EAST LANSING, Mich. — We have hundreds of types of cells in our bodies – everything from red blood cells to hair follicles to neurons. But why can't most of them create offspring for us? New research at Michigan State University suggests that separating germ cells – sperm and eggs –from somatic cells – all other cells – preserves the genetic building blocks while allowing organisms to flourish in a somewhat hazardous environment. The results, which appear in the current issue of PLOS Biology, show that having somatic cells do the organism's dirty work helps explain ...

DALLAS – May 22, 2014 – In a breakthrough discovery at the Children's Medical Center Research Institute at UT Southwestern (CRI), a research team led by Ralph DeBerardinis, M.D., Ph.D., has taken a significant step in cracking the code of an atypical metabolic pathway that allows certain cancerous tumors to thrive, providing a possible roadmap for defeating such cancers. Published in Cell Reports, and following up on Dr. DeBerardinis' landmark finding in 2011, this most recent discovery identifies the triggering mechanism that plays a key role in causing a series of ...

Working with mice, Johns Hopkins researchers report they have identified chemical signals that certain breast cancers use to recruit two types of normal cells needed for the cancers' spread. A description of the findings appears in the online early May edition of the Proceedings of the National Academy of Sciences. "Blocking one of these cell-recruiting signals in a mouse's tumor made it much less likely to metastasize or spread," says Gregg Semenza, M.D., Ph.D., a professor and director of the Vascular Biology Program in the Johns Hopkins University School of Medicine's ...

Despite worsening economic conditions for those at the bottom, infant health has steadily improved among the most disadvantaged Americans, according to a review published in Science by Princeton University's Woodrow Wilson School of Public and International Affairs. The researchers cite programs and policies like Medicaid, the Supplemental Feeding Program for Women, Infants, and Children (WIC) and the Food Stamp program – now known as Supplemental Nutrition Assistance Program (SNAP) – as the driving forces behind such marked improvements. "We've long known that the ...

VIDEO: In this TRMM 3-D simulated flyby of System 92B from May 21, some powerful convective storm tops were reaching heights of almost 17 km (about 10.5 miles). Click here for more information. NASA's Aqua and TRMM satellites captured radar and infrared data on developing tropical low pressure area System 92B as it now makes it way north through the Bay of Bengal. On May 22 at 00:51 UTC, NASA and the Japan Aerospace Exploration Agency's Tropical Rainfall Measuring Mission (TRMM) ...

Growing resistance to antibiotics and other drugs demands a coordinated global response on the same scale as efforts to address climate change, experts say. Without an international commitment to tackle the issue, the world faces a future in which simple infections that have been treatable for decades become deadly diseases, they warn. Resistance to antibiotics to tackle bacterial infections and antimicrobial drugs used to treat parasites, viruses and fungi is spreading at an alarming rate. Treatment for many infectious diseases is now reliant on just one or two drugs. Professor ...

Images taken by Rice University scientists show that some diamonds are not forever. The Rice researchers behind a new study that explains the creation of nanodiamonds in treated coal also show that some microscopic diamonds only last seconds before fading back into less-structured forms of carbon under the impact of an electron beam. The research by Rice chemist Ed Billups and his colleagues appears in the American Chemical Society's Journal of Physical Chemistry Letters. Billups and Yanqiu Sun, a former postdoctoral researcher in his lab, witnessed the interesting ...

22 May 2014, Paris, France: At EuroPCR 2014 yesterday, experts discussed the development in evidence for bioresorbable vascular scaffolds, which represent an era of vascular restoration in interventional cardiology. The available data were analysed and participants heard that bioresorbable fixed strut vascular scaffolds are associated with increased acute thrombogenicity due to flow disturbances. This means that patients who are implanted with these devices need to receive ongoing dual antiplatelet therapy. The panellists also pointed out that endothelialisation is further ...

May 22, 2014, New York, NY – A Ludwig Cancer Research study has identified a novel pathway by which proteins are actively and specifically shuttled into the nucleus of a cell. Published online today in Cell, the finding captures a precise molecular barcode that flags proteins for such import and describes the biochemical interaction that drives this critically important process. The discovery could help illuminate the molecular dysfunction that underpins a broad array of ailments, ranging from autoimmune diseases to cancers. Although small proteins can diffuse passively ...

VIDEO: This shows bees on dandelions. Click here for more information. Researchers have devised a simple way to monitor wide swaths of the landscape without breaking a sweat: by listening in on the "conversations" honeybees have with each other. The scientists' analyses of honeybee waggle dances reported in the Cell Press journal Current Biology on May 22 suggest that costly measures to set aside agricultural lands and let the wildflowers grow can be very beneficial to bees. "In ...

Chronic pain in humans is associated with worse health and a shorter lifespan, but the molecular mechanisms underlying these clinical observations have not been clear. A study published by Cell Press May 22nd in the journal Cell reveals that the activity of a pain receptor called TRPV1 regulates lifespan and metabolic health in mice. The study suggests that pain perception can affect the aging process and reveals novel strategies that could improve metabolic health and longevity in humans. "The TRPV1 receptor is a major drug target with many known drugs in the clinic ...

LA JOLLA—For most people, the urge to eat a meal or snack comes at a few, predictable times during the waking part of the day. But for those with a rare syndrome, hunger comes at unwanted hours, interrupts sleep and causes overeating. Now, Salk scientists have discovered a pair of genes that normally keeps eating schedules in sync with daily sleep rhythms, and, when mutated, may play a role in so-called night eating syndrome. In mice with mutations in one of the genes, eating patterns are shifted, leading to unusual mealtimes and weight gain. The results were published ...

