CLEVELAND--Researchers at Case Western Reserve University, using artificial intelligence (AI) to analyze simple tissue scans, say they have discovered biomarkers that could tell doctors which lung cancer patients might actually get worse from immunotherapy. Until recently, researchers and oncologists had placed these lung cancer patients into two broad categories: those who would benefit from immunotherapy, and those who likely would not. But a third category--patients called hyper-progressors who would actually be harmed by immunotherapy, including a shortened lifespan after treatment--has begun ...

PITTSBURGH, Feb. 4, 2021 - Researchers at UPMC Hillman Cancer Center and the National Cancer Institute (NCI) demonstrate that changing the gut microbiome can transform patients with advanced melanoma who never responded to immunotherapy--which has a failure rate of 40% for this type of cancer--into patients who do. The results of this proof-of-principle phase II clinical trial were published online today in Science. In this study, a team of researchers from UPMC Hillman administered fecal microbiota transplants (FMT) and anti-PD-1 immunotherapy to melanoma patients ...

Despite living in the same part of the Mojave Desert, and experiencing similar conditions, mammals and birds native to this region experienced fundamentally different exposures to climate warming over the last 100 years, a new study shows; small mammal communities there remained much more stable than birds, in the face of local climate change, it reports. The study presents an integrative approach to understanding the climate vulnerability of biodiversity in rapidly warming regions. Exposure to rising temperature extremes threatens species worldwide. It is expected to push many ever closer toward extinction. Thus, understanding ...

The soundscapes of the Anthropocene ocean are fundamentally different from those of pre-industrial times, becoming more and more a raucous cacophony as the noise from human activity has grown louder and more prevalent. In a Review, Carlos Duarte and colleagues show how the rapidly changing soundscape of modern oceans impacts marine life worldwide. According to the authors, mitigating these impacts is key to achieving a healthier ocean. From the plangent songs of cetaceans to grinding arctic sea ice, the world's oceans' natural chorus is performed by a vast ensemble of geological (geophony) and biological (biophony) sounds. However, for more than a century, ...

In February 2001, the first drafts of the human genome were published. In this Special Issue of Science, "Human Genome at 20," an Editorial, a Policy Forum, a series of NextGen Voices Letters and a Perspective explore the complicated legacy of the Human Genome Project (HGP). "Millions of people today have access to their personal genomic information, with direct-to-consumer services and integration with other 'big-data' increasingly commoditizing what was rightly celebrated as a singular achievement in February 2001," writes Science Senior Editor Brad Wible. An Editorial by Claire Frasier, director of the Institute for Genome Sciences at the University ...

Iodine plays a bigger role than thought in rapid new particle formation (NPF) in relatively pristine regions of the atmosphere, such as along marine coasts, in the Arctic boundary layer or in the upper free troposphere, according to a new study. The authors say their measurements indicate that iodine oxoacid particle formation can compete with sulfuric acid - another vapor that can form new particles under atmospheric conditions - in pristine atmospheric regions. Tiny particles suspended high in the atmosphere - aerosols - play an essential role in Earth's climate system. Clouds require airborne particles, or cloud condensation nuclei (CCN), ...

For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests. Researchers at the National Cancer Institute (NCI) Center for Cancer Research, part of the National Institutes of Health, conducted the study in collaboration with investigators from UPMC Hillman Cancer Center at the University of Pittsburgh. In the study, some patients with advanced melanoma who initially did not respond to treatment with an immune checkpoint inhibitor, a type of immunotherapy, did respond to the drug after receiving a transplant ...

Competition among sperm cells is fierce - they all want to reach the egg cell first to fertilize it. A research team from Berlin now shows in mice that the ability of sperm to move progressively depends on the protein RAC1. Optimal amounts of active protein improve the competitiveness of individual sperm, whereas aberrant activity can cause male infertility. It is literally a race for life when millions of sperm swim towards the egg cells to fertilize them. But does pure luck decide which sperm succeeds? As it turns out, there are differences in competitiveness between individual sperm. ...

