Models used for predicting the likelihood of individuals developing chronic kidney disease and for predicting disease progression in people who already have the condition are useful tools but not yet robust enough to help inform clinical guidelines, according to a study published in this week's PLOS Medicine. Chronic kidney disease is a common but serious condition which can lead to kidney failure. The condition cannot be cured but progression of the disease can be slowed by controlling high blood pressure and diabetes, both causes of chronic kidney disease, and by adopting ...

In this week's PLOS Medicine, Charles Weijer and colleagues present the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials, which aims to provide researchers and research ethics committees with detailed guidance on the ethical design, conduct, and review of CRTs. ### Funding: This work was supported by the Canadian Institutes of Health Research (grant numbers MOP85066, MOP89790). CW and JMG hold Tier I Canada Research Chairs. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the ...

New drugs derived from components of a specific diet used by children with severe, drug-resistant epilepsy could offer a new treatment, according to research published today in the journal Neuropharmacology. Scientists from Royal Holloway, in collaboration with University College London, have identified specific fatty acids that have potent antiepileptic effects, which could help control seizures in children and adults. The discovery could lead to the replacement of the ketogenic diet, which is often prescribed for children with severe drug-resistant epilepsy. The ...

Scientists from Queen Mary, University of London have sequenced the genetic code of a birch tree for the first time, which could help protect British birch populations. The genome, which is around 450 million letters, will help researchers understand the genetic basis of traits such as disease resistance and growth shape. There are over sixty species of birch trees around the world, with huge ecological and commercial importance. They are an essential part of the Boreal forest located around the North Pole, which is the world's largest land-based ecosystem. The team ...

It appears that it's not just us Brits who are fascinated with the UK weather. A group of researchers from Germany has taken to investigating the potential changes in extreme rainfall patterns across the UK as a result of future global warming and has found that in some regions, the time of year when we see the heaviest rainfall is set to shift. The study, published today, 21 November, in IOP Publishing's journal Environmental Research Letters, finds that between 2061 and 2100, the south-east of the country will likely experience its most extreme rainfall later in the ...

Research: Muscular strength in male adolescents and premature death: cohort study of one million participants Low muscle strength in adolescence is strongly associated with a greater risk of early death from several major causes, suggests a large study published on bmj.com today. The effect is similar to well established risk factors for early death like being overweight or having high blood pressure, leading the authors to call for young people, particularly those with very low strength, to engage in regular physical activity to boost their muscular fitness. High ...

Research: General health checks in adults for reducing morbidity and mortality from disease: Cochrane systematic review and meta-analysis Editorial: The value of conducting periodic health checks Researchers have found that routine general health checks, which have become common practice in some countries, do not reduce the number of deaths from cardiovascular disease or cancer. They do, however, increase the number of new diagnoses. Health checks were defined as screening for more than one disease or risk factor in more than one organ system offered to a general ...

How flowers have evolved particular colours, shapes and scents to attract pollinators has long fascinated ecologists. Now, using artificial flowers and high-speed video, researchers have gained intriguing insights into the intimate relationship between hummingbirds and the flowers they pollinate. The study, published in the British Ecological Society's journal Functional Ecology, is the first to measure how much energy hummingbirds use while hovering to feed from flowers of different orientation. Hummingbirds are among the smallest and most brightly-coloured birds on Earth, ...

Research: Sharing of clinical trial data among trialists: a cross sectional survey Nearly nine out of ten clinicians carrying out biomedical research trials believe that trial data should be shared more easily, even though they do express some practical concerns, a study published today on bmj.com reveals. BMJ has long championed transparency in medical research. Last month, the journal launched an open data campaign to compel greater accountability in healthcare, and from January 2013, it will require a commitment from trialists to make their data available on reasonable ...

Boston, MA — A new rapid test for tuberculosis (TB) could substantially and cost-effectively reduce TB deaths and improve treatment in southern Africa—a region where both HIV and tuberculosis are common—according to a new study by Harvard School of Public researchers. "This test is one of the most significant developments in TB control options in many years," said lead author Nicolas Menzies, a PhD candidate in health policy at Harvard School of Public Health. "Our study is the first to look at the long-term consequences of this test when incorporated into routine health ...

An FDA-approved drug initially used to treat insulin resistance in diabetics has shown promise as a way to improve cognitive performance in some people with Alzheimer's disease. Working with genetically engineered mice designed to serve as models for Alzheimer's, University of Texas Medical Branch at Galveston researchers found that treatment with the anti-insulin-resistance drug rosiglitazone enhanced learning and memory as well as normalized insulin resistance. The scientists believe that the drug produced the response by reducing the negative influence of Alzheimer's ...

(Santa Barbara, Calif.) –– When your neighbor asks to borrow a cup of sugar and you readily comply, is your positive response a function of the give and take that characterize your longstanding relationship? Or does it represent payment –– or prepayment –– for the cup of sugar you borrowed last week, or may need to borrow a month from now? Adrian Jaeggi, a postdoctoral researcher in anthropology at UC Santa Barbara, and a junior research fellow at the campus's SAGE Center for the Study of the Mind, is studying this question of reciprocity, using chimpanzees and bonobos ...

A medical researcher with the University of Alberta and his team just published their findings about their work on developing 'homing beacon drugs' that kill only cancer cells, not healthy ones, thanks to nano-technology. John Lewis, the Frank and Carla Sojonky Chair in Prostate Cancer Research with the Faculty of Medicine & Dentistry, published his findings in the peer-reviewed journal, Nano Letters. He is also an associate professor in the Department of Oncology, a Fellow with the National Institute for Nanotechnology at the U of A and director of the Translational Prostate ...

