WASHINGTON - Children in emergency departments can safely be treated for pain from limb injuries using intranasal ketamine, a drug more typically used for sedation, according to the results of the first randomized, controlled trial comparing intranasal analgesics in children in the emergency department. The study was published online last month in Annals of Emergency Medicine ("The PICHFORK (Pain in Children Fentanyl OR Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine and Fentanyl for the Relief of Moderate to Severe Pain in Children with Limb ...

BUFFALO, N.Y. -- Micheal L. Dent, a University at Buffalo psychologist, listens to what is inaudible to others. And what she's hearing might one day help us better understand human hearing loss. Dent studies ultrasonic vocalizations (USVs) in mice. These sounds are above the human ear's upper limit, but they can be recorded and played back using specialized equipment that has allowed Dent to capture an impressive repertoire that when graphically represented shows a variety of sweeps, arcs, dips and curves. The tempo and intensity of these vocalizations change, as does ...

TORONTO, Dec. 4, 2014 - Results from an ongoing survey conducted by the Centre for Addiction and Mental Health (CAMH) show that 2.2 per cent of adults --or over 230,000 people in Ontario, Canada -- seriously contemplated suicide in the last year. The 2013 edition of the CAMH Monitor, released today, included questions about suicidal ideation for the first time in the survey's history. "Suicide is a major public health issue, and these data confirm that large numbers of Ontario adults report having suicidal thoughts," said Dr. Hayley Hamilton, CAMH scientist and co-principal ...

AMHERST, Mass. - A new study led by biologist R. Thomas Zoeller of the University of Massachusetts Amherst provides "the strongest evidence to date" that endocrine disrupting chemicals such as polychlorinated biphenyls (PCB) found in flame retardant cloth, paint, adhesives and electrical transformers, can interfere with thyroid hormone action in pregnant women and may travel across the placenta to affect the fetus. Results appeared in an early online edition and in the December print edition of the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. ...

BELLINGHAM, Washington, USA -- Those formerly silent walls can "talk" now: Researchers have demonstrated a simple optical technique by which audio information can be extracted from high-speed video recordings. The method uses an image-matching process based on vibration from sound waves, and is reported in an article appearing in the November issue of the journal Optical Engineering, published by SPIE, the international society for optics and photonics. "One of the intriguing aspects of the paper is the ability to recover spoken words from a video of objects in the room," ...

In what is believed to be the first interview-style qualitative study of its kind among health care providers in the trenches, a team led by a Johns Hopkins geriatrician has further documented barriers to better care of older adults as they are transferred from hospital to rehabilitation center to home, and too often back again. Using comments and concerns drawn from in-depth interviews of 18 physicians and two home health care agency administrators -- all experienced in trying to coordinate care of older adults -- the researchers created a framework for evaluating what ...

VIDEO: A bat lands on the rewarded object in complete darkness (movie taken in IR). The movie shows that the bat has a general knowledge of the location of the object,... Click here for more information. In a discovery that overturns conventional wisdom about bats, researchers reporting in the Cell Press journal Current Biology on December 4 have found that Old World fruit bats--long classified as "non-echolocating"--actually do use a rudimentary form of echolocation. Perhaps ...

A new study shows that increasing sugar in the diet of male fruit flies for just 1 or 2 days before mating can cause obesity in their offspring through alterations that affect gene expression in the embryo. There is also evidence that a similar system regulates obesity susceptibility in mice and humans. The research, which is published online December 4 in the Cell Press journal Cell, provides insights into how certain metabolic traits are inherited and may help investigators determine whether they can be altered. Research has shown that various factors that are passed ...

New Caledonian crows--well known for their impressive stick-wielding abilities--show preferences when it comes to holding their tools on the left or the right sides of their beaks, in much the same way that people are left- or right-handed. Now researchers reporting in the Cell Press journal Current Biology on December 4 suggest that those bill preferences allow each bird to keep the tip of its tool in view of the eye on the opposite side of its head. Crows aren't so much left- or right-beaked as they are left- or right-eyed. "If you were holding a brush in your mouth ...

Blood cancers are more common in men than in women, but it has not been clear why this is the case. A study published by Cell Press December 4th in Cell Stem Cell provides an explanation, revealing that female sex hormones called estrogens regulate the survival, proliferation, and self-renewal of stem cells that give rise to blood cancers. Moreover, findings in mice with blood neoplasms--the excessive production of certain blood cells--suggest that a drug called tamoxifen, which targets estrogen receptors and is approved for the treatment of breast cancer, may also be a ...

In a breakthrough study to be published on the December 4th issue of the prestigious scientific journal Cell, a research team led by Miguel Soares at the Instituto Gulbenkian de Ciência (IGC; Portugal) discovered that specific bacterial components in the human gut microbiota can trigger a natural defense mechanism that is highly protective against malaria transmission. Over the past few years, the scientific community became aware that humans live under a continuous symbiotic relationship with a vast community of bacteria and other microbes that reside in the gut. ...

This discovery has a potential application in the treatment of certain blood disorders for which there is currently no cure. The study was led by Dr. Simón Méndez-Ferrer of the CNIC, working in partnership with the laboratories of Doctors Jürg Schwaller and Radek Skoda of the University Hospital in Basel (Switzerland). The study's authors have demonstrated in mice that tamoxifen, a drug already approved and widely used for the treatment of breast cancer, blocks the symptoms and the progression of a specific group of blood disorders known as myeloproliferative ...

PROVIDENCE, R.I. [Brown University] -- In a study in the journal Neuron, scientists describe a new high data-rate, low-power wireless brain sensor. The technology is designed to enable neuroscience research that cannot be accomplished with current sensors that tether subjects with cabled connections. Experiments in the paper confirm that new capability. The results show that the technology transmitted rich, neuroscientifically meaningful signals from animal models as they slept and woke or exercised. "We view this as a platform device for tapping into the richness of ...

