VIDEO: The mental health conditions of most people who commit suicide remain undiagnosed, even though many visit a primary care provider or medical specialist in the year before they die, according... Click here for more information. DETROIT – The mental health conditions of most people who commit suicide remain undiagnosed, even though many visit a primary care provider or medical specialist in the year before they die, according to a national study led by Henry Ford Health ...

PHILADELPHIA (February 24, 2014) – The increasing use of expensive medical imaging procedures in the U.S. like positron emission tomography (PET) scans is being driven, in part, by patient decisions made after obtaining information from lay media and non-experts, and not from health care providers. That is the result from a three-year-long analysis of survey data, and is published in the article , "Associations between Cancer-Related Information Seeking and Receiving PET Imaging for Routine Cancer Surveillance – An Analysis of Longitudinal Survey Data," appearing in ...

PPAR-γ agonist reverses cigarette smoke induced emphysema in mice Pulmonary emphysema results in irreversible lung damage and is most often the result of long term cigarette smoke exposure. Immune cells, such as macrophages and myeloid dendritic cells (mDCs) accumulate in the lungs of smokers with emphysema and release cytokines associated with autoimmune and inflammatory responses. In this issue of the Journal of Clinical Investigation Farrah Kheradmand and colleagues at Baylor University found that peroxisome proliferator activated receptor-γ (PPARγ) ...

Cancer cells have long been known to have higher rates of the energy-generating metabolic pathway known as glycolysis. This enhanced glycolysis, a phenomenon known as the Warburg effect, is thought to allow cancer cells to survive the oxygen-deficient conditions they experience in the center of solid tumors. A study in The Journal of Cell Biology reveals how damaged cells normally switch off glycolysis as they shut down and shows that defects in this process may contribute to the early stages of tumor development. Various stresses can cause cells to cease proliferating ...

A novel two-pronged strategy targeting DNA synthesis can treat leukemia in mice, according to a study in The Journal of Experimental Medicine. Current treatments for acute lymphoblastic leukemia (ALL), an aggressive form of blood cancer, include conventional chemotherapy drugs that inhibit DNA synthesis. These drugs are effective but have serious side effects on normal dividing tissues. In order to replicate, cells must make copies of their DNA, which is made up of building blocks called deoxyribonucleotide triphosphates (dNTPs). Cells can either make dNTPs from scratch ...

PHILADELPHIA— Half of melanoma patients with the BRAF mutation have a positive response to treatment with BRAF inhibitors, but nearly all of those patients develop resistance to the drugs and experience disease progression. Now, a new preclinical study published online ahead of print in the Journal of Clinical Investigation from Penn Medicine researchers found that in many cases the root of the resistance may lie in a never-before-seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib. Autophagy is a process by which cancer cells recycle ...

Cold Spring Harbor, NY – We are a product of our parents. Maybe you have your mother's large, dark eyes, and you inherited your father's infectious smile. Both parents contribute one copy, or allele, of each gene to their offspring, so that we have two copies of every gene for a given trait – one from mom, the other from dad. In general, both copies of a gene are switched on or off as an embryo develops into an adult. The "switching on" of a gene begins the process of gene expression that ultimately results in the production of a protein. Occasionally, a cell will arbitrarily ...

Philadelphia, Pa. (February 21, 2014) – The millions of Americans living with more than one chronic disease are at high risk of poor health outcomes, and account for a disproportionate share of health care costs. A special March supplement to Medical Care presents updates from the Agency for Healthcare Research and Quality's (AHRQ) Multiple Chronic Conditions (MCC) Research Network, formed to address knowledge gaps and research challenges in meeting the complex health care needs of this growing population. The journal is published by Lippincott Williams & Wilkins, a part ...

Philadelphia, Pa. (February 21, 2014) – Children from immigrant families now account for 42 percent of uninsured children in the United States, reports a study in the March issue of Medical Care. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. More than two-thirds of uninsured children with immigrant parents are US citizens, according to an analysis of nationwide survey data by Eric E. Seiber, PhD, of The Ohio State University College of Public Health, Columbus. He writes, "Initiatives to expand coverage or increase Medicaid ...

The mental health conditions of most people who commit suicide remain undiagnosed, even though most visit a primary care provider or medical specialist in the year before they die. To help prevent suicides, health care providers should therefore become more attuned to their patients' mental health state and possible suicide ideation. These are the findings of Brian Ahmedani from the Henry Ford Health System in Detroit, Michigan, in a new study¹ documenting the type and timing of health services sought by Americans who commit suicide. The study is the largest geographically ...

LEBANON, NH (Feb. 24, 2014) – In a study that demonstrates the potential of using social networking sites for research on health and medicine, Dartmouth researchers studied jokes made about doctors posted on Facebook. "Social networking sites, such as Facebook, have become immensely popular in recent years and present a unique opportunity for researchers to eavesdrop on the collective conversation of current societal issues," said Matthew Davis of The Dartmouth Institute of Health Policy & Clinical Practice. In one of the first studies of social networking site conversations ...

New Rochelle, NY, February 24, 2014—Over the past three funding stages, the European Commission has invested nearly $475 million in 100 projects in the gene transfer and gene therapy field. David Gancberg, Directorate-General for Research and Innovation, European Commission (Brussels), describes the substantial opportunities for funding to support basic and clinical research in gene and cell therapy to find new treatments for chronic and rare diseases and novel regenerative medicine approaches in a Commentary article in Human Gene Therapy, a peer-reviewed journal from Mary ...

