Imagine someone hands you a smoothie and asks you to identify everything that went into it. You might be able to discern a hint of strawberry or the tang of yogurt. But overall it tastes like a blend of indiscernible ingredients. Now imagine that the smoothie is made of 20,000 ground-up cells from, say, the brain. You could run tests to determine what molecules are in the sample, which is what scientists do now. That would certainly give you useful information, but it wouldn't tell you which cells those molecules originally came from. It would provide only an average ...

Many people who live in sub-Saharan Africa develop a natural immunity to malaria, through repeated exposure to Plasmodium parasites. Even so, the disease kills close to half a million children per year, according to the World Health Organization. What factors can interfere with the development of immunity? Infectious disease researchers at Emory are calling attention to a trouble-maker whose effects may be underappreciated: Epstein-Barr virus (EBV). Their experiments with mice show that co-infection with a virus closely related to EBV can make a survivable malaria parasite ...

Normal skin contains an unexpectedly high number of cancer-associated mutations, according to a study published in Science. The findings illuminate the first steps cells take towards becoming a cancer and demonstrate the value of analysing normal tissue to learn more about the origins of the disease. The study revealed that each cell in normal facial skin carries many thousands of mutations, mainly caused by exposure to sunlight. In fact, around 25 per cent of skin cells in samples from people without cancer were found to carry at least one cancer-associated mutation. ...

Tropical rainforests have long been considered the Earth's lungs, sequestering large amounts of carbon dioxide from the atmosphere and thereby slowing down the increasing greenhouse effect and associated human-made climate change. Scientists in a global research project now show that the vast extensions of semi-arid landscapes occupying the transition zone between rainforest and desert dominate the ongoing increase in carbon sequestration by ecosystems globally, as well as large fluctuations between wet and dry years. This is a major rearrangement of planetary functions. ...

(SACRAMENTO, Calif.) -- Researchers at UC Davis have conducted a comprehensive study to determine whether pediatric telemedicine consultations with rural emergency departments save money compared to telephone consults. The answer is a resounding yes. While telemedicine systems are expensive to install and maintain, they more than pay their way, saving an average $4,662 per use. The study was published in the journal Medical Decision Making. "Our previous work showed that telemedicine was good for kids, families and providers, but we didn't really address the cost issue," ...

Lawrence Livermore researchers have determined that a tunnel bomb explosion by Syrian rebels was less than 60 tons as claimed by sources. Using seismic stations in Turkey, Livermore scientists Michael Pasyanos and Sean Ford created a method to determine source characteristics of near earth surface explosions. They found the above-ground tunnel bomb blast under the Wadi al-Deif Army Base near Aleppo last spring was likely not as large as originally estimated and was closer to 40 tons. Seismology has long been used to determine the source characteristics of underground ...

This news release is available in French. Montreal, May 21, 2015 - A new study published by the team of Naguib Mechawar, Ph.D., a researcher at the Douglas Institute (CIUSSS de l'Ouest-de-l'île-de-Montréal) and Associate Professor in the Department of Psychiatry at McGill University, suggests that the integration of new neurons in the adult brain is a phenomenon more generally compromised in the brains of depressed patients. This new work confirms that neurogenesis in the human olfactory bulb is a marginal phenomenon in adults. These findings shed light ...

Alexandria, VA - In the years following the 1986 Chernobyl nuclear disaster, forest fires billowed plumes of contaminated smoke, carrying radioactive particles throughout Europe on the wind. Now, researchers fear that a shift to a hotter, drier climate in Eastern Europe could increase the frequency of these fires. Researchers from the University of South Carolina in Columbia used satellite imagery of fires in the 2000s and field measurements of radioisotope levels to model changes in the distribution of radiation over the region. The researchers found that fires likely ...

Researchers have developed a model to assess how dams affect the viability of sea-run fish species that need to pass dams as they use both fresh and marine waters during their lifetimes. NOAA's Northeast Fisheries Science Center (NEFSC) and Greater Atlantic Regional Fisheries Office (GARFO) have partnered on this project to test how varying passage efficiency at dams related to survival rates for these species. Using a model of endangered Atlantic salmon in Maine's Penobscot River as a case study, NOAA researchers found that abundance, distribution and number of fish ...

Hamilton, ON (May 21, 2015) - Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample. Specifically, stem cell scientists at McMaster can now directly convert adult human blood cells to both central nervous system (brain and spinal cord) neurons as well as neurons in the peripheral nervous system (rest of the body) that are responsible for pain, temperature and itch perception. This means that how a person's nervous system cells react and respond to ...

One of the reasons pluripotent stem cells are so popular in medical research is that they can be differentiated into any cell type. However, typical differentiation protocols lead to a heterogeneous population from which the desired type must be purified. Normally, antibodies that react to surface receptors unique to the desired cell are used for this purpose. However, in many cases the purification levels remain poor and the cells can be damaged. New RNA technology produced at CiRA may avoid these problems. Professor Hirohide Saito at the Dept. of Reprogramming Science ...

Receptors carrying built-in decoys are the latest discovery in the evolutionary battle between plants and pathogens. The decoy domains within the receptor detect pathogens and raise the cell's alarm when there is an infection. Plants display component parts of their immune system on receptors to trick pathogens into binding with them, which then triggers defence mechanisms. The discovery comes from Professor Jonathan Jones' group at The Sainsbury Laboratory, published in the high-impact journal Cell with a companion paper on a similar discovery from the Deslandes group ...

Almost 90 per cent of men with advanced prostate cancer carry genetic mutations in their tumours that could be targeted by either existing or new cancer drugs, a landmark new study reveals. Scientists in the UK and the US have created a comprehensive map of the genetic mutations within lethal prostate cancers that have spread around the body, in a paper being hailed as the disease's 'Rosetta Stone'. Researchers say that doctors could now start testing for these 'clinically actionable' mutations and give patients with advanced prostate cancer existing drugs or drug combinations ...

