​A melanoma is a malignant form of skin cancer and is one of the most aggressive types of tumors there is. Treatment is particularly difficult, because melanomas are usually resistant against conventional chemotherapy treatments. Agnieszka Gembarska and Chris Marine (VIB/KU Leuven) have found a new line of approach in which to treat these aggressive skin cancers, namely by combating the interaction between the protein MDM4 and the tumor suppressor p53. Their research offers a new angle for the development of medication and confirms that combination therapies – including ...

Philadelphia, PA, July 23, 2012 – Anxiety disorders affect approximately 40 million American adults each year, and although they are treatable, they often cause significant distress. The excessive fear and dread that accompanies anxiety disorders clearly influences the everyday decision-making processes of anxious individuals. Despite its importance, "there is surprisingly little research on how anxiety disorders influence decisions," commented neuroscientist Dr. Elizabeth Phelps, who co-authored this new review with Dr. Catherine Hartley, both of New York University. ...

The world's largest review of all the evidence on the best way of managing and treating common pre-cancerous and cancerous conditions of the oesophagus (gullet) has found that good endoscopy equipment, more endoscopic surgery, and more tissue sampling are required to improve care for patients. The multi-national team of researchers led by Professor Janusz Jankowski of the Blizard Institute of Cell and Molecular Science at Queen Mary, University of London (UK), reviewed nearly 12,000 papers on the care and treatment of Barrett's Dysplasia and early-stage oesophageal adenocarcinoma. ...

The volcanic region of La Garrotxa, with some forty volcanic cones and some twenty lava flows, is considered to be the best conserved region in the Iberian Peninsula. It is also the youngest volcanic area. Although the approximate age of some of these volcanic constructions is known, one of the main problems when studying volcanoes is to pinpoint the chronology of each of their eruptions. Several geochronological studies have been conducted, but existing data is scarce and imprecise. With regard to the chronology of the Croscat Volcano, considered one of the most recent ...

TAMPA, Fla. (Jul. 23, 2012) – In an article published in the current issue of Technology and Innovation- Proceedings of the National Academy of Inventors® (https://www.cognizantcommunication.com/journal-titles/technology-a-innovation?page=shop.product_details&flypage=flypage.tpl&product_id=56&category_id=16), Janet Gongola, Patent Reform Coordinator for the U.S. Patent and Trademark Office (USPTO), describes the process of implementing the America Invents Act (2011, H,R. 1249), the first patent law reform in 60 years. "The America Invents Act is the foundation for a 21st ...

How much ash will be injected into the atmosphere during Earth's next volcanic eruption? Recent eruptions have demonstrated our continued vulnerability to ash dispersal, which can disrupt the aviation industry and cause billions of dollars in economic loss. Scientists widely believe that volcanic particle size is determined by the initial fragmentation process, when bubbly magma deep in the volcano changes into gas-particle flows. But new Georgia Tech research indicates a more dynamic process where the amount and size of volcanic ash actually depend on what happens afterward, ...

AUGUSTA, Ga. – A new and powerful class of antioxidants could one day be a potent treatment for Parkinson's disease, researchers report. A class of antioxidants called synthetic triterpenoids blocked development of Parkinson's in an animal model that develops the disease in a handful of days, said Dr. Bobby Thomas, neuroscientist at the Medical College of Georgia at Georgia Health Sciences University and corresponding author of the study in the journal Antioxidants & Redox Signaling. Thomas and his colleagues were able to block the death of dopamine-producing brain ...

CAMBRIDGE, Mass. -- Public health crises of the past decade — such as the 2003 SARS outbreak, which spread to 37 countries and caused about 1,000 deaths, and the 2009 H1N1 flu pandemic that killed about 300,000 people worldwide — have heightened awareness that new viruses or bacteria could spread quickly across the globe, aided by air travel. While epidemiologists and scientists who study complex network systems — such as contagion patterns and information spread in social networks — are working to create mathematical models that describe the worldwide spread of disease, ...

Amsterdam, The Netherlands, July 23, 2012 – American ginseng is reported to have neurocognitive effects, and research has shown benefits in aging, central nervous system disorders, and neurodegenerative diseases. The challenges of incorporating ginseng into food are twofold: it has a bitter taste, and food processing can eliminate its healthful benefits. Reporting in the August issue of the Journal of Dairy Science®, a group of scientists has formulated low-lactose functional milk that maintained beneficial levels of American ginseng after processing. An exploratory ...

WASHINGTON, DC/LONDON (July 23, 2012) – A novel approach to discover the first new tuberculosis (TB) combination drug regimen cleared a major hurdle when Phase II clinical trial results found it could kill more than 99 percent of patients' TB bacteria within two weeks and could be more effective than existing treatments, according to a study published today in the Lancet. These results add to a growing body of evidence that the new regimen could reduce treatment by more than a year for some patients. The findings from researchers and the non-profit TB Alliance raise hope ...

Neural precursor cells (NPC) in the young brain suppress certain brain tumors such as high-grade gliomas, especially glioblastoma (GBM), which are among the most common and most aggressive tumors. Now researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité – Universitätsmedizin Berlin have deciphered the underlying mechanism of action with which neural precursor cells protect the young brain against these tumors. They found that the NPC release substances that activate TRPV1 ion channels in the tumor cells and subsequently induce the ...

COLUMBUS, Ohio - In a new study that has implications for distracted drivers, researchers found that people are better at juggling some types of multitasking than they are at others. Trying to do two visual tasks at once hurt performance in both tasks significantly more than combining a visual and an audio task, the research found. Alarmingly, though, people who tried to do two visual tasks at the same time rated their performance as better than did those who combined a visual and an audio task - even though their actual performance was worse. "Many people have this ...

