An international team of researchers, led by physician-scientists at Johns Hopkins, reports that a once-daily tablet containing a high dose of a key ragweed pollen protein effectively blocks the runny noses, sneezes, nasal congestion and itchy eyes experienced by ragweed allergy sufferers. Tests showed that treatment with the pill, which contains the protein Ambrosia artemisiifolia major allergen 1, and is placed under the tongue to be absorbed, also reduced the need for anti-allergy drugs to get relief. More than 80 million Americans are allergic to ragweed. The ...

Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer. The EPSRC-funded study, published in Biomacromolecules and undertaken by University ...

VIDEO: A bat reacts to contact call stimulus with a turning to the loudspeaker, placed on the right side. Click here for more information. Is it possible that mammals have the ability to recognize individuals of the same species, whom they know well, by their voice? A new study has found that even in nocturnal, fast-moving animals such as bats, there is an ability to recognize certain vocal aspects of other bats from their social groups. The study by Hanna Kastein from the University ...

To improve patient safety, hospitals should randomly test physicians for drug and alcohol use in much the same way other major industries in the United States do to protect their customers. The recommendation comes from two Johns Hopkins physicians and patient safety experts in a commentary published online April 29 in The Journal of the American Medical Association. In addition, the experts say, medical institutions should take a cue from other high-risk industries, like airlines, railways and nuclear power plants, and mandate that doctors be tested for drug or alcohol ...

Philadelphia, Pa. (May 7, 2013) - Interspinous spacer implantation—a less-invasive alternative surgical option for spinal stenosis—has a lower complication rate than spinal fusion, reports a study in the May 1 issue of Spine The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. However, patients receiving interspinous spacers are more likely to require repeated back surgery, according to the report by Dr Ricard A. Deyo and colleagues of Oregon Health & Science University, Portland. They conclude, "Use of interspinous spacers poses ...

The search for cleaner, low temperature nuclear fuels has produced a shock result for a team of experts at The University of Nottingham. First they created a stable version of a 'trophy molecule' that has eluded scientists for decades. Now they have discovered that the bonding within this molecule is far different than expected. Remarkably their findings have shown that it behaves in much the same way as its counterparts in the well-known transitional metals such as chromium, molybdenum and tungsten. The research, done by PhD student David King, which could help in ...

DETROIT — A Wayne State University researcher has successfully tested a technique that can lead to more effective use of nanoparticles as a drug delivery system. Joshua Reineke, Ph.D., assistant professor of pharmaceutical sciences in the Eugene Applebaum College of Pharmacy and Health Sciences, examined how a biodegradable polymer particle called polylactic-co-glycolic acid (PLGA) breaks down in live tissue. He believes the potential impact of his work is broad, as nanoparticles increasingly have been developed as carriers of drug treatments for numerous diseases ...

The following highlights summarize research papers that have been recently published in Journal of Geophysical Research-Solid Earth (JGR-B), Journal of Geophysical Research-Oceans (JGR-C), Journal of Geophysical Research-Earth Surface (JGR-F) and Tectonics. In this release: Graphite lubricates fault zones Sediment processes can be significant source of ambient noise Evolution of the Qin Mountains as part of the supercontinent Rodinia Studying how flocculation affects acoustic reflection How do braided river dynamics affect sediment storage? Charting the ...

Johns Hopkins researchers believe they may have discovered an explanation for the sleepless nights associated with restless legs syndrome (RLS), a symptom that persists even when the disruptive, overwhelming nocturnal urge to move the legs is treated successfully with medication. Neurologists have long believed RLS is related to a dysfunction in the way the brain uses the neurotransmitter dopamine, a chemical used by brain cells to communicate and produce smooth, purposeful muscle activity and movement. Disruption of these neurochemical signals, characteristic of Parkinson's ...

Some memory problems common to older adults may stem from an inability to segment daily life into discrete experiences, according to a new study published in Psychological Science, a journal of the Association for Psychological Science. The study suggests that problems processing everyday events may be the result of age-related atrophy to a part of the brain called the medial temporal lobe (MTL). "When you think back on what you did yesterday, you don't just press 'play' and watch a continuous stream of 24 hours," says psychological scientist Heather Bailey of Washington ...

May 7, 2013 - Working on a team is always a challenge, but a new study highlights a particular challenge to women: how much they credit themselves in a joint success. Women will devalue their contributions when working with men but not with other women, according to the new research. The study suggests yet another reason why women still tend to be under-represented at the highest echelons of many organizations. Michelle Haynes of the University of Massachusetts, Lowell, had examined how other people evaluate men and women working together. She decided to build on that ...

For nearly a decade, doctors have used an implanted electronic stimulator to treat severe depression in people who don't respond to standard antidepressant therapy. Now, preliminary brain scan studies conducted by researchers at Washington University School of Medicine in St. Louis are beginning to reveal the processes occurring in the brain during stimulation and may provide some clues about how the device improves depression. They found that vagus nerve stimulation brings about changes in brain metabolism weeks or even months before patients begin to feel better. The ...

WASHINGTON — Black women with breast cancer were found to be three times more likely than their white counterparts to delay treatment for more than 90 days — a time delay associated with increased deaths from the disease, according to a new study led by researchers at Georgetown Lombardi Comprehensive Cancer Center. But many women chose to forgo treatment altogether, and the study, published online in the May issue of Breast Cancer Research and Treatment, suggests that low satisfaction regarding communication between black women and their doctors is a significant reason ...

