PHILADELPHIA - According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence – the reappearance of the disease following treatment. Precisely what causes breast cancer recurrence has been poorly understood. But now a piece of the puzzle has fallen into place: Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer – a finding that suggests ...

WASHINGTON (June 11, 2013) —Researcher Michael S. Irwig, M.D., F.A.C.E., assistant professor of medicine at the George Washington University (GW) School of Medicine and Health Sciences (SMHS) and director of the Center for Andrology at The GW Medical Faculty Associates, found that men who used the medication finasteride (Propecia) and developed persistent sexual side effects, are also drinking less alcohol than before. This research will be published in the journal, Alcoholism: Clinical & Experimental Research. While robust literature exists on the interaction between ...

A series of austerity reforms made by the Spanish government could lead to the effective dismantling of large parts of the country's healthcare system, with potentially detrimental effects on the health of the Spanish people, according to new research published in BMJ. National budget cuts of 13.65% (€365m) and regional budget cuts of up to 10% to health and social care services in 2012 have coincided with increased demands on the health system, particularly affecting the elderly, disabled and those with poor mental health. The authors, led by the London School of Hygiene ...

PITTSBURGH—It turns out that helping others can also help you protect yourself from high blood pressure. New research from Carnegie Mellon University shows that older adults who volunteer for at least 200 hours per year decrease their risk of hypertension, or high blood pressure, by 40 percent. The study, published by the American Psychological Association's Psychology and Aging journal, suggests that volunteer work may be an effective non-pharmaceutical option to help prevent the condition. Hypertension affects an estimated 65 million Americans and is a major contributor ...

In women at high risk for breast cancer, a long-term drug treatment can cut the risk of developing the disease in half. Researchers supported by the National Institutes of Health have now identified two gene variants that may predict which women are most likely to benefit from this therapy—and which should avoid it. The work represents a major step toward truly individualized breast cancer prevention in women at high risk for the disease based on their age, family history of breast cancer, and personal medical history. "Our study reveals the first known genetic factors ...

SOLOMONS, MD (June 13, 2013)—A new study shows that combining improved oyster restoration methods with limits on fishing in the upper Chesapeake could bring the oyster population back to the Bay in a much shorter period of time. The study led by Michael Wilberg of the University of Maryland Center for Environmental Science's Chesapeake Biological Laboratory assessed a range of management and restoration options to see which ones would have the most likelihood success. "This new model we developed suggests that oysters should be able to come back if we help them out ...

A University of British Columbia study sheds important new light on why people attempt suicide and provides the first scientifically tested measure for evaluating the motivations for suicide. Published in the official journal of the American Association of Suicidology, the work gives doctors and researchers important new resources to advance suicide prevention, improve treatments, and reduce the likelihood of further attempts. "Knowing why someone attempted suicide is crucial – it tells us how to best help them recover," says Prof. David Klonsky, UBC Dept. of Psychology. ...

A new statistical analysis shows the world population could reach nearly 11 billion by the end of the century, according to a United Nations report issued June 13. That's about 800 million, or about 8 percent, more than the previous projection of 10.1 billion, issued in 2011. The projected rise is mostly due to fertility in Africa, where the U.N. had expected birth rates to decline more quickly than they have. "The fertility decline in Africa has slowed down or stalled to a larger extent than we previously predicted, and as a result the African population will go ...

Madrid, Spain, 13 June 2013: Data presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, show that up to one-third of rheumatoid arthritis (RA) patients discontinue or change therapy within the first year of treatment. Loss of efficacy was the most common reason given (35.8%), followed by safety (20.1%), physician or patient preference (27.8% and 17.9%, respectively) and access to treatment (9.0%). Rates and rationale for treatment discontinuation were similar for both tumour necrosis factor inhibitors (TNFi) and non-TNFi biologics. RA ...

Madrid, Spain, 13 June 2013: Epidemiological data presented today at EULAR 2013, the Annual Congress of the European League Against Rheumatism, demonstrate that pregnancy carried to childbirth (parity) increases the risk of ACPA-negative* rheumatoid arthritis (RA). The increased risk was demonstrated in women aged 18-44 who have had a child (2.1, 95% CI 1.4-3.2), but not in older women, and was more pronounced among those women with delivery during the first year of symptoms. RA is an autoimmune disease characterised by inflammation of the joints and tendons. As a ...

Madrid, Spain, 13 June 2013: Study findings first presented today at EULAR 2013, the Annual Congress of the European League Against Rheumatism, demonstrate the efficacy of canakinumab at tapering corticosteroid (CS) use in patients with SJIA. Successful CS tapering was achieved within 20 weeks in almost half of patients (44.5%, p END ...

Madrid, Spain, 13 June 2013: Data presented today at EULAR 2013, the Annual Congress of the European League Against Rheumatism, demonstrate that indicators of depression are stronger predictors of work disability in early arthritis than disease activity or response to therapy. The study showed that in a multivariable analysis none of the arthritis activity measures or cardiovascular, metabolic or pulmonary diseases investigated were associated with early retirement, yet a single depression statement "having little pleasure or interest in doing things most of the days ...

MIAMI – June 13, 2013 – The commercial value of spiny lobster (Panulirus argus) in the Caribbean reaches $1 billion annually, thus making it one of the most valuable fisheries in the region. In a new study of this iconic species, Ph.D. candidate Andrew Kough and Dr. Claire Paris of the Biophysical Interactions Lab at the University of Miami Rosenstiel School of Marine & Atmospheric Science, in collaboration with Dr. Mark Butler from Old Dominion University, studied the larval dispersal of this species in the Caribbean. The goal of the study was to describe the sources, ...

