Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies. The protein indirectly switches on an important inracellular signaling pathway active while the embryo develops and shut down in healthy cells of adults. Far Eastern Federal University (FEFU), the University of Geneva, and the Institute of Protein Research (Russia) scientists addressed the problem in Scientific Reports. Researchers have taken another step towards targeted treatment of tumors. The idea of such a therapy is to identify the necessary ...

CHAMPAIGN, Ill. -- Childhood trauma could affect the trajectory of multiple sclerosis development and response to treatment in adulthood, a new study in mice found. Mice that had experienced stress when young were more likely to develop the autoimmune disorder and less likely to respond to a common treatment, researchers at the University of Illinois Urbana-Champaign found. However, treatment that activated an immune-cell receptor mitigated the effects of childhood stress in the mice. Multiple sclerosis is a progressive autoimmune disease in which the body attacks and strips ...

It all sounds similar to a dance event - but are singles or couples dancing here? This was the question Ali Isbilir and Dr. Paolo Annibale at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) were trying to answer. However, their investigation did not involve a ballroom, but the cell membrane. The question behind their investigation: does a particular protein receptor on the surface of cancer and immune cells appear alone or connect in pairs? The receptor is called "CXCR4" - the subject of heated debate among experts in recent years due to its mysterious relationship ...

(Boston)--There is a growing awareness of systematic inequality and structural racism in American society. Science and medicine are no exception, as evidenced by historical instances of discrimination and overt racism. In a perspective piece in the Journal of the American Society of Nephrology, researchers from Boston University School of Medicine (BUSM), take an honest look at how the current practice of nephrology (kidney medicine) may have elements rooted in racist ideologies. For twenty years, kidney function has been estimated based on lab tests and equations that consider ...

A combination of reduced-dose radiotherapy using intensity-modulated radiotherapy (IMRT) combined with concurrent cisplatin met the threshold for disease control and quality of life compared to the standard of care for good-risk patients with HPV-associated oropharyngeal squamous cell carcinoma on the NRG Oncology clinical trial NRG-HN002. The outcomes from this data justify the advancement of the reduced radiotherapy dose with cisplatin to a Phase III clinical trial setting in this population. These results were recently published in the Journal of Clinical Oncology. "Currently, patients with HPV-associated ...

WHAT: The earliest eye damage from prion disease takes place in the cone photoreceptor cells, specifically in the cilia and the ribbon synapses, according to a new study of prion protein accumulation in the eye by National Institutes of Health scientists. Prion diseases originate when normally harmless prion protein molecules become abnormal and gather in clusters and filaments in the human body and brain. Understanding how prion diseases develop, particularly in the eye because of its diagnostic accessibility to clinicians, can help scientists identify ways to slow the spread of prion diseases. The scientists say their findings, published in the journal Acta Neuropathologica Communications, ...

Colorectal cancer is the third most common form of cancer. While 90% of cases are in people older than 50, there is an as-yet unexplained rising incidence in younger people. Family history ranks high among risk factors for developing colorectal cancer, and people with such a history are often advised to get more frequent screening tests or start screening sooner than the recommended age of 45 years old. Those with a family history of cancer often seek out genetic tests to look for mutations linked to cancer risk. However, those tests don't always provide helpful information. In a new paper in the American Journal of Human Genetics, Jacob Kitzman, Ph.D., of the ...

Scientists at Tokyo Institute of Technology (Tokyo Tech) produced and extensively characterized novel organic molecules with a long helical structure. Unlike previous helical molecules, these longer compounds exhibit special interactions between coils that could give rise to interesting optical and chemical properties with applications in light polarization, catalysis, and molecular springs. More often than not, organic molecules with unique 3D structures bear physicochemical properties that cannot be found in other types of compounds. Helicenes, chains of simple benzene rings that adopt a helical structure, are a good ...

For species to survive in the wild, maintaining connectivity between populations is critical. Without 'wildlife corridors', groups of animals are isolated, unable to breed and may die out. In assessing wildlife connectivity, many aspects of the landscape are measured, but the impact of human behaviour has largely been overlooked. Now, an international team led by the University of Göttingen and Humboldt University Berlin, introduce the concept of 'anthropogenic resistance', which should be studied to ensure sustainable landscapes for wildlife and people ...

