PHILADELPHIA - Double-strand breaks in DNA happen every time a cell divides and replicates. Depending on the type of cell, that can be pretty often. Many proteins are involved in everyday DNA repair, but if they are mutated, the repair system breaks down and cancer can occur. Cells have two complicated ways to repair these breaks, which can affect the stability of the entire genome. Roger A. Greenberg, M.D., Ph.D., associate investigator, Abramson Family Cancer Research Institute and associate professor of Cancer Biology at the Perelman School of Medicine, University of ...

After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancer—the first time anyone has linked the disease's reemergence to specific genetic anomalies. The discovery, co-lead by William L. Carroll, MD, director of NYU Langone Medical Center's Cancer Institute, is reported in a study published online February 3, 2013, in Nature Genetics. "There has been no progress in curing children who relapse, in spite of giving them very high doses of chemotherapy ...

A new study led by scientists at the Universities of York and Bradford has identified the two areas of the brain responsible for our perception of orientation and shape. Using sophisticated imaging equipment at York Neuroimaging Centre (YNiC), the research found that the two neighbouring areas of the cortex -- each about the size of a 5p coin and known as human visual field maps -- process the different types of visual information independently. The scientists, from the Department of Psychology at York and the Bradford School of Optometry & Vision Science established ...

Scientists have identified the gene essential for survival of antibody-producing cells, a finding that could lead to better treatments for diseases where these cells are out of control, such as myeloma and chronic immune disorders. The discovery that a gene called Mcl-1 is critical for keeping this vital immune cell population alive was made by researchers at Melbourne's Walter and Eliza Hall Institute. Associate Professor David Tarlinton, Dr Victor Peperzak and Dr Ingela Vikstrom from the institute's Immunology division led the research, which was published today in ...

DURHAM, N.C. – Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters. Reported in the Feb. 3, 2013, issue of the journal Nature Medicine, the researchers explored what had first appeared to be an anomaly among certain genetically modified mice with an abundance of epidermal growth factor in their bone marrow. The mice were protected from radiation damage, and ...

DURHAM, N.C. – By reproducing in the laboratory the complex interactions that cause human genes to turn on inside cells, Duke University bioengineers have created a system they believe can benefit gene therapy research and the burgeoning field of synthetic biology. This new approach should help basic scientists as they tease out the effects of "turning on" or "turning off" many different genes, as well as clinicians seeking to develop new gene-based therapies for human disease. "We know that human genes are not just turned on or off, but can be activated to any level ...

Cold Spring Harbor, NY – A team of plant geneticists at Cold Spring Harbor Laboratory (CSHL) has successfully demonstrated what it describes as a "simple hypothesis" for making significant increases in yields for the maize plant. Called corn by most people in North America, modern variants of the Zea mays plant are among the indispensable food crops that feed billions of the planet's people. As global population soars beyond 6 billion and heads for an estimated 8 to 9 billion by mid-century, efforts to boost yields of essential food crops takes on ever greater potential ...

Poor mental health leads to unhealthy behaviors in low-income adults – not the other way around, according to a new study¹ by Dr. Jennifer Walsh and colleagues from the Centers for Behavioral and Preventive Medicine at The Miriam Hospital in the US. In this study, stress and anxiety predicted subsequent health-compromising behaviors, such as smoking, binge drinking, illegal drug use, unprotected sex and unhealthy diets. One possible explanation for these findings is that health compromising behaviors may be used as coping mechanisms to manage the effects of stress and anxiety. ...

PHILADELPHIA (February 4, 2013) – Scientists at the Monell Center have identified the location and certain genetic characteristics of taste stem cells on the tongue. The findings will facilitate techniques to grow and manipulate new functional taste cells for both clinical and research purposes. "Cancer patients who have taste loss following radiation to the head and neck and elderly individuals with diminished taste function are just two populations who could benefit from the ability to activate adult taste stem cells," said Robert Margolskee, M.D., Ph.D., a molecular ...

