The Institute for Scientific Information on Coffee (ISIC) published a new report today, titled 'Coffee and sleep in everyday lives', authored by Professor Renata Riha, from the Department of Sleep Medicine at the University of Edinburgh. It reviews the latest research into coffee's effect on sleep and suggests that while drinking coffee early in the day can help support alertness and concentration levels1, especially when sleep patterns are disturbed; decreasing intake six hours before bedtime may help reduce its impact on sleep2. Coffee is largely consumed daily for the pleasure of its taste3, as well as its beneficial effect on wakefulness and concentration (due to its caffeine content)4. ...

A new study further highlighting a potential physiological cause of clinical depression could guide future treatment options for this serious mental health disorder. Published in Frontiers in Psychiatry, researchers show differences between the cellular composition of the brain in depressed adults who died by suicide and non-psychiatric individuals who died suddenly by other means. "We found a reduced number of astrocytes, highlighted by staining the protein vimentin, in many regions of the brain in depressed adults," reports Naguib Mechawar, a Professor at the Department of Psychiatry, McGill University, Canada, and senior author of this article. ...

Researchers from University of Notre Dame, York University (Canada), and University of New England (Australia) published a new paper in the Journal of Marketing that identifies a novel reason why people under-save and demonstrates a simple, short, and inexpensive intervention that increases intentions to save and actual savings. The study, forthcoming in the Journal of Marketing, is titled "Popping the Positive Illusion of Financial Responsibility Can Increase Personal Savings: Applications in Emerging and Western Markets" and is authored by Emily Garbinsky, Nicole Mead, and Daniel Gregg. People around the world are not saving enough money. Since increasing ...

WASHINGTON--The start of California's annual rainy season has been pushed back from November to December, prolonging the state's increasingly destructive wildfire season by nearly a month, according to new research. The study cannot confirm the shift is connected to climate change, but the results are consistent with climate models that predict drier autumns for California in a warming climate, according to the authors. Wildfires can occur at any time in California, but fires typically burn from May through October, when the state is in its dry season. The start of the rainy season, historically in November, ends wildfire season as plants become too moist to burn. California's rainy season has been starting progressively later in recent decades and climate ...

Researchers from Nanyang Technological University, Singapore (NTU Singapore), Singapore University of Technology and Design (SUTD) and Khoo Teck Puat Hospital (KTPH) have developed a new way to create "food inks" from fresh and frozen vegetables, that preserves their nutrition and flavour better than existing methods. Food inks are usually made from pureed foods in liquid or semi-solid form, then 3D-printed by extrusion from a nozzle, and assembled layer by layer. Pureed foods are usually served to patients suffering from swallowing difficulties known as dysphagia. To present the ...

Politicians around the world must be held to account for mishandling the covid-19 pandemic, argues a senior editor at The BMJ today. Executive editor, Dr Kamran Abbasi, argues that at the very least, covid-19 might be classified as 'social murder' that requires redress. Today 'social murder' may describe a lack of political attention to the conditions in which people are born, grow, live, work and age that exacerbate the pandemic. When politicians and experts say that they are willing to allow tens of thousands of premature deaths, for the sake of population immunity or in the hope of propping up the economy, is that not premeditated ...

Piezoelectric materials hold great promise as sensors and as energy harvesters but are normally much less effective at high temperatures, limiting their use in environments such as engines or space exploration. However, a new piezoelectric device developed by a team of researchers from Penn State and QorTek remains highly effective at elevated temperatures. Clive Randall, director of Penn State's Materials Research Institute (MRI), developed the material and device in partnership with researchers from QorTek, a State College, Pennsylvania-based company specializing in smart material devices and high-density power electronics. "NASA's need ...

UNIVERSITY PARK, Pa. -- Muscle wasting, or the loss of muscle tissue, is a common problem for people with cancer, but the precise mechanisms have long eluded doctors and scientists. Now, a new study led by Penn State researchers gives new clues to how muscle wasting happens on a cellular level. Using a mouse model of ovarian cancer, the researchers found that cancer progression led to fewer skeletal muscle ribosomes -- particles in the cell that make proteins. Because muscle mass is mainly determined by protein synthesis, having less ribosomes likely explains why muscles waste away in cancer. Gustavo Nader, associate professor of kinesiology and physiology at Penn State, said the findings suggest a mechanism for muscle wasting that could be relevant ...

