This news release is available in German. Apoptosis is used by cells that are changed by disease or are simply not needed any longer to eliminate themselves before they become a hazard to the body—on a cellular level, death is part of life. Disruption of this process can lead to cancer or immunodeficiencies, but also to autoimmune diseases, in which cells attack their own body. HZI scientist Prof Ingo Schmitz and his team investigate the regulation of apoptosis in the immune system. In collaboration with researchers of the Otto von Guericke University Magdeburg ...

London, United Kingdom, Friday 11 April 2014: New research announced at the International Liver CongressTM 2014 today provides new hope for the notoriously difficult-to-treat population of liver transplant patients with recurring hepatitis C (HCV). As part of a compassionate use program, 104 post-liver transplant patients with recurring HCV who had exhausted all treatment options and had poor clinical prognoses, received sofosbuvir (SOF) and ribavirin (RBV) with pegylated interferon (PEG) included at the physicians’ discretion for up to 48 weeks. Among patients whose ...

London, UK, Friday 11 April 2014: Mortality from viral hepatitis is significantly higher than from HIV/AIDS across EU countries, according to results from The Global Burden of Disease Study 2010 (GBD 2010) which was announced for the first time today at the International Liver CongressTM 2014(1). GBD 2010 is the most recent version of a large epidemiological study funded by the Bill and Melinda Gates Foundation and coordinated by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. In the EU, in 2010, there were more than 10 times ...

London, England, Friday 11 April 2014 Significant new data presented today at the International Liver Congress™ 2014 indicate that liver cancer (Hepatocellular Carcinoma (HCC)) may be treated by adoptive T-cell therapy. This new therapeutic approach in the treatment of HCC could be very important as without treatment the 5 year survival rate is just 5%. Globally, HCC accounts for 746,000 deaths, and in the UK alone is responsible for over 4,000 deaths per year. Glypican-3 (GPC3) is a tumour associated antigen expressed in up to 70% of HCC but not in healthy human tissue. ...

Tamiflu (the antiviral drug oseltamivir) shortens symptoms of influenza by half a day, but there is no good evidence to support claims that it reduces admissions to hospital or complications of influenza. This is according to the updated Cochrane evidence review, published today by The Cochrane Collaboration, the independent, global healthcare research network and The BMJ. Evidence from treatment trials confirms increased risk of suffering from nausea and vomiting. And when Tamiflu was used in prevention trials there was an increased risk of headaches, psychiatric disturbances, ...

VIDEO: On April 9, NASA's TRMM saw powerful storms in Ita's eye wall reached heights of over 14 km/8.7 miles. The tallest thunderstorm towers reached heights of over 16 km/9.9 miles... Click here for more information. Tropical Cyclone Ita has been strengthening over the last two days and by April 10, Ita had become a major hurricane in the Coral Sea when NASA's Terra satellite passed overhead. Ita's maximum sustained winds were near 115 knots/132 mph/213 kph on April 10 at 0900 ...

First spotted in 1885, silvery blue clouds sometimes hover in the night sky near the poles, appearing to give off their own glowing light. Known as noctilucent clouds, this phenomenon began to be sighted at lower and lower latitudes -- between the 40th and 50th parallel -- during the 20th century, causing scientists to wonder if the region these clouds inhabit had indeed changed -- information that would tie in with understanding the weather and climate of all Earth. A NASA mission called Aeronomy of Ice in the Mesosphere, or AIM, was launched in 2007 to observe noctilucent ...

Outdoor enthusiasts in Colorado's Front Range are occasionally rewarded with remarkable visibility brought about by dry, clear air and wind. But it's what people in the mountainous U.S. West can't see in conditions like this – ozone plunging down to the ground from high in the stratosphere, the second layer of the atmosphere – that has attracted the interest of NASA scientists, university scientists and air quality managers. Ozone in the stratosphere, located on average 10 to 48 kilometers (6 to 30 miles) above the ground, typically stays in the stratosphere. Not on days ...

