TORONTO, ON — Researchers from the University of Toronto and SickKids Research Institute announced today that they have successfully mapped the genes in the fungus that causes Dutch Elm Disease. The researchers believe this is the first time the 30 million DNA letters for the fungus Ophiostoma ulmi have been mapped. The findings, published in this week's online journal BMC Genomics, could help scientists figure out how to prevent the fungus from destroying elm trees in the future. "Essentially, Dutch Elm Disease is caused by a fungus that prevents the normal distribution ...

A virus that most people have probably never heard of, yet most of us carry, is the number 1 infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb. Major research efforts are underway to combat this invidious disease. Researchers from Cardiff University and the La Jolla Institute, California, have discovered a previously unknown cellular mechanism that could prove critical in creating a CMV vaccine. "CMV is ...

New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). Single mutations in one gene rarely cause such different diseases. This study shows that these mutations disrupt energy production in cells shedding new light on the role of VCP in these multiple disorders. In healthy cells VCP helps remove damaged ...

Valdivia, Chile, and Washington, D.C.—Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies. Now a team of Chilean researchers at The Centro de Estudios Científicos (CECs), with the collaboration of Carnegie's Wolf Frommer, has devised a molecular sensor that can detect levels of lactate in individual cells in real time. Prior to this advance, no other measurement ...

To successfully treat pathological gambling, you need to intervene at an early stage, according to Susana Jiménez-Murcia from the University Hospital of Bellvitge in Spain and colleagues. Their study shows that a patient's age influences how severe the psychopathology and clinical aspects of pathological gambling are. Their work is published online in Springer's Journal of Gambling Studies. These days, access to 24-hour, uncontrolled gambling is straightforward thanks largely to the internet. People can access both classic and modern games, from slot machines and lotteries ...

URBANA – A mutual curiosity about patterns of growth and development in pig brains has brought two University of Illinois research groups together. Animal scientists Rod Johnson and Ryan Dilger have developed a model of the pig brain that they plan to use to answer important questions about human brain development. "It is important to characterize the normal brain growth trajectory from the neonatal period to sexual maturity," said Johnson. "Until we know how the brain grows, we don't know what is going to change," added Dilger. In cooperation with the Beckman Institute, ...

Sexting: Involves sending sexually explicit messages and/or photographs, primarily between mobile phones using the SMS system was first reported in 2005. It is an obvious portmanteau of "sex" and "texting"; the word was added to the Merriam-Webster's Collegiate Dictionary in August 2012. 4% of mobile phone-owning teens claim to have sent sexually suggestive, nude or nearly nude images or videos of themselves to someone else via a mobile device while 15% claim to have received such material from someone they know. With contract cell phones and cheaper multimedia messaging ...

Work groups at Technische Universität München (TUM) under Prof. Peter Schieberle and at the University of Vienna under Prof. Veronika Somoza studied four different edible fats and oils: Lard, butterfat, rapeseed oil and olive oil. Over a period of three months, the study participants ate 500 grams of low-fat yoghurt enriched with one of the four fats or oils every day – as a supplement to their normal diet. "Olive oil had the biggest satiety effect," reports Prof. Peter Schieberle, Head of the TUM Chair of Food Chemistry and Director of the German Research Center for ...

Scientist from Dortmund, Helsinki, Potsdam, and the ESRF have revealed details of the microscopic atomic structure of water under extreme conditions. The results have now been published in the Proceedings of the National Academy of Sciences of the USA. Liquid water remains a mystery even after decades of dedicated scientific investigations and researchers still struggle to fully describe its unusual structure and dynamics. At high temperatures and high pressures, water is in the so called supercritical state and exhibits a number of peculiar characteristics that are ...

CHICAGO --- A surprisingly high number of women have postpartum depressive symptoms, according to a new, large-scale study by a Northwestern Medicine® researcher. This is the largest scale depression screening of postpartum women and the first time a full psychiatric assessment has been done in a study of postpartum women who screened positive for depression. The study, which included a depression screening of 10,000 women who had recently delivered infants at single obstetrical hospital, revealed a large percentage of women who suffered recurrent episodes of major ...

New Rochelle, NY, March 14, 2013—Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of dependency and serious adverse reactions. An alternative treatment strategy increases the levels of a naturally occurring painkiller in and around the nerves that deliver pain signals to the bladder. This new therapeutic approach is described in an article in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Human ...

MANHATTAN, KAN. -- Kansas State University civil engineers are developing the right mix to reduce concrete's carbon footprint and make it stronger. Their innovative ingredient: biofuel byproducts. "The idea is to use bioethanol production byproducts to produce a material to use in concrete as a partial replacement of cement," said Feraidon Ataie, doctoral student in civil engineering, Kabul, Afghanistan. "By using these materials we can reduce the carbon footprint of concrete materials." Concrete is made from three major components: portland cement, water and aggregate. ...

Completion rates for the human papillomavirus (HPV) vaccine series across both genders continue to remain alarmingly low nearly seven years after its introduction, suggesting that better patient education and increased public vaccine financing programs are needed, according to new research from the University of Texas Medical Branch (UTMB). The researchers report "startling" trends in a series of three separate studies published in Cancer, Human Vaccines & Immunotherapeutics and Vaccine. Using data from the 2010 National Health Interview Survey, an annual cross-sectional ...