The bacterium Salmonella Typhi causes typhoid fever in humans, but leaves other mammals unaffected. Researchers at University of California, San Diego and Yale University Schools of Medicine now offer one explanation -- CMAH, an enzyme that humans lack. Without this enzyme, a toxin deployed by the bacteria is much better able to bind and enter human cells, making us sick. The study is published in the Dec. 4 issue of Cell. In most mammals (including our closest evolutionary cousins, the great apes), the CMAH enzyme reconfigures the sugar molecules found on these animals' ...

The link between obesity and cardiovascular diseases is well acknowledged. Being obese or overweight is a major risk factor for the development of elevated blood pressure, and cardiovascular diseases. But it has net been known how obesity increases the risk of high blood pressure, making it difficult to develop evidence based therapies for obesity, hypertension and heart disease. In a ground-breaking study, published today in the prestigious journal, Cell (embargo midday EST), researchers from Monash University in Australia, Warwick, Cambridge in the UK and several American ...

Leptin, a hormone that regulates the amount of fat stored in the body, also drives the increase in blood pressure that occurs with weight gain, according to researchers from Monash University and the University of Cambridge. Being obese or overweight is a major risk factor for the development of high blood pressure and cardiovascular disease. Whilst a number of factors may be involved, the precise explanation for the link between these two conditions has been unclear. In a study published today in the journal Cell, a research team led by Professor Michael Cowley, ...

PHILADELPHIA--People with mental illness are more likely to have been tested for HIV than those without mental illness, according to a new study from a team of researchers at Penn Medicine and the U.S. Centers for Disease Control and Prevention (CDC) published online this week in AIDS Patient Care and STDs. The researchers also found that the most seriously ill - those with schizophrenia and bipolar disease - had the highest rate of HIV testing. The study assessed nationally representative data from 21,785 adult respondents from the 2007 National Health Interview Survey ...

EAST LANSING, Mich. - Take two poisonous mushrooms, and call me in the morning. While no doctor would ever write this prescription, toxic fungi may hold the secrets to tackling deadly diseases. A team of Michigan State University scientists has discovered an enzyme that is the key to the lethal potency of poisonous mushrooms. The results, published in the current issue of the journal Chemistry and Biology, reveal the enzyme's ability to create the mushroom's molecules that harbor missile-like proficiency in attacking and annihilating a single vulnerable target in the ...

Some National Football League (NFL) players have been seeking out unproven stem cell therapies to help accelerate recoveries from injuries, according to a new paper from Rice University's Baker Institute for Public Policy. While most players seem to receive treatment within the United States, several have traveled abroad for therapies unavailable domestically and may be unaware of the risks involved, the paper found. The paper is published in the 2014 World Stem Cell Report, which is a special supplement to the journal Stem Cells and Development and is the official publication ...

Today's smartphones are designed to entertain and are increasingly marketed to young adults as leisure devices. Not surprisingly, research suggests that young adults most often use their phones for entertainment purposes rather than for school or work. With this in mind, three Kent State University researchers, Andrew Lepp, Ph.D., Jacob Barkley, Ph.D. and Jian Li, Ph.D., and a Kent State graduate student, Saba Salehi-Esfahani, surveyed a random sample of 454 college students to examine how different types of cell phone users experience daily leisure. The trio from ...

Boston, MA - A study published this week in Genetics in Medicine is the first to explore new parents' attitudes toward newborn genomic testing. The findings suggest that if newborn genomic testing becomes available, there would be robust interest among new parents, regardless of their demographic background. The study, led by researchers at Brigham and Women's Hospital (BWH) and Boston Children's Hospital, found that the majority of parents surveyed were interested in newborn genomic testing. As next-generation whole-exome and genome sequencing is integrated into clinical ...

TORONTO, Dec. 4, 2014 - Results from an ongoing survey conducted by the Centre for Addiction and Mental Health (CAMH) show that 2.2 per cent of adults --or over 230,000 people in Ontario, Canada -- seriously contemplated suicide in the last year. The 2013 edition of the CAMH Monitor, released today, included questions about suicidal ideation for the first time in the survey's history. "Suicide is a major public health issue, and these data confirm that large numbers of Ontario adults report having suicidal thoughts," said Dr. Hayley Hamilton, CAMH scientist and co-principal ...

Insecticides aimed at controlling early-season crop pests, such as soil-dwelling grubs and maggots, can increase slug populations, thus reducing crop yields, according to researchers at Penn State and the University of South Florida. "Neonicotinoids are the most widely used insecticides in the world," said Margaret Douglas, graduate student in entomology, Penn State. "Seed applications of neonicotinoids are often viewed as cheap insurance against pest problems, but our results suggest that they can sometimes worsen pest problems and should be used with care." According ...

GAINESVILLE, Fla. -- It's no secret that low-birth-weight babies face significantly greater risks for certain health problems early on, such as respiratory distress or infection. Now, a new study from researchers at the University of Florida and Northwestern University shows that lower weights at birth also have an adverse effect on children's performance in school, which is likely due to the early health struggles small babies often face. Using a unique set of data that matched birth and school records from 1.6 million children born in Florida between 1992 and 2002, ...

Nalmefene (trade name Selincro) has been approved since February 2013 for people with alcohol dependence who currently drink a lot of alcohol, but who do not have physical withdrawal symptoms and who do not require immediate detoxification. The German Institute for Quality and Efficiency in Health Care (IQWiG) examined in a dossier assessment whether the drug offers an added benefit over the appropriate comparator therapy in this patient group. According to the findings, such an added benefit is not proven: In its dossier, the drug manufacturer only presented data for ...