Using NASA's Hubble Space Telescope, astronomers now can precisely measure the distance of stars up to 10,000 light-years away -- 10 times farther than previously possible. Astronomers have developed yet another novel way to use the 24-year-old space telescope by employing a technique called spatial scanning, which dramatically improves Hubble's accuracy for making angular measurements. The technique, when applied to the age-old method for gauging distances called astronomical parallax, extends Hubble's tape measure 10 times farther into space. "This new capability ...

Physicist Richard Schnee hopes to find traces of dark matter by studying particles with low masses and interaction rates, some of which have never been probed before. The ongoing search for invisible dark matter is the subject of a recent article involving physicists from Syracuse University's College of Arts and Sciences. Research by Richard Schnee, assistant professor of physics, is referenced in Symmetry magazine, a joint publication of the Stanford Linear Accelerator Center in Palo Alto, Calif., and Fermilab in Batavia, Ill. "Scientists looking for dark matter ...

Earth scientists in Syracuse University's College of Arts and Sciences have determined that the Tibetan Plateau—the world's largest, highest, and flattest plateau—had a larger initial extent than previously documented. Their discovery is the subject of an article in the journal Earth and Planetary Science Letters (Elsevier, 2014). Gregory Hoke, assistant professor of Earth sciences, and Gregory Wissink, a Ph.D. student in his lab, have co-authored the article with Jing Liu-Zeng, director of the Division of Neotectonics and Geomorphology at the Institute for Geology, ...

Physicists in Syracuse University's College of Arts and Sciences have helped confirm the existence of exotic hadrons—a type of matter that cannot be classified within the traditional quark model. Their finding is the subject of a forthcoming article, prepared by the Large Hadron Collider beauty (LHCb) Collaboration at CERN in Geneva, Switzerland. (LHCb is a multinational experiment, designed to identify new forces and particles in the universe.) Tomasz Skwarnicki, professor of physics, is one of the paper's lead authors. "We've confirmed the unambiguous observation ...

April 10, 2014 -- A new policy paper from the American College of Physicians (ACP) offers nine strategies to address the societal, health care, and regulatory barriers to reducing firearms-related violence, injuries, and deaths in the United States. Reducing Firearm-Related Injuries and Deaths in the United States is published today in the peer-reviewed medical journal, Annals of Internal Medicine. Principal among ACP's nine strategic imperatives is the recommendation to approach firearm safety as a public health issue so that policy decisions are based on scientific ...

MADISON, Wis. – When the Earned Income Tax Credit was expanded in 1993, supporters hoped it would reward poor parents for working while critics feared that it might discourage single mothers from marrying or incentivize women to have more children to boost their tax refund. A new collaborative study done by the University of Wisconsin-Madison and Cornell University reveals the EITC has helped the working poor but hasn't affected personal choices. Sarah Halpern-Meekin, assistant professor of human development and family studies and affiliate of the Institute for Research ...

Due to its well-studied genome and small size, the humble fruit fly has been used as a model to study hundreds of human health issues ranging from Alzheimer's to obesity. However, Michael Dickinson, Esther M. and Abe M. Zarem Professor of Bioengineering at Caltech, is more interested in the flies themselves—and how such tiny insects are capable of something we humans can only dream of: autonomous flight. In a report on a recent study that combined bursts of air, digital video cameras, and a variety of software and sensors, Dickinson and his team explain a mechanism for ...

In experiments with mice, Johns Hopkins Kimmel Cancer Center scientists have identified an enzyme involved in the regulation of immune system T cells that could be a useful target in treating asthma and boosting the effects of certain cancer therapies. In research described online April 6 in Nature Immunology, the investigators show that mice without the enzyme SKG1 were resistant to dust mite-induced asthma. And mice with melanoma and missing the enzyme, developed far fewer lung tumors—less than half as many—than mice with SKG1. "If we can develop a drug that blocks ...

