While molecues with a single cavity have been extensively studied in solution, the solution state functions of polycavity materials remain elusive owing to their synthetic inaccessibility. Porous aromatic polymers (PAPs) are synthesized in a single step and offer polymeric cavity frameworks with high stability, which are applicable to gas and molecule adsorption/separation only in the solid state. Due to their strong aggregation-derived insoubility, unsubstituted PAPs cannot be used in any solvent until now. To move the functions of PAPs from the solid to the solution ...

According to a recent study, in patients with frontotemporal dementia (FTD), epileptic seizures are significantly more common than previously known. The discovery deepens understanding of the symptoms of this memory disorder and emphasises the importance of taking epileptic seizures into account in the treatment and monitoring of patients.   Coordinated by Neurocenter Finland, this major project by the University of Eastern Finland and the University of Oulu examined the prevalence of epilepsy in patients with FTD. The research dataset ...

Patients with Stage II and III (early-stage) HER2+ breast cancer usually undergo pre-operative therapy with multi-agent chemotherapy in combination with anti-HER2 antibodies, followed by surgery. A less intensive, reduced chemotherapy treatment approach is currently being evaluated in the CompassHER2 pCR trial (EA1181, NCT04266249) by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN). While longer follow-up is needed to assess long-term outcomes, pathologic complete response (pCR) rates and predictors of ...

A new way of thinking about Alzheimer’s disease has yielded a discovery that could be the key to stopping the cognitive decline seen in Alzheimer’s and other neurodegenerative diseases. University of Virginia School of Medicine scientists have been investigating the possibility that Alzheimer’s is caused, at least in part, by the immune system’s wayward attempts to fix DNA damage in the brain. Their research reveals that an immune molecule called STING drives the formation of the harmful plaques and protein ...

FRANKFURT. Habitat loss, diseases, pollution, and climate change are already massively affecting amphibians – frogs, salamanders, and the caecilians native to tropical regions. The new study from the Institute for Ecology, Evolution and Diversity shows that extreme weather events serve as an additional stress factor, further intensifying this crisis. For this purpose, the scientists analyzed global weather data from the past 40 years. They compared regions with significantly increased heat waves, droughts, and cold spells with the geographical ...

As the U.S. population ages and dementia cases rise, many people are asking whether it is possible to prevent this devastating disease. According to a new study, the answer may be on your plate: People who followed a dietary pattern known as the MIND diet were significantly less likely to develop Alzheimer’s disease or related forms of dementia.   The MIND diet, which stands for Mediterranean-DASH Intervention for Neurodegenerative Delay, combines the Mediterranean diet with the blood pressure-lowering DASH (Dietary Approaches to Stop Hypertension) diet and also emphasizes proven brain-healthy ...

Older adults are quite aware of their financial abilities – and these abilities actually improve with age – that is, until dementia sets in, according to new research from Binghamton University, State University of New York. From paying bills to making change, knowing how to handle money is necessary to live and thrive in society. But what happens as we get older? Do our financial abilities decline and if so, are we even aware of our own shortcomings? To examine this, a team of researchers led by Binghamton University psychologist ...

Highlights: Infections by antimicrobial resistant (AMR) pathogens are a leading cause of death worldwide, with more than 1 million deaths annually, highlighting the need for new treatments. Researchers have synthesized a new compound called infuzide that shows activity against resistant strains of pathogens. Infuzide works against known, problematic gram-positive pathogens. In lab and mouse tests, infuzide reduced bacterial populations, suggesting it might be useful as a new treatment for drug-resistant infections.  Washington, D.C.—Antimicrobial ...

PULLMAN, Wash.--A team of Washington State University-led researchers has recreated the world's oldest synthetic pigment, called Egyptian blue, which was used in ancient Egypt about 5,000 years ago. Reporting in the journal, NPJ Heritage Science, the researchers used a variety of raw materials and heating times to develop 12 recipes for the pigments, providing useful information for archaeologists and conservation scientists who study the ancient Egyptian materials. The work was done in collaboration with Carnegie Museum of ...

