Biophysicists at Ludwig-Maximilians-Universitaet (LMU) in Munch have developed a new theory, which accounts for the observation that cells can perceive their own shapes, and use this information to direct the distribution of proteins inside the cell. Many cellular processes are critically dependent on the precise distribution and patterning of proteins on the cell membrane. Diverse studies have shown that, in addition to protein-protein interactions and transport processes, cell shape can also have a considerable impact on intracellular pattern formation. Conversely, there are patterning processes in which any dependence on cell form would be deleterious. Using starfish oocytes as a model system, LMU physicists led by Professor Erwin ...

In shallow water, less than 30 metres, the survival of hard corals depends on photosynthetic unicellular algae (zooxanthellae) living in their tissues. But how does the coral adapt at depth when the light disappears? French researchers from the CNRS, EPHE-PSL and their international collaborators, associated with Under the Pole (Expedition III), have studied for the first time the distribution of these so-called mesophotic corals in the French Polynesian archipelago, from the surface to 120 metres deep (with a record descent of 172 metres). As the amount of light decreases, the coral associates ...

DARIEN, IL - A new study found that treating obstructive sleep apnea with CPAP therapy increased self-reported physical activity in adults with a history of heart disease. During a mean follow-up period of 3.7 years, the group treated with CPAP therapy reported approximately 20% higher levels of moderate physical activity compared with the control group. The study also found the CPAP group was more likely to report activity levels consistent with expert recommendations. "We were pleased to find that our CPAP users reported that they were better able to maintain their levels of activity over the four years of the study, and that they reported fewer limitations in moderate and vigorous activities including those that are important for independent aging, like walking up the stairs," ...

The researchers used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered during SARS-CoV-2 infection. TPP monitors protein amounts and denaturation temperatures - the points at which proteins heat up so much that they lose their 3D structure. A shift in denaturation temperature indicates that a particular protein has undergone a functional change upon infection, possibly due to the virus hijacking the protein for use in its own replication. The scientists observed that infection with SARS-CoV-2 changed the abundance and thermal stability of hundreds of cellular proteins. This included ...

Psycholinguists from the HSE Centre for Language and Brain found that when reading, people are not only able to predict specific words, but also words' grammatical properties, which helps them to read faster. Researchers have also discovered that predictability of words and grammatical features can be successfully modelled with the use of neural networks. The study was published in the journal PLOS ONE. The ability to predict the next word in another person's speech or in reading has been described by many psycho- and neurolinguistic studies over the last 40 years. It is assumed that this ability allows us to process the information faster. Some recent publications on the English language have demonstrated evidence that while reading, people can ...

Canadian researchers are the first to study how different patterns in the way older adults walk could more accurately diagnose different types of dementia and identify Alzheimer's disease. A new study by a Canadian research team, led by London researchers from Lawson Health Research Institute and Western University, evaluated the walking patterns and brain function of 500 participants currently enrolled in clinical trials. Their findings are published today in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. "We have longstanding evidence showing that cognitive problems, such as poor memory and executive dysfunction, can ...

Nature has its way of maintaining balance. This statement rightly holds true for plants that are eaten by herbivores--insects or even mammals. Interestingly, these plants do not just silently allow themselves to be consumed and destroyed; in fact, they have evolved a defense system to warn them of predator attacks and potentially even ward them off. The defense systems arise as a result of inner and outer cellular signaling in the plants, as well as ecological cues. Plants have developed several ways of sensing damage; a lot of these involve the sensing of various "elicitor" molecules produced by either the predator ...

It is almost ten years since the scientific journal Science called optogenetics the "breakthrough of the decade". Put simply, the technique makes it possible to control the electrical activity of cells with pulses of light. With its help, scientists can gain new insights into the functioning of nerve cells, for example, and thus better understand neurological and psychiatric diseases such as depression and schizophrenia. Established procedure on animal cells In research on animal cells, optogenetics is now an established technique used in many fields. The picture is different in plant research: transferring the principle to plant cells and applying it widely has not been possible until now. However, this has now changed: Scientists ...

Individual variation in the shape and structure of the Achilles tendon may influence our susceptibility to injury later in life, says a study published today in eLife. The findings suggest that studying individual Achilles tendon shape (or 'morphology') could help with identifying patients at risk of injury and designing new, potentially personalised approaches for treating and preventing Achilles tendinopathy and similar conditions. The Achilles tendon is the tissue that links the calf muscles to the heel bone. It is fundamental to our movement and athletic ability. Its unique structure, which combines three smaller sub-tendons, increases the efficiency of our movement by allowing individual control from connected muscles. For this control to occur, the ...

A drug that helps us to eat less could help the more than 650 million people around the world who live with obesity. One of the emerging drug candidates that interest researchers is the hormone GDF15 that, when given to rodents, lowers their appetite and body weight. New research from the University of Copenhagen finds that the body produces large amounts GDF15 during extended bouts of vigorous exercise, presumably as a physiological stress signal. This finding highlights central differences between GDF15 given as a drug (pharmacology), and GDF15 released naturally in response to vigorous exercise (physiology). This is an important distinction ...

From 2015 to 2019, public school districts in the United States invested nearly $5 billion to upgrade their Wi-Fi networks, according to EducationSuperHighway. However, in the age of COVID-19-mandated virtual learning, millions of K-12 students still lack the minimal connectivity at home for digital learning. In a new study from the University of Notre Dame, researchers quantify how school district connectivity increases test scores, but underscore the dark side of technology -- increased behavior problems. A $600,000 increase in annual internet access spending produces a financial gain of approximately $820,000 to $1.8 million, alongside losses from disciplinary problems totaling $25,800 to $53,440, according to new research from Yixing Chen, an ...

