Researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R (HuR) protein and the malignancy of Hepatocellular Carcinoma, through a novel molecular process in the investigation of this pathology and known as neddylation. The project provides new opportunities for making advances in the quest for personalised therapeutic applications in the treatment for Hepatocarcinoma. Hepatocellular Carcinoma (HCC) is the cause of most liver cancers, the ...

DETROIT – Having diabetes may cause women to experience a greater degree of hearing loss as they age, especially if the metabolic disorder is not well controlled with medication, according to a new study from Henry Ford Hospital in Detroit. Women between the ages of 60 and 75 with well-controlled diabetes had better hearing than women with poorly controlled diabetes, with similar hearing levels to those of non-diabetic women of the same age. The study also shows significantly worse hearing in all women younger than 60 with diabetes, even if it is well controlled. Men, ...

A new system for delivering a drug to organ transplant patients, which could avoid the risk of harmful side effects, is being developed by scientists at the University of Strathclyde in Glasgow. The drug, cyclosporine (CsA), is widely used in transplant operations and helps prevent the patient's body rejecting the organ but it can cause adverse drug reactions, of which the most serious problems are kidney and liver damage, in the doses which are currently administered in the long term. The gap between a safe, effective dose of the treatment and a toxic dose is extremely ...

Multiple sclerosis (MS), a neurodegenerative disease, causes periodic attacks of neurologic symptoms such as limb weakness and mobility defects. And while MS patients' walking abilities and muscle strength are examined on a regular basis, doctors have yet to determine when the lower limb muscles begin to deteriorate. That's important because with earlier identification of mobility problems, doctors would be able to implement early intervention programs that could make all the difference for those with MS. Now, Dr. Alon Kalron and his fellow researchers from Tel Aviv ...

Scientists have found that micron-size particles which are trapped at fluid interfaces exhibit a collective dynamic that is subject to seemingly unrelated governing laws. These laws show a smooth transitioning from long-ranged cosmological-style gravitational attraction down to short-range attractive and repulsive forces. The study by Johannes Bleibel from the Max Planck Institute for Intelligent Systems in Stuttgart, Germany, and his colleagues has just been published in the journal EPJ E¹ . The authors used so-called colloidal particles that are larger than molecules ...

(WASHINGTON, January 26, 2012) – The American Society of Hematology (ASH), the world's largest professional society concerned with the causes and treatment of blood disorders, today issued a policy statement opposing mandatory screening of athletes for sickle cell trait as a prerequisite to athletic participation and urging athletics programs to adopt universal preventive interventions in their training programs to protect athletes from exertion-related illness and death. ASH's position is in direct contrast to a policy enacted in 2010 by the National Collegiate Athletic ...

HOUSTON — Scientists have connected two signature characteristics of pancreatic cancer, identifying a self-perpetuating "vicious cycle" of molecular activity and a new potential target for drugs to treat one of the most lehal forms of cancer. The research, reported in the journal Cancer Cell and led by scientists at The University of Texas MD Anderson Cancer Center, connected the molecular dots between: Mutated versions of Kras, a gene that acts as a molecular on-off switch but gets stuck in the "on" position when mutated. Heightened activity of a protein complex called ...

A hallmark of the individual is the cultivation of personal interests, but for some people, their intellectual pursuits might actually be genetically predetermined. Survey results published by Princeton University researchers in the journal PLoS ONE suggest that a family history of psychiatric conditions such as autism and depression could influence the subjects a person finds engaging. Although preliminary, the findings provide a new look at the oft-studied link between psychiatric conditions and aptitude in the arts or sciences. While previous studies have explored ...

A patient's body mass index (BMI) may not be the only factor at play when a physician diagnoses a patient as obese. According to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health, the diagnosis could also depend on the weight of your physician. Researchers examined the impact of physician BMI on obesity care and found that physicians with a normal BMI, as compared to overweight and obese physicians, were more likely to engage their obese patients in weight loss discussions (30 percent vs. 18 percent) and more likely to diagnose a patient ...

DETROIT – Performing CT scans in the emergency department for patients experiencing dizziness may not be worth the expense – an important finding from Henry Ford Hospital researchers as hospitals across the country look for ways to cut costs without sacrificing patient care. According to the Henry Ford study, less than 1 percent of the CT scans performed in the emergency department revealed a more serious underlying cause for dizziness – intracranial bleeding or stroke – that required intervention. The findings suggest that it may be more cost effective for hospitals ...

The earth is alive, asserts a revolutionary scientific theory of life emerging from Case Western Reserve University School of Medicine. The trans-disciplinary theory demonstrates that purportedly inanimate, non-living objects—for example, planets, water, proteins, and DNA—are animate, that is, alive. With its broad explanatory power, applicable to all areas of science and medicine, this novel paradigm aims to catalyze a veritable renaissance. Erik Andrulis, PhD, assistant professor of molecular biology and microbiology, advanced his controversial framework in his manuscript ...

COLUMBUS, Ohio – A new study comparing the carbon-holding power of freshwater wetlands has produced measurements suggesting that wetlands in temperate regions are more valuable as carbon sinks than current policies imply, according to researchers. The study compared several wetlands at two Ohio wetland sites: one composed of mostly stagnant water and one characterized by water regularly flowing through it. The study showed that the stagnant wetland had an average carbon storage rate per year that is almost twice as high as the carbon storage rate of the flow-through wetland. In ...

Researchers at Queen's University in Kingston, Canada have identified a possible cause for the loss of a tumour suppressor gene (known as PTEN) that can lead to the development of more aggressive forms of prostate cancer. "This discovery gives us a greater understanding of how aggressive prostate cancer develops because we now have some insight into the mechanism by which the PTEN gene is destroyed," says Jeremy Squire, a professor in the Department of Pathology and Molecular Medicine. PTEN is one of a small class of tumor suppressor genes that closely regulates the ...

