Building on the promise of emerging therapies to deploy the body's "natural killer" immune cells to fight cancer, researchers at the University of Michigan Rogel Cancer Center and U-M College of Engineering have gone one step further. They've developed what is believed to be the first systematic way to catch natural killer cells and get them to release cancer-killing packets called exosomes. These nano-scale exosomes are thousands of times smaller than natural killer cells -- or NK cells for short -- and thus better able to penetrate cancer cells' defenses. A proof-of-concept study in blood samples from five patients with non-small cell lung cancer demonstrated that the approach was able to capture natural killer cells on a microfluidic ...

Paris, France, January 27th 2021 -- COVID-19 vaccine distribution has begun across the globe, while many countries are still struggling with the rampant rise of infections. Owkin, a French-American startup pioneering AI and Federated Learning in medical research, has been focusing it's COVID-19 research efforts on aspects of the pandemic that still require much public health attention, despite the arrival of an effective vaccine. Efforts to support frontline health systems as they devote their resources to the influx of COVID-19 related hospitalizations, ...

Seawater makes up about 96% of all water on earth, making it a tempting resource to meet the world's growing need for clean drinking water and carbon-free energy. And scientists already have the technical ability to both desalinate seawater and split it to produce hydrogen, which is in demand as a source of clean energy. But existing methods require multiple steps performed at high temperatures over a lengthy period of time in order to produce a catalyst with the needed efficiency. That requires substantial amounts of energy and drives up the cost. Researchers from the University of Houston have reported an oxygen evolving catalyst that takes just minutes to grow at room temperature on commercially available nickel foam. ...

Mason scientists employ a rapid-result, saliva-based test that significantly expands testing capacity, and an antibody test that can track vaccine response. George Mason University announces it is introducing a rapid-result, saliva-based COVID-19 test that will greatly expand testing capabilities on its campuses this spring. The effort, led by Mason's faculty, is part of a comprehensive program to better track and control the virus on campus. Mason scientists, who are pushing the boundaries of technologies that are keeping Mason's campuses safe, are ...

The main culprit in cancer is healthy cells that have gone rogue and acquire the ability to divide uncontrollably. These cells acquire growth advantages over normal cells and manipulate their environment by altering the cellular pathways involved in growth and metabolism. Over the past few decades, various altered pathways and proteins have been identified as targets for therapeutic interventions. However, what remains challenging is selectively targeting cancer cells and ensuring that the drug reaches the tumor in adequate amounts, without severely affecting normal cells. And in this regard, biocompatible delivery vehicles (which are non-toxic to normal cells) can be useful. One such potential candidate is "porphyrins," a group of organic cyclic compounds that form the ...

Being stretchy and squeezable may be the key to finding space for the brain in mammals, including humans. An international study, co-led by Flinders University's Vera Weisbecker, has revealed that marsupial mammals like possums, kangaroos, and wombats appear to have a lot of flexibility when it comes to accommodating their brains into their skulls. "The brain is one of the heaviest parts of the head, particularly in smaller mammals. But it needs to be placed in a way that doesn't interfere with the many vital functions of the head, such as seeing, hearing, smelling and of course feeding," says Dr. Weisbecker. "Stowing" a large brain ...

WASHINGTON -- Researchers have developed a new approach that improves the image quality and contrast for holographic displays. The new technology could help improve near-eye displays used for virtual and augmented reality applications. "Augmented and virtual reality systems are poised to have a transformative impact on our society by providing a seamless interface between a user and the digital world," said research team member Jonghyun Kim from technology company NVIDIA and Stanford University. "Holographic displays could overcome some of the biggest ...

(Singapore--January 28, 2021 11:00 p.m. SPT/10:00 a.m. EST)----Several leading international lung cancer researchers at a press briefing held by the International Association for the Study of Lung Cancer today, presented compelling new data revealing that factors of race, gender, sexual orientation and income continue to be significant barriers to those living with lung cancer. The press briefing is part of the IASLC's World Conference on Lung Cancer 2020 Singapore. The press briefing is moderated by IASLC Communications Committee Chair Dr. Anne-Marie Baird, senior research fellow at Trinity College in ...