May 21, 2015 - A University of Wyoming faculty member led a research team that discovered a certain type of soil bacteria can use their social behavior of outer membrane exchange (OME) to repair damaged cells and improve the fitness of the bacteria population as a whole. Daniel Wall, a UW associate professor in the Department of Molecular Biology, and others were able to show that damaged sustained by the outer membrane (OM) of a myxobacteria cell population was repaired by a healthy population using the process of OME. The research revealed that these social organisms ...

When Dolphin was a typhoon on May 16, NASA's CloudSat satellite completed a stunning eye overpass of Typhoon Dolphin in the West Pacific at 0412 UTC (12:12 a.m. EDT). By May 22, Dolphin's remnants were moving through the Northern Pacific. NASA's CloudSat satellite sends pulses of microwave energy through the clouds, and some of the energy in the pulses is reflected back to the spacecraft. The time delay between when the pulse is sent and when the reflected energy is received back at the spacecraft is mapped into a distance of the cloud from the surface of the Earth, and ...

COLUMBIA, Mo. - Last year, researchers at the University of Missouri published a study on genetic diversity in American black bears in Missouri, Arkansas and Oklahoma and determined that conservation management is needed to maintain healthy populations in the region. Now, those scientists have expanded the study to include black bears throughout North America. They discovered that black bears in Alaska are more closely related to bears in the eastern regions of the U.S. and Canada than those located in western regions. Details from the study revealed ancient movement patterns ...

(PARIS, FRANCE) - Stent thrombosis following urgent angioplasty for acute heart attack occurred in less than 1% of patients in a large, "real-world" registry, regardless of whether the antithrombotic treatment used during the procedure was bivalirudin, heparin alone, or a GP IIb/IIIa inhibitor (typically in combination with heparin).* However, patients who experienced a stent thrombosis between days 2 and 30, regardless of drug regimen, were more likely to die within one year than were patients who developed stent thrombosis within the first 24 hours of their procedure. "What ...

Skin pliability and elasticity improved after treatment with onabotulinum toxin (Botox) for mild facial wrinkles and the effect lasted for up to four months, according to a report published online by JAMA Facial Plastic Surgery. Human skin has three biomechanical features: strength, pliability (the ability to stretch) and elasticity (the ability to recoil). As people age, these properties change and the loss of skin elasticity appears to be the most prominent. Physicians use a variety of methods to reverse the signs of aging and onabotulinum toxin A injections are among ...

Providing personalized education and risk assessment for patients with diabetes when they visit the ophthalmologist did not improve glycemic control as measured by hemoglobin A1c levels compared with patients who received usual care, according to a study published online by JAMA Ophthalmology. Intensive blood glucose control can reduce the onset and progression of microvascular complications in people with diabetes. However, optimal glycemic control as measured by HbA1c is notoriously difficult to achieve. A potential strategy to improve glycemic control is to leverage ...

A workplace intervention designed to reduce employees' work-family conflict and increase schedule flexibility also has a positive influence on the sleep patterns of the employees' children. The intervention, Support-Transform-Achieve-Results (STAR), includes training supervisors to be more supportive of their employees' personal and family lives, changing the structure of work so that employees have more control over their work time, and changing the culture in the workplace so that colleagues are more supportive of each other's efforts to integrate their work and personal ...

If a young man is a chronic gambler, the chances are extremely high that he also suffers from depression. This is one of the findings from a study led by Frédéric Dussault of the University of Quebec at Montreal in Canada. Published in Springer's Journal of Gambling Studies, it is the first to investigate the extent to which gambling and depression develop hand-in-hand from the teenage years to early adulthood. Data were drawn from an ongoing long-term study that began in 1984. It follows a group of 1,162 kindergarten boys from economically disadvantaged areas ...

PITTSBURGH, May 21, 2015 -- Exposure to fine particulate air pollution during pregnancy through the first two years of a child's life may be associated with an increased risk of the child developing autism spectrum disorder (ASD), a condition that affects one in 68 children, according to a University of Pittsburgh Graduate School of Public Health investigation of children in southwestern Pennsylvania. The research is funded by The Heinz Endowments and published in the July edition of Environmental Research. "Autism spectrum disorders are lifelong conditions for which ...

Online customer service agents who use emoticons and who are fast typists may have a better chance of putting smiles on their customers' faces during business-related text chats, according to researchers. In a study, people who text chatted with customer service agents gave higher scores to the agents who used emoticons in their responses than agents who did not use emoticons, said S. Shyam Sundar, Distinguished Professor of Communications and co-director of the Media Effects Research Laboratory. The customers also reported that agents who used emoticons were more personal ...

Researchers at Case Western Reserve University School of Dental Medicine have unraveled one of the mysteries of how a small group of immune cells work: That some inflammation-fighting immune cells may actually convert into cells that trigger disease. Their findings, recently reported in the journal Pathogens, could lead to advances in fighting diseases, said the project's lead researcher Pushpa Pandiyan, an assistant professor at the dental school. The cells at work A type of white blood cell, called T-cells, is one of the body's critical disease fighters. Regulatory ...

Scientists from the Institut Pasteur and CNRS, in collaboration with scientists from the Institut Gustave Roussy and CEA, have succeeded in restoring normal activity in cells isolated from patients with the premature aging disease Cockayne syndrome. They have uncovered the role played in these cells by an enzyme, the HTRA3 protease. This enzyme is overexpressed in Cockayne syndrome patient cells, and leads to mitochondrial defects, which in turn play a crucial role in the appearance of symptoms leading to aging in affected children. These findings, published in the ...