Pro-market policies for developing countries have long been based on the belief that increasing average income is key to improving public health and societal well-being. But new research on India published in the journal Social Science and Medicine shows that literacy - a non-income good - has a greater impact on public health in India. While the researchers, based at Cambridge's Department of Sociology, accept it is broadly true that "wealthier is healthier" across the roughly 500 districts in India's 'major states', accounting for 95% of the total population, they ...

Scientists at Aalto University, Finland and Utrecht University, the Netherlands have created single atom contacts between gold and graphene nanoribbons. In their article published in Nature Communications, the research team demonstrates how to make electrical contacts with single chemical bonds to graphene nanoribbons. Graphene is a single layer of carbon atoms arranged in a honeycomb lattice. It is anticipated to be a revolutionising material for future electronics. Graphene transistors functioning at room temperature require working at the size scale of less than ...

ANN ARBOR, Mich. — Striking the likes of Chicago Bulls' Derrick Rose, L.A. Lakers' Kobe Bryant and Detroit Tigers' Victor Martinez, tears in the anterior cruciate ligament (ACL) are one of the most rampant and serious knee injuries among athletes. Now, researchers from the University of Michigan Health System have identified a new drug target that may prevent one of the most dreaded consequences of an ACL tear –the weakening or loss of muscle tissue (muscle atrophy) that can be a career-killer in sports and ultimately develop into osteoarthritis. A hormone called myostatin ...

DETROIT – A specific MicroRNA, a short set of RNA (ribonuclease) sequences, naturally packaged into minute (50 nanometers) lipid containers called exosomes, are released by stem cells after a stroke and contribute to better neurological recovery according to a new animal study by Henry Ford Hospital researchers. The important role of a specific microRNA transferred from stem cells to brain cells via the exosomes to enhance functional recovery after a stroke was shown in lab rats. This study provides fundamental new insight into how stem cells affect injured tissue and ...

Researchers from North Carolina State University have developed a method for creating "nano-volcanoes" by shining various colors of light through a nanoscale "crystal ball" made of a synthetic polymer. These nano-volcanoes can store precise amounts of other materials and hold promise for new drug-delivery technologies. The researchers create the nano-volcanoes by placing spherical, transparent polymer nanoparticles directly onto the flat surface of a thin film. They then shine ultraviolet light through the transparent sphere, which scatters the light and creates a pattern ...

A colloid is a substance spread out evenly inside another substance. Everyday examples include milk, styrofoam, hair sprays, paints, shaving foam, gels and even dust, mud and fog. One of the most interesting properties of colloids is their ability to self-assemble – to aggregate spontaneously into well-defined structures, driven by nothing but local interactions between the colloid's particles. Self-assembly has been of major interest in industry, since controlling it would open up a whole host of new technologies, such as smart drug-delivery patches or novel paints that ...

The University of Exeter recently contributed to a major international project to sequence the genome of Emiliania huxleyi, the microscopic plankton species whose chalky skeletons form the iconic white cliffs of Dover. The results of the project are published this week in the journal Nature. Emiliania huxleyi is one of the most abundant marine phytoplankton species and is a key player in the process of CO2 exchange between the atmosphere and the ocean. In some marine systems 20% of the total carbon is fixed by E. huxleyi. This microscopic alga has influenced the global ...

GAINESVILLE, Fla. — A new University of Florida study suggests a promising brain-imaging technique has the potential to improve diagnoses for the millions of people with movement disorders such as Parkinson's disease. Utilizing the diffusion tensor imaging technique, as it is known, could allow clinicians to assess people earlier, leading to improved treatment interventions and therapies for patients. The three-year study looked at 72 patients, each with a clinically defined movement disorder diagnosis. Using a technique called diffusion tensor imaging, the researchers ...

Researchers at Case Western Reserve University have found that a single gene poses a double threat to disease: Not only does it inhibit the growth and spread of breast tumors, but it also makes hearts healthier. In 2012, medical school researchers discovered the suppressive effects of the gene HEXIM1 on breast cancer in mouse models. Now they have demonstrated that it also enhances the number and density of blood vessels in the heart – a sure sign of cardiac fitness. Scientists re-expressed the HEXIM1 gene in the adult mouse heart and found that the hearts grew heavier ...

Arthritis is a debilitating disorder affecting one in 10 Canadians, with pain caused by inflammation and damage to joints. Yet the condition is poorly managed in most patients, since adequate treatments are lacking – and the therapies that do exist to ease arthritis pain often cause serious side effects, particularly when used long-term. Any hope for developing more-effective treatments for arthritis relies on understanding the processes driving this condition. A new study in the Journal of Neuroscience by researchers at McGill University adds to a growing body of ...

A structure called "the microtubule network" is a crucial part of our nervous system. It acts as a transportation system within nerve cells, carrying essential proteins and enabling cell-to-cell communications. But in neurodegenerative diseases like Alzheimer's, ALS, and Parkinson's, this network breaks down, hindering motor abilities and cognitive function. Now Prof. Illana Gozes of Tel Aviv University's Sackler Faculty of Medicine has developed a new peptide in her lab, called NAP or Davunetide, that has the capacity to both protect and restore microtubule function. ...

Many disorders of the inner hear which affect both hearing and balance can be hugely debilitating and are currently largely incurable. Cochlear implants have been used for many years to replace lost hearing resulting from inner ear damage. However, to date, there has not been an analogous treatment for balance disorders resulting from inner ear disease. One potential new treatment is an implantable vestibular prosthesis which would directly activate the vestibular nerve by electrical stimulation. This prosthetic treatment is tested in a new study by Christopher Phillips ...