A group of UCL researchers (Louvain Drug Research Institute) identified an unsuspected mechanism impacting the development of obesity and diabetes type 2 after following a diet with a high dose of fat nutrition. The team of Professor Patrice D. Cani - in direct collaboration with two French teams, a Swedish expert as well as other UCL-researchers (LDRI and Ludwig Institute) - made an important discovery related to the essential role of the intestinal immune system regarding the control of the energy metabolism. Today, the work of Doctor Amandine Everard (in charge of ...

Vienna, Austria - 5 December 2014: New 3D printed heart technology could reduce the number of heart surgeries in children with congenital heart disease, according to Dr Peter Verschueren who spoke on the topic today at EuroEcho-Imaging 2014.1 Dr Verschueren brought 3D printed models of the heart to his lecture including models used to plan real cases in patients. EuroEcho-Imaging is the annual meeting of the European Association of Cardiovascular Imaging (EACVI), a branch of the European Society of Cardiology (ESC), and is held 3-6 December in Vienna, Austria. Dr Verschueren ...

Vienna, Austria - 05 December 2014: Austrian researchers have shown that a new technique which wraps chemotherapy drugs in a fatty cover (called a liposome) reduces heart damage, in a study presented today at EuroEcho-Imaging 2014 by Professor Jutta Bergler-Klein and Professor Mariann Gyöngyösi from the Medical University of Vienna, Austria. EuroEcho-Imaging is the annual meeting of the European Association of Cardiovascular Imaging (EACVI), a branch of the European Society of Cardiology (ESC), and is held 3-6 December in Vienna. Professor Bergler-Klein said: ...

(BOSTON) -- Stem cells offer great potential in biomedical engineering due to their pluripotency, which is the ability to multiply indefinitely and also to differentiate and develop into any kind of the hundreds of different cells and bodily tissues. But the precise complexity of how stem cell development is regulated throughout states of cellular change has been difficult to pinpoint until now. By using powerful new single-cell genetic profiling techniques, scientists at the Wyss Institute for Biologically Inspired Engineering and Boston Children's Hospital have uncovered ...

Is the human immune system similar to the weather, a seemingly random yet dynamical system that can be modeled based on past conditions to predict future states? Scientists at VCU Massey Cancer Center's award-winning Bone Marrow Transplant (BMT) Program believe it is, and they recently published several studies that support the possibility of using next-generation DNA sequencing and mathematical modeling to not only understand the variability observed in clinical outcomes of stem cell transplantation, but also to provide a theoretical framework to make transplantation a ...

On Dec. 4, 2014, the sun emitted a mid-level solar flare, peaking at 1:25 p.m. EST. NASA's Solar Dynamics Observatory, which watches the sun constantly, captured an image of the event. Solar flares are powerful bursts of radiation. Harmful radiation from a flare cannot pass through Earth's atmosphere to physically affect humans on the ground, however -- when intense enough -- they can disturb the atmosphere in the layer where GPS and communications signals travel. To see how this event may affect Earth, please visit NOAA's Space Weather Prediction Center at http://spaceweather.gov, ...

Forecasters at the Joint Typhoon Warning Center expect Super Typhoon Hagupit to reach peak intensity today, Dec. 4, and although expected to weaken, will remain a Category 4 typhoon when it approaches the east central Philippines. NASA's Terra satellite and NASA/JAXA's GPM and TRMM satellites have been providing forecasters with valuable data on the storm. Computer models have varied on their track for the storm based on the strength of an upper-level system, so satellite data is extremely valuable in helping determine where Hagupit will move. On Dec. 3, typhoon Hagupit ...

(Chapel Hill, N.C. - Dec 4, 2014) - Jessica Zègre-Hemsey, a cardiac monitoring expert at the University of North Carolina at Chapel Hill, and her colleagues at the University of California San Francisco, revealed more than 2.5 million alarms were triggered on bedside monitors in a single month - the first figure ever reported from a real-world hospital setting. Alarm fatigue occurs when nurses and other clinicians are exposed to a high number of physiological alarms generated by modern monitoring systems. In turn, alarms are ignored and critical alarms are missed ...

