Studies in mice demonstrate that signals from the bacteria that harmlessly—and often beneficially—inhabit the human gastrointestinal tract boost the immune system's ability to kill a major respiratory pathogen, Klebsiella pneumoniae, according to a paper published online ahead of print in the journal Infection and Immunity. The research is yet another example of how important these "commensal" bacteria are to human health and physiology, says Thomas B. Clarke, of Imperial College London, UK, the lone author of this paper. "Numerous studies have shown that changes ...

Researchers led by Dr. Helen McNeill at the Lunenfeld-Tanenbaum Research Institute have revealed an exciting and unusual biochemical connection. Their discovery has implications for diseases linked to mitochondria, which are the primary sources of energy production within our cells. Dr. McNeill's team has an international reputation for their work in understanding how cells become organized into tissues and how growth is regulated during development. The group focuses on mutations in the fat (ft) gene. The protein product of this gene, called 'Fat', acts at the cell membrane ...

Ann Arbor, Mich. — Primary care providers report many challenges to integrating genetics services into routine primary care, according to research published today in Genetics in Medicine. Medical genetics medicine has traditionally been used to identify and diagnose rare diseases, but in the last decade it has been increasingly helpful in determining patients at risk for genetically-based conditions who can benefit from preventive health care, says the study's senior author, Beth Tarini, M.D., M.S., F.A.A.P., assistant professor of pediatrics at the University of Michigan ...

One in six cancer patients enroll in hospice only during their last three days of life, according to a new study from a team from the Perelman School of Medicine at the University of Pennsylvania. Their findings, published online last month in the Journal of Clinical Oncology (JCO) also reveal a profile of patients who may be most at risk of these late admissions. "Waiting until the final days of life to begin hospice can shortchange patients and their families – skipping over many benefits of hospice care and limiting the opportunity to improve patients' quality of ...

TEMPE, Ariz. – World leaders face multiple barriers in their efforts to reach agreement on greenhouse gas emission policies. And, according to Arizona State University researchers, without globally consistent, independent emissions assessments, climate agreements will remain burdened by errors, self-reporting, and the inability to verify emissions progress. Now, an international research team led by ASU scientists has developed a new approach to estimate CO2 emissions from burning fossil fuels — one that provides crucial information to policymakers. Called the "Fossil ...

Dartmouth researchers have found that the genetic mutation BRAFV600E, frequently found in metastatic melanoma, not only secretes a protein that promotes the growth of melanoma tumor cells, but can also modify the network of normal cells around the tumor to support the disease's progression. Targeting this mutation with Vemurafenib reduces this interaction, and suggests possible new treatment options for melanoma therapy. They report on their findings in "BRAFV600E melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity," which was recently ...

Imagine a balloon that could float without using any lighter-than-air gas. Instead, it could simply have all of its air sucked out while maintaining its filled shape. Such a vacuum balloon, which could help ease the world's current shortage of helium, can only be made if a new material existed that was strong enough to sustain the pressure generated by forcing out all that air while still being lightweight and flexible. Caltech materials scientist Julia Greer and her colleagues are on the path to developing such a material and many others that possess unheard-of combinations ...

WASHINGTON (Sept. 11, 2014)—Scientists today unveiled what appears to be the first truly semiaquatic dinosaur, Spinosaurus aegyptiacus. New fossils of the massive Cretaceous-era predator reveal it adapted to life in the water some 95 million years ago, providing the most compelling evidence to date of a dinosaur able to live and hunt in an aquatic environment. The fossils also indicate that Spinosaurus was the largest known predatory dinosaur to roam the Earth, measuring more than 9 feet longer than the world's largest Tyrannosaurus rex specimen. These findings, published ...

Many pathogens are transmitted by insect bites. The abundance of vectors (as the transmitting insects are called) depends on seasonal and other environmental fluctuations. An article published on September 11thin PLOS Pathogens demonstrates that Plasmodium parasites react to mosquitoes biting their hosts, and that the parasite responses increase transmission to the mosquito vector. Sylvain Gandon, from the CNRS in Montpellier, France, and colleagues first studied the theoretical evolution of parasite evolution in a variable environment. Using a mathematical model, they ...

Solving societal challenges in food security, emerging diseases and biodiversity loss will require evolutionary thinking in order to be effective in the long run. Inattention to this will only lead to greater challenges such as short-lived medicines and agricultural treatments, problems that may ultimately hinder sustainable development, argues a new study published online today in Science Express, led by University of California, Davis and the Center for Macroecology, Evolution and Climate at the University of Copenhagen. For the first time, scientists have reviewed ...

Dartmouth researchers studying cell division in fruit flies have discovered a pathway that may improve understanding of molecular mistakes that cause older women to have babies with Down syndrome. The study shows for the first time that new protein linkages occur in immature egg cells after DNA replication and that these replacement linkages are essential for these cells to maintain meiotic cohesion for long periods. The study appears in the journal PLOS Genetics. A PDF is available on request. As women age, so do their eggs and during a woman's thirties, the chance ...

Researchers at Chalmers University of Technology are first to show the use of sound to communicate with an artificial atom. They can thereby demonstrate phenomena from quantum physics with sound taking on the role of light. The results will be published in the journal Science. The interaction between atoms and light is well known and has been studied extensively in the field of quantum optics. However, to achieve the same kind of interaction with sound waves has been a more challenging undertaking. The Chalmers researchers have now succeeded in making acoustic waves couple ...