Clear rules for engineering transgenes that can be inserted and propagated over multiple generations of nematodes include ways to protect inserted genes from the organism's natural defenses against foreign DNA. Developed by KAUST researchers, the rules have implications for many research fields, including gene therapy development. Scientists often study biological processes, such as normal and mutant gene functions, in the worm Caenorhabditis elegans because it has many genes and molecular pathways in common with humans. Specific gene functions can be investigated by injecting DNA into the worm's reproductive organs, where it links into what is known as an extra-chromosomal array. This array is eventually incorporated into the nucleus, where it is duplicated ...

A team led by Prof. SU Bing from the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences (CAS), Prof. LI Cheng from Peking University, and Prof. ZHANG Shihua from the Academy of Mathematics and Systems Science of CAS has reported the highest resolution by far of the 3D genome of the primate brain, and demonstrated the molecular regulatory mechanisms of human brain evolution through cross-species multi-omics analysis and experimental validation. The study was published in Cell. The unique pattern of human brain development stems from accumulated genetic changes during human evolution. Among the huge number of diverging genetic changes, only a small portion of the between-species ...

Studying the creation and evolution of sulfur-containing compounds in outer space is essential for understanding interstellar chemistry. CS2 is believed to be the most important molecule in comet nuclei, interstellar dust, or ice cores. CS and S2 are the photodissociation fragments of CS2. Forty years ago, the emission spectra of only CS and S2 species, and not those of CS2 species, were observed from several comets by the International Ultraviolet Explorer satellite. The photodissociation mechanism of CS2 molecules remains unclear, and S2 fragments have not been experimentally observed before. Recently, a team led by Prof. YUAN Kaijun from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS), in cooperation with Prof. WANG Xing'an's group ...

An ecologist from RUDN University together with colleagues from 14 countries compared three methods for estimating ecosystem transpiration in a study. In the first ever research with such a comprehensive data-set, the team used land-atmosphere water vapor flux data of collected at 251 locations all over the planet, from Australia to Greenland. The outcome of the research help to understand the role of plants in the global water and carbon cycles in the current predicament of global warming. The results of the study were published in the December 2020 issue of the journal Global ...

Western Carolina University researchers find a disproportionate number of inmates with violent offenses suffer from post-traumatic stress disorder, panic disorder and alcohol use disorder, and published their findings in the Journal of Criminal Psychology. Alexa Barrett, clinical psychology master's student at WCU, and Al Kopak, associate professor of criminology and criminal justice at WCU, discovered the combination of PTSD, PD and AUD significantly increased the likelihood of violent offenses while conducting research at three county detention centers in North Carolina. Supported by a Summer Research Assistantship provided by the Graduate School, the purpose of this study was to detail ...

A PhD student and 'beer scientist' has inadvertently discovered a way to conduct extremely small-scale brewing experiments, potentially leading to better beer. It came about when University of Queensland PhD candidate Edward Kerr hit a hurdle when he completed a beer brewing experiment for a paper. "I was looking at barley protein changes during the mashing stage of beer brewing, when one of the paper's reviewers asked if the changes were caused by temperature or time spent mashing the barley," Mr Kerr said. "It was a good question, but to find out I'd need to brew all over again, with an instrument that would hold at least 23 litres ...

WASHINGTON, D.C. and SAN DIEGO, CA -- In his inaugural address, President Joe Biden vowed that "help is on the way" to a nation grappling with a pandemic that has already claimed over 420,000 lives and counting. However, despite the promise of a better future, a new survey from West Health and Gallup finds Americans remain largely skeptical that issues as varied as managing the COVID-19 crisis, lowering healthcare costs, improving the economy, fixing immigration and addressing climate change, will improve anytime soon. The findings from the monthly West Health-Gallup U.S. Healthcare Study are based on a ...

Pioneering research into how our bodies manufacture the cells that make blood has moved us closer to regrowing tissues and organs. The findings also may let doctors grow the cells for transplantation into people to battle cancer, blood disorders and autoimmune diseases. Researcher Karen K. Hirschi, PhD, of the Department of Cell Biology and the Robert M. Berne Cardiovascular Research Center at the University of Virginia School of Medicine, has developed a simple and efficient way to generate "hemogenic endothelial cells." These cells are the first step in the production line of blood cells, and Hirschi's new findings provide a blueprint for creating them outside the body. "By studying how hemogenic endothelial cells develop normally, we gain insights needed ...

