A team of researchers has made a significant discovery which may have a dramatic impact on children stricken with Tay-Sachs disease, a degenerative and fatal neurological condition that often strikes in the early months of life. Available drugs may dramatically ease a child's suffering, say scientists. "There is hope for this disease," says Suleiman Igdoura, lead researcher of the study and an associate professor of biology at McMaster University. "Imagine what that could mean for parents who have a child diagnosed with this incurable condition, who may have only ...

Athens, Ga. – From the neurons that enable thought to the keratinocytes that make toenails grow–a complex canopy of sugar molecules, commonly known as glycans, envelop every living cell in the human body. These complex carbohydrate chains perform a host of vital functions, providing the necessary machinery for cells to communicate, replicate and survive. It stands to reason, then, that when something goes wrong with a person's glycans, something goes wrong with them. Now, researchers at the University of Georgia are learning how changes in normal glycan behavior are ...

Researchers from Germany have found that low levels of vitamin D are associated with high levels of hepatitis B virus (HBV) replication. Findings published online in Hepatology, a journal of the American Association for the Study of Liver Diseases, suggest seasonal fluctuations in vitamin D and HBV levels point to a link in these variables among patients with chronic HBV. While highly effective vaccines are available, HBV still remains one of the most significant infectious diseases worldwide. In fact, the World Health Organization (WHO) states that HBV is 50 to 100 ...

In a recent analysis of one outpatient clinic, one in four men seeking medical help for newly-developed erectile dysfunction (ED) was younger than 40 years, and nearly half of young men with the condition had severe ED. While larger population-based studies are needed, the findings, which were published in The Journal of Sexual Medicine, suggest that erectile dysfunction in young men may be more prevalent and more serious than previously thought. Erectile dysfunction is a common complaint in men over 40 years of age. Prevalence increases with age, but the prevalence ...

Athens, Ga. – Sub-Saharan Africa has foreign investors flocking to buy its fertile land. Sometimes referred to as "land grabbing," the large-scale buying or leasing of large tracts of land in developing countries shifts indigenous, or customary, land rights from chiefs and local communities to investors or national governments, often stripping native people of a source of income. The laws, its practices and eventual outcomes for the countries and people involved are the topic of one recent study led by University of Georgia anthropologist Laura German. Looking at ...

DURHAM, N.C. – In a first-of-its-kind operation in the United States, a team of doctors at Duke University Hospital helped create a bioengineered blood vessel and implanted it into the arm of a patient with end-stage kidney disease. The procedure, the first U.S. clinical trial to test the safety and effectiveness of the bioengineered blood vessel, is a milestone in the field of tissue engineering. The new vein is an off-the-shelf, human cell-based product with no biological properties that would cause organ rejection. Using technology developed at Duke and at a spin-off ...

ROSEMONT, Ill.—Supplemental child restraints should be used by all children through age 8. When appropriate child safety restraint systems—based on a child's age and weight—are in use during motor vehicle crashes, the rates of mortality and serious injury significantly decrease. Most parents don't know that their older children—ages 4 to 8—should use additional measures to protect them from serious injury or death in case of a crash. In a literature review appearing in the June 2013 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), researchers ...

COLUMBIA, Mo. -- Facebook and other social networking web sites have revolutionized the way people create and maintain relationships. However, new research shows that Facebook use could actually be damaging to users' romantic relationships. Russell Clayton, a doctoral student in the University of Missouri School of Journalism, found that individuals who use Facebook excessively are far more likely to experience Facebook–related conflict with their romantic partners, which then may cause negative relationship outcomes including emotional and physical cheating, breakup and ...

New Rochelle, NY, June 6, 2013— Immunocompromised mice, created by inactivating the genes that would allow them to recognize and attack donor cells or organs, are critical for studies of bone marrow reconstitution. A more rapid and reliable technique for identifying these mice in breeding colonies is described in an article in BioResearch Open Access, a peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website. Alejandro Ferrer, Adam Schrum, and Diana Gil, College of Medicine, Mayo ...

NASA's TRMM satellite passed over Tropical Storm Andrea right after it was named, while NASA's Terra satellite captured a visible image of the storm's reach hours beforehand. TRMM measures rainfall from space and saw that rainfall rates in the southern part of the storm was falling at almost 5 inches per hour. NASA's Terra satellite passed over Tropical Storm Andrea on June 5 at 16:25 UTC (12:25 p.m. EDT) and the Moderate Resolution Imaging Spectroradiometer or MODIS instrument, captured a visible image of the storm. At that time, Andrea's clouds had already extended ...

Liver transplantation is the mainstay of treatment for patients with end-stage liver disease, the 12th leading cause of death in the United States, but new research from the Icahn School of Medicine at Mount Sinai, published in the online journal Cell Stem Cell today, suggests that it may one day become possible to regenerate a liver using cell therapy in patients with liver disease. Investigators discovered that a human embryonic stem cell can be differentiated into a previously unknown liver progenitor cell, an early offspring of a stem cell, and produce mature and functional ...

Scientists at the Danish Stem Cell Center, DanStem, at the University of Copenhagen have discovered that they can make embryonic stem cells regress to a stage of development where they are able to make placenta cells as well as the other fetal cells. This significant discovery, published in the journal Cell Reports today, has the potential to shed new light on placenta related disorders that can lead to problematic pregnancies and miscarriages. Embryonic stem cells can make all kinds of adult cells in the human body such as muscle, blood or brain cells. However, these ...

Research from the University of Sheffield has found that the wider range of policy approaches and measures which have been introduced in all EU Member States over the past five years have had a significant impact on preventing businesses and people from engaging in undeclared work. The research, led Professor Colin Williams from the University of Sheffield, found an incremental decline in the size of the undeclared economy from the equivalent of 22.3 percent of GDP in 2003 to 18.4 percent by 2012 - although with big differences between countries, revealing a clear north-south ...