ARLINGTON HEIGHTS, Ill. (February 4, 2013) – Those living near the equator may find themselves sneezing and wheezing more than usual. And the reason may not be due to increasing pollen counts. According to a new study released today, in the February issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI), living in locations closest to the equator can put you at increased risk of developing allergy and asthma. "UV-B rays exposure is higher for people living in areas closer to the equator," ...

By Capt. Shafter Johnston I had the chance to fish a Yellowfin 24 Bay boat for a couple days in the everglades. The boat was outfitted with a 300 Mercury Verado, twin 10 foot PowerPole Blades, a 101 lb thrust Minn Kota trolling motor, and Simrad electronics. I have fished and guided out of quite a few diferent bay boat models bulit by several different companies but I have to say that this was the most impressive by far. Aside from its killer looks the boat performs flawlessly. The boat is incredibly fast when neccessary but more important to me and most guides ...

Luxury waterfront Realtor Tom Wagner of RE/MAX Alliance Group has closed $10,885,000 in sales in December 2012 on Manasota Key and Palm Island, signaling a strong real estate market in these two idyllic barrier islands off the Southwest Florida coast. His December closings bring his 2012 total sales to $17,927,000 (total volume sold with both seller and buyer sides included). Wagner is a member of the RE/MAX Platinum Club, one of the most elite awards in the real estate industry. He has also received the RE/MAX Hall of Fame Award, which is achieved by only 1% of ...

The new store is located at 206 Merrow Road, Citgo Express Gas Station, in Tolland. Store hours are Sunday to Saturday, from 6 a.m. to 10 p.m. Patrons of the new location may enjoy a complimentary coffee (any size) each Friday in February beginning Friday, February 1st. For more than two decades, the family-owned Between Rounds has been serving up fresh, baked-on site bagels and baked goods as well sandwiches, wraps, salads, soups and specialty coffees. Between Rounds' locations are Tolland, South Windsor (corporate headquarters), Vernon and Manchester. The new Tolland ...

2212 Marketing Group, an innovative marketing agency that creates successful and dynamic advertising, marketing, special events, promotions and campaigns to help organizations boost brand identity, has been engaged to provide marketing consulting services to the St. Louis office of the law firm Spencer Fane Britt & Browne LLC. Laura Callahan, founder and president of 2212 Marketing Group, said, "Spencer Fane Britt & Browne has the right combination of intelligence, success, experience and capabilities to ensure that legal needs for its clients are met with ...

The adoption of Computerized Physician Order Entry (CPOE) technologies has been slow in the US, although 2014 is the proposed start date for Stage 2 of the Meaningful Use Requirements. For effective implementation, "clinical leadership is critical," said Chris Snyder, Chief Medical Information Officer, Peninsula Regional Medical Center. The Center was one of the early adopters of CPOE eight years ago, and Snyder found the input from medical and support staff essential, he went on to say. A speaker at the marcus evans National Healthcare CMO/CMIO Summit 2013, ...

New York Plantings Garden Designers and Landscape Contractors had a tremendous achievement in completing the renovation of Future Condominium's courtyard at 200 East 32nd Street, New York , NY. New York Plantings revived the glorious courtyard that serves as recreational, strolling and relaxation spot of Future Condominiums tenants, guests, and passers in Manhattan, New York. It is also New York Plantings biggest irrigation and lighting project that comprised installing different irrigation system in every cement planters and courtesy lights in different corners of the ...

Festa Parties will be participating in the CHICAGO Dance Marathon, which takes place on March 2, 2013 from 8 a.m. until 9 p.m. The Chicago Dance Marathon is a 13.1-hour-long charity event during which participants can dance and hear the inspiring stories of patient families from the Ann & Robert H. Lurie Children's Hospital of Chicago. The hospital, formerly Children's Memorial Hospital, is a new state-of-the-art hospital located in downtown Chicago on the campus of its academic partner, Northwestern University Feinberg School of Medicine. Lurie Children's is ranked ...