Petaluma, CA - Just like us, grasslands need rest to improve their health. A study just published by Point Blue Conservation Science in the journal Ecological Restoration shows a 72 percent increase in where native perennial grasses were found on a coastal California ranch when cattle grazing was changed to give the land more time to rest. Over the last 300 years, nonnative annual grasses have invaded California's grasslands. These exotic grasses complete their lifecycle in one year and out-compete the native perennial grasses (grasses that live for multiple years). ...

WASHINGTON - Fear of police, language barriers, lack of knowledge of cardiac arrest symptoms and financial concerns prevent Latinos - particularly those of lower socioeconomic status - from seeking emergency medical help and performing cardiopulmonary resuscitation (CPR), according to a study published online yesterday in Annals of Emergency Medicine ("Barriers to Calling 911 and Learning and Performing Cardiopulmonary Resuscitation (CPR) for Residents of Primarily Latino, High-Risk Neighborhoods in Denver, Colorado"). "Residents of low-income, minority neighborhoods ...

WHAT: Two medical imaging techniques, called positron emission tomography (PET) and computed tomography (CT), could be used in combination as a biomarker to predict the effectiveness of antibiotic drug regimens being tested to treat tuberculosis (TB) patients, according to researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. With multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) on the rise worldwide, new biomarkers are needed to determine whether a particular TB ...

El Niño, the abnormal warming of sea surface temperatures in the Pacific Ocean, is a well-studied tropical climate phenomenon that occurs every few years. It has major impacts on society and Earth's climate - inducing intense droughts and floods in multiple regions of the globe. Further, scientists have observed that El Niño greatly influences the yearly variations of tropical cyclones (a general term which includes hurricanes, typhoons and cyclones) in the Pacific and Atlantic Oceans. However, there is a mismatch in both timing and location between this climate ...

While Ebola has attracted much of the world's attention recently, a severe HIV epidemic rages on around the world and in sub-Saharan Africa in particular. Globally, more than 34 million people are infected with HIV; in sub-Saharan Africa alone, 3 million new infections occur annually. In an attempt to stop the spread of HIV, governments in the region are considering providing antiretroviral drugs to people who do not have the virus but are at risk for becoming infected. Such drugs are known as pre-exposure prophylaxis, or PrEP. Although the conventional strategy -- ...

Intracranial hypertension--increased blood pressure inside the head--can predict a child's risk of death from malaria. A study published on December 4th in PLOS Pathogens reports that accumulation of white blood cells impairs the blood flow out of the brain and causes blood pressure increases in mice with experimentally induced cerebral malaria. Ute Frevert, from New York University School of Medicine, USA, and colleagues compared the blood vessel architecture in the brain between two different mouse malaria models. Mice infected with one particular species of the malaria ...

The Social Cost of Carbon puts a dollar value on the climate damages per ton of CO2 released, and is used by - among others -policymakers to help determine the costs and benefits of climate policies. In the latest issue of the journal Science, a group of economists and lawyers urge several improvements to the government's Social Cost of Carbon figure that would impose a regular, transparent and peer-reviewed process to ensure the figure is reliable and well-supported by the latest facts. "By providing an estimate of the damages from an extra ton of CO2 emissions, the ...

People regularly engage in sophisticated 'mentalizing' (i.e. guessing the intentions or beliefs of others) whenever they convince, teach, deceive, and so on. Research published this week in PLOS Computational Biology demonstrates the laws that govern these intuitions and how efficient they are for anticipating the behaviour of other people. Jean Daunizeau and colleagues from INSERM and CNRS combine mathematical modelling, experimental psychology and behavioural economics to measure the sophistication of human 'mentalizing'. The authors asked 26 participants to play ...

