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UBC team finds a glitch in hummingbird hovering

2014-12-09
Hummingbirds rely on their ability to hover in order to feed off the nectar of flowers. It's an incredible feat of flying requiring mind boggling visual processing power, but two University of British Columbia researchers found a glitch in the system, something the tiny birds are powerless to control. The researchers put hovering hummingbirds through a virtual reality experiment that showed the birds can't control their inflight response to some visual stimuli. In a laboratory flight arena, hummingbirds hovered around a plastic feeder while images were projected on ...

New technique could harvest more of the sun's energy

2014-12-09
As solar panels become less expensive and capable of generating more power, solar energy is becoming a more commercially viable alternative source of electricity. However, the photovoltaic cells now used to turn sunlight into electricity can only absorb and use a small fraction of that light, and that means a significant amount of solar energy goes untapped. A new technology created by researchers from Caltech, and described in a paper published online in the October 30 issue of Science Express, represents a first step toward harnessing that lost energy. Sunlight is ...

Ancient engravings rewrite human history

Ancient engravings rewrite human history
2014-12-09
An international team of scientists has discovered the earliest known engravings from human ancestors on a 400,000 year-old fossilised shell from Java. The discovery is the earliest known example of ancient humans deliberately creating pattern. "It rewrites human history," said Dr Stephen Munro from School of Archaeology and Anthropology at The Australian National University (ANU). "This is the first time we have found evidence for Homo erectus behaving this way," he said. The newly discovered engravings resemble the previously oldest-known engravings, which are ...

How pace of climate change will challenge ectotherms

2014-12-09
Animals that regulate their body temperature through the external environment may be resilient to some climate change but not keep pace with rapid change leading to potentially disastrous outcomes for biodiversity. A study by the University of Sydney and University of Queensland showed many animals can modify the function of their cells and organs to compensate for changes in the climate and have done so in the past, but the researchers warn that the current rate of climate change will outpace animals' capacity for compensation (or acclimation). The research has just ...

Common chemotherapy is not heart toxic in patients with BRCA1/2 mutations

2014-12-09
SAN ANTONIO -- Use of anthracycline-based chemotherapy, a common treatment for breast cancer, has negligible cardiac toxicity in women whose tumors have BRCA1/2 mutations -- despite preclinical evidence that such treatment can damage the heart. The findings, to be presented at the 2014 San Antonio Breast Cancer Symposium (SABCS), represent a unique effort between cardiologists and oncologists at Georgetown Lombardi Comprehensive Cancer Center and MedStar Heart & Vascular Institute in Washington to answer a vital clinical question. "Our study was prompted by evidence from ...

Three new Myriad studies highlighted at 2014 San Antonio Breast Cancer Symposium

2014-12-09
SALT LAKE CITY, Utah, Dec. 9, 2014 - Myriad Genetics, Inc. (NASDAQ: MYGN) today announced results from a new study that demonstrated the ability of the myRisk™ Hereditary Cancer test to detect 105 percent more mutations in cancer causing genes than conventional BRCA testing alone. The Company also presented two key studies in triple negative breast cancer (TNBC) that show the myChoice™ HRD test accurately predicted response to platinum-based therapy in patients with early-stage TNBC and that the BRACAnalysis® molecular diagnostic test significantly predicted ...

Temperature anomalies are warming faster than Earth's average

Temperature anomalies are warming faster than Earth's average
2014-12-09
BLOOMINGTON, Ind. -- It's widely known that the Earth's average temperature has been rising. But research by an Indiana University geographer and colleagues finds that spatial patterns of extreme temperature anomalies -- readings well above or below the mean -- are warming even faster than the overall average. And trends in extreme heat and cold are important, said Scott M. Robeson, professor of geography in the College of Arts and Sciences at IU Bloomington. They have an outsized impact on water supplies, agricultural productivity and other factors related to human health ...

Warmer Pacific Ocean could release millions of tons of seafloor methane

Warmer Pacific Ocean could release millions of tons of seafloor methane
2014-12-09
Off the West Coast of the United States, methane gas is trapped in frozen layers below the seafloor. New research from the University of Washington shows that water at intermediate depths is warming enough to cause these carbon deposits to melt, releasing methane into the sediments and surrounding water. Researchers found that water off the coast of Washington is gradually warming at a depth of 500 meters, about a third of a mile down. That is the same depth where methane transforms from a solid to a gas. The research suggests that ocean warming could be triggering the ...

Long-term endurance training impacts muscle epigenetics

Long-term endurance training impacts muscle epigenetics
2014-12-09
A new study from Karolinska Institutet in Sweden shows that long-term endurance training in a stable way alters the epigenetic pattern in the human skeletal muscle. The research team behind the study, which is being published in the journal Epigenetics, also found strong links between these altered epigenetic patterns and the activity in genes controlling improved metabolism and inflammation. The results may have future implications for prevention and treatment of heart disease, diabetes and obesity. "It is well-established that being inactive is perilous, and that regular ...

