PHILADELPHIA - New Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related concussion can predict the severity of post-concussion symptoms in professional athletes. The complete findings were released today in the Journal of Neurotrauma. This new study builds on previous research from this group showing that elevated blood levels of SNTF on the day of a mild traumatic brain injury treated in the emergency room predicted those ...

TORONTO, Nov. 29, 2014--A chemical produced in the pancreas that prevented and even reversed Type 1 diabetes in mice had the same effect on human beta cells transplanted into mice, new research has found. GABA, or gamma-aminobutryic acid, is an amino acid produced by the same beta cells that make and secrete insulin. Drs. Gerald Prud'homme and Qinghua Wang of the Keenan Research Centre for Biomedical Sciences of St. Michael's Hospital published a paper in 2011 showing for the first time that GABA injections not only prevented Type 1 diabetes in mice, but even reversed ...

LIVERMORE, Calif. - Nanoporous metals -- foam-like materials that have some degree of air vacuum in their structure -- have a wide range of applications because of their superior qualities. They posses a high surface area for better electron transfer, which can lead to the improved performance of an electrode in an electric double capacitor or battery. Nanoporous metals offer an increased number of available sites for the adsorption of analytes, a highly desirable feature for sensors. Lawrence Livermore National Laboratory (LLNL) and the Swiss Federal Institute of ...

WACO, Texas (Nov. 25, 2014) - Note to venture capitalists: Entrepreneurs are watching to see if you're naughty or nice. A recently published study of more than 550 decisions and responses from 144 experienced entrepreneurs reveals that "knowledge of explicit ethical or unethical behavior (by venture capitalists) profoundly shapes the entrepreneurs' willingness to partner." Baylor University researcher Matthew S. Wood, Ph.D., assistant professor of entrepreneurship in Baylor's Hankamer School of Business, co-authored the study, "Take the money or run? Investors' ethical ...

A measles vaccine made of fine dry powder and delivered with a puff of air triggered no adverse side effects in early human testing and it is likely effective, according to a paper to be published November 28 in the journal Vaccine. The paper is now available online. In 2013, measles killed 145,700 people, most of them children, according to the World Health Organization. That's despite the fact that the conventional injectable vaccine against the measles virus is effective. "Delivering vaccines in the conventional way, with needle injections, poses some serious challenges, ...

Treatment for obstructive sleep apnea with continuous positive airway pressure (CPAP) or mandibular advancement devices (MADs) can lead to modest improvements in depressive symptoms, according to a study published by Marcus Povitz, Carmelle Bolo, and colleagues from University of Calgary, Canada, in this week's PLOS Medicine. The researchers identified 22 randomized controlled trials that investigated the effects of CPAP or MAD treatment on patients with obstructive sleep apnea and that measured depressive symptoms before and after treatment. By pooling the results from ...

HOUSTON - (Nov. 25, 2014) - An international collaboration of scientists including Baylor College of Medicine has completed the first genome sequence of a myriapod, Strigamia maritima - a member of a group venomous centipedes that care for their eggs - and uncovered new clues about their biological evolution and unique absence of vision and circadian rhythm. Over 100 researchers from 12 countries completed the project. They published their work online today in the journal PLOS Biology. "This is the first myriapod and the last of the four classes of arthropods to have ...

The arthropods are one of Earth's real success stories, with more species of arthropod than in any other animal phylum, but our knowledge of arthropod genomes has been heavily skewed towards the insects. Recent work has furnished us with the genome sequences of an arachnid and a crustacean, but the myriapods (centipedes and millipedes) have remained the one class of arthropods whose genomes are still in the dark. An international team of scientists (over 100 from 15 countries) with Stephen Richards (Baylor College of Medicine) as senior author has now sequenced the genome ...

Centipedes, those many-legged creatures that startle us in our homes and gardens, have been genetically sequenced for the first time. In a new study in the journal PLoS Biology, an international team of over 100 scientists today reveals how this humble arthropod's DNA gave them new insight into how life developed on our planet. Centipedes are members of the arthropods, a group with numerous species including insects, spiders and other animals. Until now, the only class of arthropods not represented by a sequenced genome was the myriapods, which include centipedes and ...

Learning-related brain activity in Parkinson's patients improves as much in response to a placebo treatment as to real medication, according to a new study by researchers at the University of Colorado Boulder and Columbia University. Past research has shown that while Parkinson's disease is a neurological reality, the brain systems involved may also be affected by a patient's expectations about treatment. The new study, published in the journal Nature Neuroscience, explains how the placebo treatment -- when patients believe they have received medication when they have ...

Endangered Snake River sockeye salmon are regaining the fitness of their wild ancestors, with naturally spawned juvenile sockeye migrating to the ocean and returning as adults at a much higher rate than others released from hatcheries, according to a newly published analysis. The analysis indicates that the program to save the species has succeeded and is now shifting to rebuilding populations in the wild. Biologists believe the increased return rate of sockeye spawned naturally by hatchery-produced parents is high enough for the species to eventually sustain itself in ...

MAYWOOD, Il. - An award-winning study by a Loyola University Chicago Stritch School of Medicine researcher has documented how homeless, mentally ill women in India face a vicious cycle: During psychotic episodes, they wander away from home, sometimes for long distances, and wind up in homeless shelters. They then are returned to their families before undergoing sufficient psychosocial rehabilitation to deal with their illness. Consequently, they suffer mental illness relapses and wind up homeless again. "The study illustrates how there must be a balance between reintegrating ...

