In a new perspective piece published in the Feb. 5 issue of Science, pharmacologist Namandje Bumpus, Ph.D. -- who recently became the first African American woman to head a Johns Hopkins University School of Medicine department, and is the only African American woman leading a pharmacology department in the country -- outlines the molecular origins for differences in how well certain drugs work among distinct populations. She also lays out a four-part plan to improve the equity of drug development. "Human beings are more similar than we are different," says Bumpus. "Yet, the slightest variations in our genetic material ...

The COVID-19 pandemic has affected people's behavior everywhere. Fear, apprehensiveness, sadness, anxiety, and other troublesome feelings have become part of the daily lives of many families since the first cases of the disease were officially recorded early last year. These turbulent feelings are often expressed in dreams reflecting a heavier burden of mental suffering, fear of contamination, stress caused by social distancing, and lack of physical contact with others. In addition, dream narratives in the period include a larger proportion of terms relating to cleanliness and contamination, as well as anger and sadness. All this is reported in a study published in PLOS ONE. The principal investigator was Natália ...

Surface and interface play critical roles in energy storage devices, thus calling for in-situ/operando methods to probe the electrified surface/interface. However, the commonly used in-situ/operando characterization techniques such as X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray spectroscopy and topography, and nuclear magnetic resonance (NMR) are based on the structural, electronic and chemical information in bulk region of the electrodes or electrolytes. Surface science methodology including electron spectroscopy and scanning probe microscopy can provide rich information about how reactions ...

Scientists globally aim to control chemical reactions--an ambitious goal that requires identifying the steps taken by initial reactants to arrive at the final products as the reaction takes place. While this dream remains to be realized, techniques for probing chemical reactions have become sufficiently advanced to render it possible. In fact, chemical reactions can now be monitored based on the change of electronic properties of a single molecule! Thanks to the scanning tunneling microscope (STM), this is also simple to accomplish. Why not then utilize ...

Plastics are among the most successful materials of modern times. However, they also create a huge waste problem. Scientists from the University of Groningen (The Netherlands) and the East China University of Science and Technology (ECUST) in Shanghai produced different polymers from lipoic acid, a natural molecule. These polymers are easily depolymerized under mild conditions. Some 87 per cent of the monomers can be recovered in their pure form and re-used to make new polymers of virgin quality. The process is described in an article that was published in the journal Matter on 4 February. A problem with recycling plastics is that it usually results in a lower-quality product. The best results are obtained by chemical recycling, in which the polymers are broken ...

A pilot program to offer mental health services offered resident physicians at the University of Colorado School of Medicine provides a model for confidential and affordable help, according to an article published today by the journal Academic Medicine. For the 2017-2018 class, 80 resident physicians in the internal medicine and in internal medicine-pediatrics programs were enrolled in a mental health program that provided scheduled appointments at the campus mental health center. Residents were allowed to opt-out of the appointments. The cost of the appointments was covered by the residency programs, not charged to residents. Programs received ...

Scientists of Far Eastern Federal University (FEFU) have advanced the technology of high-speed sintering for optical ceramics (Nd3+:YAG), i.e. active elements generating laser emission in the near-infrared wavelength range (1.06 μm) for cutting the edge microelectronics and medicine. The researchers have managed to reduce significantly the initial nanopowders consolidation period (10 - 100 times) forming a nanostructure with ensured high optical transparency of the ceramic material. A related article appears in Optical Materials. Diode-pumped ...

Inflammation is supposed to help protect us--it's part of an immune response to fight off pathogens and clear infections. But patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present. In a recent study published in Circulation, immunologists at Tufts University School of Medicine in collaboration with investigators at Vanderbilt University and Tufts Medical Center revealed a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart. "Not all inflammation is the same," says Pilar Alcaide, a Kenneth and JoAnn G. Wellner Professor at Tufts School of Medicine and corresponding ...