In northern Canada, the forest floor is carpeted with reindeer lichens. They look like a moss made of tiny gray branches, but they're stranger than that: they're composite organisms, a fungus and algae living together as one. They're a major part of reindeer diets, hence the name, and the forest depends on them to move nutrients through the ecosystem. They also, at least in parts of Quebec, are having a lot more sex than scientists expected. In a new study in the American Journal of Botany, researchers found that the reindeer lichens they examined have unexpected levels of genetic diversity, indicating that the lichens have been doing more gene-mixing with each other than the scientists would have guessed. "We were surprised because this species of reindeer lichen had ...

(Singapore--January 29, 2021 11:00 p.m. SPT/10:00 a.m. EST)--On February 27, 2020, the flagship journal of the International Association for the Study of Lung Cancer, the Journal of Thoracic Oncology, published a case study that described two patients from Wuhan, China who recently underwent lung lobectomies for adenocarcinoma and were retrospectively found to have had COVID-19 at the time of surgery. Eleven months later, the lung cancer research community gathered virtually at the IASLC 2020 World Conference on Lung Cancer Singapore to share a number of research ...

CHICAGO (January 29, 2021): Trauma patients and patients who need emergency surgery have little to no opportunity to get acquainted with the surgeon and team that will perform their operation. However, a large study has found that effective and meaningful physician communication is a more important contributor to the overall satisfaction of trauma patients and those having emergency surgery than it is for patients admitted to the hospital for medical reasons or for elective procedures. The study was selected for the 2020 Southern Surgical Association Program and published as an "article in press" on the website of the Journal of the American College of Surgeons in advance of print. The researchers found an unexpectedly significant effect of physician communication ...

In a study evaluating the BioNTech-Pfizer COVID-19 vaccine's ability to neutralize the B.1.1.7 ("UK") viral variant, researchers found no loss of immune protection compared to that against the original Wuhan reference strain. Their analysis was based on blood samples from 40 people who had received the BioNTech-Pfizer COVID-19 vaccine during clinical trials. The authors conclude their results show it is "unlikely that the UK variant virus will escape ... protection" as mediated by this vaccine. In September 2020, the SARS-CoV-2 lineage B.1.1.7 was discovered in the United Kingdom. It subsequently increased in prevalence, showed enhanced transmissibility, and spread to other continents. ...

[Abstract] The National Institute of Information and Communications Technology (NICT), Tohoku University, Toin University of Yokohama, and Japan Science and Technology Agency (JST) have succeeded in developing a scanless high-speed holographic fluorescence microscopy system with submicron resolution for a 3D space. The system is based on digital holography. The developed microscopy system has an algorithm to acquire 3D information of fluorescent objects toward scanless 3D measurement in less than 1 millisecond. Scanless 3D sensing with submicron resolution and color-multiplexed holographic fluorescence imaging have been demonstrated using the algorithm. The microscopy system will be further developed to achieve holographic 3D motion-picture sensing of specimens ...

Thrombosis, the clogging of blood vessels, is a major cause of heart attacks and embolism. Scientists have now engineered the first inhibitors of thrombin, a protease promoting thrombosis, that is three-fold efficient. In a study published in the journal Angewandte Chemie, the authors demonstrate that attacking three sites of the thrombin molecule is more efficient than attacking only two sites, which is the mode of action of many natural agents. Soon after an injury, thrombin appears at the site of the wound, promoting platelet coagulation and fibrin development to clog the wound and grow new tissue. Unfortunately, inside blood ...

An international team of scientists, coordinated by the Seville Institute of Biomedicine (IBiS) and the University of Seville has solved one of the hitherto unresolved enigmas of basic biology: how exactly do lipids distribute proteins within a cell? To do this, they used a new, completely innovative microscopy technology, which they applied to "mutant" cells they designed in their laboratory. This discovery represents a major advance in understanding how proteins are distributed in cells to perform their vital functions, and could open the door to understanding the causes of diseases associated with failures in protein distribution at the ...