Ceramic matrix composites (CMCs) are incredibly strong materials used in jet engines, gas turbines, and cutting tools for nickel superalloys. Aluminum oxide (Al2O3) is hard and chemically inert, and tungsten carbide (WC) is used as a superhard material, but past efforts to create an Al2O3-WC CMC yielded unsatisfactory results. Recently, a study by Japanese scientists, published in Scientific Reports, shows that adding zirconium atoms results in improved Al2O3-WC CMCs. Given the potential utility of Al2O3-WC CMCs as superhard materials, researchers around the world have tested several formulations to identify one with a high bending strength, which is a measure of the physical stress a material can be subjected to before it becomes permanently bent or broken. Previously, ...

In a first-of-its-kind study, researchers discovered that light pollution leads to more than just wasted energy and washed-out starlight--it can increase the likelihood of a preterm birth by almost 13%. Laura Argys, professor of economics at the University of Colorado Denver, collaborated with scientists at Lehigh University and Lafayette College to produce this study. Skyglow, the brightness of the night sky apart from discrete light sources such as the moon and visible stars, is one of the most pervasive forms of light pollution. When you have increased artificial brightness at night, coming from sources like streetlamps, outdoor advertising, and buildings, it reduces your ability to see the dark ...

Aging and lifestyle-related metabolic imbalances, such as hyperglycemia, hyperlipidemia, and oxidative-stress, cause the accumulation of advanced glycation end products (AGEs), including pentosidine (PEN, crosslinked type) and carboxymethyl-lysine (CML, non-crosslinked type). Osteoporosis is a widespread metabolic skeletal disease characterized by diminished bone mineral density (BMD) or bone strength, which increases the risk of fractures. To date, the association of PEN and CML with osteoporotic fracture has been reported, and the accumulation of AGEs in bone ...

When it comes to drones, the Singapore public is not as keen for them to be used to provide services around their living spaces, finds a study by researchers at the Nanyang Technological University, Singapore (NTU Singapore). However, they are more accepting of drones being used in areas like recreational spots or industrial areas. There is growing global interest in the use of drones to provide a range of applications - from building inspection to last mile commercial delivery - that promise productivity gains and cost reductions. In Singapore, the use of drones is picking up, with the government adopting them for various projects in the Smart Nation drive, where technology ...

Cambridge, Massachusetts - They may be the youngest astronomers to make a discovery yet. This week, 16-year-old Kartik Pinglé and 18-year-old Jasmine Wright have co-authored a peer-reviewed END ...

Across many animal species there is great evolutionary pressure on males, who often engage in combat for the rights to copulation. This phenomenon, called sexual selection, often ends up favoring males with larger weapons, such as horns or pincers. Interestingly, scientists have noted that males endowed with smaller weapons adopt alternative reproductive tactics in some species. For example, instead of fighting other more powerful males, they may try to sneak around or disperse in search of a lonely female. Variability in sexual behavior according to a male's weapon size has been widely studied. However, it's worth noting that bigger is not always better. Though larger weapons usually help in fights for reproductive rights, they can also be ...

Blood is vital to life, and a healthy body replenishes worn-out blood cells with new ones throughout one's lifetime. If something goes wrong with this process, serious illness will result. Researchers from the National University of Singapore (NUS) have now discovered a mechanism controlling the replenishment of blood cells, which could have relevance for new treatments for blood cancers and other blood-related diseases. The international research team, helmed by Dr Akihiko Numata while he was a Postdoctoral Fellow in the laboratory of Professor Daniel Tenen of the Cancer Science Institute of Singapore and Yong Loo Lin School of Medicine ...

Countries around the world are seeing a surge in the number of computer science students. Enrolment in related university programs in the U.S. and Canada tripled between 2006-2016 and Europe too has seen rising numbers. At the same time, the age to start coding is becoming younger and younger because governments in many different countries are pushing K-12 computer science education. Despite the increasing popularity of computer programming, little is known about how our brains adapt to this relatively new activity. A new study by researchers in Japan has examined the brain activity ...

A cross-institutional research group has revealed for the first time in the world that infants with symptomatic congenital cytomegalovirus (CMV) infection who were treated with a combination of immunoglobulin fetal therapy and neonatal therapy with antiviral drugs were less likely to experience the severe aftereffects associated with the infection than those who only received the neonatal therapy. It is hoped that the number of children suffering severe aftereffects resulting from congenital CMV infection will decrease in the future. The research group included the following members: Doctor YAMADA Hideto ...