ABSTRACTS: 216, 219, 1011  SAN DIEGO ― Three clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated significant positive results from novel triplet therapies in the treatment of relapsed or refractory and newly diagnosed leukemias. The results were presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition. More information on all ASH Annual Meeting content from MD Anderson can be found at MDAnderson.org/ASH.   Study demonstrates strong ...

INDIANAPOLIS — A study by Indiana University School of Medicine researchers sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment. It was recently published with special distinction in the Journal of Biological Chemistry. Toxoplasma gondii is a single-celled parasite that people catch from cat feces, unwashed produce or undercooked meat. The parasite has infected up to one-third of the world's population, and after causing mild illness, it persists by entering a dormant ...

The numbers of e-scooter and e-bike injuries have tripled in the US since 2019, fuelled by alcohol and substance use, finds a nationwide analysis of emergency department visits, published online in the journal Injury Prevention.   And the odds of alcohol and substance use were much higher among 10-17 year old riders with these injuries than they were among older age groups, the findings show. E-scooters and e-bikes, collectively known as micromobility devices, have become increasingly popular, thanks to their zero emissions, amid higher fuel prices and better biking infrastructure, note the researchers.  Emerging evidence points to increasing numbers of injuries associated ...

Despite a fall in the number of people with asthma over the past decade who say that cost has stopped them taking their meds as prescribed, financial hardship still remains a deterrent for 1 in 6 with the condition, suggests research published online in the respiratory medicine journal Thorax. Failure to stick to their drug treatment was associated with a near doubling in the risk of an asthma attack and a more than 60% heightened risk of an emergency department visit, the findings indicate. The findings reinforce the importance of healthcare policy in promoting equitable access to drug treatment, concludes a linked editorial. In 2021, the Centers for Disease Control ...

Psychedelic substances like psilocybin (found in magic mushrooms), MDMA (commonly known as ecstasy), LSD (commonly known as acid), and ayahuasca have shown potential in treating conditions such as depression, post-traumatic stress disorder (PTSD), and addiction. These substances can induce profound psychological experiences that, when paired with psychotherapy — a form of talk therapy — have been proposed to lead to significant therapeutic benefits. Why Now? Despite the growing interest and media coverage, no major regulatory agency has yet approved psychedelics for specific medical use. Access to these treatments remains limited to clinical ...

Removing 10 per cent of a patient’s blood before major liver surgery and giving it back afterwards reduced transfusions by half, according to a large clinical trial published in The Lancet Gastroenterology & Hepatology. Known as hypovolemic phlebotomy, this practice could save one in every 11 patients having this surgery from needing a transfusion. “Blood loss is a major concern in liver surgery. Taking out half a litre of blood right before major liver surgery is the best thing we’ve found so far for reducing blood loss and transfusions,” said co-lead author Dr. Guillaume Martel, a surgeon and scientist who holds the Arnie Vered Family Chair in Hepato-Pancreato-Biliary ...

Despite a decade of global efforts, the world is far from reaching essential nutrition 2030 milestones set by the World Health Assembly, with critical gaps threatening the health of millions. According to a new Global Burden of Disease analysis, most countries are struggling to meet the six global nutrition targets set in 2012 to combat low birthweight, inadequate breastfeeding, child malnutrition, and anemia in reproductive-age women.   By 2021, limited success was seen with only a few countries meeting some of the targets: five countries achieved breastfeeding ...

EPA study finds that U.S. public schools with the highest potential exposure risk to air toxics have higher proportions of disabled Latino, Hispanic, and Asian children     Children are at greater risk from inhaled air pollutants than adults, as they have higher respiratory rates. Research has shown that air pollutants in the form of respiratory toxicants (such as some  pesticides and solvents) can represent a significant health risk to children.  The Environmental Protection Agency (EPA) has completed a nationwide study to assess the estimated non-cancer exposure risks of public school ...

About The Study: This randomized controlled trial secondary analysis examines the association between treatment expectancies and the relative efficacy of psilocybin compared with escitalopram for major depressive disorder.  Corresponding Author: To contact the corresponding author, Ethan Dutcher, MD, PhD, email ethan.dutcher@ucsf.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2024.4387) Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London provides valuable insights into the brain-body immune connection identifying key communication hubs in the dural sinuses and skull bone marrow at the back of the head.  The research, which was supported by funding from the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC) and published in the journal Brain, used neuroimaging techniques to establish that the dural sinuses, a region at the ...

Online training that helps people recognise and understand new voices could be key to helping older adults improve communication in everyday environments, finds research by UCL experts. The study, published in the Journal of Experimental Psychology: Applied, tested whether learned voices were easier to understand than unfamiliar voices in 20 older (55-73 years) and 20 younger (18-34 years) adults. Participants took part in some preparatory online training, where they were trained to understand three new voices by listening to them each say 10 meaningful sentences until they became “familiar”. They then had to listen to one of these voices speak ...

Short-term cognitive boost from exercise may last for 24 hours The short-term boost our brains get after we do exercise persists throughout the following day, suggests a new study led by UCL (University College London) researchers. Previous research in a laboratory setting has shown that people’s cognitive performance improves in the hours after exercise, but how long this benefit lasts is unknown. The new study, published in the International Journal of Behavioral Nutrition and Physical Activity, ...

The United States Agency for International Development (USAID) has awarded $75 million to a consortium of leading global institutions, including the Pulte Institute for Global Development at the University of Notre Dame’s Keough School of Global Affairs, to enhance the effectiveness of poverty alleviation programs through research. The Promoting Impact and Learning with Cost-Effectiveness Evidence (PILCEE) partnership, led by the Center for Effective Global Action at the University of California, Berkeley, represents a historic ...