Scientists at The University of Texas at Austin have discovered that a protein produced by the influenza A virus helps it outwit one of our body's natural defense mechanisms. That makes the protein a potentially good target for antiviral drugs directed against the influenza A virus. Better antiviral drugs could help the millions of people annually infected by flu, which kills up to 500,000 people each year. When an influenza virus infects a human cell, it uses some of the host's cellular machinery to make copies of itself, or replicate. In this study, the researchers ...

Surgical decision making for sick, elderly patients should be orchestrated by a multidisciplinary team, including the patient, his or her family, the surgeon, primary care physician, nurses and non-clinicians, such as social workers, advocates Laurent G. Glance, M.D., in a perspective piece published in the New England Journal of Medicine. For this group of patients, surgery can be very risky. Glance, professor and vice-chair for research in the Department of Anesthesiology at the University of Rochester School of Medicine and Dentistry believes a more patient-centered, ...

Lebanon, N.H. (April 10, 2014) – The methodology Medicare uses to adjust the billions of dollars it pays health plans and hospitals to account for how sick their patients are is flawed and should be replaced, according to a new study by Dartmouth investigators published in the journal BMJ that weighed the performance of Medicare's methodology against alternatives. The researchers from the Dartmouth Atlas Project compared Medicare's current risk-adjustment methodology, which is based on the diagnoses recorded in patients' claims records, against adjustment indices based ...

Washington, DC, April 10, 2014 -- The American College of Physicians (ACP) today released a policy paper on the medical liability crisis, which continues to have a profound effect on the medical system. "Medical Liability Reform—Innovative Solutions for a New Health Care System" provides an update of the medical liability landscape, state-based activity on medical liability reform, and summarizes traditional and newer reform proposals and their ability to affect system efficiency and encourage patient safety. "While medical liability premiums have leveled off in the ...

PHILADELPHIA — The consequences of modern life -- shift work, cell phone addiction, and travel across time zones -- all disturb internal clocks. These are found in the brain where they regulate sleep and throughout the body where they regulate physiology and metabolism. Disrupting the clocks is called circadian misalignment, which has been linked to metabolic problems, even in healthy volunteers. Researchers from the Perelman School of Medicine at the University of Pennsylvania and the University of Memphis describe in PLOS Genetics the development of new cell models ...

HOUSTON -- A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014. The findings, also published in the journal Nature on April 10, provide evidence in support of the "histone code" hypothesis. The theory holds that histone proteins, which combine with DNA to form chromosomes, are more intimately involved in gene expression ...

GAINESVILLE, Fla. --- Conservation of coastal rivers of the northern Gulf of Mexico is vital to the survival of the alligator snapping turtle, including two recently discovered species, University of Florida scientists say. A new study appearing this week in the journal Zootaxa shows the alligator snapping turtle, the largest freshwater turtle in the Western Hemisphere and previously believed to be one species, is actually three separate species. The limited distribution of the species, known to weigh as much 200 pounds, could potentially affect the conservation of ...

Tax evasion is widely assumed to be an eternal problem for governments — but how widespread is it? For the first time, a new study, co-authored by an MIT professor, has put a cost on a particular kind of tax evasion, known as "round-tripping," that the U.S. government has been trying to thwart. In round-tripping, U.S. investors move funds to offshore tax havens, then invest in U.S. equity and debt markets with these "foreign" funds. In essence, the U.S. investors are disguising themselves as foreign investors, who are not subject to the same tax rates on capital gains ...

A team of international scientists, including a trio from Simon Fraser University, has published the world's first ranking of evolutionary distinct birds under threat of extinction. These include a cave-dwelling bird that is so oily it can be used as a lamp and a bird that has claws on its wings and a stomach like a cow. The research, published today in Current Biology, the shows that Indonesia, Australia and New Zealand all score high on responsibility for preserving irreplaceable species. The researchers examined nearly 10,000 bird species and identified more than 100 ...