Researchers have completed the first ever multi-level hydrological tracking of the Yangtze River from the ground, air and space in order to investigate the properties of cloud formation during the mei-yu--an intense rainy season that forms part of East Asia's summer monsoon. The effort should permit greater understanding of the mei-yu precipitation process and thus enable much more accurate forecasts of this key meteorological phenomenon in the region. The mei-yu, also known as the "Plum Rain", is a period of severe, concentrated rainfall that lasts for up to two months during the late ...

Knowledge about health is a cornerstone in a child's development of physical and psychosocial health. Since 2016, around 25,000 pupils in years 4-6 in 86 of Denmark's municipalities have taken part in the project "11 for Health in Denmark", an 11-week exercise and health education programme offered to all schools in a collaboration between the University of Southern Denmark and the Danish Football Association. More than 3,000 of these pupils completed questionnaires before and after the programme aimed at determining their knowledge about health and understanding their experience of the 11-week programme. An increase of 10 percentage ...

New particle formation (NPF) is a major source of aerosol particles in the global atmosphere. In polluted megacities, such as Beijing, the role of new particle formation events and their contribution to haze formation through subsequent growth is still unclear. To improve the understanding of the sources, meteorological conditions, and chemistry behind air pollution, the research teams led by Prof. Yele Sun with the Institute of Atmospheric Physics at the Chinese Academy of Sciences and Prof. Markku Kulmala with the University of Helsinki performed simultaneous measurements ...

Research on manufacturing battery cells is gaining momentum - and there is a strong need, considering the future demand for energy storage: For the year 2030, global production of rechargeable batteries will double from today's 750 gigawatt hours (GWh) per year to 1,500 GWh. A recently published review article in the magazine "Nature Energy" on cell production of various battery types suggests that the currently established lithium-ion batteries (LIB) dominate the market of rechargeable high-energy batteries in the coming years. Alternative battery technologies, ...

Large parts of today's Sahara Desert were green thousands of years ago. Prehistoric engravings of giraffes and crocodiles testify to this, as does a stone-age cave painting in the desert that even shows swimming humans. However, these illustrations only provide a rough picture of the living conditions. Recently, more detailed insights have been gained from sediment cores extracted from the Mediterranean Sea off the coast of Libya. An international research team examined these cores and discovered that the layers of the seafloor tell the story of major environmental changes in North Africa over ...

The biological process of photosynthesis is found at the beginning of nearly all food chains. It produces oxygen to breathe and provides the energetic foundation for using biotechnological processes to synthesize biofuels and chemical feedstock. Therefore, researchers are particularly interested in rapidly growing cyanobacteria. These organisms use light as an energy source and can carry out photosynthesis, similar to plants. However, the required photosynthetic protein complexes bind many nutrients. Vanessa Krauspe and Prof. Dr. Wolfgang Hess from the working group for Genetics & Experimental Bioinformatics of the Faculty of Biology of ...

Who hasn't at some point been chewing on an almond and tasted an unpleasant and unexpected aftertaste that has nothing to do with the taste we are used to from one of the most consumed nuts in the world? The culprit has a name: amygdalin, a diglucoside that, when in contact with enzymes present in saliva, breaks down into glucose, benzaldehyde (the cause of the bitter taste) and hydrogen cyanide. To reduce this unpleasant 'surprise', the Farming Systems Engineering (AGR-128) and Food Technology (AGR-193) research groups at the University of Cordoba's School of Agricultural and Forestry Engineering, ...

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing SORLA from cancer cells sensitized anti-HER2 resistant breast cancer brain metastasis to targeted therapy. HER2 protein is a strong driver of tumor growth. HER2 amplification occurs ...

High-intensity tropical cyclones have been moving closer to coasts over the past 40 years, potentially causing more destruction than before. The trend of tropical cyclones - commonly known as hurricanes or typhoons - increasingly moving towards coasts over the past 40 years appears to be driven by a westward shift in their tracks, say the study's authors from Imperial College London. While the underlying mechanisms are not clear, the team say it could be connected to changes in tropical atmospheric patterns possibly caused by climate change. The research is published today in Science. Globally, 80 to 100 cyclones develop over tropical oceans each year, impacting regions in the Pacific, ...