The Hedding Law Firm, a famous and renowned firm, is one of the best firms in Los Angeles when it comes to dealing with criminal offense cases, especially drinking while intoxication cases. They are the most preferred firm when it comes to handing DUI cases. The Hedding Law Firm has a stupendous record in dealing with many DUI cases with utmost success and it is the most reliable and trusted firms in Los Angeles. This firm is considered to be a premier Driving while intoxicated case defense firms and brings with it several years of experience and expertise in this field. Driving ...

Landings Magazine, Kansas City's premiere building and real estate entrepreneur's publication, recently launched its latest edition of the popular publication. The edition features insights from Monte Boultinghouse, Jessica Fields-Leone, and Joyce O'Connor, all part of the incredible talent pool of Reece & Nichols. "With the launch of each edition, we find ourselves right along with our readership—excited about every page," enthused Landings Magazine publisher, Brett Miller. Landings Magazine, vibrant, full-color building and real estate publication ...

Elite Ayrshire Business Circle executive chairman and Frazer Coogans Commercial Solicitors managing partner Norman Geddes has returned from a week-long visit to China, and reports that the trip was both enjoyable and beneficial. The visit was at the invitation of Mr and Mrs Michael Zhou and mineral water bottling and distribution company Ganten, who recently purchased Blairquhan Castle in South Ayrshire. Also on the trip were Norman's wife Katrina and daughter Clare, former Blairquhan Castle owners Sir Patrick and Lady Hunter Blair and members of their family, and ...

Everyone has appliances in their homes. Just think about how we depend for our daily living on the appliances in the home. The very simplest of them is probably the electric kettle. In the old days the Kettles were a simple element plugged into the Power supply. Statistics show that over 60% of energy consumption is consumed by heating water. And of course most people fill the kettle to the brim as before they switch it on. Realizing the wasted power coming from boiled kettles half used firstly thermostats and then the kettles themselves became cordless. And then the ...

The winners of the inaugural Grassroot Diplomat Initiative Awards were announced a few days ago at a ceremony in London. Over 120 distinguished guests from embassies, political offices, universities and non-government organisations gathered to celebrate the achievements of outstanding diplomats and politicians representing the people's interest at the highest level. Host and director of Grassroot Diplomat Talyn Rahman-Figueroa described the nominees as "worthy examples for all others... committed to listening and respecting the needs of the people". The competition ...

If you are going to be having a wedding and you want to find Bridesmaids Dresses, you should definitely look on the Alexia Designs online website. For 2013, they have brand-new bridesmaids dresses available for you to choose from. They are a Bridesmaids Dresses 2013 business and they can help you save a lot of money when you are shopping for bridesmaids dresses and clothing. Alexia Designs has been providing quality bridesmaids dresses for several years. They recently revamped their website to include new dresses from brand-name manufacturers and designers. If you want ...

World Stem Cells, LLC offers advanced stem cell treatments for qualified patients at their facilities World Stem Cells Clinic in Cancun. Their newly constructed state-of-the art (cGTP)laboratory at the Tulum Trade Center in Cancun, utilizes multiple tools and equipment to assess stem cell counts and viability, along with Cytometry analysis, sorting, cell expansion and cryo. World Stem Cells Clinic's research has developed the best protocols to maximize patients benefit from stem cell treatments, operating under the stringent guidelines as established by The International ...

The Grauer School announced today the appointment of Grauer School Alumna Sara Hunt as Technology Specialist to The Grauer School staff. Ms. Hunt, a 2012 graduate of Chapman University in Orange, CA, with a BFA in Creative Writing (magna cum laude, with minors in Women's and GLBT Studies), graduated from The Grauer School in 2008 as a National Honors Society Member and three-time Presidential Gold Award for Academics (3.75+ GPA) Recipient. Ms. Hunt honed her teaching skills as a Writing Tutor at the Chapman Univeristy Center for Academic Success, where she mentored students ...