DURHAM, NC – A potentially lethal fungal infection appears to gain virulence by being able to anticipate and disarm a hostile immune attack in the lungs, according to findings by researchers at Duke Medicine. Defense mechanisms used by the fungus Cryptococcus neoformans enable it to lead to fatal meningitis, which is one of the opportunistic infections often associated with death in HIV/AIDS patients, organ transplant recipients, diabetics and other immunosuppressed patients. In describing the complex process of how C. neoformans averts destruction in the lungs of mice, ...

INDIANAPOLIS -- Innovative medical records software developed by geriatricians and informaticians from the Regenstrief Institute and the Indiana University Center for Aging Research will provide more personalized health care for older adult patients, a population at significant risk for mental health decline and disorders. A new study published in eGEMs, a peer-reviewed online publication recently launched by the Electronic Data Methods Forum, unveils the enhanced Electronic Medical Record Aging Brain Care Software, an automated decision-support system that enables care ...

ROCHESTER, Minn. -- Collaborators from Mayo-Illinois Alliance for Technology Based Healthcare have developed a new, single molecule test for detecting methylated DNA. Methylation -- the addition of a methyl group of molecules to a DNA strand -- is one of the ways gene expression is regulated. The findings appear in the current issue of Scientific Reports (Nature Publishing Group). "While nanopores have been studied for genomic sequencing and screening analysis, this new assay can potentially circumvent the need for some of the current processes in evaluating epigenetics-related ...

Rice University researchers have found a way to divide and modify enzymes to create what amounts to a genetic logic gate. Biochemist Matthew Bennett and graduate student David Shis created a library of AND gates by mutating a protein from a bacterial virus. The well-understood protein known as T7 RNA polymerase (RNAP) is a strong driver of transcription in cells. Their discovery should help overcome a bottleneck in the development of synthetic gene networks that mimic digital circuitry. These networks could become diagnostic systems that look for signs of disease and, ...

Disarming One of the Deadliest Pathogens Francisella tularensis, the cause of tularemia and one of the deadliest respiratory pathogens in existence, is considered a potential biological weapon because it is readily aerosolized and exhibits a high degree of infectivity and lethality in humans. While a live attenuated vaccine strain has been developed, it remains unlicensed because scientists have been unable to understand the basis for its attenuated virulence. In an attempt to find an acceptable live attenuated vaccine strain, researchers from Harvard Medical School ...

For the first time, a UCLA team has used a technique normally employed in treating brain aneurysms to treat severe, life-threatening irregular heart rhythms in two patients. This unique use of the method helped stop ventricular arrhythmias — which cause "electrical storms" — that originated in the septum, the thick muscle that separates the heart's two ventricles. This area is virtually impossible to reach with conventional treatment. The research is published in the February issue of Heart Rhythm, the official journal of the Heart Rhythm Society, and is highlighted ...

URBANA – College-age kids who don't consume at least three servings of dairy daily are three times more likely to develop metabolic syndrome than those who do, said a new University of Illinois study. "And only one in four young persons in the study was getting the recommended amount of dairy," said Margarita Teran-Garcia, a U of I professor of food science and human nutrition. That alarming finding means that three-fourths of the 18- to 25-year-old college applicants surveyed are at risk for metabolic syndrome, the researcher said. Metabolic syndrome occurs when ...

The six science instruments that comprise the Particles and Fields Package that will characterize the solar wind and ionosphere of Mars have been integrated aboard NASA's Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft. The spacecraft is on track for launch later this year. The Solar Wind Electron Analyzer (SWEA) was the last of the six instruments to be delivered, and was integrated late last week at Lockheed Martin in Littleton, Colo. SWEA measures the properties of electrons at Mars, one electron at a time, and can process up to one million events per second. The ...

System 96P has been moving through the Coral Sea near northeastern Australia over the last couple of days, and today, March 14, NASA's Aqua satellite captured the storm as it matured into Tropical Storm Tim. The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard NASA's Aqua satellite captured a visible image of Tropical Cyclone Tim in the Coral Sea on March 13, 2013 at 04:05 UTC (12:05 a.m. EDT). The MODIS image showed a large band of thunderstorms wrapping into the center of circulation from the south and east. Cyclone Tim's northeastern quadrant ...

On March 13, it was announced the most vigorous bursts of star birth in the cosmos took place much earlier than previously thought - results now published in a set of papers in Nature and the Astrophysical Journal. As these findings are published, three of the scientists at the forefront of this research - including the lead researcher of the latest findings – offered their insights about what this reveals about the history of our universe, and how the Atacama Large Millimeter/submillimeter Array (ALMA) is providing a "zoom lens" into the early universe. This includes ...

Ann Arbor, Mich. — Few situations can provoke more anxiety for people with peanut or tree-nut allergies than having an allergic reaction while flying on an airplane and being unable to get help. But in a new study, published in the Journal of Allergy and Clinical Immunology-In Practice, researchers found passengers who engaged in eight mitigating factors were less likely to report an allergic reaction. This is the first study to show that in-flight peanut and tree nut allergy is an international problem, says lead author and pediatrician Matthew Greenhawt, M.D., M.B.A., ...

This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge. "Using surveillance of influenza cases in humans and birds, we've come up with a technique to predict sites where these viruses could mix and generate a future pandemic," said lead author Trevon Fuller, a UCLA postdoctoral research fellow at the Institute of the Environment and Sustainability's Center ...