While the turkey you eat on Thursday will bring your stomach happiness and could probably kick-start an afternoon nap, it may also save your life one day. That's because the biological machinery needed to produce a potentially life-saving antibiotic is found in turkeys. Looks like there is one more reason to be grateful this Thanksgiving. "Our research group is certainly thankful for turkeys," said BYU microbiologist Joel Griffitts, whose team is exploring how the turkey-born antibiotic comes to be. "The good bacteria we're studying has been keeping turkey farms healthy ...

How is it that vultures can live on a diet of carrion that would at least lead to severe food-poisoning, and more likely kill most other animals? This is the key question behind a recent collaboration between a team of international researchers from Denmark's Centre for GeoGenetics and Biological Institute at the University of Copenhagen, Aarhus University, the Technical University of Denmark, Copenhagen Zoo and the Smithsonian Institution in the USA. An "acidic" answer to this question is now published in the scientific journal Nature Communications. When vultures eat ...

Who knew Blu-ray discs were so useful? Already one of the best ways to store high-definition movies and television shows because of their high-density data storage, Blu-ray discs also improve the performance of solar cells -- suggesting a second use for unwanted discs -- according to new research from Northwestern University. An interdisciplinary research team has discovered that the pattern of information written on a Blu-ray disc -- and it doesn't matter if it's Jackie Chan's "Supercop" or the cartoon "Family Guy" -- works very well for improving light absorption across ...

New York, NY, November 25, 2014 - Testosterone (T) therapy is routinely used in men with hypogonadism, a condition in which diminished function of the gonads occurs. Although there is no evidence that T therapy increases the risk of prostate cancer (PCa), there are still concerns and a paucity of long-term data. In a new study in The Journal of Urology®, investigators examined three parallel, prospective, ongoing, cumulative registry studies of over 1,000 men. Their analysis showed that long-term T therapy in hypogonadal men is safe and does not increase the risk of ...

LAWRENCE -- Physicists at the University of Kansas have fabricated an innovative substance from two different atomic sheets that interlock much like Lego toy bricks. The researchers said the new material -- made of a layer of graphene and a layer of tungsten disulfide -- could be used in solar cells and flexible electronics. Their findings are published today by Nature Communications. Hsin-Ying Chiu, assistant professor of physics and astronomy, and graduate student Matt Bellus fabricated the new material using "layer-by-layer assembly" as a versatile bottom-up nanofabrication ...

The bacterium Helicobacter pylori is strongly associated with gastric ulcers and cancer. To combat the infection, researchers at University of California, San Diego School of Medicine and Jacobs School of Engineering developed LipoLLA, a therapeutic nanoparticle that contains linolenic acid, a component in vegetable oils. In mice, LipoLLA was safe and more effective against H. pylori infection than standard antibiotic treatments. The results are published online Nov. 24 in the Proceedings of the National Academy of Sciences. "Current H. pylori treatments are facing ...

Medford/Somerville, Mass--Researchers in human genetics have known that long nucleotide repeats in DNA lead to instability of the genome and ultimately to human hereditary diseases such Freidreich's ataxia and Huntington's disease. Scientists have believed that the lengthening of those repeats occur during DNA replication when cells divide or when the cellular DNA repair machinery gets activated. Recently, however, it became apparent that yet another process called transcription, which is copying the information from DNA into RNA, could also been involved. A Tufts ...

Researchers at the University of Leeds have shed light on a gene mutation linked to autistic traits. The team already knew that some people with autism were deficient in a gene called neurexin-II. To investigate whether the gene was associated with autism symptoms, the Leeds team studied mice with the same defect. They found behavioural features that were similar to autism symptoms, including a lack of sociability or interest in other mice. Dr Steven Clapcote, Lecturer in Pharmacology in the University's Faculty of Biological Sciences, who led the study published ...

Flexible electronics have been touted as the next generation in electronics in various areas, ranging from consumer electronics to bio-integrated medical devices. In spite of their merits, insufficient performance of organic materials arising from inherent material properties and processing limitations in scalability have posed big challenges to developing all-in-one flexible electronics systems in which display, processor, memory, and energy devices are integrated. The high temperature processes, essential for high performance electronic devices, have severely restricted ...

Cancer stem cells are particularly difficult to eradicate and are at the heart of why it is so hard to more effectively treat cancer patients, as the post-treatment survival of cancer stem cells drives tumour recurrence, the systemic spread of cancer and, ultimately, treatment failure. The researchers, based at the University's Institute of Cancer Sciences and the Cancer Research UK Manchester Institute - both part of the Manchester Cancer Research Centre - investigated the role of mitochondria which produce and release energy within cells. In this context, the new ...

CHICAGO (November 25, 2014) - New research shows providing detainees wash cloths treated with a skin cleanser could reduce the prevalence of Staphylococcus aureus (S. aureus) bacteria in U.S. jails. Researchers looked at the effect on transmission of S. aureus of using wash cloths treated with chlorhexidine gluconate (CHG) compared with wash cloths with only plain water in detainees at Dallas County Jail. The study was published in the December issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America (SHEA). ...

CHICAGO (November 25, 2014) - A new study finds a decrease in an emergent strain of methicillin-resistant S. aureus (MRSA) that is resistant to last line defense antibiotics. Researchers examined the prevalence of vancomycin-resistant Staphylococcus aureus (VRSA) infections in southeastern Michigan, where the majority of these infections have occurred in the U.S. The study is published in the December issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America (SHEA). "Vancomycin is one of the few antimicrobial ...

With research and development costs for many drugs reaching well into the billions, pharmaceutical companies want more than ever to determine whether their drugs already at market have any hidden therapeutic benefits that could warrant putting additional indications on the label and increase production. Such repurposing of drugs requires evidence of efficacy, and to find candidate drugs for randomized controlled repurposing trials, investigators can use computer simulation and scans of health care billing data, in addition to in vitro and in vivo testing. A study led ...