The 2019-2020 flu season in the U.S. was unusual in a number of ways. Cases picked up in August rather than the more typical fall and early winter months, and it hit children particularly hard. It was also dominated early on by a Type B influenza virus instead of one of the much more common Type A viruses like H1N1 or H3N2. A new study by researchers at the University of Georgia suggests that these dynamics were driven largely by a new, more transmissible strain encountering a population with very little existing immunity to it. Their findings, just published in the Proceedings of the National Academy of Sciences, have implications for future vaccination ...

A new white paper from The Gerontological Society of America (GSA) highlights the variety of challenges that persons with dementia-related psychosis and their caregivers have encountered during moves through different health care settings -- and proposes strategies to address these challenges. It is estimated that over 2 million Americans with dementia experience delusions (false beliefs) and hallucinations (seeing or hearing things that others do not see or hear). This group of symptoms, known as dementia-related psychosis, frequently goes undetected in people who may ...

NEWPORT, Ore. - Researchers can now determine the age and sex of living beluga whales in Alaska's Cook Inlet thanks to a new DNA-based technique that uses information from small samples of skin tissue. Accurate age estimates are vital to conservation efforts for Cook Inlet belugas, which were listed as endangered following a significant population decline in the 1990s. Previously, researchers could only determine the age of beluga whales by studying the teeth of dead animals. The new aging method uses DNA methylation data and machine learning to develop a model that captures ...

If you have a second, try typing "time management" into your favourite search engine. You will get literally millions of results: books, tips, lessons, do's and don'ts. It's a big industry. But as END ...

A new analysis of a horse previously believed to be from the Ice Age shows that the animal actually died just a few hundred years ago--and was raised, ridden and cared for by Native peoples. The study sheds light on the early relationships between horses and their guardians in the Americas. The findings, published today in the journal American Antiquity, are the latest in the saga of the "Lehi horse." In 2018, a Utah couple was doing landscaping in their backyard near the city of Provo when they unearthed something surprising: an almost complete skeleton of a horse about the size of a Shetland pony. Scientists and the media took note. Preliminary data suggested ...

For a girl in Ethiopia, her mother's wealth can protect her from becoming a child bride - but if a father prefers child marriage, his own wealth may increase the likelihood that she will be married before 18, according to a Rutgers University-New Brunswick study. Published in the journal World Development, the study found that girls whose mothers have more asset holdings - a cellphone, bicycle, sewing machine, jewelry or other valuables - have a reduced rate of entering into a child marriage, while the rate is higher for girls whose fathers have more asset holdings. "Child marriage is concerning from a human rights, health and economic perspective," said the study's author Felix Muchomba, assistant professor at the Rutgers School of Social Work. "Girls married before ...

Getting children to eat their vegetables can seem like an insurmountable task, but nutrition researchers at The University of Texas at Austin have found one way: school gardens and lessons on using what's grown in them. Researchers worked with 16 elementary schools across Central Texas to install vegetable gardens and teach classes to students and parents about nutrition and cooking. In a study recently published in the END ...

Humans, wildlife, and the environment are all interconnected and play a role in one another's health and well-being. Sentinel species, such as birds, are good indicators of environmental health, and they can send subtle warning signs that humans may be in danger next. In an experimental exposure study, Kendra Sewall, an associate professor of biological sciences in the College of Science, and a diverse team of scientists and students have found that lead levels like those reported in Flint, Michigan, can interfere with the neural mechanisms of vocal development of songbirds and affect mate attraction. By examining the effects of lead exposure ...

Floating sea macro-litter is a threat to the conservation of marine ecosystems worldwide. The largest density of floating litter is in the great ocean gyres -systems of circular currents that spin and catch litter- but the polluting waste is abundant in coastal waters and semi closed seas such as the Mediterranean. MARLIT, an open access web app based on an algorithm designed with deep learning techniques, will enable the detection and quantification of floating plastics in the sea with a reliability over 80%, according to a study published in the journal Environmental Pollution and carried out by experts ...

