Researchers from the Hubrecht Institute mapped the recovery of the heart after a heart attack with great detail. They found that heart muscle cells - also called cardiomyocytes - play an important role in the intracellular communication after a heart attack. The researchers documented their findings in a database that is accessible for scientists around the world. This brings the research field a step closer to the development of therapies for improved recovery after heart injury. The results were published in Communications Biology on the 29th of January. In the Netherlands, an average of 95 people end up in the hospital each day ...

Efforts to understand when corals reproduce have been given a boost thanks to a new resource that gives scientists open access to more than forty years' worth of information about coral spawning. Led by researchers at Newcastle University, UK, and James Cook University, Australia, the Coral Spawning Database (CSD) for the first time collates vital information about the timing and geographical variation of coral spawning. This was a huge international effort that includes over 90 authors from 60 institutions in 20 countries. The data can be used by scientists and conservationists to better understand the environmental cues that influence when coral ...

(Singapore--16:45 p.m. SPT/3:45 EST January 29, 2021)--Two presentations from the ADAURA clinical trial advanced previous research that demonstrated improved disease-fee survival (DFS) outcomes for patients with surgically resected non-small cell lung cancer (NSCLC) receiving osimertinib. The data were reported today at the International Association for the Study of Lung Cancer's 2020 World Conference on Lung Cancer (WCLC) Singapore. Osimertinib is a third-generation, irreversible, central nervous system-active, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. ADAURA is a randomized Phase III trial comparing adjuvant osimertinib with placebo in patients ...

Beyond the ski slopes, one of the most iconic symbols of the Alps are the alpine flowers. These plants are not only beautiful -- they are also used in liqueurs and medicines, and they form the foundation of the local food chains. But a recent study in Frontiers in Ecology and Evolution shows that, although plant diversity may initially increase with glacier retreat, many of these species may soon become endangered. "Our results indicate that plant diversity will ultimately decrease once the glaciers disappear -- and up to 22% of the species we analyzed may locally disappear or even go extinct once the glaciers are gone," says lead author Dr Gianalberto Losapio of Stanford University in the USA. "We show that 'not all species are equal before global warming' and that there are some species ...

Methane (CH4) is the second most important greenhouse gas after carbon dioxide (CO2). Its concentration in the atmosphere has increased more than twice since the preindustrial era due to enhanced emissions from human activities. While the global warming potential of CH4 is 86 times as large as that of CO2 over 20 years, it stays in the atmosphere for about 10 years, much shorter than more than centuries of CO2. It is therefore expected that emission controlling of CH4 can benefit for relatively short time period toward the Paris Agreement target to limit the global warming well below 2 degrees. A study by an international team, published ...

New research from the University of Sheffield has found being overweight is an additional burden on brain health and it may exacerbate Alzheimer's disease. The pioneering multimodal neuroimaging study revealed obesity may contribute toward neural tissue vulnerability, whilst maintaining a healthy weight in mild Alzheimer's disease dementia could help to preserve brain structure. The findings, published in The Journal of Alzheimer's Disease Reports, also highlight the impact being overweight in mid-life could have on brain health in older age. Lead author of the study, Professor Annalena Venneri from the University of Sheffield's Neuroscience Institute and NIHR Sheffield Biomedical Research Centre, ...

Four million UK patients could benefit annually from genetic testing before being prescribed common medicines, according to new research from the University of East Anglia (UEA) in collaboration with Boots UK and Leiden University (Netherlands). Researchers looked through 2019 NHS dispensing data across the UK to see how many patients are started on new prescriptions each year that could be potentially optimised by genetic testing. They studied 56 medicines, including antidepressants, antibiotics, stomach ulcer treatments and painkillers where there are known drug-gene interactions. And they found that in more than one in five occasions (21.1 ...

An interdisciplinary team of the Institut national de la recherche scientifique (INRS) used an innovative imaging technique for a better understanding of motor deficits in Amyotrophic Lateral Sclerosis (ALS). The researchers were able to follow the escape behaviour of normal and disease zebrafish models, in 3D. Their results have recently been published in Optica, the flagship journal of the Optical Society (OSA). Professor Jinyang Liang, expert in ultra-fast imaging and biophotonics, joined an effort with Professor Kessen Patten, specialist in genetics and neurodegenerative diseases. The two groups were able to track the position of ...