RIVERSIDE, Calif. – Does antimatter behave differently in gravity than matter? Physicists at the University of California, Riverside have set out to determine the answer. Should they find it, it could explain why the universe seems to have no antimatter and why it is expanding at an ever increasing rate. In the lab, the researchers took the first step towards measuring the free fall of "positronium" – a bound state between a positron and an electron. The positron is the antimatter version of the electron. It has identical mass to the electron, but a positive charge. ...

Asian women who consumed an average of 200 milligrams or more of caffeine a day—the equivalent of roughly two cups of coffee—had elevated estrogen levels when compared to women who consumed less, according to a study of reproductive age women by researchers at the National Institutes of Health and other institutions. However, white women who consumed 200 milligrams or more of caffeine a day had slightly lower estrogen levels than women who consumed less. Black women who consumed 200 milligrams or more of caffeine a day were found to have elevated estrogen levels, but ...

NEW YORK – January 26, 2012 – When a firm experiences a negative shock – e.g. a drop in revenues, loss of the CEO – it will face difficulties when raising new debt for many reasons. The most obvious reason for this difficulty is that the fundamentals of the firm are weaker and lenders recognize that there is less chance the firm can generate the necessary cash flows to repay the loan. Another primary reason is that a lender may worry that the bad news will scare off other creditors and will drive the firm into bankruptcy. This leads to the possibility of inefficient "creditor ...

Bethesda, MD – In his State of the Union address, President Barack Obama presented the nation with a new economic blueprint which includes maintaining our commitment to funding research and development that can improve our quality of life. Noting that "innovation also demands basic research," the President urged Congress not to gut investments in the nation's research budgets. He also pointed out that students come from all over the world to train at American research institutions. "Don't let other countries win the race for the future. Support the same kind of research ...

Montreal, January 26, 2011 – 'Stand by me' is a common refrain when it comes to friendship but new research from Concordia University proves that the concept goes beyond pop music: keeping friends close has real physiological and psychological benefits. The presence of a best friend directly affects children going through negative experiences, as reported in the recent Concordia-based study, which was published in the journal Developmental Psychology and conducted with the collaboration of researchers at the Cincinnati Children's Hospital Medical Center and the University ...

DURHAM, N.H. – People with disabilities trying to find employment in the U.S. hospitality industry face employers who are often reluctant to hire them because of preconceived notions that they cannot do the job and that they are more costly to employ that people without disabilities, according to new research from the University of New Hampshire. UNH researchers Andrew Houtenville, associate professor of economics and research director of the UNH Institute on Disability, and Valentini Kalargyrou, assistant professor of hospitality management, analyzed data from 320 ...

In a study that holds major implications for breast cancer research as well as basic cell biology, scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered a rotational motion that plays a critical role in the ability of breast cells to form the spherical structures in the mammary gland known as acini. This rotation, which the researchers call "CAMo," for coherent angular motion, is necessary for the cells to form spheres. Without CAMo, the cells do not form spheres, which can lead to random motion, loss ...

MIT researchers have discovered that certain photosynthetic ocean bacteria need to beware of viruses bearing gifts: These viruses are really con artists carrying genetic material taken from their previous bacterial hosts that tricks the new host into using its own machinery to activate the genes, a process never before documented in any virus-bacteria relationship. The con occurs when a grifter virus injects its DNA into a bacterium living in a phosphorus-starved region of the ocean. Such bacteria, stressed by the lack of phosphorus (which they use as a nutrient), have ...

Lab scientists and international collaborators have created the shortest, purest X-ray laser pulses ever achieved, fulfilling a 45-year-old prediction and ultimately opening the door to new medicines, devices and materials. The researchers, reporting today (Jan. 26) in Nature, aimed radiation from Linac Coherent Light Source (LCLS), located at the Stanford Linear Accelerator Center (SLAC), at a cell containing neon gas, setting off an avalanche of X-ray emissions to create a new "atomic X-ray laser." "X-rays give us a penetrating view into the world of atoms and ...

GALVESTON, Jan. 26, 2012 – Discoveries made in some underwater caves by Texas &M University at Galveston researchers in the Bahamas could provide clues about how ocean life formed on Earth millions of years ago, and perhaps give hints of what types of marine life could be found on distant planets and moons. Tom Iliffe, professor of marine biology at the Texas A&M-Galveston campus, and graduate student Brett Gonzalez of Trabuco Canyon, Calif., examined three "blue holes" in the Bahamas and found that layers of bacterial microbes exists in all three, but each cave had specialized ...

PASADENA, Calif.—A key feature of human and animal brains is that they are adaptive; they are able to change their structure and function based on input from the environment and on the potential associations, or consequences, of that input. For example, if a person puts his hand in a fire and gets burned, he learns to avoid flames; the simple sight of a flame has acquired a predictive value, which in this case, is repulsive. To learn more about such neural adaptability, researchers at the California Institute of Technology (Caltech) have explored the brains of insects and ...

Could depression in adulthood be tied to a parent's level of education? A new study led by Amélie Quesnel-Vallée, a medical sociologist from McGill University, suggests this is the case. Drawing from 29 years of data from the National Longitudinal Survey of Youth 1979 (NLSY79), Quesnel-Vallée and co-author Miles Taylor, an assistant professor in the Department of Sociology at Florida State University, looked at pathways between a parent's education level and their children's education level, household income and depressive symptoms. The team found that higher levels ...