Chemists at the University of Leicester have reported a breakthrough in techniques to develop new drugs in the fight against diseases such as cancer and Alzheimer's. The team has developed an innovative process allowing them to generate a particular type of synthetic amino acid – and a particular type of designer protein - that has not been done before. The advance is announced by the Jamieson Research Group in the Department of Chemistry at the University of Leicester. Their work, funded by the Engineering and Physical Sciences Research Council (EPSRC), is published ...

The majority of athletes included in a new study by researchers at the University of North Carolina School of Medicine were able to return to play after having knee surgery to repair an anterior cruciate ligament (ACL) injury. In addition, the study found that athletes who had ACL surgery when they were in high school or younger were much more likely to suffer repeat ACL reinjuries than athletes who experienced their first ACL injury during collegiate play. "It's very clear from our data that the younger the elite athlete, the higher risk for reinjury," said Ganesh ...

Irvine, Calif. — Abundant supplies of natural gas will do little to reduce harmful U.S. emissions causing climate change, according to researchers at UC Irvine, Stanford University, and the nonprofit organization Near Zero. They found that inexpensive gas boosts electricity consumption and hinders expansion of cleaner energy sources, such as wind and solar. The study results, which appear Sept. 24 in the journal Environmental Research Letters, are based on modeling the effect of high and low gas supplies on the U.S. power sector. Coal-fired plants, the nation's largest ...

Female populations have been larger than male populations throughout human history, according to research published today in the open access journal Investigative Genetics. The research used a new technique to obtain higher quality paternal genetic information to analyse the demographic history of males and females in worldwide populations. The study compared the paternally-inherited Y chromosome (NRY) with maternally inherited mitochondrial DNA (mtDNA) of 623 males from 51 populations. The analysis showed that female populations were larger before the out-of-Africa migration ...

The mechanism by which statins increase the risk of type 2 diabetes has been investigated in a large-scale analysis from an international team led by researchers from UCL and the University of Glasgow, using information from genetic studies and clinical trials. Published in The Lancet, the work received support from a number of funders including the Medical Research Council, British Heart Foundation, Rosetrees Trust and National Institute for Health Research University College London Hospitals Biomedical Research Centre. Among nearly 130 000 participants from clinical ...

Skin colour displayed amongst one species of monkey provides a key indicator of how successfully they will breed, a new study has shown. The collaborative international research also shows that skin colouration in male and female rhesus macaques is an inherited quality – the first example of heritability for a sexually-selected trait to be described in any mammal. The team of scientists collected more than 250 facial images of free-ranging rhesus macaques, which are native to South, Central and Southeast Asia and which display red skin colouring around the face, as ...

COLUMBUS, Ohio—Researchers at The Ohio State University have gained new insight into how the body moves when we're walking. They learned everything they needed to know by watching people walk naturally on a treadmill. In normal walking, humans place their foot at slightly different positions on each step. To the untrained eye, this step-to-step variation in foot position just looks random and noisy. But in the Sept. 24, 2014, issue of the journal Biology Letters, the researchers describe a mathematical model that can explain over 80 percent of this apparent randomness ...

Cardiac arrest outside of hospital is a common and catastrophic medical emergency experienced by about 60,000 people a year in the UK. Less than 10% survive to discharge from hospital.   Immediate cardiopulmonary resuscitation (CPR) offers the best chance of survival and ambulance services throughout the developed world tend to take patients in cardiac arrest to hospital, with CPR ongoing.   This seems intuitive, writes Jonathan Benger, Professor of Emergency Care at the University of the West of England, and Consultant at University Hospitals Bristol NHS Foundation ...

Brain cells that multiply to help birds sing their best during breeding season are known to die back naturally later in the year. For the first time researchers have described the series of events that cues new neuron growth each spring, and it all appears to start with a signal from the expiring cells the previous fall that primes the brain to start producing stem cells. If scientists can further tap into the process and understand how those signals work, it might lead to ways to exploit these signals and encourage replacement of cells in human brains that have lost neurons ...

For thousands of years, man has domesticated animals, selecting the best traits possible for survival. Now, livestock such as sheep offer an intriguing animal to examine adaptation to climate change, with a genetic legacy of centuries of selected breeding and a wealth of livestock genome-wide data available. In a first-of-its kind study that combined molecular and environmental data, professor Meng-Hua Li et al., performed a search for genes under environmental selection from domesticated sheep breeds. Their results were published in the advanced online edition of the ...

An early age of onset (AO) of drinking is a risk factor for subsequent heavy drinking and negative outcomes. New research looks at both an early AO, as well as a quick progression from initial alcohol use to drinking to the point of intoxication, as risk factors. Findings indicate that both are associated with high-school student alcohol use and binge drinking. Although starting to drink at an early age is one of the most frequently studied risk factors for subsequent heavy drinking and related negative outcomes, findings have been inconsistent. An alternative ...

Alcohol use that begins during adolescence affects the development of alcohol use disorders during adulthood. A new study looks at the effects of interplay between peer drinking and the functional variant rs1229984 in the alcohol dehydrogenase 1B gene (ADH1B) among adolescents. Peer drinking reduces the protective effects of this ADH1B variant. Patterns of alcohol use that begin during adolescence are important factors in the development of alcohol use disorders (AUDs) during adulthood. While researchers know that adolescent drinking is influenced by both genetic and ...

Increasing cigarette taxes and smoke-free policies are known to reduce smoking prevalence. New findings show that these measures may also lead to a decrease in alcohol consumption. These findings apply to beer and spirits, but not wine. Smoking and drinking are often complementary behaviors: smokers are more likely than non-smokers to drink alcohol, and heavy smokers are more likely to be heavy drinkers. While increasing state cigarette excise taxes and strengthening smoke-free air laws are known to reduce smoking prevalence, it is less clear if such policies may also ...