New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy. Working in a mouse model, Rachel Schroeder, a student in the UI Interdisciplinary Graduate Program in Neuroscience, drew a connection between the work of her two mentors, Hanna Stevens, MD, PhD, UI associate professor of psychiatry and Ida P. Haller Chair of Child and Adolescent Psychiatry, and Andrew A. Pieper, MD, PhD, a former UI faculty member, now Morley-Mather Chair of Neuropsychiatry at Case Western Reserve ...

-- Experts call for policy reform to improve ethnic equity of socioeconomic opportunity, service provision, and health outcomes. They also call for long-term studies to investigate how structural and institutional racism generate these ethnic inequalities in health. In 15 out of 17 minority ethnic groups, health-related quality of life in older age (over 55 year-olds) was worse on average for either men, women, or both, than for White British people according to an observational study published in The Lancet Public Health journal. In five of those groups - Bangladeshi, Pakistani, ...

Peer-reviewed / Simulation or Modelling / People A new modelling study has estimated that from 2000 to 2030 vaccination against 10 major pathogens - including measles, rotavirus, HPV and hepatitis B - will have prevented 69 million deaths in low-income and middle-income countries (LMICs). The study estimated that, as a result of vaccination programmes, those born in 2019 will experience 72% lower mortality from the 10 diseases over their lifetime than if there was no immunisation. The greatest impact of vaccination was estimated to occur in children under five - mortality from the 10 diseases in ...

Cities are not all the same, or at least their evolution isn't, according to new research from the University of Colorado Boulder. These findings, out this week in Nature Communications Earth and Environment and Earth System Science Data, buck the historical view that most cities in the United States developed in similar ways. Using a century's worth of urban spatial data, the researchers found a long history of urban size (how big a place is) "decoupling" from urban form (the shape and structure of a city), leading to cities not all evolving the same--or even close. The researchers hope that by providing this look at the past with this unique data set, they'll be able to glimpse the future, including the impact of population growth on cities or ...

Boulder, Colo., USA: For most of Earth's history, life was limited to the microscopic realm, with bacteria occupying nearly every possible niche. Life is generally thought to have evolved in some of the most extreme environments, like hydrothermal vents deep in the ocean or hot springs that still simmer in Yellowstone. Much of what we know about the evolution of life comes from the rock record, which preserves rare fossils of bacteria from billions of years ago. But that record is steeped in controversy, with each new discovery (rightfully) critiqued, questioned, and analyzed from every angle. Even then, uncertainty ...

Scientists are opening new windows into understanding more about the constantly shifting evolutionary arms race between viruses and the hosts they seek to infect. Host organisms and pathogens are in a perennial chess match to exploit each other's weaknesses. Such research holds tantalizing clues for human health since the immune system is on constant alert to deploy counter measures against new viral attacks. But unleashing too much of a defensive response can lead to self-inflicted tissue damage and disease. A new study published in the journal eLife by biologists at the University ...

Scientists have created a new way to detect the proteins that make up the pandemic coronavirus, as well as antibodies against it. They designed protein-based biosensors that glow when mixed with components of the virus or specific COVID-19 antibodies. This breakthrough could enable faster and more widespread testing in the near future. The research appears in Nature. To diagnose coronavirus infection today, most medical laboratories rely on a technique called RT-PCR, which amplifies genetic material from the virus so that it can be seen. This technique requires specialized staff and equipment. It also consumes lab supplies ...

Housing instability and homelessness are widely understood to have an impact on health, and certain housing problems have been linked to specific childhood health conditions, such as mold with asthma. But it has not been clear how overall housing quality may affect children--especially those who are at risk from other social determinants of health such as food insecurity or poverty. A new nationally representative study in the Journal of Child Health Care, led by researchers at Nationwide Children's Hospital, has found poor-quality housing is independently associated with poorer pediatric health, ...

As states and municipalities begin to roll out mass vaccination campaigns, some people have dared to ask: When will it be safe to resume "normal" activities again? For those in most parts of the United States, the risk of COVID-19 infection remains extremely high. People now have access to better real-time information about infection rates and transmission at the county or city level, but they still need a framework to help them decide what is safe to do. Social distancing and shutting businesses have reduced the number of cases, but there is mounting pressure to reopen businesses and classrooms. Life is likely to continue in this limbo for some time. A new model co-authored by ...