Nanotechnology against malaria parasites

Nanotechnology against malaria parasites
2014-12-09
Malaria parasites invade human red blood cells; they then disrupt them and infect others. Researchers at the University of Basel and the Swiss Tropical and Public Health Institute (Swiss TPH) have now developed so-called nanomimics of host cell membranes that trick the parasites. This could lead to novel treatment and vaccination strategies in the fight against malaria and other infectious diseases. Their research results have been published in the scientific journal ACS Nano. For many infectious diseases no vaccine currently exists. In addition, resistance against ...

Toxic fruits hold the key to reproductive success

Toxic fruits hold the key to reproductive success
2014-12-09
This news release is available in German. In the course of evolution, animals have become adapted to certain food sources, sometimes even to plants or to fruits that are actually toxic. The driving forces behind such adaptive mechanisms are often unknown. Scientists at the Max Planck Institute for Chemical Ecology in Jena, Germany, have now discovered why the fruit fly Drosophila sechellia is adapted to the toxic fruits of the morinda tree. Drosophila sechellia females, which lay their eggs on these fruits, carry a mutation in a gene that inhibits egg production. ...

Stain every nerve

Stain every nerve
2014-12-09
Scientists can now explore nerves in mice in much greater detail than ever before, thanks to an approach developed by scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy. The work, published online today in Nature Methods, enables researchers to easily use artificial tags, broadening the range of what they can study and vastly increasing image resolution. "Already we've been able to see things that we couldn't see before," says Paul Heppenstall from EMBL, who led the research. "Structures such as nerves arranged around a hair on the skin; ...

New treatment strategy for epilepsy

New treatment strategy for epilepsy
2014-12-09
Researchers found out that the conformational defect in a specific protein causes Autosomal Dominant Lateral Temporal Lobe Epilepsy (ADLTE) which is a form of familial epilepsy. They showed that treatment with chemical corrector called "chemical chaperone" ameliorates increased seizure susceptibility in a mouse model of human epilepsy by correcting the conformational defect. This was published in Nature Medicine (December 8, 2014 electronic edition). Mutations in the gene LGI1, encoding a secreted protein, cause familial temporal lobe epilepsy. The research group of ...

Turning biological cells to stone improves cancer and stem cell research

Turning biological cells to stone improves cancer and stem cell research
2014-12-09
ALBUQUERQUE, N.M. -- Changing flesh to stone sounds like the work of a witch in a fairy tale. But a new technique to transmute living cells into more permanent materials that defy rot and can endure high-powered probes is widening research opportunities for biologists who are developing cancer treatments, tracking stem cell evolution or even trying to understand how spiders vary the quality of the silk they spin. The simple, silica-based method also offers materials scientists the ability to "fix" small biological entities like red blood cells into more commercially ...

The winds of Titan

The winds of Titan
2014-12-09
As sand dunes march across the Sahara, vast dunes cross the surface of Saturn's largest moon, Titan. New research from a refurbished NASA wind tunnel reveals the physics of how particles move in Titan's methane-laden winds and could help to explain why Titan's dunes form in the way they do. The work is published online Dec. 8 in the journal Nature. "Conditions on Earth seem natural to us, but models from Earth won't work elsewhere," said Bruce White, professor of mechanical and aerospace engineering at the University of California, Davis, and a co-author on the study. ...

Smoking still causes large proportion of cancer deaths in the United States

2014-12-09
ATLANTA - December 9, 2014- A new American Cancer Society study finds that despite significant drops in smoking rates, cigarettes continue to cause about three in ten cancer deaths in the United States. The study, appearing in the Annals of Epidemiology, concludes that efforts to reduce smoking prevalence as rapidly as possible should be a top priority for the U.S. public health efforts to prevent cancer deaths. More than 30 years ago, a groundbreaking analysis by famed British researchers, Richard Doll and Richard Peto, calculated that 30 percent of all cancer deaths ...

Paying attention makes touch-sensing brain cells fire rapidly and in sync

2014-12-09
Whether we're paying attention to something we see can be discerned by monitoring the firings of specific groups of brain cells. Now, new work from Johns Hopkins shows that the same holds true for the sense of touch. The study brings researchers closer to understanding how animals' thoughts and feelings affect their perception of external stimuli. The results were published Nov. 25 in the journal PLoS Biology. "There is so much information available in the world that we cannot process it all," says Ernst Niebur, Ph.D., a professor of neuroscience in the Johns Hopkins ...

