A disruption of circadian rhythms, when combined with a high-fat, high-sugar diet, may contribute to inflammatory bowel disease and other harmful conditions, according to a recent study conducted by researchers at Rush University Medical Center. The study is online at the peer-reviewed, open-access journal, PLOS ONE. "Circadian rhythms, which impose a 24-hour cycle on our bodies, are different from sleep patterns," said Robin M. Voigt, PhD, assistant professor at Rush Medical College and first author of the study. "Sleep is a consequence of circadian rhythms," Voigt said. While ...

Surgical site infections (SSIs) acquired by patients in Veterans Affairs (VA) hospitals are associated with costs nearly twice as high compared to patients who do not have this complication. The greatest SSI-related costs are among patients undergoing neurosurgery. SSIs are associated with increased complications and death. Treatment can include long courses of antibiotics, physical therapy, hospital readmissions and reoperations. Costs associated with SSIs after surgery have been under scrutiny since the Centers for Medicare and Medicaid stopped paying for increased ...

Many women diagnosed with cancer in one breast consider, and eventually undergo, a contralateral prophylactic mastectomy (CPM) to remove both breasts, although few of them have a clinically significant risk of developing cancer in both breasts. Patients deciding to undergo CPM as part of initial treatment for breast cancer is a growing challenge in management of the disease. Removing the unaffected breast has not been shown to increase survival. The Society of Surgical Oncology suggests CPM be considered for a minority of patients at higher than average risk of developing ...

Methamphetamine users showed less sensitivity to risk and reward in one region of the brain and greater sensitivity in other brain regions compared with non-users when performing an exercise involving risky decision making. Deficiencies in decision making are linked to addiction. Chronic methamphetamine use is associated with abnormalities in the neural circuits of the brain involved in risky decision making. Faulty decision making is targeted in addiction therapy so understanding its causes could help in the development of more effective treatments. The authors ...

BOZEMAN, Mont. – Dryland ecosystems, which include deserts to dry-shrublands, play a more important role in the global carbon cycle than previously thought. In fact, they have emerged as one of its drivers, says Montana State University faculty member Ben Poulter. Surprised by the discovery, Poulter and his collaborators explained their findings in Nature. At the same time, they urged global ecologists to include the emerging role of dryland ecosystems in their research. Nature is a weekly international journal that publishes peer-reviewed research in all fields of science ...

Application of a technology currently used to disinfect food products may help to get around one of the most challenging problems in medicine today, the proliferation of bacteria resistant to antibiotics and other antimicrobial drugs. In a paper appearing in the June issue of the journal Technology and already released online, investigators from the Massachusetts General Hospital (MGH) Center for Engineering in Medicine describe how the use of microsecond-pulsed, high-voltage non-thermal electric fields successfully killed resistant bacteria infecting experimentally induced ...

LA JOLLA, CA—May 21, 2014—In surprise findings, scientists at The Scripps Research Institute (TSRI) have discovered that a protein with a propensity to form harmful aggregates in the body when produced in the liver protects against Alzheimer's disease aggregates when it is produced in the brain. The results suggest that drugs that can boost the protein's production specifically in neurons could one day help ward off Alzheimer's disease. "This result was completely unexpected when we started this research," said TSRI Professor Joel N. Buxbaum, MD. "But now we realize that ...

DOWNERS GROVE, Ill. – May 21, 2014 – According to a new systematic review article, radiofrequency ablation and complete endoscopic resection are equally effective in the short-term treatment of dysplastic Barrett's esophagus, but adverse event rates are higher with complete endoscopic resection. The article comparing the two treatments appears in the May issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE). Barrett's esophagus is a condition in which the lining of the esophagus ...

Couples often go grocery shopping together, make joint financial decisions, and choose entertainment options to share. Products and programs like shared gym memberships and joint credit cards are designed with couples in mind. According to a new study in the Journal of Consumer Research, how a couple succeeds or fails in these types of joint endeavors depends on their individual levels of self-control. "We studied the role self-control plays in the joint decisions made by couples," write authors Hristina Dzhogleva (Boston College) and Cait Poynor Lamberton (University ...

Type 2 diabetes is a chronic disease of global relevance. Due to the fear that comes with the long-term bodily degenerative processes, people with the disease often do not actively seek information on the health risks. According to a new study in the Journal of Consumer Research, modern day technologies like interactive games and virtual reality platforms can help people with Type 2 diabetes make better choices and monitor their health on a regular basis. "Our findings bring to light the unrealized power of information communication technologies as social platforms," ...

Conventional oil and gas development in northern Pennsylvania altered bird communities, and the current massive build-out of shale-gas infrastructure may accelerate these changes, according to researchers in Penn State's College of Agricultural Sciences. The commonwealth's Northern Tier -- one of the largest blocks of Eastern deciduous forest in the entire Appalachian region -- is an important breeding area for neotropical migrant songbirds. These diminutive, insect-eating creatures, which breed in Pennsylvania and winter in Central and South America, contribute greatly ...

A type of retina cell plays a more critical role in vision than previously known, a team led by Johns Hopkins University researchers has discovered. Working with mice, the scientists found that the ipRGCs – an atypical type of photoreceptor in the retina – help detect contrast between light and dark, a crucial element in the formation of visual images. The key to the discovery is the fact that the cells express melanopsin, a type of photopigment that undergoes a chemical change when it absorbs light. "We are quite excited that melanopsin signaling contributes to vision ...

When a supernova – the explosion of a distant star —was discovered last year, astrophysicists, with the help of telescopes around the globe, rushed to observe the fireworks. In its dramatic dying flares, this star – a rare type over 10 times the mass of our sun – can tell us something about the life of these fascinating cosmic bodies, as well as helping paint the picture of how all the heavier elements in the universe are formed. To understand the star that produced the supernova, the researchers identified the mix of elements that was thrown off right before the explosion ...

