Starting January 1, 2013 the Archives journals will have new titles and a new distribution schedule. Please provide proper attribution to the new journal names. On first reference, one time only, we would prefer that you provide this attribution: "a study published online today in JAMA Neurology (formerly Archives of Neurology) ..." The names are JAMA (specialty), not the Journal of the American Medical Association (specialty). Here are the new titles and new embargo schedule: Mondays 3pm central time/4pm eastern time JAMA Pediatrics JAMA Neurology JAMA Internal ...

Despite more than 25 years of research on antiobesity drugs, few medications have shown long-term success. Now researchers reporting online on December 21 in the Cell Press journal Trends in Endocrinology & Metabolism say that targeting taste sensors in the gut may be a promising new strategy. The gut "tastes" what we eat—bitter, sweet, fat, and savory—in much the same way as the tongue and through the use of similar signaling mechanisms. The result is the release of hormones to control satiety and blood sugar levels when food reaches the gut. The sensors, or receptors, ...

The X-factor in liver metabolism After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway contributes to the liver's metabolic switch. In this issue of the Journal of Clinical Investigation, researchers led by Phillip Scherer at the University of Texas Southwestern Medical Center report that activation of the UPR triggers the expression of Xbp1s, a protein that regulates genes needed for the metabolic ...

After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway contributes to the liver's metabolic switch. In this issue of the Journal of Clinical Investigation, researchers led by Phillip Scherer at the University of Texas Southwestern Medical Center report that activation of the UPR triggers the expression of Xbp1s, a protein that regulates genes needed for the metabolic switch. Scherer and colleagues found ...

H. pylori frequently causes gastric ulcers and is also one of the greatest risk factors for gastric cancer. H. pylori infection is also associated with another gastric cancer risk factor, iron deficiency. In this issue of the Journal of Clinical Investigation, researchers led by Richard Peek at Vanderbilt University investigated the influence of iron on H. pylori-induced gastric cancer. Peek and colleagues found that low iron accelerated the development of H. pylori-associated cancerous lesions in gerbils. Further, H. pylori strains isolated from a human population at high ...

Scientists at Karolinska Institutet in Sweden, in collaboration with colleagues in Germany and the Netherlands, have identified a previously unknown group of nerve cells in the brain. The nerve cells regulate cardiovascular functions such as heart rhythm and blood pressure. It is hoped that the discovery, which is published in the Journal of Clinical Investigation, will be significant in the long term in the treatment of cardiovascular diseases in humans. The scientists have managed to identify in mice a previously totally unknown group of nerve cells in the brain. These ...

PHILADELPHIA—Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients, according to a pre-clinical study published ahead of print on December 21 in the Journal of Clinical Investigation by researchers at the Kimmel Cancer Center at Jefferson. The group, headed by Karen E. Knudsen, Ph.D., Professor and Hilary Koprowski Chair, Departments of Cancer Biology, Urology, and Radiation Oncology at Thomas Jefferson University and Deputy Director for Basic Science at the KCC, found that Cyclin D1b, a variant of the ...

Someday, Oahu's Koolau and Waianae mountains will be reduced to nothing more than a flat, low-lying island like Midway. But erosion isn't the biggest culprit. Instead, scientists say, the mountains of Oahu are actually dissolving from within. "We tried to figure out how fast the island is going away and what the influence of climate is on that rate," said Brigham Young University geologist Steve Nelson. "More material is dissolving from those islands than what is being carried off through erosion." The research pitted groundwater against stream water to see which ...

Over the past couple of years research into miRNAs has become increasingly diversified and attracted a great number of research articles across genetics and medicine. This should hardly come as a surprise to any scientist in the field, especially since it has become clear that miRNAs, a recently discovered class of non-coding RNAS, are represented in nearly all cellular functions and molecular pathways. A growing list of reports demonstrates that microRNAs play a critical role in cancer initiation and progression, and that miRNA alterations are ubiquitous in human cancers. ...

Theoretical physicist Elad Eizner from Ben Gurion University, Israel, and colleagues created models to study the attractive forces affecting atoms located at a wide range of distances from a surface, in the hundreds of nanometers range. Their results, about to be published in EPJ D, show that these forces depend on electron diffusion, regardless of whether the surface is conducting or not. Ultimately, these findings could contribute to designing minimally invasive surface probes. Bombarding a surface with atoms helps us understand the distribution of its electrons and ...

The putative remains of Carin Göring, wife of Nazi leader Herman Göring, were found in 1991 at a site close to where she had been buried. In a recently published article, Maria Allen, professor of forensic genetics at Uppsala University, Sweden, and her associates present evidence supporting that it is Carin Göring's remains that have been identified. The Swedish Carin Göring was married to the well-known Nazi leader Herman Göring. When she died in 1931 she was buried in Stockholm, but three years later Herman Göring had her remains moved to his residence Karinhall outside ...

This press release is available in German. Using the world's most powerful X-ray free-electron laser, an international team of researchers, including scientists of the Max Planck Institute for Medical Research in Heidelberg, has obtained new insight into the structure of a medicinally important protein that may serve as a blueprint for the development of drugs to fight sleeping sickness. Science magazine have chosen the experimental study as one of the top ten scientific breakthroughs of the year. Sleeping sickness is caused by the unicellular organism Trypanosoma ...

In a recent publication, researchers achieved new accuracy in the ability to measure energy differences between states of molecules, thus predicting which states will be observed. It has been known since the seventies that excessive salt causes DNA to reverse its twist, from a right-handed spiral to a left-handed one. DNA in the Z form is treated by our natural repair enzymes as damaged, and is therefore usually deleted from the cell. Deletion of genetic material can lead to cancer or to other problems, so the B-Z transition is no mere curiosity. However such is the ...