Numerous studies have linked exposure to bisphenol A (BPA) in plastic, receipt paper, toys, and other products with various health problems from poor growth to cancer, and the FDA has been supporting efforts to find and use alternatives. But are these alternatives safer? Researchers reporting in the Cell Press journal Chemistry & Biology have developed new tests that can classify such compounds' activity with great detail and speed. The advance could offer a fast and cost-effective way to identify safe replacements for BPA. Millions of tons of BPA and related compounds ...

VIDEO: This video shows how the constant addition of tubulin bound to GTP provides a cap that prevents the microtubule from falling apart. UC Berkeley scientists found that the hydrolyzation of... Click here for more information. University of California, Berkeley, scientists have discovered the extremely subtle effect that the prescription drug Taxol has inside cells that makes it one of the most widely used anticancer agents in the world. The details, involving the drug's ...

Researchers at Karolinska Institutet in Sweden have for the first time identified a gene driving the development of pernicious adipose tissue in humans. The findings imply, which are published in the scientific journal Cell Metabolism, that the gene may constitute a risk factor promoting the development of insulin resistance and type 2 diabetes. Adipose tissue can expand in two ways: by increasing the size and/or the number of the fat cells. It is well established that subjects with few but large fat cells, so-called hypertrophy, display an increased risk of developing ...

Scientists have developed a sophisticated computer modelling simulation to explore how cells of the fruit fly react to changes in the environment. The research, published today in the science journal Cell, is part of an on-going study at The Universities of Manchester and Sheffield that is investigating how external environmental factors impact on health and disease. The model shows how cells of the fruit fly communicate with each other during its development. Dr Martin Baron, who led the research, said: "The work is a really nice example of researchers from different ...

HOUSTON – Fibrous tissue long suspected of making pancreatic cancer worse actually supports an immune attack that slows tumor progression but cannot overcome it, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cancer Cell. "This supportive tissue that's abundant in pancreatic cancer tumors is not a traitor as we thought but rather an ally that is fighting to the end. It's a losing battle with cancer cells, but progression is much faster without their constant resistance," said study senior author Raghu Kalluri, Ph.D., M.D., chair ...

Blocking a pain receptor in mice not only extends their lifespan, it also gives them a more youthful metabolism, including an improved insulin response that allows them to deal better with high blood sugar. "We think that blocking this pain receptor and pathway could be very, very useful not only for relieving pain, but for improving lifespan and metabolic health, and in particular for treating diabetes and obesity in humans," said Andrew Dillin, a professor of molecular and cell biology at the University of California, Berkeley, and senior author of a new paper describing ...

Duke University researchers have found an antibody that simultaneously blocks the sensations of pain and itching in studies with mice. The new antibody works by targeting the voltage-sensitive sodium channels in the cell membrane of neurons. The results appear online on May 22 in Cell. Voltage-sensitive sodium channels control the flow of sodium ions through the neuron's membrane. These channels open and close by responding to the electric current or action potential of the cells. One particular type of sodium channel, called the Nav1.7 subtype, is responsible for ...

To guarantee efficient use of nutrients, cells have systems that permit them to capture and transport the available nutrient molecules to their interior. But if several nutrients are available, cells can select those that are of most interest and discard undesired molecules. Inside cells, nutrients are conducted to the mitochondria, the specialized cell organelles in which nutrients are combusted to release the energy held in their chemical bonds. Both sugars (glucose) and fats (fatty acids) are 'burned' in mitochondria, but these organelles need to adjust their molecular ...

The world has great expectations that stem cell research one day will revolutionize medicine. But in order to exploit the potential of stem cells, we need to understand how their development is regulated. Now researchers from University of Southern Denmark offer new insight. Stem cells are cells that are able to develop into different specialized cell types with specific functions in the body. In adult humans these cells play an important role in tissue regeneration. The potential to act as repair cells can be exploited for disease control of e.g. Parkinson's or diabetes, ...

ANN ARBOR, Mich. — New research represents a significant change in the understanding of how pancreatic cancer grows – and how it might be defeated. Unlike other types of cancer, pancreatic cancer produces a lot of scar tissue and inflammation. For years, researchers believed that this scar tissue, called desmoplasia, helped the tumor grow, and they've designed treatments to attack this. But new research led by Andrew D. Rhim, M.D., from the University of Michigan Comprehensive Cancer Center, finds that when you eliminate desmoplasia, tumors grow even more quickly and ...

The way a woman feels about tackling everyday physical activities, including exercise, may be a predictor of how much weight she'll retain years after childbirth says a Michigan State University professor. James Pivarnik, a professor of kinesiology and epidemiology at MSU, co-led a study that followed 56 women during pregnancy and measured their physical activity levels, along with barriers to exercise and the ability to overcome them. Six years later, the research team followed up with more than half of the participants and found that the women who considered themselves ...

Over the past several decades, neurostimulation techniques such as transcranial direct current stimulation (tDCS) have gradually gained favour in the public eye. In a new report, published yesterday in the prestigious scientific journal Neuron, IRCM ethics experts raise important questions about the rising tide of tDCS coverage in the media, while regulatory action is lacking and ethical issues need to be addressed. TDCS is a non-invasive form of neurostimulation, in which constant, low current is delivered directly to areas of the brain using small electrodes. Originally ...

22 May 2014, Paris, France: The value of analysing published clinical trials and the benefit of informed discussion were highlighted yesterday when the ACCOAST trial data were discussed in a new session format—Will this trial change my practice?— at EuroPCR 2014. ACCOAST trial results demonstrate that pre-treatment with prasugrel in NSTEMI patients undergoing percutaneous coronary intervention (PCI) is inferior to treatment with the drug after angiography. Several other trials are also being scrutinised in the same format, which ends with a discussion with the audience ...