Results from a phase 3 clinical trial published in the New England Journal of Medicine, today (June 2nd) show that patients with lung cancer who received an immunotherapy drug, nivolumab, along with standard chemotherapy before surgery had improved long term survival compared to those who received chemotherapy alone, at 5 years after completing treatment.  Prof. Patrick Forde of the Trinity St. James’s Cancer Institute (TSJCI), Trinity College Dublin School of Medicine presented the findings at the American ...

The SWOG S2302 Pragmatica-Lung trial, which broke new ground with its streamlined pragmatic design, unusually broad eligibility criteria, and reduced data collection, has quickly answered its primary question, finding that the investigational combination it tested did not significantly extend overall survival compared to standard of care treatments.  Importantly, the phase 3 trial’s rapid development and implementation, coupled with its successful enrollment of a group of patients broadly representative of the larger U.S. population, establish Pragmatica-Lung as a paradigm-shifting model for the design and conduct of future large randomized studies. Results will be presented ...

Daejeon, South Korea, and Vilnius, Lithuania, 2 June 2025 – Kongsberg NanoAvionics (NanoAvionics), a leading small satellite bus manufacturer and mission integrator, has been selected by the Institute for Basic Science (IBS) in South Korea to build the first CubeSat for the world’s first long-term planetary science campaign which will use a series of CubeSats to monitor Venus from low Earth orbit. This long-term Venus observation initiative, the CLOVE project (Chasing the Long-term Variability of Our Nearest Neighbor Planet ...

A trial of an interactive game that trains people to alter their brain waves has shown promise as a treatment for nerve pain – offering hope for a new generation of drug-free treatments. The PainWaive technology, developed by UNSW Sydney researchers, teaches users how to regulate abnormal brain activity linked to chronic nerve pain, offering a potential in-home, non-invasive alternative to opioids. A recent trial of the technology, led by Professor Sylvia Gustin and Dr Negin Hesam-Shariati from UNSW Sydney’s NeuroRecovery Research Hub, has delivered promising results, published in the Journal of Pain. The study compared ...

Artificial intelligence (AI) is ubiquitous in this era. As a result, human-AI interactions are becoming more frequent and complex, and this trend is expected to accelerate soon. Therefore, scientists have made remarkable efforts to better understand human-AI relationships in terms of trust and companionship. However, these man-machine interactions can possibly also be understood in terms of attachment-related functions and experiences, which have traditionally been used to explain human interpersonal bonds. In an innovative work, which incorporates two pilot studies and one formal study, a group of researchers from Waseda University, Japan, including Research ...

As artificial intelligence and smart devices continue to evolve, machine vision is taking an increasingly pivotal role as a key enabler of modern technologies. Unfortunately, despite much progress, machine vision systems still face a major problem: processing the enormous amounts of visual data generated every second requires substantial power, storage, and computational resources. This limitation makes it difficult to deploy visual recognition capabilities in edge devices—such as smartphones, drones, or autonomous vehicles. Interestingly, the human visual system ...

DARIEN, IL – A new study to be presented at the SLEEP 2025 annual meeting found that adolescents who prefer to sleep and wake up later (“night owls”) reported greater impulsivity than those who prefer to sleep and wake up earlier (“morning larks”). Results show that adolescents with self-reported evening preference, or “night owl” tendencies, reported greater negative urgency and lack of perseverance, which are two aspects of impulsivity. This means that they were more likely to act impulsively when experiencing negative emotions and quit difficult tasks. In contrast, ...

Scientists analysing an ultra-hot giant planet believe it was formed by absorbing lightweight gases like methane evaporating from tiny space pebbles, whilst being bombarded with large rocky objects.  Using the James Webb Space Telescope (JWST) to explore the atmosphere of WASP-121b, researchers successfully detected water (H₂O), carbon monoxide (CO), and silicon monoxide (SiO) in the side facing its star or ‘dayside’. They also found methane (CH₄) in the planet’s ‘nightside’ atmosphere.   Publishing ...

