The shortage of oxygen, or hypoxia, created when rapidly multiplying kidney cancer cells outgrow their local blood supply can accelerate tumor growth by causing a nuclear protein called SPOP—which normally suppresses tumor growth—to move out of the nucleus to the cytoplasm, where it has the opposite effect, promoting rapid proliferation. In the March 20, 2014, issue of the journal Cancer Cell, researchers from Chicago and Beijing describe the mechanisms that enable hypoxia to cause the overexpression of SPOP. They show that hypoxia also stimulates the shuttling of SPOP ...

Scientists using passive acoustic monitoring to track minke whales in the Northwest Atlantic have found clues in the individual calling behaviors and movements of this species. These findings, recently published online in the journal Behaviour, provide insight into one of the least studied baleen whales. "Although we regularly observe minke whales in our Gulf of Maine surveys, we know very little about minke whale vocalizations and how they use sound in their behavioral and social interactions," said Denise Risch, lead author of the study and a marine mammal researcher ...

At first glance, colonies of thousands of social spiders all look the same and are busy with the same tasks. Not so, says researchers Carl Keiser and Devin Jones of the University of Pittsburgh in the US, after carefully studying various gatherings of Stegodyphus dumicola social spiders of the Kalahari Desert in South Africa. The size and condition of a particular spider's body indicates which task it generally performs within a colony. In addition, neighboring colonies can have different "personalities" too, writes Keiser, lead author of a study published in Springer's ...

CHAMPAIGN, Ill. — New research from two University of Illinois economics professors who study election trends analyzes how polarization on social issues affects competing candidates' economic platforms. In the paper, co-authors Stefan Krasa and Mattias Polborn develop a theory of candidate competition that accounts for the influence of both economic and cultural issues on individual voting behavior. "Many pundits and academics have argued that political polarization, particularly on social and cultural issues, has increased in the U.S.," said Polborn, also a professor ...

Researchers at the University of Texas Medical Branch at Galveston have discovered a way to potentially halt the progression of dementia caused by accumulation of a protein known as tau. Normally, tau protein is involved in microtubule formation, which acts as a brain cell's transportation system for carrying nutrients in and waste out. In the absence of tau protein, brain cells become dysfunctional and eventually die. In many forms of dementia, such as Alzheimer's disease and chronic traumatic encephalopathy caused by multiple concussions, the tau protein starts behaving ...

You wouldn't hear the mating song of the male fruit fly as you reached for the infested bananas in your kitchen. Yet, the neural activity behind the insect's amorous call could help scientists understand how you made the quick decision to pull your hand back from the tiny swarm. Male fruit flies base the pitch and tempo of their mating song on the movement and behavior of their desired female, Princeton University researchers have discovered. In the animal kingdom, lusty warblers such as birds typically have a mating song with a stereotyped pattern. A fruit fly's song, ...

From smart phones to smart cars, both public and private entities must consider the needs of older adults in order to help them optimize the use of new technologies, according to the latest issue of Public Policy & Aging Report (PP&AR), titled "Aging and Technology: The Promise and the Paradox." A total of eight articles all from authors affiliated with the Massachusetts Institute of Technology AgeLab are featured. "Remarkable technological advances are all around us, and leaders in the business and scientific communities are keenly aware of 'the aging of America' and ...

The surface of immune system cells is home to a number of receptors which are able to detect pathogens. As soon as these receptors are activated, inflammation occurs and the body's defense mechanisms kick in. Immune cells also have receptors that regulate or even suppress immunological responses to prevent damage to individual cells. There are other immune receptors that recognize endogenous substances that are released when tissue damage or cell death occurs. As such, the organism can defend itself even in cases where the damage caused by the pathogen, but not the pathogen ...

Until the '50s, bluefin tuna fishing was a thriving industry in Norway, second only to sardine fishing. Every year, bluefin tuna used to migrate from the eastern Mediterranean up to the Norwegian coasts. Suddenly, however, over no more than 4-5 years, the tuna never went back to Norway. In an attempt to solve this problem, Giancarlo De Luca from SISSA (the International School for Advanced Studies of Trieste) together with an international team of researchers (from the Centre for Theoretical Physics - ICTP – of Trieste and the Technical University of Denmark) started to ...

COLUMBUS, Ohio – Anticancer agents that inhibit tumor growth by targeting a regulatory protein called CDK4 might actually promote the development and progression of certain B-cell lymphomas, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James). The study indicates that inhibiting CDK4, a regulator of the cell cycle, promotes genetic instability and the development or progression of B-cell lymphomas that are driven by the MYC oncogene. The ...

According to a recent Pew Research poll, a majority of Americans believe that there is still at least some racism against African Americans in this country. But new research by Jane L. Risen of the University of Chicago Booth School of Business shows that people are more likely to deny the persistence of racism after being exposed to a successful African American. Notably, people who are most thoughtful seem to be the ones who are most vulnerable to making these quick inferences. In "If He Can Do It, So Can They: Exposure to Counterstereotypically Successful Exemplars ...

Connecting extreme weather to climate change distracts from the need to protect society from high-impact weather events which will continue to happen irrespective of human-induced climate change, say experts. Writing in the journal Weather, Climate and Society, the University of Manchester researchers argue that cutting greenhouse gas emissions, while crucial to reducing humanity's longer-term impact on the planet, will not eliminate violent storms, tornadoes or flooding and the damage they cause. The authors suggest that developing greater resilience to extreme weather ...

It is very costly to present textiles interactively on a computer screen. Until recently, this process often took several days to weeks. Using recently engineered simulation software, now this process takes just seconds. Designers, pattern makers and tailors can create their clothes in real time. Just as they do in reality. Besides needle and thread, the computer mouse is increasingly turning into one of their most indispensable tools. A few clicks suffice to make just the right adjustments to color, material and cut pattern. Shadowing, optical and mechanical qualities ...

