A high proportion of survivors of Ebola experienced a resurgence in antibody levels nearly a year after recovery, a new University of Liverpool study has found. Published today in Nature, the finding hints that hidden reservoirs of virus could exist long after symptoms ease and has implications for monitoring programmes and vaccine strategies. When a person is infected with Ebola virus, their body produces antibodies to fight the disease. Antibody concentrations peak and then decline slowly over time, providing the body with some degree of immune protection ...

Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The latest study from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes Research is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission. Diabetes mellitus is a complex disease characterized by the loss or dysfunction of insulin-producing beta cells in the islets of Langerhans, ...

Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. In the journal Angewandte Chemie, scientists have now introduced a new type of reaction for making amide bonds. Called an ASHA ligation, this reaction is fast, efficient, works under mild aqueous conditions, and is broadly applicable. Amide bonds are the bond between a carbonyl carbon (C=O) and an organic nitrogen atom. It is amide bonds that link individual amino acids together into proteins and bind monomers into polyamide plastics like perlon ...

Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles' heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics. The coronavirus is an RNA virus that has, in its enzymatic toolkit, a "proofreading" exoribonuclease, called nsp14-ExoN, which can correct errors in the RNA sequence that occur during replication, when copies of the virus are generated. Using cutting-edge technologies and novel bioinformatics approaches, the researchers discovered that this ExoN also regulates the rate of recombination, the ability of the coronavirus ...

Reaching zero net emissions of carbon dioxide from energy and industry by 2050 can be accomplished by rebuilding U.S. energy infrastructure to run primarily on renewable energy, at a net cost of about $1 per person per day, according to new research published by the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab), the University of San Francisco (USF), and the consulting firm Evolved Energy Research. The researchers created a detailed model of the entire U.S. energy and industrial system to produce the first detailed, peer-reviewed study of how to achieve carbon-neutrality by 2050. According to the Intergovernmental Panel on Climate Change (IPCC), the world must reach zero net CO2 ...

CHAMPAIGN, Ill. -- Culture, civic-mindedness and privacy concerns influence how willing people are to share personal location information to help stem the transmission of COVID-19 in their communities, a new study finds. Such sharing includes giving public health authorities access to their geographic information via data gathered from phone calls, mobile apps, credit card purchases, wristband trackers or other technologies. Reported in the International Journal of Geo-Information, the study will help public health officials better tailor their COVID-19 mitigation strategies to specific cultural contexts, the ...

Climate change mitigation is about more than just CO2. So-called "short-lived climate-forcing pollutants" such as soot, methane, and tropospheric ozone all have harmful effects. Climate policy should be guided by a clearer understanding of their differentiated impacts. It is common practice in climate policy to bundle the climate warming pollutants together and express their total effects in terms of "CO2 equivalence". This 'equivalence' is based on a comparison of climate effects on a 100-year timescale. This approach is problematic, as IASS scientist Kathleen ...

In a new article published in the scientific journal Communications Chemistry, a research group at Uppsala University show, using computer simulations, that ions do not always behave as expected. In their research on molten salts, they were able to see that, in some cases, the ions in the salt mixture they were studying affect one another so much that they may even move in the "wrong" direction - that is, towards an electrode with the same charge. Research on the next-generation batteries is under way in numerous academic disciplines. Researchers at the Department of Cell and Molecular Biology, Uppsala University have developed and studied a model for alkali halides, of which ordinary table salt (sodium chloride) is the best-known example. If these ...

Researchers at the Francis Crick Institute, the UCL Cancer Institute, and the Cancer Research UK Lung Cancer Centre of Excellence have identified genetic changes in tumours which could be used to predict if immunotherapy drugs would be effective in individual patients. Immunotherapies have led to huge progress treating certain types of cancer, but only a subset of patients respond, and hence a challenge for doctors and researchers is understanding why they work in some people and not others, and predicting who will respond well to treatment. In their paper, published in Cell today (27 January), the scientists looked for genetic and gene expression changes in tumours in over 1,000 patients being treated with checkpoint inhibitors, a type of immunotherapy which stops cancer cells ...

