Think the nest of cables under your desk is bad? Try keeping the trillions of connections crisscrossing your brain organized and free of tangles. A new study coauthored by researchers at UC San Francisco and the Freie Universität Berlin reveals this seemingly intractable job may be simpler than it appears. The researchers used high-resolution time-lapse imaging of the developing brains of pupal fruit flies (Drosophila melanogaster) paired with mathematical simulations to unravel a trick of neural wiring that had stumped neuroscientists for decades. They discovered ...

Adult fruit flies given a cancer drug live 12% longer than average, according to a UCL-led study researching healthy ageing. The drug targets a specific cellular process that occurs in animals, including humans, delaying the onset of age-related deaths by slowing the ageing process. The study published today in Cell and funded by the Max Planck Society and Wellcome Trust shows for the first time that a small molecule drug, which limits the effects of a protein called Ras, can delay the ageing process in animals. The treated fruit flies outlived the control group by staying ...

Boston, MA -- A new study led by researchers at Harvard T.H. Chan School of Public Health finds that a malaria parasite protein called calcineurin is essential for parasite invasion into red blood cells. Human calcineurin is already a proven target for drugs treating other illnesses including adult rheumatoid arthritis and lupus, and the new findings suggest that parasite calcineurin should be a focus for the development of new antimalarial drugs. "Our study has great biological and medical significance, particularly in light of the huge disease burden of malaria," said ...

LA JOLLA--As a tumor grows, its cancerous cells ramp up an energy-harvesting process to support its hasty development. This process, called autophagy, is normally used by a cell to recycle damaged organelles and proteins, but is also co-opted by cancer cells to meet their increased energy and metabolic demands. Salk Institute and Sanford Burnham Prebys Medical Discovery Institute (SBP) scientists have developed a drug that prevents this process from starting in cancer cells. Published June 25, 2015 in Molecular Cell, the new study identifies a small molecule drug that ...

Washington, DC (June 25, 2015) - Comment sections on websites continue to be an environment for trolls to spew racist opinions. The impact of these hateful words shouldn't have an impact on how one views the news or others, but that may not be the case. A recent study published in the journal Human Communication Research, by researchers at the University of Canterbury, New Zealand, found exposure to prejudiced online comments can increase people's own prejudice, and increase the likelihood that they leave prejudiced comments themselves. Mark Hsueh, Kumar Yogeeswaran, ...

June 25 -- During the wars in Iraq and Afghanistan, U.S. combat support hospitals treated at least 650 children with severe, combat-related head injuries, according to a special article in the July issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Wolters Kluwer. "Given the challenging environment and limited available resources, coalition forces were able to provide quality, timely, and life-saving care to many children" with severe head injuries, write Dr. Paul Klimo, Jr., of Semmes-Murphy Neurologic & Spine ...

A large number of patients use online communication tools such as email and Facebook to engage with their physicians, despite recommendations from some hospitals and professional organizations that clinicians limit email contact with patients and avoid "friending" patients on social media, new research suggests. The findings from Johns Hopkins Bloomberg School of Public Health researchers suggest a disconnect between what patients expect and what physicians -- concerned about confidentiality and being overwhelmed in off-hours -- are willing to do when it comes to online ...

June 25, 2015 - New results in animals highlight a major safety concern regarding a class of magnetic resonance imaging (MRI) contrast agents used in millions of patients each year, according to a paper published online by the journal Investigative Radiology. The journal is published by Wolters Kluwer. The study adds to concerns that repeated use of specific "linear"-type gadolinium-based contrast agents (GBCAs) lead to deposits of the heavy-metal element gadolinium in the brain. The results will have a major impact on the multimillion-dollar market for MRI contrast agents, ...

Many patients in the latter stage of Parkinson's disease are at high risk of dangerous, sometimes fatal, falls. One major reason is the disabling symptom referred to as Freezing of Gait (FoG) -- brief episodes of an inability to step forward that typically occurs during gait initiation or when turning while walking. Patients who experience FoG often lose their independence, which has a direct effect on their already degenerating quality of life. In the absence of effective pharmacological therapies for FoG, technology-based solutions to alleviate the symptom and prolong ...

While the use of antiangiogenesis drugs that block the growth of new blood vessels can improve the treatment of some cancers, clinical trials of their ability to prevent the development of new metastases have failed. Now a study from the Massachusetts General Hospital (MGH) Cancer Center may have found at least one reason why. In their paper published online in the Journal of the National Cancer Institute, an MGH research team reports finding that the growth of metastases in lymph nodes -- the most common site of cancer spread -- does not require new blood vessels but instead ...

A good or mediocre appetizer has the potential to significantly change how the main course is enjoyed, according to one Drexel food science professor. Jacob Lahne, PhD, an assistant professor in the Center for Hospitality and Sport Management, recently found that a comparatively good appetizer could make people enjoy the main course less than if it were preceded by a mediocre appetizer. Lahne tested and analyzed subjects' hedonic (liking) responses to a main dish of "pasta aglio e olio" (pasta with garlic and oil) after they had either a good or mediocre bruschetta ...

Nature loves crystals. Salt, snowflakes and quartz are three examples of crystals - materials characterized by the lattice-like arrangement of their atoms and molecules. Industry loves crystals, too. Electronics are based on a special family of crystals known as semiconductors, most famously silicon. To make semiconductors useful, engineers must tweak their crystalline lattice in subtle ways to start and stop the flow of electrons. Semiconductor engineers must know precisely how much energy it takes to move electrons in a crystal lattice. This energy measure is the ...