This news release is available in German. Loading a lithium-ion battery produces lithium atoms that are taken up by the graphite layers of the negative electrode. However, the capacity of graphite is limited to one lithium atom per six carbon atoms. Silicon could take up to ten times more lithium. But unfortunately, it strongly expands during this process – which leads to unsolved problems in battery applications. Looking for an alternative to pure silicon, scientists at the Technische Universitaet Muenchen have now synthesized a novel framework structure consisting ...

Every 6.6 years, the comet Giacobini-Zinner circulates through the inner solar system and passes through the perihelion, the closest point to the Sun of its orbit. Then, the comet sublimates the ices and ejects a large number of particles that are distributed in filaments. The oldest of these particles have formed a swarm that the Earth passes trough every year in early October. The result is a Draconid meteor shower –meteors from this comet come from the northern constellation Draco–, which hits the Earth's atmosphere at about 75,000 km/h, a relatively slow speed in comparison ...

PROVIDENCE, R.I. [Brown University] — A new study by researchers from Brown University finds more evidence that breastfeeding is good for babies' brains. The study made use of specialized, baby-friendly magnetic resonance imaging (MRI) to look at the brain growth in a sample of children under the age of 4. The research found that by age 2, babies who had been breastfed exclusively for at least three months had enhanced development in key parts of the brain compared to children who were fed formula exclusively or who were fed a combination of formula and breastmilk. The ...

Cold Spring Harbor, N.Y. – Human Argonautes (hAgo), are key proteins involved in a process known as RNA interference. RNAi, as it is often called, is a mechanism that cells use to regulate gene expression. Human Argonaute-2 (hAgo2) is known as "slicer" for its unique ability among the 4 human Argonaute proteins to directly cut messenger RNA -- which carries the information coded in genomic DNA to make a protein -- and thus disable "messages" generated from genes. The atomic resolution structure of hAgo2 solved previously, revealed the active site, a region of the enzyme ...

CHAPEL HILL, N.C. - While aspirin has been shown to be effective in preventing heart attacks in men, it also increases the risk of gastrointestinal bleeding and possibly stroke, even at low doses. As such, national guidelines suggest that aspirin be used for prevention only in men at higher risk for cardiovascular events, so that the benefits of aspirin are greater than its adverse effects. Recent data suggest that aspirin may also be effective for reducing cancer deaths. Would the possible combined health benefits of reducing heart attacks and cancer outweigh the risks ...

LA JOLLA, CA – June 6, 2013 – Humans have been raising cows for their meat, hides and milk for millennia. Now it appears that the cow immune system also has something to offer. A new study led by scientists from The Scripps Research Institute (TSRI) focusing on an extraordinary family of cow antibodies points to new ways to make human medicines. "These antibodies' structure and their mechanism for creating diversity haven't been seen before in other animals' antibodies," said Vaughn V. Smider, assistant professor of cell and molecular biology at TSRI and principal investigator ...

Conservatives are more likely than liberals to identify mixed-race individuals as Black, according to a series of new studies by researchers at New York University. Their findings, which appear in the Journal of Experimental Social Psychology, suggest that there is a link between political ideology and racial categorization. "A person's race is often thought to be clear-cut and fixed," explains Amy Krosch, a doctoral student in New York University's Department of Psychology and the lead author of the paper. "However, our research suggests that the perception of a person ...

CHICAGO --- A phase 1 clinical trial for the first treatment to reset the immune system of multiple sclerosis (MS) patients showed the therapy was safe and dramatically reduced patients' immune systems' reactivity to myelin by 50 to 75 percent, according to new Northwestern Medicine research. In MS, the immune system attacks and destroys myelin, the insulating layer that forms around nerves in the spinal cord, brain and optic nerve. When the insulation is destroyed, electrical signals can't be effectively conducted, resulting in symptoms that range from mild limb numbness ...

Grenoble, 5 June 2013: An international team of researchers has announced the discovery of the world's oldest known fossil primate skeleton representing a previously unknown genus and species named Archicebus achilles. The fossil was unearthed from an ancient lake bed in central China's Hubei Province, near the course of the modern Yangtze River. In addition to being the oldest known example of an early primate skeleton, the new fossil is crucial in elucidating a pivotal event in primate and human evolution—the evolutionary divergence that led to modern monkeys, apes and ...

An international team of researchers has announced the discovery of the world's oldest known fossil primate skeleton, an animal that lived about 55 million years ago and was even smaller than today's smallest primate, the pygmy mouse lemur. The new specimen, named Archicebus achilles, was unearthed from an ancient lake bed in central China's Hubei Province, near the course of the modern Yangtze River. In addition to being the oldest known example of an early primate skeleton, this almost complete new fossil is crucial for illuminating a pivotal event in primate and human ...

A new Lancet series on maternal and childhood nutrition finds that over 3 million children die every year of malnutrition—accounting for nearly half of all child deaths under 5. Along with state-of-the-art global estimates on the long-term burden of malnutrition, the series presents a new framework for prevention and treatment that considers underlying factors, such as food security, social conditions, resources, and governance. Professor Robert Black, Department of International Health at the Johns Hopkins Bloomberg School of Public Health, led the consortium of experts ...

A team of researchers from Emory, University of Miami and Scripps Research Institute has identified a compound that can reduce PTSD-like symptoms in mice after they are exposed to stress. The discovery could lead to a treatment given to people shortly after a traumatic event, aimed at preventing possible PTSD (post-traumatic stress disorder). The results are scheduled for publication Wednesday in the journal Science Translational Medicine. The team's research meshes with recent studies – one looking at military personnel injured in Iraq -- hinting that morphine administration ...