RUB-Researchers from the Chair for Biophysics have developed a new method for the detailed study of the interaction between pharmaceuticals and their target proteins. The pharmaceutical industry has already taken notice of the new infrared spectroscopy technique; the method is supposed to be implemented to investigate pharmacological agent-protein interactions in the EU project K4DD, which is supported by various major European pharmaceutical companies. "We now have a tool in our hands with which we can research the dynamics of pharmacologically interesting proteins in ...

Jerusalem, Sept. 3, 2012 – Researchers at the Hebrew University of Jerusalem have discovered that a neuronal pathway -- part of the autonomic nervous system -- reaches the bones and participates in the control of bone development. The newly discovered pathway has a key role in controlling bone density during adolescence, which in turn determines the skeletal resistance to fracture throughout one's entire life, say the researchers. They emphasize that understanding the mechanisms connecting the brain and the bones could have implications for possible future therapies ...

Using a new method, diabetes researchers at Lund University, Sweden, have been able to reveal more of the genetic complexity behind type 2 diabetes. The new research findings have been achieved as a result of access to human insulin-producing cells from deceased donors and by not only studying one gene variant, but many genes and how they influence the level of the gene in pancreatic islets and their effect on insulin secretion and glucose control of the donor. "With this approach, we can explain 25 per cent of variations in blood sugar levels. Previously, the best studies ...

The aim of the study was to assess the applicability across Europe of a generic framework for the professional development of researchers based on the Vitae Researcher Development Framework (RDF). The RDF is a UK-context framework set up with the purpose to better define researcher's professional profiles and to develop guidance for the continuous professional development of researchers. The report reveals that there is a real demand among researchers for a more structured approach towards researcher´s professional development and active career planning. This new ESF-co-funded ...

HEIDELBERG, 3 September 2012 – Scientists from the United States and Sweden have discovered a new control point that could be important as a drug target for the treatment of diabetes and other metabolic diseases. A-kinase anchoring proteins or AKAPs are known to influence the spatial distribution of kinases within the cell, crucial enzymes that control important molecular events related to the regulation of glucose levels in the blood. In a new study published in The EMBO Journal, the team of researchers led by Simon Hinke and John Scott reveal for the first time that AKAPs ...

A centralized prescription network providing real-time information to pharmacists in British Columbia, Canada, resulted in dramatic reductions in inappropriate prescriptions for opioid analgesics and benzodiazepines, widely used and potentially addictive drugs. The findings are reported in a study in CMAJ (Canadian Medical Association Journal). The study found that PharmaNet, a real-time prescription system implemented in BC pharmacies in July 1995, reduced potentially inappropriate prescriptions for opioids and benzodiazepines in two groups of patients — those on social ...

To promote good parenting, Canada should remove section 43 of its Criminal Code because it sends the wrong message that using physical punishment to discipline children is acceptable, argues Dr. John Fletcher, Editor-in-Chief, CMAJ (Canadian Medical Association Journal) in an editorial. Section 43 of the Criminal Code of Canada states "…a parent is justified in using force by way of correction…if the force does not exceed what is reasonable under the circumstances." The debate over whether spanking children is acceptable as a disciplinary tool for parents or whether ...

Tumor growth is dependent on interactions between cancer cells and adjacent normal tissue, or stroma. Stromal cells can stimulate the growth of tumor cells; however it is unclear if tumor cells can influence the stroma. In the September issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth. Honami Naora and colleagues found that expression of HOXA9 was correlated with poor outcomes in cancer patients and ...

Ovarian cancer cells hijack surrounding tissues to enhance tumor growth Tumor growth is dependent on interactions between cancer cells and adjacent normal tissue, or stroma. Stromal cells can stimulate the growth of tumor cells; however it is unclear if tumor cells can influence the stroma. In this issue of the Journal of Clinical Investigation, researchers at MD Anderson Cancer Center report that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor growth. Honami Naora and colleagues found that expression ...

Alexandria, VA – "Warm" and "Antarctica" are not commonly used in the same sentence; however, for scientists, "warm" is a relative term. A team of researchers has discovered that, contrary to previous thinking, the Antarctic continent has experienced periods of warmth since the onset of its most recent glaciation. Lodged in ocean sediment nearly 20 million years old, ancient pollen and leaf wax samples taken from the Ross Ice Shelf suggest that two brief warming spells, each of which lasted less than 30,000 years, punctuated the omnipresent cold of Antarctica. Warm, ...

A study led by researchers at the UC San Diego Stem Cell Research program and funded by the California Institute for Regenerative Medicine (CIRM) looks at an important RNA binding protein called LIN28, which is implicated in pluripotency and reprogramming as well as in cancer and other diseases. According to the researchers, their study – published in the September 6 online issue of Molecular Cell – will change how scientists view this protein and its impact on human disease. Studying embryonic stem cells and somatic cells stably expressing LIN28, the researchers defined ...

An interdisciplinary team of researchers at Vanderbilt University have developed a way to combine the photosynthetic protein that converts light into electrochemical energy in spinach with silicon, the material used in solar cells, in a fashion that produces substantially more electrical current than has been reported by previous "biohybrid" solar cells. The research was reported online on Sep. 4 in the journal Advanced Materials and Vanderbilt has applied for a patent on the combination. "This combination produces current levels almost 1,000 times higher than we were ...

LEXINGTON, Ky. (Sept. 4, 2012) — A new study by University of Kentucky researchers shows promise for developing ultrastable RNA nanoparticles that may help treat cancer and viral infections by regulating cell function and binding to cancers without harming surrounding tissue. The study, published in Nano Today, was carried out in the laboratory of Peixuan Guo, the William S. Farish Endowed Chair in Nanobiotechnology at the UK Markey Cancer Center, in collaboration with Dr. Mark Evers, director of the UK Markey Cancer Center. The study uses RNA (ribonucleic acid) as ...