DURHAM, N.C. -- Harsher immigration law enforcement by U.S. Immigration and Customs Enforcement leads to decreased use of prenatal care for immigrant mothers and declines in birth weight, according to new Duke University research. In the study, published in PLOS ONE, researchers examine the effects of the federal 287(g) immigration program after it was introduced in North Carolina in 2006. Under 287(g) programs, which are still in effect, local law officers are deputized to act as Immigration and Customs Enforcement (ICE) agents, with authority to question individuals about immigration status, detain them, and if necessary, begin deportation proceedings. According to the study findings, the 2006 policy change reduced birth weight ...

BIRMINGHAM, Ala. - Hypoxia -- where a tissue is deprived of an adequate supply of oxygen -- is a feature inside solid cancer tumors that renders them highly invasive and resistant to treatment. Study of how cells adapt to this critical stressor, by altering their metabolism to survive in a low-oxygen environment, is important to better understand tumor growth and spread. Researchers led by Rajeev Samant, Ph.D., professor of pathology at the University of Alabama at Birmingham, now report that chronic hypoxia, surprisingly, upregulates RNA polymerase I activity and alters the methylation patterns on ribosomal RNAs. These altered epigenetic marks on the ribosomal RNAs appear to create a pool of specialized ribosomes that can differentially ...

As a native animal, kangaroos aren't typically considered a threat to Australian vegetation. While seen as a pest on farmland - for example, when competing with livestock for resources - they usually aren't widely seen as a pest in conservation areas. But a new collaborative study led by UNSW Sydney found that conservation reserves are showing signs of kangaroo overgrazing - that is, intensive grazing that negatively impacts the health and biodiversity of the land. Surprisingly, the kangaroos' grazing impacts appeared to be more damaging to the land than rabbits, an introduced species. "The kangaroos had severe impacts on soils and vegetation that were symptomatic of overgrazing," says Professor Michael Letnic, senior author of the paper and ...

Mathematicians from RUDN University suggested and tested a new method to assess the productivity of fifth-generation (5G) base stations. The new technology would help get rid of mobile access stations and even out traffic fluctuations. The results of the study were published in the IEEE Conference Publication. Stations of the new 5G New Radio (NR) communication standard developed by the 3GPP consortium are expected to shortly be installed in large quantities all over the world. First of all, the stations will be deployed in places with high traffic ...

ITHACA, N.Y. -Wind energy scientists at Cornell University have released a new global wind atlas - a digital compendium filled with documented extreme wind speeds for all parts of the world - to help engineers select the turbines in any given region and accelerate the development of sustainable energy. This wind atlas is the first publicly available, uniform and geospatially explicit (datasets tied to locations) description of extreme wind speeds, according to the research, "A Global Assessment of Extreme Wind Speeds For Wind Energy Applications," published in Nature Energy. "Cost-efficient expansion of the wind-energy industry is enabled by access ...

One of the most important ways to stop the spread of COVID-19 is for people who have tested positive, or have symptoms, to isolate themselves from the other people they live with. But a new University of Michigan poll suggests that nearly one in five older adults don't have the ability to do this - and that those who are Hispanic or Black, or who have lower incomes or poor health to begin with, are more likely to lack a safe isolation place in their home. The poll also shows significant inequality in another key aspect of staying safe and healthy during the pandemic: the ability to get outside for fresh air and exercise, and to engage safely with friends, ...

Despite worldwide use of lithium batteries, the exact dynamics of their operation has remained elusive. X-rays have proven to be a powerful tool for peering inside of these batteries to see the changes that occur in real time. Using the ultrabright X-rays of the Advanced Photon Source (APS), a U.S. Department of Energy (DOE) Office of Science User Facility at the DOE's Argonne National Laboratory, a research team recently observed the internal evolution of the materials inside solid-state lithium batteries as they were charged and discharged. This detailed 3D ...

The speed of light has come to 3D printing. Northwestern University engineers have developed a new method that uses light to improve 3D printing speed and precision while also, in combination with a high-precision robot arm, providing the freedom to move, rotate or dilate each layer as the structure is being built. Most conventional 3D printing processes rely on replicating a digital design model that is sliced into layers with the layers printed and assembled upwards like a cake. The Northwestern method introduces the ability to manipulate the original design layer by layer and pivot the printing direction without recreating the model. This "on-the-fly" ...

How do the normal pains of everyday life, such as headaches and backaches, influence our ability to think? Recent studies suggest that healthy individuals in pain also show deficits in working memory, or the cognitive process of holding and manipulating information over short periods of time. Prior research suggests that pain-related impairments in working memory depend on an individual's level of emotional distress. Yet the specific brain and psychological factors underlying the role of emotional distress in contributing to this relationship are not well understood. A new study, titled "Modeling neural and self-reported factors of affective distress in the relationship between pain and working memory in healthy individuals," and published in the journal ...