INDIANAPOLIS -- A group of 11 genes can successfully predict whether an individual is at increased risk of alcoholism, a research team from the United States and Germany reported Tuesday. "This powerful panel of just 11 genes successfully identified who has problems with alcohol abuse and who does not in tests in three patient populations on two continents, in two ethnicities and in both genders," said Alexander B. Niculescu III, M.D., Ph.D., principal investigators and associate professor of psychiatry and medical neuroscience at the Indiana University School of Medicine. ...

With the discovery of a compound that can slow the degradation of insulin in animals, scientists at Harvard have opened the door to a potential new treatment for diabetes. The new approach, described by Professor of Chemistry and Chemical Biology David Liu and Associate Professor of Chemistry and Chemical Biology Alan Saghatelian, uses a newly discovered compound to inhibit insulin degrading enzyme (IDE). Inhibiting IDE in mice, they show, elevates insulin levels and promotes insulin signaling in vivo. Eventually, the use of this compound in patients may help maintain ...

Our Sun may seem pretty impressive: 330,000 times as massive as Earth, it accounts for 99.86 percent of the Solar System's total mass; it generates about 400 trillion trillion watts of power per second; and it has a surface temperature of about 10,000 degrees Celsius. Yet for a star, it's a lightweight. The real cosmic behemoths are Wolf-Rayet stars, which are more than 20 times as massive as the Sun and at least five times as hot. Because these stars are relatively rare and often obscured, scientists don't know much about how they form, live and die. But this is changing, ...

Drug-resistant bacteria annually sicken 2 million Americans and kill at least 23,000. A driving force behind this growing public health threat is the ability of bacteria to share genes that provide antibiotic resistance. Bacteria that naturally live in the soil have a vast collection of genes to fight off antibiotics, but they are much less likely to share these genes, a new study by researchers at Washington University School of Medicine in St. Louis has revealed. The findings suggest that most genes from soil bacteria are not poised to contribute to antibiotic resistance ...

Washington, D.C.—Wolf-Rayet stars are very large and very hot. Astronomers have long wondered whether Wolf-Rayet stars are the progenitors of certain types of supernovae. New work from the Palomar Transient Factory team, including Carnegie's Mansi Kasliwal, is homing in on the answer. They have identified a Wolf-Rayet star as the likely progenitor of a recently exploded supernova. This work is published by Nature. Wolf-Rayet stars are notable for having strong stellar winds and being deficient in hydrogen when compared with other stars. Taken together, these two factors ...

NEW HYDE PARK, NY – A recent study by investigators from LIJ Medical Center demonstrated that using magnetic resonance imaging (MRI) in men with an elevated prostate specific antigen (PSA) resulted in a prostate cancer detection rate that was twice as high as data reported in the March 1999 Prostate journal that analyzed men undergoing the standard 12-core biopsy with an elevated PSA. Physicians in the recent trial used a targeted approach to evaluate prostate cancer that combines MR imaging and transrectal ultrasound fusion guided prostate biopsy. Given the limitations ...

Babies are cute. Kittens are cute. But for some people, products that emphasize baby features like chubby cheeks and large eyes cause them to be more careful and restrained. According to a new study in the Journal of Consumer Research, products that are cute in a playful and whimsical way can bring out more indulgent behavior. "We were not convinced that all cute products would lead to the restrained behavior that stems from baby-cuteness. Our research examined whether there are indeed different types of cuteness, and if these differences could lead to more or less indulgent ...

People who drive BMWs and wear expensive suits must surely occupy roles of power and authority. According to a new study in the Journal of Consumer Research, when we can separate societal expectations of power from how power makes us feel, we have better control over what it means to be powerful. "When a person is placed into a powerless or powerful role, they sometimes conform to the expectations of that role. But when they are focused on the internal feeling of having or lacking power, we observed the opposite patterns of behavior," write authors Derek D. Rucker (Kellogg ...

Coolness helps sell everything from fashion and music to electronics and cigarettes. According to a new study in the Journal of Consumer Research, people and brands become cool by understanding what is considered normal, obeying the rules considered necessary, and then diverging from the rules considered expendable. "Our research explores how brands and people become cool in the eyes of consumers. We reasoned that brands could become cool by breaking rules that seemed unnecessary or unfair, but not by breaking legitimate rules," write authors Caleb Warren (Texas A&M University) ...

When people purchase luxury items like expensive watches and high-end automobiles, they often consider themselves members of a select group of consumers. According to a new study in the Journal of Consumer Research, when outsiders show an interest in a luxury brand, they help improve its overall value. "Just as tourists boost the pride of citizens toward their home country and reinforce the attractiveness and desirability of the place they visit, brand tourists (as fans of the brand) inspire feelings of membership pride and enhance brand image," write authors Silvia Bellezza ...

When face-to-face with our failures, it's hard not to deny the consequences of our shortcomings—and sometimes we make problems worse by engaging in the behaviors we have been trying so hard to avoid. According to a new study in the Journal of Consumer Research, practicing self-acceptance may be the best way to boost our self-worth and avoid self-deprecating behaviors and consequences. "Consider the person who has just realized that they are poorly prepared financially for retirement," write authors Soo Kim and David Gal (both Kellogg School of Management, Northwestern ...

As a human race we strive for perfection, knowing that no one is perfect. A new study in the Journal of Consumer Research offers insight into why we surround ourselves with people who help bring out our best but don't make us feel terrible when we stray from perfection. "In a situation requiring two people to use self-control, either both indulge, both abstain, or one indulges while the other abstains. Our research looks at how these different outcomes impact people who are friends," write authors Michael L. Lowe (Texas A&M University) and Kelly L. Haws (Vanderbilt University). In ...