LIVERMORE, Calif. -- Volcanic eruptions in the early part of the 21st century have cooled the planet, according to a study led by Lawrence Livermore National Laboratory. This cooling partly offset the warming produced by greenhouse gases. Despite continuing increases in atmospheric levels of greenhouse gases, and in the total heat content of the ocean, global-mean temperatures at the surface of the planet and in the troposphere (the lowest portion of the Earth's atmosphere) have shown relatively little warming since 1998. This so-called 'slow-down' or 'hiatus' has received ...

If a driver is traveling to New York City, I-95 might be their route of choice. But they could also take I-78, I-87 or any number of alternate routes. Most cancers begin similarly, with many possible routes to the same disease. A new study found evidence that assessing the route to cancer on a case-by-case basis might make more sense than basing a patient's cancer treatment on commonly disrupted genes and pathways. The study found little or no overlap in the most prominent genetic malfunction associated with each individual patient's disease compared to malfunctions ...

"Mottronics" is a term seemingly destined to become familiar to aficionados of electronic gadgets. Named for the Nobel laureate Nevill Francis Mott, Mottronics involve materials – mostly metal oxides - that can be induced to transition between electrically conductive and insulating phases. If these phase transitions can be controlled, Mott materials hold great promise for future transistors and memories that feature higher energy efficiencies and faster switching speeds than today's devices. A team of researchers working at Berkeley Lab's Advanced Light Source (ALS) have ...

A new University of British Columbia study identifies an important molecular change that occurs in the brain when we learn and remember. Published this month in Nature Neuroscience, the research shows that learning stimulates our brain cells in a manner that causes a small fatty acid to attach to delta-catenin, a protein in the brain. This biochemical modification is essential in producing the changes in brain cell connectivity associated with learning, the study finds. In animal models, the scientists found almost twice the amount of modified delta-catenin in the brain ...

Reports coming from Australia are more positive than negative now with regards to the Morwell fire, but officials say they still have a "long way to go." Considerable progress has been made in extinguishing the fire, but there is still significant heat that continues to generate smoke from the open mine. Fire activity has been cut in half since February 11, but there are still "weeks of firefighting ahead" according to Craig Lapsley, Fire Services Commissioner on the County Fire Authority website. According to the Australian News, "The [Morwell] fire, which started ...

February 24, 2014 – (BRONX, NY) –One in every six people in the U.S. is Hispanic/Latino and as a group they live longer than non-Hispanic whites (81.4 years vs. 78.8 years). Yet, despite their strong representation and relative longevity, little is understood about this group's health conditions and behaviors. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the landmark research study of Hispanic/Latino health funded by the National Institutes of Health (NIH), has released initial findings that show significant variations in disease prevalence and health ...

MANHATTAN -- A critical job performance evaluation can have a negative effect on any employee, a Kansas State University researcher has found. By studying how people view positive or negative feedback, Satoris Culbertson, assistant professor of management, has determined that nobody -- even people who are motivated to learn -- likes negative performance reviews. Culbertson is developing ways to help managers improve the process for reviewing employees. Culbertson and collaborators at Eastern Kentucky University and Texas A&M University surveyed more than 200 staffers ...

Producing second-generation biofuel from dead plant tissue is environmetally friendly - but it is also expensive because the process as used today needs expensive enzymes, and large companies dominate this market. Now a Danish/Iraqi collaboration presents a new technique that avoids the expensive enzymes. The production of second generation biofuels thus becomes cheaper, probably attracting many more producers and competition, and this may finally bring the price down. The world's need for fuel will persist, also when the Earth's deposits of fossil fuels run out. Bioethanol, ...

DURHAM, N.H. – New research from Plymouth State University and the University of New Hampshire indicates that collecting and bleeding horseshoe crabs for biomedical purposes causes short-term changes in their behavior and physiology that could exacerbate the crabs' population decline in parts of the east coast. Each year, the U.S. biomedical industry harvests the blue blood from almost half a million living horseshoe crabs for use in pharmaceuticals — most notably, a product called Limulus amebocyte lysate (LAL), used to ensure vaccines and medical equipment are free ...

DENVER –The findings of a recent study indicate that routine testing with both fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) may enhance the detection of ALK-positive non-small cell lung cancer (NSCLC). Accurate determination of ALK-positive tumors is necessary to identify patients with advanced NSCLC who are most likely to benefit from targeted therapy with an ALK inhibitor. The discovery of ALK rearrangement in about 1% to 7% of NSCLCs led to the development of ALK inhibitors, such as crizotinib, which have significantly improved treatment ...

In a surprising new finding, researchers have discovered that bacterial movement is impeded in flowing water, enhancing the likelihood that the microbes will attach to surfaces. The new work could have implications for the study of marine ecosystems, and for our understanding of how infections take hold in medical devices. The findings, the result of microscopic analysis of bacteria inside microfluidic devices, were made by MIT postdoc Roberto Rusconi, former MIT postdoc Jeffrey Guasto (now an assistant professor of mechanical engineering at Tufts University), and Roman ...

There's more to dieting than just sheer willpower and self-control. The presence of friends, late night cravings or the temptation of alcohol can often simply be too strong to resist. Research led by Heather McKee of the University of Birmingham in the UK monitored the social and environmental factors that make people, who are following weight management programs, cheat. The study¹ is published in the Springer journal Annals of Behavioral Medicine.² Eighty people who were either part of a weight-loss group or were dieting on their own participated in the one-week study. ...

DENVER – Researchers have developed a novel technique for detecting ALK rearrangements in non-small cell lung cancers (NSCLCs) that is more sensitive and easier to perform than currently available techniques. The technique can help enhance the routine practice of diagnostic ALK testing on NSCLCs, which is crucial for identifying patients with advanced NSCLC who are most likely to benefit from targeted therapy with an ALK inhibitor. None of the current three routine methods used to detect ALK rearrangements in NSCLC is without drawbacks, especially for tissue specimens ...