The Antarctic ice sheet is a giant water reservoir. The ice cap on the southern continent is on average 2,100 meters thick and contains about 70 percent of the world's fresh water. If this ice mass were to melt completely, it could raise the global sea level by 60 meters. Therefore scientists carefully observe changes in the Antarctic. In the renowned international journal Science, researchers from Germany, the UK, the US and Japan are now publishing data according to which water temperatures, in particular on the shallow shelf seas of West Antarctica, are rising. "There ...

In a new study, published in Science, researchers at Uppsala University demonstrate an association between smoking and loss of the Y chromosome in blood cells. The researchers have previously shown that loss of the Y chromosome is linked to cancer. Since only men have the Y chromosome, these results might explain why smoking is a greater risk factor for cancer among men and, in the broader perspective, also why men in general have a shorter life expectancy. Smoking is a risk factor for various diseases, not only lung cancer. Epidemiological data show that male smokers ...

Cholera is caused when the bacterium Vibrio cholerae infects the small intestine, resulting in severe diarrhea and vomiting, which can result in dehydration and death. The main treatment involves oral rehydration therapy, where the patient drinks water mixed with salts and glucose. But although proven to be enormously effective, there are concerns that the glucose content might actually worsen the disease. EPFL scientists have now shown that this is indeed the case, as glucose increases the toxicity of the cholera bacterium, whereas replacing glucose with starch can reduce ...

A public summer jobs program for high school students from disadvantaged neighborhoods in Chicago reduced violent crime arrests by 43 percent over a 16-month period, according to a new study from the University of Chicago Crime Lab and the University of Pennsylvania. The randomized controlled trial is published in the journal Science. This research comes as youth employment in the summer months, when teenagers are most likely to work, is near a 60-year low. The challenges facing minority and low-income youth are particularly stark; the 2010 employment rate for low-income ...

Magnetite (or Fe3O4) is an elaborate kind of rust - a regular lattice of oxygen and iron atoms. But this material plays an increasingly important role as a catalyst, in electronic devices and in medical applications. Scientists at the Vienna University of Technology have now shown that the atomic structure of the magnetite surface, which everybody had assumed to be well-established, has in fact been wrong all along. The properties of magnetite are governed by missing iron atoms in the sub-surface layer. "It turns out that the surface of Fe3O4 is not Fe3O4 at all, but ...

Highly expressed in the testis, a gene named Ranbp9 has been found to play a critical role in male fertility by controlling the correct expression of thousands of genes required for successful sperm production. A group of researchers led by Professor Wei Yan, at the University of Nevada School of Medicine has discovered that a loss of function of Ranbp9 leads to severely reduced male fertility due to disruptions in sperm development. A paper reporting this finding was published in PLOS Genetics on December 4, 2014. Male infertility affects 1 out of 20 men of reproductive ...

A genetic variant which causes smokers to smoke more heavily has been shown to be associated with increased body mass index (BMI) - but only in those who have never smoked, according to new research led by the University of Bristol, UK and published today in PLOS Genetics. It is likely that this finding has not come to light before because it has been masked by the effect of smoking, which acts to reduce BMI. Professor Marcus Munafo from Bristol's School of Experimental Psychology and colleagues studied a variant in the CHRNA5-A3-B4 gene cluster which is known to increase ...

Researchers from the Medical Research Council Lifecourse Epidemiology Unit (MRC LEU), University of Southampton have shed new light on how grip strength changes across the lifespan. Previous work has shown that people with weaker grip strength in midlife and early old age are more likely to develop problems, such as loss of independence and to have shorter life expectancy. However, there is little information on what might be considered a normal grip strength at different ages. This latest research, which combined information from 12 British studies and is published in ...

An international team, including scientists from DESY, has caught a light sensitive biomolecule at work with an X-ray laser. The study proves that X-ray lasers can capture the fast dynamics of biomolecules in ultra slow-motion, as the scientists led by Prof. Marius Schmidt from the University of Wisconsin-Milwaukee write in the journal Science. "Our study paves the way for movies from the nano world with atomic spatial resolution and ultrafast temporal resolution", says Schmidt. The researchers used the photoactive yellow protein (PYP) as a model system. PYP is a receptor ...