Researchers at the University of Chicago, the University of Birmingham, and Bournemouth University have uncovered evidence that physical embodiment can occur without the sense of touch, thanks to a study involving two participants who lack the ability to feel touch. The research was published on Feb. 12 in END ...

Coral reefs have thrived for millions of years in their shallow ocean water environments due to their unique partnerships with the algae that live in their tissues. Corals provide a safe haven and carbon dioxide while their algal symbionts provide them with food and oxygen produced from photosynthesis. Using the corals Orbicella annularis and Orbicella faveolate in the southern Caribbean, researchers at the Carl R. Woese Institute for Genomic Biology (IGB) have improved our ability to visualize and track these symbiotic interactions in the face of globally warming sea surface temperatures and ...

In coming decades as coastal communities around the world are expected to encounter sea-level rise, the general expectation has been that people's migration toward the coast will slow or reverse in many places. However, new research co-authored by Princeton University shows that migration to the coast could actually accelerate in some places despite sea-level change, contradicting current assumptions. The research, published in Environmental Research Letters, uses a more complex behavioral decision-making model to look at Bangladesh, whose coastal zone is at high risk. They found job opportunities are most abundant in coastal cities across Bangladesh, attracting more ...

It's no secret that the risk related to the coronavirus (COVID-19) increases with age, making older adults more vulnerable than younger people. Less examined has been effects on pregnancy and birthing. According to a new study led by Sarah DeYoung, assistant professor in the Department of Sociology and Criminal Justice, and Michaela Mangum, a master's student in disaster science and management, the pandemic causes additional stress for people who were pregnant or gave birth during the pandemic. The stress was especially prevalent if the person ...

A new study from the Smidt Heart Institute at Cedars-Sinai shows that women have a lower “normal” blood pressure range compared to men. The findings were published today in the peer-reviewed journal Circulation.Currently, established blood pressure guidelines state that women and men have the same normal healthy range of blood pressure. But the new research shows there are differences in normal blood pressure between the sexes.“Our latest findings suggest that this one-size-fits-all approach to considering blood pressure may be detrimental to a woman’s health,” ...

Mammals and cold-blooded alligators share a common four-chamber heart structure - unique among reptiles - but that's where the similarities end. Unlike humans and other mammals, whose hearts can fibrillate under stress, alligators have built-in antiarrhythmic protection. The findings from new research were reported Jan. 27 in the journal Integrative Organismal Biology. "Alligator hearts don't fibrillate - no matter what we do. They're very resilient," said Flavio Fenton, a professor in the School of Physics at the Georgia Institute of Technology, researcher ...

COLUMBIA, Mo. -- Throughout her career, Lori Popejoy provided hands-on clinical care in a variety of health care settings, from hospitals and nursing homes to community centers and home health care agencies. She became interested in the area of care coordination, as patients who are not properly cared for after being discharged from the hospital often end up being readmitted in a sicker, more vulnerable state of health. Now an associate professor in the University of Missouri Sinclair School of Nursing, Popejoy and her research team conducted a study to determine the most effective way patients ...

Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body's glucose levels, which is important for the development of metabolic diseases like diabetes. In a recent study, published in END ...

Investigators at the University of Chicago Medicine have found that women are less likely to be represented as chairs and reviewers on study sections for the National Institutes of Health (NIH), based on data from one review cycle in 2019. The results, published on Feb. 15 in JAMA Network Open, have implications for the distribution of federal scientific funding. The NIH is the top source of federal funding for biomedical research in the U.S., providing critical support and guidance on the nation's research programs. The study sought to understand the gender distribution ...

New research from North Carolina State University has found that Campylobacter bacteria persist throughout poultry production - from farm to grocery shelves - and that two of the most common strains are exchanging genetic material, which could result in more antibiotic-resistant and infectious Campylobacter strains. Campylobacter is a well-known group of foodborne bacteria, spread primarily through consumption of contaminated food products. In humans it causes symptoms commonly associated with food poisoning, such as diarrhea, fever and cramps. However, Campylobacter infections also constitute one of the leading precursors ...

Surface rupturing during earthquakes is a significant risk to any structure that is built across a fault zone that may be active, in addition to any risk from ground shaking. Surface rupture can affect large areas of land, and it can damage all structures in the vicinity of the fracture. Although current seismic codes restrict the construction in the vicinity of active tectonic faults, finding the exact location of fault outcrop is often difficult. In many regions around the world, engineering structures such as earth dams, buildings, pipelines, landfills, bridges, roads and railroads have been built in areas very close to active fault segments. Strike-slip fault rupture occurs when the rock masses slip past each other ...

Cancer cells and immune cells share something in common: They both love sugar. Sugar is an important nutrient. All cells use sugar as a vital source of energy and building blocks. For immune cells, gobbling up sugar is a good thing, since it means getting enough nutrients to grow and divide for stronger immune responses. But cancer cells use sugar for more nefarious ends. So, what happens when tumor cells and immune cells battle for access to the same supply of sugar? That's the central question that Memorial Sloan Kettering researchers Taha Merghoub, Jedd Wolchok, and Roberta Zappasodi explore in a new study published February 15 in the journal Nature. Using mouse models and data ...

Ithaca, NY--The COVID-19 pandemic has changed life as we know it all around the world. It's changed human behavior, and that has major consequences for data-gathering citizen-science projects such as eBird, run by the Cornell Lab of Ornithology. This worldwide database now contains more than a billion observations and is a mainstay of many scientific studies of bird populations. Newly published research in the journal Biological Conservation finds that when human behaviors change, so do the data. "We examined eBird data submitted during April 2020 and compared them to data from April of prior years," explains lead ...

Researchers from the UCLA School of Dentistry have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide. The findings from their study in mice, END ...