Health authorities should develop targeted health messages for vaping product and e-liquid packaging to encourage smokers to switch from cigarettes to e-cigarettes and to prevent non-smokers from taking up vaping, a researcher at the University of Otago, Wellington, New Zealand says. Professor Janet Hoek, a Co-Director of the University's ASPIRE 2025 Research Centre has led new research analysing the impact of on-package messaging on e-liquids. The research team found messages presenting electronic nicotine delivery systems as a lower risk alternative to smoking could encourage about a third of smokers to trial them. On the other hand, messages about the ...

As Covid-19 continues to put pressure on healthcare providers around the world, engineers at the University of Bath have published a mathematical model that could help clinicians to safely allow two people to share a single ventilator. Members of Bath's Centre for Therapeutic Innovation and Centre for Power Transmission and Motion Control have published a first-of-its-kind research paper on dual-patient ventilation (DPV), following work which began during the first wave of the virus in March 2020. Professor Richie Gill, Co-Vice Chair of the Centre ...

Scientists have calculated the mass range for Dark Matter - and it's tighter than the science world thought. Their findings - due to be published in Physics Letters B in March - radically narrow the range of potential masses for Dark Matter particles, and help to focus the search for future Dark Matter-hunters. The University of Sussex researchers used the established fact that gravity acts on Dark Matter just as it acts on the visible universe to work out the lower and upper limits of Dark Matter's mass. The results show that Dark Matter cannot be either 'ultra-light' or 'super-heavy', as some have theorised, unless an as-yet undiscovered force also acts upon it. The team used the assumption that the only force acting on Dark Matter is gravity, ...

Although the reputation of Champagne is well established, the history of Champagne wines and vineyards is poorly documented. However, a research team led by scientists from the CNRS and the Université de Montpellier at the Institut des sciences de l'évolution de Montpellier* has just lifted the veil on this history by analysing the archaeological grape seeds from excavations carried out in Troyes and Reims. Dated to between the 1st and 15th centuries AD, the seeds shed light on the evolution of Champagne wine growing, prior to the invention of the famous Champagne, for the first time. According to the researchers, "wild"** ...

Even after accounting for differences in income, education, caregiver support, special education services and parental reports of misbehavior and family conflict, elementary school-age Black children are 3.5 times more likely to be suspended or placed in detention than their white peers, a new study finds. The results were unsettling even to the researchers themselves, who were familiar with previous research into racial disparities in school discipline. Previous studies primarily used school records, but this study was able to use a nationwide self-reported dataset, with data collected as part of a long-term investigation into how the ...

A newly discovered trace fossil of an ancient burrow has been named after University of Alberta paleontologist Murray Gingras. The fossil, discovered by a former graduate student, has an important role to play in gauging how salty ancient bodies of water were, putting together a clearer picture of our planet's past. "One could not find a more passionate and influential teacher of science in the classroom, in the field or at a conference," said Ryan King, lead author of the study and now an adjunct professor at Western Colorado University. "Naming the fossil after Gingras was a straightforward decision since his research focuses ...

Boulder, Colo., USA: Benthic plastic litter is a main source of pollutants in oceans, but how it disperses is largely unknown. This study by Guangfa Zhong and Xiaotong Peng, published today in Geology, presents novel findings on the distribution patterns and dispersion mechanisms of deep-sea plastic waste in a submarined canyon located in the northwestern South China Sea. Evidence collected from a series of manned submersible dives indicate that the plastic litter items transported and deposited in the canyon are most likely controlled by turbidity currents. Here the plastic litter items are highly heterogeneously distributed: Up to 89% of them occur in a few scours of the canyon. The plastic items are mostly accumulated in longitudinal litter piles of 2-61 m long, 0.5-8 m wide, ...

JANUARY 26, 2021, NEW YORK - A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients. Their findings appear in the current issue of the Journal of Experimental Medicine. "Our study identifies two families of gut bacteria that interfere with radiotherapy in mice and describes the mechanism by which a metabolite they produce--a short chain fatty acid called butyrate--undermines the therapy," said Weichselbaum. A wide variety of commensal bacteria inhabit ...

