Steroid hormone receptor prefers working alone to shut off immune system genes
Researchers at Emory University School of Medicine have obtained a detailed molecular picture that shows how glucocorticoid hormones shut off key immune system genes. The finding could help guide drug discovery efforts aimed at finding new anti-inflammatory drugs with fewer side effects. The results are scheduled for publication Sunday, Dec. 9 by the journal Nature Structural & Molecular Biology. Synthetic glucocorticoid hormones – for example, prednisone and dexamethasone -- are widely used to treat conditions such as allergies, asthma, autoimmune diseases and cancer. ...
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