Vienna, Austria: Sleep apnoea severity has been associated with increased cancer mortality in a new study. The research, which will be presented today (Tuesday 4 September 2012) at the European Respiratory Society's (ERS) Annual Congress in Vienna, adds to evidence presented earlier this year highlighting a link between severe sleep apnoea and cancer. Two further studies presented at the ERS Congress, also show evidence suggesting an increase in cancer incidence among sleep apnoea patients and an association between the spread of cancer and sleep apnoea. In the first ...

Vienna, Austria: The prevalence of smoking in Christchurch, New Zealand, increased following the 2010 earthquake, according to a new study. The results of the study will be presented today (4 September 2012) at the European Respiratory Society's Annual Congress in Vienna. The 7.1-magnitude Christchurch earthquake, and subsequent aftershocks, have caused a huge amount of damage and dramatically changed the social, working and living conditions for residents in the city. To investigate the effects of the disaster on smoking levels, researchers from the Canterbury ...

Vienna, Austria: Exposure to volcanic ash can increase respiratory symptoms such as an extreme cough, or phlegm, according to a new study. The research, which will be presented today (4 September 2012) at the European Respiratory Society's Annual Congress in Vienna, investigated the effects of living close to the Icelandic Volcano, Eyjafjallajökull. Eyjafjallajökull erupted in April 2010 and created a huge ash cloud which spread across Europe, causing widespread disruption to air travel on the continent. Researchers from the University of Iceland have now examined ...

EAST LANSING, Mich. — Witch hunts are common and sometimes deadly in the tea plantations of Jalpaiguri, India. But a surprising source – small groups of women who meet through a government loan program – has achieved some success in preventing the longstanding practice, a Michigan State University sociologist found. Soma Chaudhuri spent seven months studying witch hunts in her native India and discovered that the economic self-help groups have made it part of their agenda to defend their fellow plantation workers against the hunts. "It's a grassroots movement and it's ...

SEATTLE – A team of scientists led by a bone marrow transplant researcher at Fred Hutchinson Cancer Research Center has shed new light on why most bone marrow transplant patients who receive tissue-matched cells from unrelated donors still suffer acute graft-versus-host disease (GVHD). The answer appears to lie in the discovery of previously undetected genetic differences in the DNA of patients and unrelated marrow donors. The laboratory-based study findings by Effie Petersdorf, M.D., and colleagues soon will be translated to the clinic when a Hutchinson Center transplant ...

Los Angeles, CA (September 4, 2012) While the effects of sexualized media on young women has long been debated, a new study finds that women who read sex-related magazine articles from popular women's magazines like Cosmopolitan are less likely to view premarital sex as a risky behavior. Additionally, the women who are exposed to these articles are more supportive of sexual behavior that both empowers women and prioritizes their own sexual pleasure. This study was published in a recent article from Psychology of Women Quarterly (published by SAGE). Study authors Janna ...

Might it one day be possible to transmit electricity from an offshore wind turbine to land-based users without any loss of current? Materials known as "high temperature" superconductors (even though they must be maintained at -140°C!), which can conduct electricity without any losses, were supposed to make this dream a reality. But over the past twenty-five years, scientists have not been able to make any progress in this area. Research being done in EPFL's Laboratory for Quantum Magnetism (LQM) could change that. Their study of magnetism at extremely small scales could ...

Released en masse, sterile Mexican fruit flies can undermine a wild population of the fruit-damaging pests so that fewer applications of insecticide are needed. But the irradiation used to sterilize the flies weakens them, hindering their ability to outcompete wild-type males for female mates. Now, U.S. Department of Agriculture (USDA) and collaborating scientists have devised a hormone therapy for making sterile flies "more macho," improving their chances of mating with female flies before their wild rivals do. Peter Teal, a chemist with USDA's Agricultural Research ...

Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress. "We discovered common variants in the HACE1 and LIN28B genes that increase the risk of developing neuroblastoma. For LIN28B, these variants also appear to contribute to the tumor's progression once it forms," said ...

Coastline recession The anticipated rise in sea levels due to climate change will result in coastlines receding worldwide through erosion. This is a known phenomenon that can in principle be calculated and predicted based on a given sea-level rise, by means of the so-called Bruun effect. However, things are a little more complicated when it comes to coastlines in the vicinity of inlets, such as river mouths, lagoons and estuaries. These places are affected by other factors, such as changes in rainfall due to climate change, and certain compensating effects (basin infilling). Accurate ...

A lone rooster sees a lot of all the hens in the flock, but the hen with the largest comb gets a bigger dose of sperm - and thus more chicks. This sounds natural, but behind all this is humanity's hunger for eggs. For thousands of years, people have tinkered with the development of domestic chickens. Through selective breeding for a few characteristics such as large muscle mass and increased egg-laying, we have at the same time caused numerous other radical changes in appearance and behaviour. A research group at Linköping University in Sweden has now shown how the size ...

A new fungal species, called 'Hebelomagriseopruinatum', has now officially been included in the list of species. The fungus, whose name can be translated into 'the grey-dewy tear leaf', was discovered on Zealand in Denmark during a mushroom-hunting tour headed by postdoc Jacob Heilman-Clausen from the University of Copenhagen. During a mushroom-hunting excursion in 2009, postdoc Jacob Heilman-Clausen from the Center for Macroecology, Evolution and Climate at the Department of Biology, University of Copenhagen, was handed a very interesting looking fungus. Following ...