Birds play an underrecognized role in spreading tickborne disease due to their capacity for long-distance travel and tendency to split their time in different parts of the world - patterns that are shifting due to climate change. Knowing which bird species are able to infect ticks with pathogens can help scientists predict where tickborne diseases might emerge and pose a health risk to people. A new study published in the journal Global Ecology and Biogeography used machine learning to identify bird species with the potential to transmit the Lyme disease bacterium (Borrelia burgdorferi) to feeding ticks. The team developed a model that identified birds known to spread Lyme disease with 80% accuracy and flagged 21 new species that should be prioritized for surveillance. Lead author Daniel ...

The rapid development of two-dimensional quantum materials, such as twisted bilayer graphene, monolayer copper superconductors, and quantum spin Hall materials, has demonstrated both important scientific implications and promising application potential. To characterize the electronic structure of these materials/devices, angle-resolved photoemission spectroscopy (ARPES) is commonly used to measure the energy and momentum of electrons photoemitted from samples illuminated by X-ray or vacuum ultraviolet (VUV) light sources. Although the X-ray-based spatially resolved ARPES has the highest spatial resolution (~100 nm) benefitting from the relatively short wavelength, its energy resolution is typically mediocre (>10 meV), ...

The overuse of antibiotics occurs due to the mistaken widespread belief that they are beneficial for a broad array of conditions and because many physicians are willing to prescribe antibiotics if patients ask for the medication, according to a Rutgers study. The study, published in the journal BioEssays, reviewed more than 200 peer-reviewed studies to examine the causes behind antibiotic overuse, which can lead harmful bacteria to become drug-resistant and cause harmful effects on the microbiome, the collection of beneficial germs that live in and on our bodies. Martin Blaser, director of the Center for Advanced Biotechnology and Medicine at Rutgers and lead author, said the global use of antibiotics between 2000 and 2015 increased 39 percent, with ...

p>AUSTIN, Texas -- Trauma-focused psychotherapy is widely considered the best available treatment for posttraumatic stress disorder (PTSD). However, the ways in which this method affects the brain to promote recovery from PTSD are not well understood. In a END ...

A research group from Kumamoto University (Japan) has developed an automated measurement system to assess healthy lifespans using nematodes (C. elegans). Based on qualitative differences in lifespans, this system can classify populations of nematodes that are, on average, healthy and long-lived, healthy and die prematurely, and living with long periods of poor health. Since there are many similarities between the mechanisms that determine the lifespan of C. elegans and humans, the researchers believe that this system will make it easier to develop drugs and find foods that extend the ...

A tree grows strong from years of generating its own food. Now imagine if products could be strengthened with the same living materials that provide nutrients to strengthen trees. This is the work of USC Viterbi School of Engineering Civil and Environmental Engineering Professor Qiming Wang whose research lab is one of the first to infuse 3-D printer ink with living material. The material has potential for greater strength, to be flexible and self-heal. The work is documented in a paper published in The Proceedings of the National Academy of Sciences. The idea for this bio-inspired ink came from trees that harness the power of photosynthesis to produce glucose that transform to ...

In our body, unnecessary cells are removed by regulated cell death. Understanding of the mechanism underlying regulated cell death is critical for the development of therapies for many diseases. Professor Nakano's research group has demonstrated that Mind bomb-2 (MIB2), a ubiquitin ligase, binds to and directly ubiquitinates the cell death suppressor protein cFLIP (Cellular FLICE-inhibitory protein). cFLIP is encoded by CFLAR gene; alternative splicing results in two forms, the long form (cFLIPL) and the short form (cFLIPs). cFLIPL plays a dominant role in suppression ...

January 27, 2021 - For many of us, as we get older the skin on our face begins to sag and we seem to lose volume around our eyes, cheeks and chin. Is gravity taking its toll in our later years or do we lose fat over the course of several years that many of us associate with youth, vibrancy and energy? Understanding the cause is paramount to how plastic surgeons treat the signs of facial aging. The traditional theory is sagging: the facial soft tissues simply yield to the effects of gravity over time. And while the idea that weakening ligaments in the midface could result in soft tissue descent still has merit, more recent studies point in another direction. Perhaps the real culprit behind facial aging ...