A new study led by the University of Kent's Durrell Institute of Conservation and Ecology (DICE) has found that elephants living around the world-famous Masai Mara National Reserve, Kenya, are crop-raiding closer to the protected area, more frequently and throughout the year but are causing less damage when doing so. Findings show that the direct economic impact of this crop-raiding in the Trans Mara region has dropped, yet farmers have to spend more time protecting their fields, further reducing support for conservation in communities who currently receive few benefits from living with wildlife. The research published by Biological Conservation ...

BUFFALO, N.Y. -- All things being equal, large, long-lived animals should have the highest risk of cancer. The calculation is simple: Tumors grow when genetic mutations cause individual cells to reproduce too quickly. A long life creates more opportunities for those cancerous mutations to arise. So, too, does a massive body: Big creatures -- which have many more cells -- should develop tumors more frequently. Why, then, does cancer rarely afflict elephants, with their long lifespans and gargantuan bodies? They are some of the world's largest land animals. A new study delves into this ...

Laparoscopic surgery, a less invasive alternative to conventional open surgery, involves inserting thin tubes with a tiny camera and surgical instruments into the abdomen. To visualize specific surgical targets, ultrasound imaging is used in conjunction with the surgery. However, ultrasound images are viewed on a separate screen, requiring the surgeon to mentally combine the camera and ultrasound data. Modern augmented reality (AR)-based methods have overcome this issue by embedding ultrasound images into the video taken by the laparoscopic camera. These AR methods precisely map the ultrasound data coordinates to the coordinates of the ...

Over the past 30 years, the use of soil fumigants and nematicides used to protect cole crops, such as broccoli and Brussel sprouts, against cyst nematode pathogens in coastal California fields has decreased dramatically. A survey of field samples in 2016 indicated the nematode population has also decreased, suggesting the existence of a natural cyst nematode controlling process in these fields. Thanks to California's pesticide-use reporting program, nematologists have been able to follow the amounts of fumigants and nematicides used to control cyst nematodes over the past three decades. "Application of these pesticides steadily declined until they were completely eliminated in ...

As the coronavirus pandemic continues to devastate communities worldwide, Black Americans who face racial discrimination in hospitals and doctor's offices weather additional stresses that can exacerbate threats from COVID-19. A new University of Georgia study examines the interplay between the perceptions of coronavirus threat and psychological distress among Black Americans. The additional stresses arise from the prevalent belief among Black Americans worried that they might not recover from how hospitals treat them if they become infected with the coronavirus. "While the notion has been floated among commentators, this is the first study that uses nationally representative data to assess whether this threat, or feeling, ...

BOSTON - Tiny particles of air pollution -- called fine particulate matter -- can have a range of effects on health, and exposure to high levels is a known risk factor for cardiovascular disease. New research led by investigators at Massachusetts General Hospital (MGH) reveals that fine particulate matter has a detrimental impact on cardiovascular health by activating the production of inflammatory cells in the bone marrow, ultimately leading to inflammation of the arteries. The findings are published in the END ...

By tweaking a single gene, Harvard scientists engineered zebrafish that show the beginning formation of limb-like appendages. The researchers stumbled upon this mutation, which may shed light on the sea-to-land transition of vertebrates, while screening for various gene mutants and their impact on fish development. Their discovery, outlined February 4th in the journal Cell, marks a fundamental step in our understanding of fin-to-limb evolution and how surprisingly simple genetic changes can create great leaps in the development of complex structures. "It was a little bit unbelievable that just one mutation was able to create completely new bones and joints," says M. Brent Hawkins (@Homeobox), first author of ...

Fin-to-limb transition is an icon of key evolutionary transformations. Many studies focus on understanding the evolution of the simple fin into a complicated limb skeleton by examining the fossil record. In a paper published February 4 in Cell, researchers at Harvard and Boston Children's Hospital examined what's occurring at the genetic level to drive different patterns in the fin skeleton versus the limb skeleton. Researchers, led by M. Brent Hawkins, a recent doctoral recipient in the Department of Organismic and Evolutionary Biology, performed forward genetic screens in zebrafish looking for mutations that affect the fin skeleton. Unlike tetrapod limbs, which have complex skeletons with many bones that articulate ...