Taste strongly influences food and beverage intake, including alcohol. Furthermore, genetic variation in chemosensory genes can explain variability in individual perception of and preference for alcoholic drinks. A new study has examined the relationship between variation in alcohol-related sensations and polymorphisms in bitter taste receptors genes previously linked to alcohol intake, and for the first time, polymorphisms in a burn receptor gene. The findings indicate that genetic variations in taste receptors influence intensity perceptions. Results will be published ...

Following a doubling of the incidence and prevalence of diabetes in the U.S. from 1990-2008, new data suggest a plateauing of the rate between 2008 and 2012 for adults, however the incidence continued to increase in Hispanic and non-Hispanic black adults, according to a study in the September 24 issue of JAMA. Although there has been an increase in the prevalence and incidence of diabetes in the United States in recent decades, no studies have systematically examined long-term, national trends of this disease, according to background information in the article. Linda ...

An intervention for pregnant women that included a computerized, interactive decision-support guide regarding prenatal genetic testing, and no cost for testing, resulted in less prenatal test use and more informed choices, according to a study in the September 24 issue of JAMA. Since the introduction of amniocentesis, prenatal genetic testing guidelines have focused on identifying women at increased risk of giving birth to an infant with Down syndrome or other chromosomal abnormalities, for whom invasive diagnostic testing should be recommended. Prenatal genetic testing ...

An analysis of 70 studies finds that use of the diagnostic imaging procedure of fludeoxyglucose F18 (FDG)-positron emission tomography (PET) combined with computed tomography (CT) may not reliably distinguish benign disease from lung cancer in populations with endemic (high prevalence) infectious lung disease compared with nonendemic regions, according to a study in the September 24 issue of JAMA. Depending on the risk for cancer, diagnostic guidelines suggest or recommend FDG combined with PET as a noninvasive test to assess the risk of cancer or benign disease, according ...

A new analysis of published studies found that FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common. Misdiagnosis of lung lesions suspicious for cancer could lead to unnecessary tests and surgeries for patients, with additional potential complications and mortality. Histoplasmosis and other fungal diseases are linked to fungi that are often concentrated in bird droppings and are found in soils. The study by investigators at Vanderbilt University and the Tennessee ...

SALT LAKE CITY, Sept. 23, 2014 – What's rocky, about a mile wide, orbits between Mars and Jupiter and poses no threat to Earth? An asteroid named "Univofutah" after the University of Utah. Discovered on Sept. 8, 2008, by longtime Utah astronomy educator Patrick Wiggins, the asteroid also known as 391795 (2008 RV77) this month was renamed Univofutah by the International Astronomical Union's Minor Planet Center in Cambridge, Massachusetts. "It's neat," Wiggins says. "There aren't too many other universities on the whole planet with asteroids named after them. So that ...

The successful rise and fall of an athlete's moving body relies on an orchestrated response of bones, joints, ligaments and tendons, putting the many angles and intersecting planes – literally the geometry – of a critical part like a knee joint to the test. But it's more than just a footfall error at the root of one of the most devastating of sports injuries: the ACL or anterior cruciate ligament tear. In fact, size – of the femoral notch that sits at the center of the knee joint – and volume of the ACL combine to influence the risk of suffering a noncontact ACL injury. ...

COLUMBIA, Mo. – Infants' vocalizations throughout the first year follow a set of predictable steps from crying and cooing to forming syllables and first words. However, previous research had not addressed how the amount of vocalizations may differ between hearing and deaf infants. Now, University of Missouri research shows that infant vocalizations are primarily motivated by infants' ability to hear their own babbling. Additionally, infants with profound hearing loss who received cochlear implants to help correct their hearing soon reached the vocalization levels of their ...

Edmonton—Cleaning up oil sands tailings has just gotten a lot greener thanks to a novel technique developed by University of Alberta civil engineering professors that uses solar energy to accelerate tailings pond reclamation efforts by industry. Instead of using UV lamps as a light source to treat oil sands process affected water (OSPW) retained in tailings ponds, professors Mohamed Gamal El-Din and James Bolton have found that using the sunlight as a renewable energy source treats the wastewater just as efficiently but at a much lower cost. "We know it works, so now ...

Antarctic fish that manufacture their own "antifreeze" proteins to survive in the icy Southern Ocean also suffer an unfortunate side effect, researchers funded by the National Science Foundation (NSF) report: The protein-bound ice crystals that accumulate inside their bodies resist melting even when temperatures warm. "We discovered what appears to be an undesirable consequence of the evolution of antifreeze proteins in Antarctic notothenioid fish," said University of Oregon doctoral student Paul Cziko, who led the research with University of Illinois animal biology ...

Genomic medicine is rapidly developing, bringing with its advances promises of individualized genetic information to tailor and optimize prevention and treatment interventions. Genetic tests are already guiding treatments of the human immunodeficiency virus (HIV) and hepatitis c virus (HPC), and emerging research is showing genetic variants may be used to screen for an individual's susceptibility to addiction to a substance, and even inform treatments for addiction. While there appear to be many benefits inherent in the development of this field and related research, ...

(PHILADELPHIA) – Researchers have encountered variants or isoforms in microRNAs (miRNAs) before, but assumed that these variants were accidental byproducts. A recent study, published in the journal Oncotarget this month, shows that certain so called isomiRs have abundances that depend on geographic subpopulations and gender and that the most prevalent variant of a given miRNA may not be the one typically listed in the public databases. "This study shows that microRNA isoforms are much more common than we had previously assumed. The fact that some isoforms are shared by ...