As surgeons balance the need to control their patients' post-surgery pain with the risk that a routine operation could become the gateway to long-term opioid use or addiction, a new study shows the power of an approach that takes a middle way. In a new letter in JAMA Surgery, a team from Michigan Medicine at the University of Michigan reports on findings from a study of 620 patients who had surgery in hospitals across Michigan, had their painkiller use tracked, and took surveys within one to three months after their operations. Half of the patients received pre-surgery counseling that emphasized non-opioid pain treatment as their first option. Some patients in this group received small, "just in case" prescriptions, but a third of them didn't receive any opioid prescription ...

LA JOLLA--A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus--beyond the key sites on the virus's spike protein. By attacking the virus from many angles, the body has the tools to potentially recognize different SARS-CoV-2 variants. The new research, published January 27, 2021 in Cell Report Medicine, is the most detailed analysis so far of which proteins on SARS-CoV-2 stimulate the strongest responses from the immune system's "helper" CD4+ T cells and "killer" CD8+ T cells. "We ...

INDIANAPOLIS--Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified how breast cancer cells hide from immune cells to stay alive. The discovery could lead to better immunotherapy treatment for patients. Xinna Zhang, PhD, and colleagues found that when breast cancer cells have an increased level of a protein called MAL2 on the cell surface, the cancer cells can evade immune attacks and continue to grow. The findings are published this month in The Journal of Clinical Investigation and featured on the journal's cover. The lead author of the study, Zhang is a member of the ...

Members of Syracuse University's College of Arts and Sciences are shining new light on an enduring mystery--one that is millions of years in the making. A team of paleontologists led by Professor Cathryn Newton has increased scientists' understanding of whether Devonian marine faunas, whose fossils are lodged in a unit of bedrock in Central New York known as the Hamilton Group, were stable for millions of years before succumbing to waves of extinctions. Drawing on 15 years of quantitative analysis with fellow professor Jim Brower (who died in 2018), Newton has continued to probe the structure of these ancient fossil communities, among the most renowned on Earth. The group's findings, reported by the Geological Society of America (GSA), provide critical ...

Irvine, CA - January 27, 2021 - A new University of California, Irvine-led study finds a new method for identifying biomarkers may aid in early cancer diagnosis. The study focused on lung cancer, however the Cell Heterogeneity-Adjusted cLonal Methylation (CHALM) method has been tested on aging and Alzheimer's diseases as well and is expected to be effective for studying other diseases. "We found the CHALM method may be a valuable tool in helping researchers to identify more reliable differentially methylated genes from sequence-based methylation data," ...

Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities. However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy. Led by VCU physicist Jason Reed, Ph.D., the team developed a technique that combines a process called digital polymerase chain reaction (dPCR) with high-speed atomic force microscopy (HSAFM) to create an image with such nanoscale resolution that users can measure differences in ...

Historically redlined neighborhoods are more likely to have a paucity of greenspace today compared to other neighborhoods. The study by researchers at Columbia University Mailman School of Public Health and the University of California, Berkeley and San Francisco, demonstrates the lasting effects of redlining, a racist mortgage appraisal practice of the 1930s that established and exacerbated racial residential segregation in the United States. Results appear in Environmental Health Perspectives. In the 1930s, the Home Owners' Loan Corporation (HOLC) assigned risk grades to neighborhoods across the country based on racial demographics and other factors. "Hazardous" areas--often those whose residents included people ...

LAWRENCE -- For at least a century, ecologists have wondered at the tendency for populations of different species to cycle up and down in steady, rhythmic patterns. "These cycles can be really exaggerated -- really huge booms and huge busts -- and quite regular," said Daniel Reuman, professor of ecology & evolutionary biology at the University of Kansas and senior scientist at the Kansas Biological Survey. "It attracted people's attention because it was kind of mysterious. Why would such a big thing be happening?" A second observation in animal populations ...

(Boston)--Researchers from Boston University School of Medicine (BUSM) have identified proteins that are essential for the viability of whole genome doubled tumor cells, yet non-essential to normal cells that comprise the majority of human tissue. "Exploiting these vulnerabilities represents a highly significant and currently untapped opportunity for therapeutic intervention, particularly because whole genome doubling is a distinguishing characteristic of many tumor types," said corresponding author Neil J. Ganem, PhD, associate professor of pharmacology and medicine, section of hematology and medical oncology, at Boston University School of Medicine (BUSM). The vast majority of human cells are diploid, meaning that they possess two copies of each ...

