Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer in adults. They have also, in experiments with mice, been able to slow eye tumor growth with an existing FDA-approved drug. The findings are published online in the May 29 issue of the journal Cancer Cell. "The beauty of our study is its simplicity," said Kun-Liang Guan, PhD, professor of pharmacology at UC San Diego Moores Cancer Center and co-author of the study. "The genetics of this cancer are very simple ...

When electrical pulses are applied to the ventral tegmental area of their brain, macaques presented with two images change their preference from one image to the other. The study by researchers Wim Vanduffel and John Arsenault, KU Leuven and Massachusetts General Hospital, is the first to confirm a causal link between activity in the ventral tegmental area and choice behavior in primates. The ventral tegmental area is located in the midbrain and helps regulate learning and reinforcement in the brain's reward system. It produces dopamine, a neurotransmitter that plays an ...

Artificially stimulating a brain region believed to play a key role in learning, reward and motivation induced monkeys to change which of two images they choose to look at. In experiments reported online in the journal Current Biology, researchers from Massachusetts General Hospital (MGH) and the University of Leuven in Belgium confirm for the first time that stimulation of the ventral tegmental area (VTA) – a group of neurons at the base of the midbrain – can change behavior through activation of the brain's reward system. "Previous studies had correlated increased ...

Baltimore, MD— A woman's supply of eggs is a precious commodity because only a few hundred mature eggs can be produced throughout her lifetime and each must be as free as possible from genetic damage. Part of egg production involves a winnowing of the egg supply during fetal development, childhood and into adulthood down from a large starting pool. New research by Carnegie's Alex Bortvin and postdoctoral fellow Safia Malki have gained new insights into the earliest stages of egg selection, which may have broad implications for women's health and fertility. The work is reported ...

Scientists combined observations from two NASA missions to check out the moon's lopsided shape and how it changes under Earth's sway – a response not seen from orbit before. The team drew on studies by NASA's Lunar Reconnaissance Orbiter, which has been investigating the moon since 2009, and by NASA's Gravity Recovery and Interior Laboratory, or GRAIL, mission. Because orbiting spacecraft gathered the data, the scientists were able to take the entire moon into account, not just the side that can be observed from Earth. "The deformation of the moon due to Earth's pull ...

Lincoln, Neb., May 29, 2014 -- Using a genetically modified form of the HIV virus, a team of University of Nebraska-Lincoln scientists has developed a promising new approach that could someday lead to a more effective HIV vaccine. The team, led by chemist Jiantao Guo, virologist Qingsheng Li and synthetic biologist Wei Niu, has successfully tested the novel approach for vaccine development in vitro and has published findings in the international edition of the German journal Angewandte Chemie. With the new approach, the UNL team is able to use an attenuated -- or weakened ...

New research by an international consortium, including a researcher from Lawrence Livermore National Laboratory, may help physicians better understand the chronological development of a brain aneurysm. Using radiocarbon dating to date samples of ruptured and unruptured cerebral aneurysm (CA) tissue, the team, led by neurosurgeon Nima Etminan, found that the main structural constituent and protein – collagen type I – in cerebral aneurysms is distinctly younger than once thought. The new research helps identify patients more likely to suffer from an aneurysm and embark ...

New Rochelle, NY, May 29, 2014—Women have accounted for half the students in U.S. medical schools for nearly two decades, but as professors, deans, and department chairs in medical schools their numbers still lag far behind those of men. Why long-held gender stereotypes are keeping women from achieving career advancement in academic medicine and what can be done to change the institutional culture are explored in an article in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's ...

Crime fighters could have a new tool at their disposal following promising research by Queen's professor Diane Beauchemin. Dr. Beauchemin (Chemistry) and student Lily Huang (MSc'15) have developed a cutting-edge technique to identify human hair. Their test is quicker than DNA analysis techniques currently used by law enforcement. Early sample testing at Queen's produced a 100 per cent success rate. "My first paper and foray into forensic chemistry was developing a method of identifying paint that could help solve hit and run cases," explains Dr. Beauchemin. "Last year, ...

New research from North Carolina State University pinpoints the areas of the cerebral cortex that are affected in mice with absence epilepsy and shows that transplanting embryonic neural cells into these areas can alleviate symptoms of the disease by reducing seizure activity. The work may help identify the areas of the human brain affected in absence epilepsy and lead to new therapies for sufferers. Absence epilepsy primarily affects children. These seizures differ from "clonic-tonic" seizures in that they don't cause muscle spasms; rather, patients "zone out" or stare ...

WEST LAFAYETTE, Ind. - Global malnutrition could fall 84 percent by the year 2050 as incomes in developing countries grow - but only if agricultural productivity continues to improve and climate change does not severely damage agriculture, Purdue University researchers say. "The prevalence and severity of global malnutrition could drop significantly by 2050, particularly in the poorest regions of the world," said Thomas Hertel, Distinguished Professor of Agricultural Economics. "But if productivity does not grow, global malnutrition will worsen even if incomes increase. ...

PHILADELPHIA – It's almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood. Neurodegenerative diseases – including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (Lou Gehrig's disease), Huntington's disease, and spinocerebellar ataxias – exact a devastating toll on aging populations throughout the world. "Yet, there is virtually no cure for any of these diseases, and clinical trials have yielded ...

VIDEO: This animation shows how Cloudsat was able to get the image shown. Click here for more information. Tropical Storm Amanda continues to weaken in the eastern Pacific from dry air and wind shear. NASA's CloudSat satellite captured a view of the storm from the side revealing heavy precipitation when the storm was the most powerful May Eastern Pacific on record. NASA's CloudSat satellite flew over Hurricane Amanda in the east Pacific on May 25, 2014 at 2100 UTC (5 p.m. EDT) ...

