapies.   Findings were reported today at TCT® 2025, the annual scientific symposium of the Cardiovascular Research Foundation® (CRF®). TCT is the world’s premier ...

A new University of Phoenix survey conducted by The Harris Poll finds that while 90% of U.S. workers are actively learning or developing new skills on the job, many don’t realize those experiences may translate into college credit. While 45% of employed Americans do not believe work experience can count towards a degree, among workers without a college degree, nearly 3 in 5 (57%) don’t know that work experience could count toward a degree. Evaluating prior learning — sometimes called ...

SAN FRANCISCO – OCTOBER 26, 2025 – New study findings show that utilizing super-high-pressure non-compliant balloons (NCB) is non-inferior to intravascular lithotripsy (IVL) balloon catheters for lesion preparation and stent expansion in severely calcified lesions during percutaneous coronary intervention (PCI).   Findings were reported today at TCT® 2025, the annual scientific symposium of the Cardiovascular Research Foundation® (CRF®). TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine.   The ...

Hani K. Najm, MD, MSc, FACC, will be the next vice president of the American College of Cardiology, a global cardiovascular organization dedicated to transforming cardiovascular care and improving heart health for all. Najm will assume the role of vice president during the American College of Cardiology’s Annual Scientific Session (ACC.26) on March 28 – 30 in New Orleans. “It is a profound honor to serve as Vice President of the American College of Cardiology — an organization that has been the heartbeat of cardiovascular innovation and collaboration around the world,” Najm said. “From my early years in Riyadh to my current role at the Cleveland ...

Embargoed for release until 5:00 p.m. ET on Monday 27 October 2025    Follow @Annalsofim on X, Facebook, Instagram, Bluesky, and Linkedin              Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms ...

The way you walk: 10–15 minute bouts of walking better for your cardiovascular health than shorter strolls  People who walk at least 10-15 minutes in a single stretch reduce their risk of developing cardiovascular disease by two thirds compared to those who walk less than five minutes in one go  When walking the same number of steps, longer accumulations of steps in one go have a greater health benefit than short bouts spread out across the day    An international study ...

Many modern artificial intelligence (AI) applications, such as surgical robotics and real-time financial trading, depend on the ability to quickly extract key features from streams of raw data. This process is currently bottlenecked by traditional digital processors. The physical limits of conventional electronics prevent the reduction in latency and the gains in throughput required in emerging data-intensive services. The answer to this might lie in harnessing the power of light. Optical computing—or using light to perform demanding computations—has the potential to greatly accelerate feature extraction. In particular, optical diffraction operators, which are plate-like structures ...

Embargoed until 27-Oct-2025 15:00 ET (27-Oct-2025 19:00 GMT/UTC) Between 2008 and 2010, polarization in society increased dramatically alongside a significant shift in social behavior: the number of close social contacts rose from an average of two to four or five people. The connection between these two developments could provide a fundamental explanation for why societies around the world are increasingly fragmenting into ideological bubbles. [Vienna, 23.10.2025]—"The big question that not only we, but many countries are currently grappling with, is why polarization has increased so dramatically in recent years," says ...

Touch the branches of Leptogorgia chilensis, a soft coral found along the Pacific coast from California to Chile, and its flexible arms stiffen, like Marvel’s Mr. Fantastic warding off a foe.  Now, Penn Engineers have discovered the mechanism underlying this astonishing ability, one that could advance fields as varied as medicine, robotics and manufacturing.  In a new paper in Proceedings of the National Academy of Sciences (PNAS), a group led by Ling Li, Associate Professor in Materials Science and Engineering and in Mechanical Engineering and Applied Mechanics, describes how the coral’s skeleton — made of millions of mineral ...

Metagenomics is the study of all organisms present in a particular environment, such as soil, water, or the human body. A key part of metagenomic analysis is understanding what species are present (classification), how much of each there is (abundance), and the function of the microorganisms present. Real-time metagenomics - the immediate analysis of data while sequencing is in progress - holds the potential to speed up the detection, monitoring, and response to microbial threats in a multitude of settings, including agricultural, environmental, and biosecurity. However, one of the key barriers to realising the full potential of real-time metagenomics is the ...

Difficulty completing everyday tasks. Failing memory. Unusually poor concentration. For many people living with schizophrenia, cognitive challenges are part of daily life. Alongside well-known symptoms such as hallucinations and delusions, these difficulties can make it hard to live the life they want. That is why researchers at the University of Copenhagen are working to find ways to prevent such symptoms - and they may now be one step closer. In a new study, researchers discovered that a specific ...

ROCHESTER, Minn. — When it comes to treating disease, one promising avenue is addressing the presence of senescent cells. These cells — also known as "zombie cells" — stop dividing but don't die off as cells typically do. They turn up in numerous diseases, including cancer and Alzheimer's disease, and in the process of aging. While potential treatments aim to remove or repair the cells, one hurdle has been finding a way to identify them among healthy cells in living tissue.  In the journal Aging Cell, Mayo Clinic ...

New Cleveland Clinic research reveals that up to 5% of Americans – approximately 17 million people – carry genetic mutations or “variants” linked to increased cancer susceptibility, regardless of risk factors like personal or family cancer history. Published in JAMA, the study suggests that these mutations may be more common than previously thought and highlights the potential for expanded genetic screening to identify more individuals at risk and improve early detection. The ...