Berkeley -- In the arid Mojave Desert, small burrowing mammals like the cactus mouse, the kangaroo rat and the white-tailed antelope squirrel are weathering the hotter, drier conditions triggered by climate change much better than their winged counterparts, finds a new study published today in Science. Over the past century, climate change has continuously nudged the Mojave's searing summer temperatures ever higher, and the blazing heat has taken its toll on the desert's birds. Researchers have documented a collapse in the region's bird populations, likely resulting ...

Treatment for HIV has improved tremendously over the past 30 years; once a death sentence, the disease is now a manageable lifelong condition in many parts of the world. Life expectancy is about the same as that of individuals without HIV, though patients must adhere to a strict regimen of daily antiretroviral therapy, or the virus will come out of hiding and reactivate. Antiretroviral therapy prevents existing virus from replicating, but it can't eliminate the infection. Many ongoing clinical trials are investigating possible ways to clear HIV infection. In a study published Feb. 4 in the journal Science, researchers at Washington University School of Medicine in St. Louis have identified a potential way to eradicate ...

In 2018, the physics world was set ablaze with the discovery that when an ultrathin layer of carbon, called graphene, is stacked and twisted to a "magic angle," that new double layered structure converts into a superconductor, allowing electricity to flow without resistance or energy waste. Now, in a literal twist, Harvard scientists have expanded on that superconducting system by adding a third layer and rotating it, opening the door for continued advancements in graphene-based superconductivity. The work is described in a new paper in Science and can one day help lead toward superconductors that operate at higher or even close to room temperature. These superconductors are considered the holy grail of condensed matter physics ...

Black children have significantly higher rates of shellfish and fish allergies than White children, in addition to having higher odds of wheat allergy, suggesting that race may play an important role in how children are affected by food allergies, researchers at Ann & Robert H. Lurie Children's Hospital of Chicago, Rush University Medical Center and two other hospitals have found. Results of the study were published in the February issue of the Journal of Allergy and Clinical Immunology: In Practice. "Food allergy is a common condition in the U.S., and we know from our previous research that there are important differences between Black and White children with food allergy, but there is so much we need to know to be able to help our patients ...

In a new perspective piece published in the Feb. 5 issue of Science, pharmacologist Namandje Bumpus, Ph.D. -- who recently became the first African American woman to head a Johns Hopkins University School of Medicine department, and is the only African American woman leading a pharmacology department in the country -- outlines the molecular origins for differences in how well certain drugs work among distinct populations. She also lays out a four-part plan to improve the equity of drug development. "Human beings are more similar than we are different," says Bumpus. "Yet, the slightest variations in our genetic material ...

The COVID-19 pandemic has affected people's behavior everywhere. Fear, apprehensiveness, sadness, anxiety, and other troublesome feelings have become part of the daily lives of many families since the first cases of the disease were officially recorded early last year. These turbulent feelings are often expressed in dreams reflecting a heavier burden of mental suffering, fear of contamination, stress caused by social distancing, and lack of physical contact with others. In addition, dream narratives in the period include a larger proportion of terms relating to cleanliness and contamination, as well as anger and sadness. All this is reported in a study published in PLOS ONE. The principal investigator was Natália ...

Surface and interface play critical roles in energy storage devices, thus calling for in-situ/operando methods to probe the electrified surface/interface. However, the commonly used in-situ/operando characterization techniques such as X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray spectroscopy and topography, and nuclear magnetic resonance (NMR) are based on the structural, electronic and chemical information in bulk region of the electrodes or electrolytes. Surface science methodology including electron spectroscopy and scanning probe microscopy can provide rich information about how reactions ...

Scientists globally aim to control chemical reactions--an ambitious goal that requires identifying the steps taken by initial reactants to arrive at the final products as the reaction takes place. While this dream remains to be realized, techniques for probing chemical reactions have become sufficiently advanced to render it possible. In fact, chemical reactions can now be monitored based on the change of electronic properties of a single molecule! Thanks to the scanning tunneling microscope (STM), this is also simple to accomplish. Why not then utilize ...