Storing hydrogen underground could boost transportation, energy security

Storing hydrogen underground could boost transportation, energy security
2014-12-09
LIVERMORE, Calif. -- Large-scale storage of low-pressure, gaseous hydrogen in salt caverns and other underground sites for transportation fuel and grid-scale energy applications offers several advantages over above-ground storage, says a recent Sandia National Laboratories study sponsored by the Department of Energy's Fuel Cell Technologies Office. Geologic storage of hydrogen gas could make it possible to produce and distribute large quantities of hydrogen fuel for the growing fuel cell electric vehicle market, the researchers concluded. Geologic storage solutions ...

Stroke: Promising results of an important study published in the scientific journal Brain

Stroke: Promising results of an important study published in the scientific journal Brain
2014-12-09
Neuro-rehabilitation (physical therapy, occupational therapy, etc.) helps hemaparetic stroke patients confronted with loss of motor skills on one side of their body, to recover some of their motor functions after a cerebrovascular accident. One of the most promising tracks in neuro-rehabilitation consists in amplifying the motor learning ability after a stroke, in other words how to learn (again) how to make movements with the parts of the human body impacted after a stroke. Pilot studies have shown at this matter that tDCS (transcranial direct current stimulation) - ...

Ancient balloon-shaped animal fossil sheds light on Earth's ancient seas

Ancient balloon-shaped animal fossil sheds light on Earth's ancient seas
2014-12-09
Nidelric pugio fossil dates to half a billion years ago and teaches us about the diversity of life in Earth's ancient seas In life the animal was a 'balloon' shape and was covered in spines, but the squashed fossil resembles a bird's nest Named in honour of Professor Richard Aldridge from the University of Leicester A rare 520 million year old fossil shaped like a 'squashed bird's nest' that will help to shed new light on life within Earth's ancient seas has been discovered in China by an international research team - and will honour the memory of a University of ...

Data published on ANG4043, anti-HER2 monoclonal antibody for treatment of brain metastases

2014-12-09
Montreal, Canada, November x, 2014 - Angiochem, a clinical stage biotechnology company creating and developing drugs that cross the blood-brain barrier, today announced the publication in Molecular Cancer Therapeutics demonstrating that ANG4043, a peptide-monoclonal antibody (mAb) conjugate, entered the brain at therapeutic concentrations, resulting in significantly prolonged survival in mice. The antibody is directed against HER2, which is the protein targeted by Herceptin®. Because the mAb is conjugated to Angiopep-2, it is recognized by the LRP1 receptor and takes ...

Sleep disturbance linked to amyloid in brain areas affected by Alzheimer's disease

2014-12-09
Phoenix, AZ (December 9th, 2014) - Healthy, elderly research participants who report being more sleepy and less rested have higher levels of amyloid deposition in regions of the brain that are affected in Alzheimer's disease, according to a report presented today at the American College of Neuropsychopharmacology annual meeting in Phoenix (Arizona). If sleep disturbance is a cause of amyloid accumulation, it may be an early target for intervention to prevent the progression of cognitive deficits in late life. Numerous studies have shown the importance of sleep and the ...

Brain scans link frontal abnormalities to suicidal behaviors in adolescents, young adults

2014-12-09
Phoenix, AZ (December 9th, 2014) - Abnormalities in the prefrontal cortex and related brain areas are observed in adolescents who have attempted suicide, according to a report today at the American College of Neuropsychopharmacology annual meeting in Phoenix Arizona. The study suggests that deficits in frontal systems may be associated with risk for suicide attempts in youths with mood disorders. Most suicide attempts occur in the context of mood disorders, including bipolar disorder and major depressive disorder. Bipolar disorder has a prevalence of 3-4% in the U.S. population, ...

Immunotherapy shows clinical benefit in relapsed transplant recipients

2014-12-09
A multicenter phase 1 trial of the immune checkpoint blocker ipilimumab found clinical benefit in nearly half of blood cancer patients who had relapsed following allogeneic stem cell transplantation, according to investigators from Dana-Farber Cancer Institute, who developed and lead the study. The study reported at the American Society of Hematology annual meeting is the first in which ipilimumab was given in multiple doses over an extended time period, the researchers said. At a median follow-up time of six months, "We have seen less toxicity than expected and a strong ...

PRM-151 therapy well tolerated in patients with advanced myelofibrosis

PRM-151 therapy well tolerated in patients with advanced myelofibrosis
2014-12-09
A study that investigated the potential of the compound PRM-151 (PRM) for reducing progressive bone marrow fibrosis (scarring) in patients with advanced myelofibrosis has shown initial positive results. Myelofibrosis is a life-threatening bone marrow cancer. The study, led by Srdan Verstovsek, M.D., Ph.D., professor of leukemia at The University of Texas MD Anderson Cancer Center, showed the compound was well tolerated in observing 27 patients. Verstovsek's research results were presented today at the 56th Annual Meeting of the American Society of Hematology (ASH) annual ...
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