In the Paris Agreement of 2015, the international community of countries agreed to limit global warming to well below 2 °C, and preferably to 1.5 °C, compared to pre-industrial levels. This refers to the increase in global surface air temperature, inspected at any time of interest as an average over 20 years. The latest IPCC report expected the 1.5 °C threshold to be reached between 2030 and 2035. Climate researcher Gottfried Kirchengast from the Wegener Center and Institute of Physics at the University of Graz now has to revise this estimate: “Our ...

Flooding in coastal communities is happening far more often than previously thought, according to a new study from North Carolina State University and the University of North Carolina at Chapel Hill. The study also found major flaws with the widely used approach of using marine water level data to capture instances of flooding. “Government agencies and researchers use data from tide gauges to measure water levels in coastal areas, then use that data to estimate flood frequency in the region,” says Miyuki Hino, corresponding author of a paper on the study and assistant professor of city and regional planning at UNC. “Those estimates ...

Forests in the Peruvian Amazon aren’t growing back after gold mining — not just because the soil is damaged from toxic metals, but because the land has been depleted of its water. A common mining method known as suction mining reshapes the terrain in ways that drain moisture and trap heat, creating harsh conditions where even replanted seedlings can’t survive. The findings, published in Communications Earth & Environment, revealed why reforestation efforts in the region have struggled. One of the study’s co-authors is Josh West, professor of Earth sciences and environmental studies at the USC Dornsife College of Letters, Arts and Sciences. “We’ve ...

Observations with the James Webb Space Telescope (JWST) have provided new clues about how the exoplanet WASP-121b has formed and where it might have originated in the disc of gas and dust around its star. These insights stem from the detection of multiple key molecules: water vapour, carbon monoxide, silicon monoxide, and methane. With these detections, a team led by astronomers Thomas Evans-Soma and Cyril Gapp was able to compile an inventory of the carbon, oxygen, and silicon in the atmosphere of WASP-121b. The detection of methane in particular also suggests strong vertical winds on the cooler nightside, a process often ignored in current ...

A study has revealed why some patients don’t respond to immune checkpoint blockade (ICB) therapy for solid cancer tumours and identifies a new combination treatment. Publishing in Nature Immunology, the international group of experts led by scientists at Newcastle University, UK has identified the biological mechanisms leading to a revolution in our understanding of ICB resistance. They identify a new combination strategy for treating ICB resistant metastatic skin cancers and suggest  that this can also be of benefit in the immunotherapy treatment of other solid cancers. Dr Shoba Amarnath, Reader in Immune Regulation at Newcastle University led the research. ...

As the global population ages, the risk of developing neurodegenerative diseases such as dementia, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) continues to rise. But the molecular mechanisms behind the deterioration of brain cells have remained elusive. Now, a new study by University of California San Diego School of Medicine researchers has found that old neurons have unique defects resulting from molecular stress that make them especially vulnerable to neurodegeneration. “Aging ...

When cancer spreads from a primary tumor to new sites throughout the body, it undergoes changes that increase its genetic complexity. A new study from researchers at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center (MSK) provides fresh insights about how cancers evolve when they metastasize — insights that could aid in developing strategies to improve the effectiveness of treatment. The team — led by collaborators Dr. Luc Morris, a surgeon and cancer genetics research lab director at MSK, Dr. Xi Kathy Zhou, a professor of research in population health sciences at Weill Cornell Medicine, and Dr. Chaitanya Bandlamudi, a cancer genomics researcher at MSK — ...

Intensive exercise- and sport changes the heart of an athlete. Research led by Amsterdam UMC shows that the hearts of female athletes have different characteristics than those of male athletes. Whereas a thickening in combination with a dilation of the heart muscle is characteristic in male top athletes, dilation of the heart chambers is mainly seen in female elite athletes. An important observation that can help doctors to better distinguish between normal sports-related changes and possible heart disease ...