Scientists from UCL (University College London) have designed a chemical compound that has reduced the growth of pancreatic cancer tumours by 80 percent in treated mice. The compound, called MM41, was designed to block faulty genes. It appears to do this by targeting little knots in their DNA, called quadruplexes, which are very different from normal DNA and which are especially found in faulty genes. The findings, published in Nature Scientific Reports, showed that MM41 had a strong inhibiting effect on two genes -- k-RAS and BCL-2 -- both of which are found in the ...

Wading bird numbers in the Florida Everglades are driven by water patterns that play out over multiple years according to a new study by the U.S. Geological Survey and Florida Atlantic University. Previously, existing water conditions were seen as the primary driving factor affecting numbers of birds, but this research shows that the preceding years' water conditions and availability are equally important. "We've known for some time that changes in water levels trigger a significant response by wading birds in the Everglades," said James Beerens, the study's lead author ...

Researchers from The University of Manchester are part of a team that has identified an important new approach to diagnose infections in critically ill patients rapidly and accurately. A study by colleagues in Salford and Manchester found that chemically analysing breath specimens from patients in intensive care can reveal bacterial infection in the lower respiratory tract of ventilated patients at risk of developing pneumonia. Although the work is in its early stages, the findings so far look very exciting and could potentially have a huge effect on clinical practice ...

A pioneering new technique to produce high-quality, low cost graphene could pave the way for the development of the first truly flexible 'electronic skin', that could be used in robots. Researchers from the University of Exeter have discovered an innovative new method to produce the wonder material Graphene significantly cheaper, and easier, than previously possible. The research team, led by Professor Monica Craciun, have used this new technique to create the first transparent and flexible touch-sensor that could enable the development of artificial skin for use in ...

Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have used DNA barcoding to elucidate the diversity of the sponge fauna found in Antarctic waters. The data provide new insights into the evolution of this poorly characterized group. Sponges constitute an important component of marine ecosystems in the waters around Antarctica. As filter feeders that rely on food particles suspended in the water passing through complex networks of canals lined with flagellated cells, they provide protected niches for many other organisms. "In spite of their considerable ecological ...

How a chimpanzee views a video of an infant chimp from another group being killed gives a sense of how human morality and social norms might have evolved. So says Claudia Rudolf von Rohr of the University of Zurich in Switzerland, lead author of a paper in Springer's journal Human Nature. It provides the first evidence that chimpanzees, like humans, are sensitive to the appropriateness of behaviors, especially those directed toward infants. It also shows that these primates might only take action when a member of their own group is being harmed. The researchers filmed ...

Working with heart muscle cells from diabetic rats, scientists at Johns Hopkins have located what they say is the epicenter of mischief wreaked by too much blood sugar and used a sugar-gobbling enzyme to restore normal function in the glucose-damaged cells of animal heart muscles. In addition to much-needed insight into the process of diabetes-related heart damage, the study, described June 24 in the journal Diabetes, offers a clue to a possible treatment strategy for diabetic cardiomyopathy, a condition marked by progressive weakening of the heart muscle found in 60 ...

Nashville, Tenn., June 25, 2015--Collecting and reporting hospital infection data to federal health agencies takes more than 5 hours each day, at the expense of time needed to ensure that frontline healthcare personnel are adhering to basic infection prevention practices such as hand hygiene, according to a recent case study, to be presented on Saturday, June 27 at the 42nd Annual Conference of the Association for Professionals in Infection Control and Epidemiology (APIC). Infection preventionists (IPs) play a critical role in the effort to eliminate healthcare-associated ...

Nashville, Tenn., June 25 -- A pilot antibiotic stewardship program at a pediatric long-term care facility brought about a 59 percent decrease in use of a topical antibiotic and an 83 percent decrease in orders for antibiotics without proper documentation during a six-month period, according to a new study. When the infection prevention team at Elizabeth Seton Pediatric Center in Yonkers, N.Y. noticed that certain antibiotics were being prescribed for a prolonged period of time and for non-infection indications, they launched a trial program to make improvements in antibiotic ...

New research from Lund University in Sweden questions the prevailing doctrine on how the brain absorbs and processes information. The idea that the brain has a mechanism to maintain activity at the lowest possible level is incorrect. What happens in the brain when we think and which components make up a thought? Researchers in Lund have taken a major step towards understanding this central issue. Since the 1980s, there has been a general consensus among neuroscientists that the brain has a system to maintain brain activity at the lowest possible level while retaining ...

In a comprehensive assessment of Antarctic biodiversity, published in Nature this week, scientists have revealed the region is more diverse and biologically interesting than previously thought. The team of scientists, led by Monash University, along with colleagues from the British Antarctic Survey, University of Waikato in New Zealand, and Australian National University, looked at how recent investigations have revealed the continent and surrounding ocean is rich in species. They are also very highly diversified into a variety of distinct ecological regions that differ ...

A unique program combining a life review writing workshop with conversations between seniors and college students enhances the sense of meaning in life for older adults living independently, finds a new study by NYU's Steinhardt School of Culture, Education, and Human Development. The study is published in the July/August issue of the American Journal of Occupational Therapy. Americans are living longer than ever. The majority of older adults in our aging population want to remain in their own home or "age in place," as opposed to moving to housing for seniors or moving ...

London, UK (June 25, 2015)- We all feel emotion, we all get upset, can feel low, angry and overjoyed, but when do these emotional responses become something of a medical concern? When are these feelings inappropriate, too intense, or lasting too long? When is the emotional state you are in classed as depression? In light of the 5th revision of the influential Diagnostic and Statistical Manual of Mental Disorders (DSM- 5), where a person can now be diagnosed as undergoing a "major depressive episode" if showing depressive symptoms for more than two weeks after bereavement, ...