ITHACA, N.Y. – Why do we become saucer-eyed from fear and squint from disgust? These near-opposite facial expressions are rooted in emotional responses that exploit how our eyes gather and focus light to detect an unknown threat, according to a study by a Cornell University neuroscientist. Media note: Images, video and research paper available at: https://cornell.box.com/EyeEvolution Our eyes widen in fear, boosting sensitivity and expanding our field of vision to locate surrounding danger. When repulsed, our eyes narrow, blocking light to sharpen focus and pinpoint ...

HUNTSVILLE, TX (3/20/14) -- Parents who use alcohol, marijuana, and drugs have higher frequencies of children who pick up their habits, according to a study from Sam Houston State University. The study, "Intergenerational Continuity of Substance Use," found that when compared to parents who did not use substances, parents who used alcohol, marijuana, and other illicit drugs were significantly more likely to have children who used those same drugs. Specifically, the odds of children's alcohol use were five times higher if their parents used alcohol; the odds of children's ...

Alexandria, Va., USA – Today, at the 43rd Annual Meeting & Exhibition of the American Association for Dental Research (AADR), held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, R. Constance Wiener, from West Virginia University, Morgantown, will present a research study titled "Association of Tooth Loss and Depression and Anxiety." Tooth loss from caries and periodontal disease is an outcome from complex, chronic conditions. Several biopsychosocial factors are involved, including accessing care. Individuals reporting dental ...

Over 35 percent of American adults and 17 percent of American children are considered obese, according to the latest survey conducted by the Centers for Disease Control and Prevention. Associated with diabetes, heart disease, stroke, and even certain types of cancer, obesity places a major burden on the health care system and economy. It's usually treated through a combination of diet, nutrition, exercise, and other techniques. To understand how obesity develops, Prof. Amit Gefen, Dr. Natan Shaked and Ms. Naama Shoham of Tel Aviv University's Department of Biomedical ...

PITTSBURGH, March 20, 2014 – Discussions with a dietary coach to learn about healthy eating were as effective as meeting with a counselor for problem-solving or "talk" therapy in preventing major depression among older black and white adults with mild symptoms of the mood disorder, according to researchers at the University of Pittsburgh and the University of Maryland. Their findings were published online recently in Psychiatric Services. Depression is common and treatments often don't completely resolve the disability that attends the illness, said senior author Charles ...

Breastfeeding until at least nine months of age increases prevalence in the gastrointestinal tract of Lactobacilli and Bifidobacteria, species which are known to contribute to development of a healthy immune system, according to a paper describing the establishment of the intestinal microbiota during the first three years of life. The research was published ahead of print in the journal Applied and Environmental Microbiology. In the study, the investigators sampled the gut microbiota in the feces of 300 children at 9, 18, and 36 months of age. The nutritional factor ...

This news release is available in French. Montreal, March 19, 2014 — As spring finally emerges after a ferocious winter,, our battered roads will soon be re-exposed. While potholes and cracks might make news, a bigger concern should be the deterioration to pavement markings, from yellow to white lines, which are a big factor in preventing traffic accidents. A study from Concordia University, funded by Infrastructure Canada and published in Structure and Infrastructure Engineering, found that snowplows are the biggest culprit in erasing roadway markings. The research ...

Tampa, FL (Mar. 20, 2014) – Traumatic brain injuries (TBI), sustained by close to 2 million Americans annually, including military personnel, are debilitating and devastating for patients and their families. Regardless of severity, those with TBI can suffer a range of motor, behavioral, intellectual and cognitive disabilities over the short or long term. Sadly, clinical treatments for TBI are few and largely ineffective. In an effort to find an effective therapy, neuroscientists at the Center of Excellence for Aging and Brain Repair, Department of Neurosurgery in the ...

Addictive behavior such as drug and alcohol abuse could be associated with poor development of the so-called "love hormone" system in our bodies during early childhood, according to researchers at the University of Adelaide. The groundbreaking idea has resulted from a review of worldwide research into oxytocin, known as the "love hormone" or "bonding drug" because of its important role in enhancing social interactions, maternal behavior and partnership. This month's special edition of the international journal Pharmacology, Biochemistry and Behavior deals with the current ...

1. Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have developed a method to generate human induced pluripotent stem cells (hiPSCs) from a single drop of finger-pricked blood. The method also enables donors to collect their own blood samples, which they can then send to a laboratory for further processing. The easy access to blood samples using the new technique could potentially boost the recruitment of greater numbers and diversities of donors, and could lead to the establishment of large-scale hiPSC banks. 2. By genetic reprogramming, matured ...

Algae are organisms useful in many ways in the transition towards a bio-economy. Even in a cool climate as in Finland, algae might be used to produce biochemicals and biofuels, besides use in capture of industrial carbon dioxide emissions. The ALGIDA project coordinated by VTT Technical Research Centre of Finland explored algae growing in Finland. Algae are not yet profitably cultivated for energy production purposes. The cultivation is challenging especially in cool climate where there is little daylight in winter. Production is expensive compared with wood and agricultural ...

EAST LANSING, Mich. — Scientists have presented the most conclusive evidence yet that genes play a significant role in parenting. A study by two Michigan State University psychologists refutes the popular theory that how adults parent their children is strictly a function of the way they were themselves parented when they were children. While environmental factors do play a role in parenting, so do a person's genes, said S. Alexandra Burt, associate professor of psychology and co-author of a study led by doctoral student Ashlea M. Klahr. "The way we parent is not ...