This press release is available in German. Flowers need water and light to grow. Even children learn that plants use sunlight to gather energy from earth and water. Members of Professor Dr. Olaf Kruse's biological research team at Bielefeld University have made a groundbreaking discovery that one plant has another way of doing this. They have confirmed for the first time that a plant, the green alga Chlamydomonas reinhardtii, not only engages in photosynthesis, but also has an alternative source of energy: it can draw it from other plants. This finding could also have ...

CHESTNUT HILL, MA (Nov. 20, 2012) – The executive pay provisions of the TARP – the Troubled Asset Relief Program – stoked controversy. Bankers claimed the rules would thwart their efforts to attract and retain the best executives. But the pay rules may have had an unintended benefit of reducing the scope of the program, researchers say. A newly published report in the Journal of Banking, Finance & Accounting finds that pay provisions did discourage some banks from participating in TARP, which was intended to help banks weather the 2008-2009 financial crisis, according ...

Some grey seal mums adopt risky tactics when it comes to the future of their young, a strategy that can give their pup a real advantage, according to scientists. Researchers from Durham University, UK, and the University of St Andrews, looking at grey seal colonies in Scotland, found that some seal mothers are flexible in the parenting style they adopt and 'gamble' on the outcome of their actions, whilst other play it safe and steady. The study is the first to demonstrate how variation in personality traits in large marine mammals in the wild can persist, rather than ...

WASHINGTON, Nov. 20, 2012 — The American Chemical Society (ACS) today launched a new video series that highlights headline-making research from the society's suite of more than 40 peer-reviewed scientific journals. The first episode of Breakthrough Science focuses on research reported in one of those journals, ACS Nano. It involved development of new transparent solar cells, an advance toward giving windows in homes and other buildings the ability to generate electricity while still allowing people to see outside. The video is available at http://pubs.acs.org/page/videos/breakthroughscience.html. Breakthrough ...

Providence, RI - - Electroconvulsive therapy (ECT) is considered the most effective treatment option for patients with severe depression who cannot find symptom relief through antidepressant medications or psychotherapy. In a new study, researchers at Butler Hospital and Bradley Hospital in Rhode Island found a sharp decline in the availability and use of ECT in general hospitals across the U.S. The findings were published online in the journal Biological Psychiatry on October 10, 2012. The researchers analyzed data from a nationally representative survey of US general ...

Health professionals may soon have a new method of diagnosing Parkinson's disease, one that is noninvasive and inexpensive, and, in early testing, has proved to be effective more than 90 percent of the time. In addition, this new method has the potential to track the progression of Parkinson's, as well as measure the effectiveness of treatments for the disorder, said Rahul Shrivastav, professor and chairperson of Michigan State University's Department of Communicative Sciences and Disorders and a member of the team developing the new method. It involves monitoring a ...

Called BRIGHTs, the tiny probes described in the online issue of Advanced Materials on Nov. 15, bind to biomarkers of disease and, when swept by an infrared laser, light up to reveal their location. Tiny as they are, the probes are exquisitely engineered objects: gold nanoparticles covered with molecules called Raman reporters, in turn covered by a thin shell of gold that spontaneously forms a dodecahedron. The Raman reporters are molecules whose jiggling atoms respond to a probe laser by scattering light at characteristic wavelengths. The shell and core create an ...

The risk of developing pelvic inflammatory disease (PID) following insertion of an intrauterine device (IUD) is very low, whether or not women have been screened beforehand for gonorrhea and chlamydia, according to a joint study of nearly 60,000 women by researchers at the University of California, San Francisco (UCSF), and Kaiser Permanente Northern California Division of Research. The study appears this week in the current online issue of Obstetrics & Gynecology, the official journal of the American College of Obstetricians and Gynecologists, also known as Green Journal. The ...

WINSTON-SALEM, N.C., – Nov. 20, 2012 – Researchers at Wake Forest Baptist Medical Center have modified electrically-conductive polymers, commonly used in solar energy applications, to develop revolutionary polymer nanoparticles (PNs) for a medical application. When the nanoparticles are exposed to infrared light, they generate heat that can be used to kill colorectal cancer cells. The study was directed by Assistant Professor of Plastic and Reconstructive Surgery, Nicole H. Levi-Polyachenko, Ph.D., and done in collaboration with colleagues at the Center for Nanotechnology ...

UNIVERSITY PARK, Pa. -- "And don't let the bed bugs bite" is no longer a harmless adage. In reality today, these bloodthirsty bugs infest thousands of homes. According to a team of Penn State entomologists, biopesticides -- naturally occurring microorganisms -- might provide an answer to this pest problem. Bed bugs need blood meals for growth and development throughout their life cycle. Increased travel, widespread insecticide resistance and changes in management practices have caused a resurgence in those insects throughout North America and Europe. Compounding the problem ...

WEST LAFAYETTE, Ind. – Scotch tape, a versatile household staple and a mainstay of holiday gift-wrapping, may have a new scientific application as a shape-changing "smart material." Researchers used a laser to form slender half-centimeter-long fingers out of the tape. When exposed to water, the four wispy fingers morph into a tiny robotic claw that captures water droplets. The innovation could be used to collect water samples for environmental testing, said Babak Ziaie, a Purdue University professor of electrical and computer engineering and biomedical engineering. The ...

Children with Prader-Willi syndrome may receive relief from sleep disorders after undergoing an adenotonsillectomy, suggests a new study from Nationwide Children's Hospital published in the November print issue of the Archives of Otolaryngology-Head and Neck Surgery. "Patients with Prader-Willi syndrome are at risk for sleep disordered breathing as growth hormone commonly used to treat their condition can cause the tonsils and adenoids to enlarge," said the study's lead author Kris Jatana, MD, FAAP, with Otolaryngology Head & Neck Surgery at Nationwide Children's. "Growth ...