Scientists have pinpointed for the first time the genetic cause in some people of an incurable muscle-wasting disease, Emery-Dreifuss muscular dystrophy (EDMD). The international research team led by the University of Leicester say the finding of two target genes opens the possibility of developing drugs to tackle the disease in these patients. Their work has been published today in the journal PLOS Genetics. The research was funded by The Wellcome Trust and was only possible by the University of Leicester team collaborating with groups in Germany (University of Greifswald), ...

In a research paper published this week in Science, the collaboration led by MIT's theory professor Leonid Levitov and Manchester's Nobel laureate Sir Andre Geim report a material in which electrons move at a controllable angle to applied fields, similar to sailboats driven diagonally to the wind. The material is graphene – one atom-thick chicken wire made from carbon – but with a difference. It is transformed to a new so-called superlattice state by placing it on top of boron nitride, also known as `white graphite', and then aligning the crystal lattices of the two materials. ...

Blame the "hot Jupiters." These large, gaseous exoplanets (planets outside our solar system) can make their suns wobble when they wend their way through their own solar systems to snuggle up against their suns, according to new Cornell University research to be published in Science, Sept. 11. Images: https://cornell.box.com/lai "Although the planet's mass is only one-thousandth of the mass of the sun, the stars in these other solar systems are being affected by these planets and making the stars themselves act in a crazy way," said Dong Lai, Cornell professor of ...

As humans transform the planet to meet our needs, all sorts of wildlife continue to be pushed aside, including many species that play key roles in Earth's life-support systems. In particular, the transformation of forests into agricultural lands has dramatically reduced biodiversity around the world. A new study by scientists at Stanford and the University of California, Berkeley, in this week's issue of Science shows that evolutionarily distinct species suffer most heavily in intensively farmed areas. They also found, however, that an extraordinary amount of evolutionary ...

When people practice simple word classification tasks before nodding off—knowing that a "cat" is an animal or that "flipu" isn't found in the dictionary, for example—their brains will unconsciously continue to make those classifications even in sleep. The findings, reported in the Cell Press journal Current Biology on September 11, show that some parts of the brain behave similarly whether we are asleep or awake and pave the way for further studies on the processing capacity of our sleeping brains, the researchers say. "We show that the sleeping brain can be far more ...

Annual flu epidemics cause millions of cases of severe illness and up to half a million deaths every year around the world, despite widespread vaccination programs. A study published by Cell Press on September 11th in Immunity reveals that gut microbes play an important role in stimulating protective immune responses to the seasonal flu vaccine in mice, suggesting that differences in the composition of gut microbes in different populations may impact vaccine immunity. The study paves the way for global public health strategies to improve the effectiveness of the flu vaccine. ...

Using human induced pluripotent stem cells (hiPSCs), researchers have gained new insight into what may cause schizophrenia by revealing the altered patterns of neuronal signaling associated with this disease. They did so by exposing neurons derived from the hiPSCs of healthy individuals and of patients with schizophrenia to potassium chloride, which triggered these stem cells to release neurotransmitters, such as dopamine, that are crucial for brain function and are linked to various disorders. By discovering a simple method for stimulating hiPSCs to release neurotransmitters, ...

Mice treated with antibiotics to remove most of their intestinal bacteria or raised under sterile conditions have impaired antibody responses to seasonal influenza vaccination, researchers have found. The findings suggest that antibiotic treatment before or during vaccination may impair responses to certain vaccines in humans. The results may also help to explain why immunity induced by some vaccines varies in different parts of the world. In a study to be published in Immunity, Bali Pulendran, PhD, and colleagues at Emory University demonstrate a dependency on gut ...

Bacteria that normally live in and upon us have genetic blueprints that enable them to make thousands of molecules that act like drugs, and some of these molecules might serve as the basis for new human therapeutics, according to UC San Francisco researchers who report their new discoveries in the September 11, 2014 issue of Cell. The scientists purified and solved the structure of one of the molecules they identified, an antibiotic they named lactocillin, which is made by a common bacterial species, Lactobacillus gasseri, found in the microbial community within the vagina. ...

DURHAM, N.C. -- Living cells are like miniature factories, responsible for the production of more than 25,000 different proteins with very specific 3-D shapes. And just as an overwhelmed assembly line can begin making mistakes, a stressed cell can end up producing misshapen proteins that are unfolded or misfolded. Now Duke University researchers in North Carolina and Singapore have shown that the cell recognizes the buildup of these misfolded proteins and responds by reshuffling its workload, much like a stressed out employee might temporarily move papers from an overflowing ...

A study comparing how blood stem cells and leukemia cells consume nutrients found that cancer cells are far less tolerant to shifts in their energy supply than their normal counterparts. The results suggest that there could be ways to target leukemia metabolism so that cancer cells die but other cell types are undisturbed. Harvard Stem Cell Institute scientists at the Massachusetts General Hospital Center for Regenerative Medicine and the Harvard University Department of Stem Cell and Regenerative Biology led the work, published in the journal Cell, in collaboration with ...

Using human induced pluripotent stem cells (hiPSCs), researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego have discovered that neurons from patients with schizophrenia secrete higher amounts of three neurotransmitters broadly implicated in a range of psychiatric disorders. The findings, reported online Sept. 11 in Stem Cell Reports, represent an important step toward understanding the chemical basis for schizophrenia, a chronic, severe and disabling brain disorder that affects an estimated one in 100 persons at some ...

Washington, DC—Postmenopausal women with diverse gut bacteria exhibit a more favorable ratio of estrogen metabolites, which is associated with reduced risk for breast cancer, compared to women with less microbial variation, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Since the 1970s, it has been known that in addition to supporting digestion, the intestinal bacteria that make up the gut microbiome influence how women's bodies process estrogen, the primary female sex hormone. The colonies of bacteria ...