Scientists have discovered a potential cause of Earth's "icehouse climate" cooling trend of the past 45 million years. It has everything to do with the chemistry of the world's oceans. "Seawater chemistry is characterized by long phases of stability, which are interrupted by short intervals of rapid change," says geoscientist Ulrich Wortmann of the University of Toronto, lead author of a paper reporting the results and published this week in the journal Science. "We've established a new framework that helps us better interpret evolutionary trends and climate change ...

(Edmonton) A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals. U of A chemistry researcher Frederick West and his team have developed compounds that clear prions from infected cells derived from the brain. "When these designer molecules were put into infected cells in our lab experiments, the numbers of misfolded proteins diminished—and in some cases we couldn't detect any remaining misfolded prions," ...

Parents are increasingly conscious of the dangers of childhood obesity. There is a growing recognition of health problems associated with extra pounds, including the risk of diabetes, heart disease, and joint and muscle pain. New research from Tel Aviv University has revealed another significant reason for children to maintain a healthy weight. Dr. Ari Shamiss and Dr. Adi Leiba of TAU's Sackler Faculty of Medicine and the Sheba Medical Center and their fellow researchers found that obesity in adolescence, defined as a Body Mass Index (BMI) in the 85th percentile and ...

Researchers at the Center for Laser Applications at the University of Tennessee Space Institute in Tullahoma have developed a technology that goes on a "seek and destroy" mission for cancerous tumors. They have harnessed the power of lasers to find, map and non-invasively destruct cancerous tumors. Christian Parigger, associate professor of physics, and Jacqueline Johnson, associate professor of mechanical, aerospace, and biomedical engineering, along with Robert Splinter of Splinter Consultants, have developed the invention. The technology uses a femtosecond laser, ...

Aspirin use appears to reduce the risk of Barrett's esophagus (BE), the largest known risk factor for esophageal cancer, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association. "The protective effect of aspirin use appears robust because the analyses suggests a dose-response relationship in which high-dose aspirin was significantly associated with decreased Barrett's esophagus risk," said Chin Hur, MD, MPH, of the Massachusetts General Hospital Institute for Technology ...

A University of Connecticut researcher and his team have discovered that a species of tiny aquatic organism prominent in harmful algal blooms sometimes called "red tide" is even deadlier than first thought, with potential consequences for entire marine food chains. Professor Hans Dam and his research group in the school's Department of Marine Sciences have discovered that the plankton species Alexandrium tamarense contains not one but two different types of toxins, one that's deadly to large organisms and one that's deadly to small predators. "If it's killing multicellular ...

Toronto, Canada – Neuroscientists have found strong evidence that vivid memory and directly experiencing the real moment can trigger similar brain activation patterns. The study, led by Baycrest's Rotman Research Institute (RRI), in collaboration with the University of Texas at Dallas, is one of the most ambitious and complex yet for elucidating the brain's ability to evoke a memory by reactivating the parts of the brain that were engaged during the original perceptual experience. Researchers found that vivid memory and real perceptual experience share "striking" similarities ...

PROVIDENCE, R.I. [Brown University] — A new study finds that mice have a distinct neural subsystem that links the nose to the brain and is associated with instinctually important smells such as those emitted by predators. That insight, published online this week in Proceedings of the National Academy of Sciences, prompts the question whether mice and other mammals have specially hardwired neural circuitry to trigger instinctive behavior in response to certain smells. In the series of experiments and observations described in the paper, the authors found that nerve cells ...

Premature babies are more likely to survive when they are born in high-level neonatal intensive care units (NICUs) than in hospitals without such facilities, and this benefit is considerably larger than previously reported. The likelihood that an extremely premature baby will survive if born in a high-technology, high-volume hospital unit was already known, but the current study, the largest to date, revealed a stronger effect. Pediatric researchers who analyzed more than 1.3 million premature births over a 10-year span found that the survival benefits applied not only ...

(Boston) - Researchers from Boston University School of Medicine (BUSM) in partnership with Indian researchers and HIV positive networks groups, have found that in India, non-disclosure of HIV serostatus to sex partners among both HIV-infected female sex workers (FSWs) and HIV-infected clients of FSWs is exceedingly common. These findings currently appear online in the journal AIDS and Behavior. No previous studies in India specifically, and few internationally, have assessed FSWs' and male clients' disclosure of HIV status to sex partners. Disclosure of HIV serostatus ...

A paleontological team that includes scientists from the American Museum of Natural History; University of California, Santa Barbara; and Case Western Reserve University has described two ancient species of South American rodents, including the oldest chinchilla, a discovery that substantiates what might be the earliest grasslands in the world. The two new species lived near a chain of volcanoes about 32.5 million years ago in what are now the steep slopes of a river valley in the Chilean Andes. Studies of the teeth of the ancient chinchilla support evidence from other ...

WASHINGTON (July 23, 2012) – A new study conducted by GW School of Medicine and Health Sciences (SMHS) researchers Edward C. De Fabo, Ph.D., Frances P. Noonan, Ph.D., and Anastas Popratiloff, M.D., Ph.D., has been published in the journal Nature Communications. Their paper, entitled "Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment," was published in June 2012. "This is the first time that UV-induced melanin formation (tanning), traditionally thought to protect against skin cancer, is shown to be directly involved in melanoma ...

CLEMSON, S.C. — Clemson University plant breeders announced a new high-yielding variety of oats. Named Graham, the new variety grows to medium height, withstands falling over (lodging), matures earlier and produces more seed than comparable varieties. "Graham has excellent seed yield potential, exceeding the Rodgers variety by 20 bushels per acre at some locations and produces a 32.2-pound bushel compared to 31.9-pound bushel for Rodgers," said Chris Ray, director of the S.C. Crop Improvement Association, which grows certified seed for sale to the public. The new ...