ITHACA, N.Y. – Tadpole species that lost their lungs through evolution never re-evolve them, even when environmental change would make it advantageous – bucking long-standing assumptions about how lost traits can reemerge, according to a new Cornell University study. Typical tadpoles have three main ways to get oxygen: from the air, with lungs; from the water, through gills; and from the air through their skin. Curiously, all frogs have lungs, so tadpoles retain the developmental genetics to regain lungs when environmental pressures might favor having them but instead evolve alternate solutions for acquiring oxygen from the air.  The study, ...

UNIVERSITY PARK, Pa. — In the age of social media, the battle against invasive species in nature is increasingly unfolding online. A new study analyzing over 500,000 tweets posted between 2006 and 2021 examines public discourse around invasive species on the social media platform Twitter, which became X in 2023. The study by an international team of researchers, including an ecologist at Penn State, was recently published in the journal Ecology & Society. The team found that mammals, especially urban pests like cats, pigs and squirrels, dominated ...

When finding the right Airbnb property, reviews really matter. That’s the takeaway from new study involving the Binghamton University School of Management, which found that reviews mentioning an Airbnb property’s neighborhood safety problems can reduce bookings, lower nightly prices and make customers less likely to return — even if those represent a fraction of all the property’s online reviews. The study, co-authored by Assistant Professor Yidan Sun, explores how platforms like Airbnb balance financial incentives with customer welfare. While platforms might be ...

ITHACA, N.Y. – Every day, millions of people are discharged after extended hospital stays, but matching these patients with appropriate care facilities can be arduous, often reliant on months-old, inaccurate data. Now, a text message-based, hybrid computer-human system that regularly updates both patients’ and care facilities’ availability statuses, developed by a Cornell doctoral student, is smoothing that time-consuming process. The system was tested at a hospital in Hawaii for 14 months, beginning in early 2022, and helped place nearly 50 patients in care facilities. In fact, the system worked so well, the hospital ...

About 85% of elementary schools studied in California experienced some loss of trees between 2018 and 2022, according to a paper from the University of California, Davis, published this month in the journal Urban Forestry and Urban Greening. Members of the UC Davis Urban Science Lab found that while the average decline was less than 2%, some districts in the Central Valley — including schools with few trees to lose – lost up to a quarter of their tree cover. The most severe losses were concentrated in Tulare ...

The ever-growing use of technology in society makes it clear that computer programming may be a valuable skill. But how do our brains learn to code? Cultural skills, like reading and math, typically emerge by repurposing brain networks that function for more innate purposes. Yun-Fei Liu and Marina Bedny, from Johns Hopkins University, tested whether this may be the case when people learn computer programming in their JNeurosci paper.  The researchers recorded brain activity in study volunteers with no programming experience before and after they learned how to code using Python. A neural network in the left ...

Using psychedelics to treat psychiatric diseases has become less controversial as scientists continue to reveal their underlying mechanisms. In a new eNeuro paper, researchers led by Pavel Ortinski, from the University of Kentucky, used male rats to assess how psychedelic drugs target the claustrum, a brain region with many receptors that psychedelics interact with.  The researchers found that activating claustrum neurons targeting a cognitive area implicated in psychiatric diseases (the anterior cingulate cortex) under psychedelic drug exposure strengthened projections onto these claustrum ...

Children can sometimes develop health, behavioral, and attachment issues that persist when their needs are not met by their caregiver. New from eNeuro, Arie Kaffman and colleagues at Yale University School of Medicine explored whether mouse pups also experience these issues from early life adversity. Their discoveries provide an opportunity for researchers to explore the mechanisms of health and behavioral deficits from early life adversity.  When the researchers limited bedding for making nests, this impaired maternal care and increased stress hormone signaling ...

Computer programming powers modern society and enabled the AI revolution but little is known about how our brains learn this essential skill. To help answer that question, Johns Hopkins University researchers studied the brain activity of university students before and after they learned how to code. After the students took a programming course, parts of their brain activated as they read code. Inside these areas, groups of neurons represented the meaning of code. Surprisingly, before the students took the class or knew anything about programming, the same groups of neurons also fired when the students read the programs described in plain English. The federally-funded ...

About The Study: Among adults with prediabetes and overweight or obesity, referral to a fully automated AI-led Diabetes Prevention Program (DPP) was noninferior to referral to a human-led DPP in achieving a composite outcome based on weight reduction, physical activity, and HbA1c. Corresponding Author: To contact the corresponding author, Nestoras Mathioudakis, MD, MHS, email nmathio1@jh.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.19563) Editor’s Note: Please see the article for additional information, ...

Researchers from Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health report that an AI-powered lifestyle intervention app for prediabetes reduced the risk of diabetes similarly to traditional, human-led programs in adults.  Funded by the National Institutes of Health and published in JAMA Oct. 27, the study is believed to be the first phase III randomized controlled clinical trial to demonstrate that an AI-powered diabetes prevention program (DPP) app helps patients meet diabetes risk-reduction benchmarks established by the Centers for Disease Control and Prevention (CDC) at rates comparable to those in human-led programs.  An estimated 97.6 ...

A major new study, which has recently begun recruiting, is hoped to lead to earlier detection of lung cancers. People living in Leeds, Bath, Hull and Stoke-on-Trent will be among those approached to take part. The study is funded by National Institute for Health and Care Research (NIHR). At the moment, chest X-ray is the test GPs are advised to use in almost for almost all symptoms to rule out or confirm a cancer. Symptoms can include a cough that persists for several weeks. Worryingly, however, chest X-rays are not always conclusive. ...