LOS ANGELES - New research from the Center for Cardiac Arrest Prevention in the Smidt Heart Institute has found for the first time that during nighttime hours, women are more likely than men to suffer sudden death due to cardiac arrest. Findings were published in the journal Heart Rhythm. "Dying suddenly during nighttime hours is a perplexing and devastating phenomenon," said Sumeet Chugh, MD, senior author of the study and director of the Center for Cardiac Arrest Prevention. "We were surprised to discover that being female is an independent predictor of these events." Medical experts are mystified, Chugh says, because during these late hours, most patients are in a resting state, with reduced metabolism, heart rate and blood pressure. Sudden cardiac arrest-also called sudden cardiac ...

LOS ANGELES (Feb. 3, 2021) -- For the first time in humans, investigators at Cedars-Sinai have identified the neurons responsible for canceling planned behaviors or actions--a highly adaptive skill that when lost, can lead to unwanted movements. Known as "stop signal neurons," these neurons are critical in powering someone to stop or abort an action they have already put in process. "We have all had the experience of sitting at a traffic stop and starting to press the gas pedal but then realizing that the light is still red and quickly pressing the brake again," said Ueli Rutishauser, PhD, professor of Neurosurgery, Neurology and Biomedical Sciences at Cedars-Sinai and senior author of the study published ...

NEW YORK and LA JOLLA, CA--A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today. The vaccine showed success in stimulating production of rare immune cells needed to start the process of generating antibodies against the fast-mutating virus; the targeted response was detected in 97 percent of participants who received the vaccine. "This study demonstrates proof of principle for a new vaccine concept for HIV, a concept that could be applied to other pathogens, as well," says William Schief, Ph.D., a professor and immunologist at Scripps Research and executive director of vaccine design at IAVI's Neutralizing Antibody Center, whose laboratory developed the vaccine. "With our many collaborators ...

CHARLOTTE, N.C. - Feb. 3, 2021 - New research on gender inequality indicates that fewer leadership prospects in the workplace apply even to women who show the most promise early on in their academic careers. Jill Yavorsky, an assistant professor of sociology at UNC Charlotte, co-led the study, "The Under-Utilization of Women's Talent: Academic Achievement and Future Leadership Positions," with Yue Qian, an assistant professor of sociology at the University of British Columbia. In their paper, published in a leading social science journal, Social Forces, the social scientists discovered that men supervise more individuals ...

ROCHESTER, Minn. -- A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells. "Immune checkpoint inhibitors have improved the prognosis for patients with a wide range of malignancies including melanoma, non-small cell lung cancer and renal cancer," says Sandra Herrmann, M.D., ...

URBANA, Ill. - For decades, kibble has been our go-to diet for dogs. But the dog food marketplace has exploded in recent years, with grain-free, fresh, and now human-grade offerings crowding the shelves. All commercial dog foods must meet standards for complete and balanced nutrition, so how do consumers know what to choose? A new University of Illinois comparison study shows diets made with human-grade ingredients are not only highly palatable, they're extremely digestible. And that means less poop to scoop. Up to 66% less. "Based on past research we've conducted I'm not surprised with the results when feeding human-grade compared to an extruded dry diet," says Kelly Swanson, the Kraft Heinz Company Endowed Professor in Human Nutrition in the ...

Like weeds sprouting from cracks in the pavement, cancer often forms in sites of tissue damage. That damage could be an infection, a physical wound, or some type of inflammation. Common examples include stomach cancer caused by H. pylori infection, Barrett's esophagus caused by acid reflux, and even smoking-induced lung cancer. Exactly how tissue damage colludes with genetic changes to promote cancer isn't fully understood. Most of what scientists know about cancer concerns advanced stages of the disease. That's especially true for cancers such as pancreatic cancer that are usually diagnosed very late. Researchers ...

Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Professor Francisco Sánchez-Madrid have found that dendritic cells, which initiate specific immune responses, can reprogram their genes to improve their immune response. The results of the study, funded by Fundación 'la Caixa' and published today in Science Advances, could have important applications in the development of new vaccination and immunotherapy strategies. Dendritic cells are professional antigen-presenting cells that initiate adaptive or specific immune responses. As described by the research team, "dendritic cells capture possible pathogenic agents in different tissues and entry sites, process their components, and transport them to lymph nodes. Here, they ...