The Asia Pacific Consortium on Osteoporosis (APCO) has today launched the first pan-Asia Pacific clinical practice standards for the screening, diagnosis, and management of osteoporosis, targeting a broad range of high-risk groups. Published in Osteoporosis International today, 'The APCO Framework' comprises 16 minimum clinical standards set to serve as a benchmark for the provision of optimal osteoporosis care in the region. Developed by APCO members representing key osteoporosis stakeholders, and multiple medical and surgical specialities, this set of clear, concise, relevant and pragmatic clinical standards aims to support national societies, guidelines development authorities, and health care policy makers with ...

People who take opioid medications for chronic pain may have a hard time finding a new primary care clinic that will take them on as a patient if they need one, according to a new "secret shopper" study of hundreds of clinics in states across the country. Stigma against long-term users of prescription opioids, likely related to the prospect of taking on a patient who might have an opioid use disorder or addiction, appears to play a role, the University of Michigan research suggests. Simulated patients who said their doctor or other primary care provider had retired were more likely to be told they could be accepted as new patients, compared with those who said their provider had stopped prescribing opioids to them for an unknown reason. The U-M primary care provider ...

Neurons, the fundamental units of the brain, are complex computers by themselves. They receive input signals on a tree-like structure - the dendrite. This structure does more than simply collect the input signals: it integrates and compares them to find those special combinations that are important for the neurons' role in the brain. Moreover, the dendrites of neurons come in a variety of shapes and forms, indicating that distinct neurons may have separate roles in the brain. A simple yet faithful model In neuroscience, there has historically been a tradeoff between a model's faithfulness to the underlying biological neuron and its complexity. Neuroscientists have constructed ...

Being constantly flooded by a mass of stimuli, it is impossible for us to react to all of them. The same holds true for a little fish. Which stimuli should it pay attention to and which not? Scientists at the Max Planck Institute of Neurobiology have now deciphered the neuronal circuit that zebrafish use to prioritize visual stimuli. Surrounded by predators, a fish can thus choose its escape route from this predicament. Even though we are not exposed to predators, we still have to decide which stimuli we pay attention to - for example, when crossing a street. Which cars should we avoid, which ones can we ignore? "The ...

A massive simulation of the cosmos and a nod to the next generation of computing A team of physicists and computer scientists from the U.S. Department of Energy's (DOE) Argonne National Laboratory performed one of the five largest cosmological simulations ever. Data from the simulation will inform sky maps to aid leading large-scale cosmological experiments. The simulation, called the Last Journey, follows the distribution of mass across the universe over time -- in other words, how gravity causes a mysterious invisible substance called "dark matter" to clump ...

Many genetic mutations have been found to be associated with a person's risk of developing Parkinson's disease. Yet for most of these variants, the mechanism through which they act remains unclear. Now a new study in Nature led by a team from the University of Pennsylvania has revealed how two different variations--one that increases disease risk and leads to more severe disease in people who develop Parkinson's and another that reduces risk--manifest in the body. The work, led by Dejian Ren, a professor in the School of Arts & Sciences' Department of Biology, showed that the variation that raises disease risk, which about 17% of people possess, causes a reduction in function of an ion channel ...

Dr. Richi Gill, MD, is back at work, able to enjoy time with his family in the evening and get a good night's sleep, thanks to research. Three years ago, Gill broke his neck in a boogie board accident while on vacation with his young family. Getting mobile again with the use of a wheelchair is the first thing, Gill says, most people notice. However, for those with a spinal cord injury (SCI), what is happening inside the body also severely affects their quality of life. "What many people don't realize is that a spinal cord injury prevents some systems within the body from regulating automatically," ...

Among infectious diseases that have caused pandemics and epidemics, smallpox stands out as a success story. Smallpox vaccination led to the disease's eradication in the twentieth century. Until very recently, smallpox vaccine was delivered using a technique known as skin scarification (s.s.), in which the skin is repeatedly scratched with a needle before a solution of the vaccine is applied. Almost all other vaccines today are delivered via intramuscular injection, with a needle going directly into the muscle, or through subcutaneous injection to the layer of tissue beneath the skin. But Thomas Kupper, MD, chair of the Department of Dermatology, and colleagues, had reason to suspect that vaccines delivered ...