Plastics are among the most successful materials of modern times. However, they also create a huge waste problem. Scientists from the University of Groningen (The Netherlands) and the East China University of Science and Technology (ECUST) in Shanghai produced different polymers from lipoic acid, a natural molecule. These polymers are easily depolymerized under mild conditions. Some 87 per cent of the monomers can be recovered in their pure form and re-used to make new polymers of virgin quality. The process is described in an article that was published in the journal Matter on 4 February. A problem with recycling plastics is that it usually results in a lower-quality product. The best results are obtained by chemical recycling, in which the polymers are broken ...

A pilot program to offer mental health services offered resident physicians at the University of Colorado School of Medicine provides a model for confidential and affordable help, according to an article published today by the journal Academic Medicine. For the 2017-2018 class, 80 resident physicians in the internal medicine and in internal medicine-pediatrics programs were enrolled in a mental health program that provided scheduled appointments at the campus mental health center. Residents were allowed to opt-out of the appointments. The cost of the appointments was covered by the residency programs, not charged to residents. Programs received ...

Scientists of Far Eastern Federal University (FEFU) have advanced the technology of high-speed sintering for optical ceramics (Nd3+:YAG), i.e. active elements generating laser emission in the near-infrared wavelength range (1.06 μm) for cutting the edge microelectronics and medicine. The researchers have managed to reduce significantly the initial nanopowders consolidation period (10 - 100 times) forming a nanostructure with ensured high optical transparency of the ceramic material. A related article appears in Optical Materials. Diode-pumped ...

Inflammation is supposed to help protect us--it's part of an immune response to fight off pathogens and clear infections. But patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present. In a recent study published in Circulation, immunologists at Tufts University School of Medicine in collaboration with investigators at Vanderbilt University and Tufts Medical Center revealed a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart. "Not all inflammation is the same," says Pilar Alcaide, a Kenneth and JoAnn G. Wellner Professor at Tufts School of Medicine and corresponding ...

The 2019-2020 flu season in the U.S. was unusual in a number of ways. Cases picked up in August rather than the more typical fall and early winter months, and it hit children particularly hard. It was also dominated early on by a Type B influenza virus instead of one of the much more common Type A viruses like H1N1 or H3N2. A new study by researchers at the University of Georgia suggests that these dynamics were driven largely by a new, more transmissible strain encountering a population with very little existing immunity to it. Their findings, just published in the Proceedings of the National Academy of Sciences, have implications for future vaccination ...

A new white paper from The Gerontological Society of America (GSA) highlights the variety of challenges that persons with dementia-related psychosis and their caregivers have encountered during moves through different health care settings -- and proposes strategies to address these challenges. It is estimated that over 2 million Americans with dementia experience delusions (false beliefs) and hallucinations (seeing or hearing things that others do not see or hear). This group of symptoms, known as dementia-related psychosis, frequently goes undetected in people who may ...

NEWPORT, Ore. - Researchers can now determine the age and sex of living beluga whales in Alaska's Cook Inlet thanks to a new DNA-based technique that uses information from small samples of skin tissue. Accurate age estimates are vital to conservation efforts for Cook Inlet belugas, which were listed as endangered following a significant population decline in the 1990s. Previously, researchers could only determine the age of beluga whales by studying the teeth of dead animals. The new aging method uses DNA methylation data and machine learning to develop a model that captures ...

If you have a second, try typing "time management" into your favourite search engine. You will get literally millions of results: books, tips, lessons, do's and don'ts. It's a big industry. But as END ...

A new analysis of a horse previously believed to be from the Ice Age shows that the animal actually died just a few hundred years ago--and was raised, ridden and cared for by Native peoples. The study sheds light on the early relationships between horses and their guardians in the Americas. The findings, published today in the journal American Antiquity, are the latest in the saga of the "Lehi horse." In 2018, a Utah couple was doing landscaping in their backyard near the city of Provo when they unearthed something surprising: an almost complete skeleton of a horse about the size of a Shetland pony. Scientists and the media took note. Preliminary data suggested ...