Washington — Environmental scientists and synthetic biologists have for the first time developed a set of key research areas to study the potential ecological impacts of synthetic biology, a field that could push beyond incremental changes to create organisms that transcend common evolutionary pathways. The Synthetic Biology Project at the Wilson Center and the Program on Emerging Technologies at the Massachusetts Institute of Technology convened the interdisciplinary group of scientists and are releasing the report, Creating a Research Agenda for the Ecological Implications ...

Traumatic bone injuries such as blast wounds are often so severe that the body can't effectively repair the damage on its own. To aid the recovery, clinicians inject patients with proteins called growth factors. The treatment is costly, requiring large amounts of expensive growth factors. The growth factors also disperse, creating unwanted bone formation in the area around the injury. A new technology under development at the Georgia Institute of Technology could one day provide more efficient delivery of the bone regenerating growth factors with greater accuracy and ...

War wounds that heal successfully frequently contain different microbial species from those that heal poorly, according to a paper published ahead of print in the Journal of Clinical Microbiology. These and other findings have important implications for improving wound healing, says first author Nicholas Be of Lawrence Livermore National Laboratory, Livermore, California. The problem the researchers were addressing is that culture-based identification, which has been used to assay war wound infections, misses the many species that are difficult or impossible to culture. ...

A fossilised tooth belonging to a fearsome marine predator has been recorded as the largest of its kind found in the UK, following its recent discovery. A team of palaeontologists have verified the tooth, which was found near Chesil Beach in Dorset, as belonging to a prehistoric relative of modern crocodiles known as Dakosaurus maximus. The tooth, which has a broken tip, is approximately 5.5 cm long. Researchers and curators from University of Edinburgh and the Natural History Museum in London identified the item after it was bought at an online auction by a fossil ...

CORVALLIS, Ore. – Lyme disease is a stealthy, often misdiagnosed disease that was only recognized about 40 years ago, but new discoveries of ticks fossilized in amber show that the bacteria which cause it may have been lurking around for 15 million years – long before any humans walked on Earth. The findings were made by researchers from Oregon State University, who studied 15-20 million-year-old amber from the Dominican Republic that offer the oldest fossil evidence ever found of Borrelia, a type of spirochete-like bacteria that to this day causes Lyme disease. They ...

TORONTO -- Combined assessment of parathyroid hormone along with vitamin D may be needed to assess the impact of vitamin D status on sugar metabolism, according to Toronto researchers. Their study is published on-line in Diabetes on May 29 2014. The new findings might explain why studies of vitamin D alone have been conflicting and why clinical trials of vitamin D supplementation to improve diabetes have been disappointing, says principal investigator Dr. Ravi Retnakaran. He is a clinician-scientist at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital ...

FRESNO, CA – New research presented this week at the Association for Research in Vision and Ophthalmology conference in Orlando, Florida suggests that regular grape consumption may play a role in eye health by protecting the retina from deterioration. Specifically, a grape-enriched diet resulted in a protective effect on retinal structure and function. The retina is the part of the eye that contains the cells that respond to light, known as photoreceptors. There are two types of photoreceptors: rods and cones. Retinal degenerative diseases affect over 5 million people ...

Grabbing chocolate milk after a hard swim could give swimmers a performance edge, according to new research presented at one of the nation's top sports medicine conferences – the American College of Sports Medicine's annual conference.1 In a sport where seconds and even tenths of a second can make a big difference and intense practice routines are the norm, Indiana University researchers found that when collegiate, trained swimmers recovered with chocolate milk after an exhaustive swim, they swam faster in time trials later that same day. On average, they shaved off 2.1 ...

A new eyeless cavefish is described from Indiana and named after the Indiana Hoosiers. It is the first new cavefish species described from the U.S. in 40 years. Notably, it has an anus right behind its head, and the females brood their young in their gill chamber. The new species was described in the open access journal ZooKeys. The new species, Amblyopsis hoosieri, is the closest relative of a species (A. spelaea) from the longest cave system in the world, Mammoth Cave in Kentucky. These two species are separated by the Ohio River, which also separates the states of ...

One of the reasons we don't yet have self-driving cars and mini-helicopters delivering online purchases is that autonomous vehicles tend not to perform well under pressure. A system that can flawlessly parallel park at 5 mph may have trouble avoiding obstacles at 35 mph. Part of the problem is the time it takes to produce and interpret camera data. An autonomous vehicle using a standard camera to monitor its surroundings might take about a fifth of a second to update its location. That's good enough for normal operating conditions but not nearly fast enough to handle ...

A disheartening new study from researchers at Utah State University, BYU and Rutgers University reveals that discrimination is still tainting the American Dream for minorities. The three-part research article, which appears online in the Journal of Consumer Research, finds that minorities seeking small business loans are treated differently than their white counterparts, despite having identical qualifications on paper. While discrimination in housing, employment and education is well documented, the study shows that minorities also face discrimination in the marketplace. ...

(Edmonton) It looks like just another rock, but what Jesse Reimink holds in his hands is a four-billion-year-old chunk of an ancient protocontinent that holds clues about how the Earth's first continents formed. The University of Alberta geochemistry student spent the better part of three years collecting and studying ancient rock samples from the Acasta Gneiss Complex in the Northwest Territories, part of his PhD research to understand the environment in which they formed. "The timing and mode of continental crust formation throughout Earth's history is a controversial ...