URBANA, Ill. - With cities around the globe locking down yet again amid soaring COVID-19 numbers, could seasonality be partially to blame? New research from the University of Illinois says yes. In a paper published in Evolutionary Bioinformatics, Illinois researchers show COVID-19 cases and mortality rates, among other epidemiological metrics, are significantly correlated with temperature and latitude across 221 countries. "One conclusion is that the disease may be seasonal, like the flu. This is very relevant to what we should expect from now on after the vaccine controls these first waves of COVID-19," says Gustavo ...

An upsurge of matter from deep beneath the Earth's crust could be pushing the continents of North and South America further apart from Europe and Africa, new research has found. The plates attached to the Americas are moving apart from those attached to Europe and Africa by four centimetres per year. In between these continents lies the Mid-Atlantic Ridge, a site where new plates are formed and a dividing line between plates moving to the west and those moving to the east; beneath this ridge, material rises to replace the space left by the plates as they move apart. Conventional wisdom is that this process is normally driven by distant gravity forces as denser parts of the plates sink back into the Earth. However, the driving force behind the separation of the Atlantic ...

Scientists have resolved a key climate change mystery, showing that the annual global temperature today is the warmest of the past 10,000 years - contrary to recent research, according to a Rutgers-led study in the journal Nature. The long-standing mystery is called the "Holocene temperature conundrum," with some skeptics contending that climate model predictions of future warming must be wrong. The scientists say their findings will challenge long-held views on the temperature history in the Holocene era, which began about 12,000 years ago. "Our reconstruction shows that the first half of the Holocene was colder than in industrial times due to the cooling effects of remnant ice sheets from the previous glacial period - contrary to previous reconstructions of global temperatures," ...

STOCKHOLM: With impacts from climate change threatening to be as abrupt and far-reaching in the coming years as the current pandemic, leading scientists have released a compilation of the 10 most important insights on the climate from the last year to help inform collective action on the ongoing climate crisis. In a report presented today to Patricia Espinosa, Executive Secretary of the United Nations Framework Convention on Climate Change (UNFCCC), report authors outlined some of 2020's most important findings within the field of climate science, ranging from improved models that reveal the need for aggressive emission cuts in order to meet the Paris Agreement to the growing use of human rights litigation to catalyze climate action. The report alleviates some worries that ...

In experiments at the Paul Scherrer Institute PSI, an international research collaboration has measured the radius of the atomic nucleus of helium five times more precisely than ever before. With the aid of the new value, fundamental physical theories can be tested and natural constants can be determined even more precisely. For their measurements, the researchers needed muons - these particles are similar to electrons but are around 200 times heavier. PSI is the only research site in the world where enough so-called low-energy muons are produced for such experiments. The researchers are publishing their results today in the journal Nature. After hydrogen, helium is the second most abundant element in the universe. Around one-fourth of the ...

People with schizophrenia, a mental disorder that affects mood and perception of reality, are almost three times more likely to die from the coronavirus than those without the psychiatric illness, a new study shows. Their higher risk, the investigators say, cannot be explained by other factors that often accompany serious mental health disorders, such as higher rates of heart disease, diabetes, and smoking. Led by researchers at NYU Grossman School of Medicine, the investigation showed that schizophrenia is by far the biggest risk factor (2.7 times increased odds of dying) after ...

The inner ear of a 400 million-year-old 'platypus fish' has yielded new insights into early vertebrate evolution, suggesting this ancient creature may be more closely related to modern-day sharks and bony fish than previously thought. A team of scientists from the University of Birmingham in the UK, and institutions in China, Australia and Sweden, used 'virtual anatomy' techniques, including MicroCT scanning (using x-rays to look inside the fossil) and digital reconstruction to examine previously unseen areas within the braincase of these mysterious fossils. They discovered the fish, called ...

BOSTON -- For the first time, scientists have identified the individual neurons critical to human social reasoning, a cognitive process that requires us to acknowledge and predict others' hidden beliefs and thoughts. A team of neuroscientists at Massachusetts General Hospital (MGH) and Massachusetts Institute of Technology (MIT) had a rare look at how individual neurons represent the beliefs of others by recording neuron activity in patients undergoing neurosurgery to alleviate symptoms of motor disorders such as Parkinson's disease. Their findings are published in Nature. The researchers were studying a very complex social cognitive ...