MADISON – For plants and animals forced to tough out harsh winter weather, the coverlet of snow that blankets the north country is a refuge, a stable beneath-the-snow habitat that gives essential respite from biting winds and subzero temperatures. But in a warming world, winter and spring snow cover in the Northern Hemisphere is in decline, putting at risk many plants and animals that depend on the space beneath the snow to survive the blustery chill of winter. In a report published May 2 in the journal Frontiers in Ecology and the Environment, a team of scientists ...

A University of Colorado Cancer Center study recently published in the journal Cell Death & Disease shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot – and without the unwanted side effects. It's a bit like the classic thought experiment known as the "tumor problem" formulated by Karl Dunker in 1945 and used frequently in the problem-solving literature: Imagine a person suffers from a malignant tumor in the center of her body. Radiation strong enough to kill the tumor kills any healthy tissue ...

SAN DIEGO – Giving patients better access to primary health care could save nearly $4 billion a year in unnecessary emergency room visits for a single common complaint – urinary tract infections – according to a study by the Vattikuti Urology Institute at Henry Ford Hospital in Detroit. The study set out to determine the economic burden of 10.8 million patients, with a primary diagnosis of urinary tract infection, who went to U.S. emergency rooms for treatment from the beginning of 2006 to the end of 2009. The findings will be presented May 6 at the annual meeting of ...

1. Ambrisentan Not Appropriate for Patients with Idiopathic Pulmonary Fibrosis Ambrisentan should not be used to treat patients for idiopathic pulmonary fibrosis (IPF). IPF is a fatal form of chronic, progressive lung disease characterized by irreversible scarring around both lungs. IPF causes about 5,000 deaths each year and currently there is no approved treatment. Researchers do not know what causes IPF, but a protein called endothelin-1 that causes the blood vessels to contract and induces lung scarring and proliferation has been associated with the disease. Researchers ...

MINNEAPOLIS – Contrary to a widely accepted belief, African-Americans may have a higher rather than lower risk of developing multiple sclerosis (MS) than Caucasians, according to a new study in the May 7, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology. "Our population-based study is the first of its kind to look at this question. The belief (that African- Americans have a lower risk of developing MS) was based on evidence that was problematic," said study author Annette Langer-Gould, MD, with Kaiser Permanente Southern California ...

Minneapolis, MN, May 6, 2013 – Adults with end-stage respiratory failure and pulmonary hypertension requiring ECMO (extracorporeal membrane oxygenation) have been "bridged" toward lung transplantation with novel lung assist devices such as the Novalung. This and related devices work based on pumpless application of oxygenators. A presentation by David M. Hoganson, MD, and colleagues from Washington University School of Medicine in St. Louis at the Congenital Heart Disease Session of the 93rd AATS Annual Meeting describes the first time application of this technology to ...

PASADENA, Calif., May 6, 2013 – Multiple sclerosis is more common in black women than in white women, according to a Kaiser Permanente study published today in the journal Neurology. The findings run contrary to the widely accepted belief that blacks are less susceptible to MS, according to the researchers. Researchers examined the electronic health records of more than 3.5 million members of Kaiser Permanente Southern California between January 2008 and December 2011 and identified 496 people newly diagnosed with MS. Of these diagnosed cases, black patients had a 47 ...

Boston, Mass. –A quality improvement platform developed at Boston Children's Hospital could help health care provider groups continuously improve their medical practice, curbing costs and improving patient outcomes. Successful outcomes associated with the platform, called Standardized Clinical Assessment and Management Plans (SCAMPs) and supported by a consortium of Massachusetts payers, are featured in the May issue of Health Affairs. SCAMPs start with existing practice recommendations, but are continuously revised as clinicians learn from everyday patient encounters. ...

Research from King's College London reveals the detailed mechanism behind how stress hormones reduce the number of new brain cells - a process considered to be linked to depression. The researchers identified a key protein responsible for the long-term detrimental effect of stress on cells, and importantly, successfully used a drug compound to block this effect, offering a potential new avenue for drug discovery. The study, published in Proceedings of the National Academy of Sciences (PNAS) was co-funded by the National Institute for Health Research Biomedical Research ...

Around 150 million people globally are chronically infected with the hepatitis C virus (HCV) – a major cause of liver disease and the fastest growing cause of liver transplantation and liver cancer. 1 New prevention strategies are urgently required as people are continuing to be infected with HCV. Findings, published in Hepatology, reveal the impact of a new antiviral treatment that could potentially reduce HCV rates in some cities affected by chronic HCV prevalence by half over 15 years. In Europe, the US and other developed countries the majority of HCV infections ...

Some of the earliest results from The Environmental Determinants of Diabetes in The Young (TEDDY) study - a major Europe-USA consortium exploring the causes of type 1 diabetes in children – has found no evidence for viral infection as a cause of the rapid-onset form of the condition. The research appears in Diabetologia, the journal of the European Association for the Study of Diabetes (EASD) and is by Professor Anette-Gabriele Ziegler of the German Research Centre for Environmental Health (Helmholtz Zentrum München), Munich, Germany, and colleagues across the USA and Europe, ...

VIDEO: Cally Harper of Brown University explains how the bats she studied have evolved to lap up extra nectar using blood-filled "hairs " on their tongues. She also discusses how they could... Click here for more information. PROVIDENCE, R.I. [Brown University] — Nectar-feeding bats and busy janitors have at least two things in common: They want to wipe up as much liquid as they can as fast as they can, and they have specific equipment for the job. A study in the ...