The climate after the largest mass extinction so far 252 million years ago was cool, later very warm and then cool again. Thanks to the cooler temperatures, the diversity of marine fauna ballooned, as paleontologists from the University of Zurich have reconstructed. The warmer climate, coupled with a high CO2 level in the atmosphere, initially gave rise to new, short-lived species. In the longer term, however, this climate change had an adverse effect on biodiversi-ty and caused species to become extinct. Until now, it was always assumed that it took flora and fauna ...

CHAMPAIGN, Ill. — Six weeks of weight training can significantly improve blood markers of cardiovascular health in young African-American men, researchers report in the Journal of Human Hypertension. The researchers measured blood markers associated with inflammation, immune response or the remodeling of arteries that normally occur after tissue damage, infection or other types of stress. They found that levels of two of these markers dropped significantly in African-American men but not in Caucasian men after six weeks of resistance training. "This suggests that resistance ...

AUSTIN, Texas—Researchers at The University of Texas at Austin have designed a simulation that for the first time emulates key properties of electronic topological insulators. Their simulation, which was described this week in Nature Materials, is part of a rapidly moving scientific race to understand and exploit the potential of topological insulators, which are a state of matter that was only discovered in the past decade. These insulators may enable dramatic advances in quantum computing and spintronics. "The discovery of these materials, which are insulators in ...

New Rochelle, NY, December 20, 2012—Small interfering RNAs (siRNAs) are a potent new drug class that can silence a disease-causing gene, but delivering them to a target cell can be challenging. An innovative delivery approach that dramatically increases the efficacy of an siRNA drug targeted to the liver and has made it possible to test the drug in non-human primates is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers (http://www.liebertpub.com). The article is available on the Nucleic Acid Therapeutics ...

CORVALLIS, Ore. – Researchers at Oregon State University today announced the discovery of an underlying genetic cause of atopic dermatitis, a type of eczema most common in infancy that also affects millions of adults around the world with dry, itchy and inflamed skin lesions. The findings were just published in PLoS ONE, a professional journal, and may set the stage for new therapeutic approaches to this frustrating syndrome, which is difficult to treat and has no known cure. Eczema is also related to, and can sometimes cause asthma, a potentially deadly immune dysfunction. Pharmaceutical ...

Highlights Six months of steroid treatment in children with nephrotic syndrome did not reduce relapse rates or side effects compared with three months of treatment. Because many children with nephrotic syndrome face frequent relapses, future research should focus on preventing relapses through new treatment strategies. Nephrotic syndrome has an estimated incidence of two to seven cases per 100,000 children and a prevalence of nearly 16 cases per 100,000. Washington, DC (December 20, 2012) — Extending steroid treatment for the most common form of kidney disease ...

Highlights Retention of certain compounds that are normally excreted by the kidneys may cause insulin resistance, or prediabetes, in kidney disease patients. When mice with kidney disease were treated with a prebiotic that reduces blood levels of these compounds, insulin resistance and lipid abnormalities were prevented. Washington, DC (December 20, 2012) —Insulin resistance, or prediabetes, in individuals with kidney disease may be caused by the progressive retention of certain compounds that are normally excreted by the kidneys in healthy individuals, ...

The observation of an elusive sub-atomic particle, known as the Higgs boson, has been heralded by the journal Science as the most important scientific discovery of 2012. This particle, which was first hypothesized more than 40 years ago, holds the key to explaining how other elementary particles (those that aren't made up of smaller particles), such as electrons and quarks, get their mass. In addition to recognizing the detection of this particle as the 2012 Breakthrough of the Year, Science and its international nonprofit publisher, AAAS, have identified nine other ...

Until today, Alfred Russell Wallace's century old map from 1876 has been the backbone for our understanding of global biodiversity. Thanks to advances in modern technology and data on more than 20,000 species, scientists from University of Copenhagen have now produced a next generation map depicting the organisation of life on Earth. Published online in Science Express today, the new map provides fundamental information regarding the diversity of life on our planet and is of major significance for future biodiversity research. An essential question in understanding life ...

PASADENA, Calif.—Protein engineers at the California Institute of Technology (Caltech) have tapped into a hidden talent of one of nature's most versatile catalysts. The enzyme cytochrome P450 is nature's premier oxidation catalyst—a protein that typically promotes reactions that add oxygen atoms to other chemicals. Now the Caltech researchers have engineered new versions of the enzyme, unlocking its ability to drive a completely different and synthetically useful reaction that does not take place in nature. The new biocatalysts can be used to make natural products—such ...

AMHERST, Mass. – Malaria brings misery and death to millions in the developing world each year, and fighting it keeps medical researchers up at night because the mosquito-borne parasite Plasmodium falciparum, which causes the deadliest form of the disease, has developed resistance to every drug thrown at it. Resistance has cut short the useful life of nearly every therapy tried so far, experts say. But now molecular parasitologist Stephen Rich at the University of Massachusetts Amherst has led a research team who report a promising new low-cost combined therapy with a ...

Johns Hopkins researchers have developed a new way of looking at standard MRI scans that more accurately measures damage to the blood-brain barrier in stroke victims, a process they hope will lead to safer, more individualized treatment of blood clots in the brain and better outcomes. The blood-brain barrier is a unique shielding of blood vessels that limits the passage of molecules from the blood stream into the brain. Without it, the brain is open to infection, inflammation and hemorrhage. Ischemic stroke patients are at risk of bleeding into the brain when there is ...