ABSTRACT: 805 SAN DIEGO – Adult patients with newly diagnosed malignancy-associated hemophagocytic lymphohistiocytosis (mHLH) – a rare, aggressive hyperinflammatory condition – who were treated with the first-in-class monoclonal antibody, ELA026, experienced a 100% response rate and an improved survival rate at two months, according to researchers from The University of Texas MD Anderson Cancer Center. Data from the Phase Ib trial were presented today at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition by Abhishek Maiti, M.D., assistant professor of Leukemia and the trial’s principal investigator. ...

Playing video games is a rite of passage for many adolescents, but for some, it could also be the first step to a gaming addiction. “A number one concern for parents of children and teenagers is how much screen time and how much gaming is enough gaming and how to figure out where to draw the line,” said John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester and co-author of a study out today in the Journal of Behavioral Addictions that discovered a key marker in the brain of teens who develop gaming addiction symptoms. “These data begin to give us some answers.” Researchers ...

Embargoed for release until 5:00 p.m. ET on Monday 9 December 2024     @Annalsofim          Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.          ----------------------------          1. ...

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/About The Study: In hospitalized adults, daily procalcitonin -guided protocol reduced antibiotic duration safely compared with standard care, but daily C-reactive protein -guided protocol does not. All-cause mortality for C-reactive protein was inconclusive.  Corresponding Author: To contact the corresponding author, Paul Dark, MD, PhD, email adaptsepsistrial@warwick.ac.uk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.26458) Editor’s ...

Members of the American Meteorological Society (AMS) have elected Alan Sealls to the position of AMS president-elect for 2025. Sealls is an AMS Fellow and Certified Broadcast Meteorologist who retired this year from a 37-year broadcast career, which included serving as chief meteorologist at WPMI-TV in Mobile, Alabama. He will be inducted as president-elect on Sunday, 12 January, 2025, during the 105th AMS Annual Meeting in New Orleans, Louisiana.  At the meeting, the AMS—the professional society for weather, water, and climate sciences ...

A new study from UC San Diego’s Comparative Cognition Lab shows that dogs trained to use soundboards to “talk” are capable of making two-word button combinations that go beyond random behavior or simple imitation of their owners. Published in the journal Scientific Reports from Springer Nature, the study analyzed data from 152 dogs over 21 months, capturing more than 260,000 button presses – 195,000 of which were made by the dogs themselves. “This is the first scientific study to analyze how dogs actually use soundboards,” said lead researcher Federico Rossano, associate professor of cognitive science at UC San Diego and director ...

Animals showcase a remarkable diversity of colors and patterns, from the shimmery appearance of a peacock’s tail to the distinctive rosettes on a jaguar’s fur. Quantifying animal color has been a longtime goal of evolutionary biologists, who aim to understand how color evolved over time—and the physical and genetic mechanisms involved. Ultimately, studying animal color is important because it can reveal how evolutionary forces, such as natural and sexual selection, favor certain traits over others. However, fully capturing animal color is challenging because researchers must choose between high spatial resolution (as in traditional ...

Researchers at the State University of Campinas (UNICAMP) in São Paulo state, Brazil, have developed a sourdough bread formulation enriched with jabuticaba peel that could be an alternative for people with diabetes and others who need to control blood sugar. An article describing their research and test results is published in the journal Foods. As noted in the article, the high carbohydrate content of bread can sharply raise blood sugar levels, risking hyperglycemia. Given the high demand for healthier bread, which is widely consumed, artisanal bakers seek to diversify their products with formulations that add nutritional value while involving fermentation ...

WASHINGTON, D.C. - Today, the U.S. Department of Energy (DOE) announced 29 projects totaling $36 million to 42 institutions in 16 states for traineeships for undergraduate students, graduate students, and postdoctoral researchers in science, technology, engineering, and mathematics (STEM). The funding, through the DOE Office of Science’s RENEW initiative, will support hands-on research experience, professional development activities to build or reinforce STEM identity, and mentorship to support personal and professional growth of trainees.  “The RENEW program provides new entry points to science for ...

AUSTIN, TX, Dec 9, 2024 – Malware (malicious software) is a worldwide threat to network security for organizations. Individual users within those networks may inadvertently download or interact with malware like viruses and ransomware by browsing unsafe websites, downloading software, or clicking on phishing links in emails.   Cybersecurity researchers from the University of Trento and Vrije Universiteit Amsterdam and the global cybersecurity firm Trend Micro wondered what behaviors bring the greatest risk of malware infection: working at night, browsing adult content, gambling, having a lot of software installed or just visiting strange places?   The ...

New research has revealed less than a quarter of the remaining tropical rainforests around the globe can safeguard thousands of threatened species from extinction. The research, co-authored by The University of Queensland’s Professor James Watson, evaluated the global availability of structurally intact, minimally disturbed tropical rainforests for more than 16,000 species of mammals, birds, reptiles, and amphibians. “Using remote sensing and forest integrity indicators, we analysed the quality of the rainforests across the ranges of the forest-dependent vertebrates,” Professor Watson said. “Overall, up to 90 per cent of ...

Freshwater fish populations that dwell nearer the poles are outperforming their equatorial counterparts, researchers have found. Large-bodied migratory species such as Atlantic salmon are thriving as warming temperatures opens up new habitats at the poleward edge of their ranges. The study, published today in PNAS, was based on a dataset of over 10,000 time series and included over 600 species of fishes.  Climate change has emerged as a key threat to biodiversity, leading to broad-scale shifts in distributions of marine and terrestrial species as they attempt to track thermally suitable habitat. Despite ...