A University of Otago study explored factors which influence Americans' levels of concern over climate change, providing discussion on how those factors could impact mitigation efforts. A key thread of the research examined the ability of people to visualize the future. Results showed that while 74 per cent of respondents were concerned about climate change, only 29 per cent discussed lower carbon options when asked to describe travel in the year 2050. "This suggests actively envisioning a sustainable future was less prevalent than climate change concern. So while the majority were concerned, ...

UNIVERSITY PARK, Pa. -- People who do not accept inequality are more likely to negatively evaluate companies that have committed wrongdoings than people who do accept inequality, and this response varies by culture, according to researchers at Penn State. The team also found that companies can improve their standing with consumers when they offer sincere apologies and remedies for the harm they caused to victims. "Some prominent examples of company moral transgressions include Nike's and Apple's questionable labor practices in developing countries, BP's oil spill in the Gulf of Mexico and Volkswagen's emissions scandal," said Felix Xu, graduate student in marketing at Penn State. In their paper, which published on Jan. 22 in the Journal of Consumer Research, the team ...

Thermoelectric materials, which can generate an electric voltage in the presence of a temperature difference, are currently an area of intense research; thermoelectric energy harvesting technology is among our best shots at greatly reducing the use of fossil fuels and helping prevent a worldwide energy crisis. However, there are various types of thermoelectric mechanisms, some of which are less understood despite recent efforts. A recent study from scientists in Korea aims to fill one such gap in knowledge. Read on to understand how! One of these mechanisms mentioned earlier is the spin Seebeck effect (SSE), which was discovered in 2008 by a research team led by Professor Eiji Saitoh from Tokyo University, Japan. The SSE is a phenomenon in which ...

DALLAS - Jan. 28, 2021 - Simulation can be a viable way to quickly evaluate and refine new medical guidelines and educate hospital staff in new procedures, a recent study from UT Southwestern's Department of Pediatrics shows. The findings, published recently in the journal Pediatric Quality and Safety and originally shaped around new COVID-19-related pediatric resuscitation procedures at UTSW and Children's Health, could eventually be used to help implement other types of guidelines at medical centers nationwide. For decades, U.S. hospitals have used the same standard procedures ...

"King Solomon made for himself the carriage; he made it of wood from Lebanon. Its posts he made of silver, its base of gold. Its seat was upholstered with purple, its interior inlaid with love." (Song of Songs 3:9-10) For the first time, rare evidence has been found of fabric dyed with royal purple dating from the time of King David and King Solomon. While examining the colored textiles from Timna Valley - an ancient copper production district in southern Israel - in a study that has lasted several years, the researchers were surprised to find remnants of woven fabric, a tassel and fibers of wool dyed with royal purple. Direct radiocarbon ...

(For Immediate Release--Singapore--January 28, 2021)-- In the phase II CodeBreak 100 trial, sotorasib provided durable clinical benefit with a favorable safety profile in patients with pretreated non-small cell lung cancer (NSCLC) and who harbor KRAS p.G12C mutations, validating CodeBreak 100's phase I results, according to research presented today at the International Association for the Study of Lung Cancer World Conference on Lung Cancer. Outcome in patients with advanced NSCLC on second- or third-line therapies is poor, with a response rate of less than 20% and median progression-free survival of fewer than four months. Approximately 13% of patients with lung adenocarcinomas harbor KRAS p.G12C mutations. Sotorasib is a first-in-class small molecule that specifically ...

An international joint research team from the Shanghai Advanced Research Institute of the Chinese Academy of Sciences, along with Zhejiang University and the Technical University of Denmark, reported an in-situ strategy to manipulate interfacial structure with atomic precision during catalytic reactions. Results were published in the latest issue of Science. The interface between nanoparticles and substrates plays a critical role in heterogeneous catalysis because most active sites are located at the perimeter of the interface. It is generally believed that this interface is immobile and unchangeable, thus can hardly be adjusted in reactive environments. As a result, it has been challenging to promote catalytic activity through precise control of the interfacial ...

The emergence of SARS-CoV-2 virus variants that are adding twists in the battle against COVID-19 highlight the need for better genomic monitoring of the virus, says Katia Koelle, associate professor of biology at Emory University. "Improved genomic surveillance of SARS-CoV-2 across states would really help us to better understand how the virus causing the pandemic is evolving and spreading in the United States," Koelle says. "More federal funding is needed, along with centralized standards for sample collection and genetic sequencing. Researchers need access to such metadata to better track how the virus is spreading geographically, and to identify any new variants ...