SCOTTSDALE, Ariz. — A new cancer drug combination demonstrated significant improvement in overall survival of late-stage pancreatic cancer patients compared to those receiving standard treatment, according to results of a Phase III clinical trial led by physicians from Scottsdale Healthcare's Virginia G. Cancer Center Clinical Trials, a partnership with the Translational Genomics Research Institute (TGen). Physicians at the Virginia G. Piper Cancer Center at Scottsdale Healthcare were first to design a clinical trial to determine the safety, tolerability and effectiveness ...

Countless studies demonstrate the virtues of complete smoking cessation, including a lowered risk of disease, increased life expectancy, and an improved quality of life. But health professionals acknowledge that quitting altogether can be a long and difficult road, and only a small percentage succeed. Every day, doctors are confronted with patients who either cannot or will not quit, says Vicki Myers, a researcher at Tel Aviv University's Sackler Faculty of Medicine. To address this reality, Myers and her fellow researchers, Dr. Yariv Gerber and Prof. Uri Goldbourt of ...

TORONTO, ON – Astrophysicists at the University of Toronto and other institutions across the United States, Europe and Asia have discovered a 'super-Jupiter' around the massive star Kappa Andromedae. The object, which could represent the first new observed exoplanet system in almost four years, has a mass at least 13 times that of Jupiter and an orbit somewhat larger than Neptune's. The host star around which the planet orbits has a mass 2.5 times that of the Sun, making it the highest mass star to ever host a directly observed planet. The star can be seen with the naked ...

AUSTIN, Texas — "Zero- tolerance" policies that rely heavily on suspensions and expulsions hinder teens who have been arrested from completing high school or pursuing a college degree, according to a new study from The University of Texas at Austin. In Chicago, 25,000 male adolescents are arrested each year. One quarter of these arrests occurred in school, according to the Chicago Police Department. The stigma of a public arrest can haunt an individual for years — ultimately stunting academic achievement and transition into adulthood, says David Kirk, associate professor ...

The structure and processes of United Nations climate negotiations are "antiquated", unfair and obstruct attempts to reach agreements, according to research published today. The findings come ahead of the 18th UN Climate Change Summit, which starts in Doha on November 26. The study, led by Dr Heike Schroeder from the University of East Anglia (UEA) and the Tyndall Centre for Climate Change Research, argues that the consensus-based decision making used by the United Nations Framework Convention on Climate Change (UNFCCC) stifles progress and contributes to negotiating ...

When a paralyzed person imagines moving a limb, cells in the part of the brain that controls movement still activate as if trying to make the immobile limb work again. Despite neurological injury or disease that has severed the pathway between brain and muscle, the region where the signals originate remains intact and functional. In recent years, neuroscientists and neuroengineers working in prosthetics have begun to develop brain-implantable sensors that can measure signals from individual neurons, and after passing those signals through a mathematical decode algorithm, ...

By fabricating graphene structures atop nanometer-scale "steps" etched into silicon carbide, researchers have for the first time created a substantial electronic bandgap in the material suitable for room-temperature electronics. Use of nanoscale topography to control the properties of graphene could facilitate fabrication of transistors and other devices, potentially opening the door for developing all-carbon integrated circuits. Researchers have measured a bandgap of approximately 0.5 electron-volts in 1.4-nanometer bent sections of graphene nanoribbons. The development ...

New nanoparticle tricks and resets immune system in mice with MS First MS approach that doesn't suppress immune system Clinical trial for MS patients shows why nanoparticle is best option Nanoparticle now being tested in Type 1 diabetes and asthma CHICAGO --- In a breakthrough for nanotechnology and multiple sclerosis, a biodegradable nanoparticle turns out to be the perfect vehicle to stealthily deliver an antigen that tricks the immune system into stopping its attack on myelin and halt a model of relapsing remitting multiple sclerosis (MS) in mice, according ...

Reporters, please see "For news media only" box at the end of the release for embargoed sound bites of researchers. In a mouse model of multiple sclerosis (MS), researchers funded by the National Institutes of Health have developed innovative technology to selectively inhibit the part of the immune system responsible for attacking myelin—the insulating material that encases nerve fibers and facilitates electrical communication between brain cells. Autoimmune disorders occur when T-cells—a type of white blood cell within the immune system—mistake the body's own tissues ...

(SACRAMENTO, Calif.) -- An international team of geneticists, pediatricians, surgeons and epidemiologists from 23 institutions across three continents has identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis ― premature closure of the bony plates of the skull. "We have discovered two genetic factors that are strongly associated with the most common form of premature closure of the skull," said Simeon Boyadjiev, professor of pediatrics and genetics, principal investigator for the study and leader of the International ...

The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening, according to Yale School of Medicine researchers. Published in the Nov. 18 issue of Nature, the study paves the way for assessing the extent of gene variation, and for better understanding human development and disease. "We found that humans are made up of a mosaic of cells with different genomes," ...

STANFORD, Calif. — Whether you are an apple tree or an antelope, survival depends on using your energy efficiently. In a difficult or dangerous situation, the key question is whether exerting effort — sending out roots in search of nutrients in a drought or running at top speed from a predator — will be worth the energy. In a paper to be published online Nov. 18 in Nature, Karl Deisseroth, MD, PhD, a professor of bioengineering and of psychiatry and behavioral sciences at Stanford University, and postdoctoral scholar Melissa Warden, PhD, describe how they have isolated ...

STANFORD, Calif. — Stanford University School of Medicine scientists have demonstrated, in a study conducted jointly with researchers at Yale University, that induced-pluripotent stem cells — the embryonic-stem-cell lookalikes whose discovery a few years ago won this year's Nobel Prize in medicine — are not as genetically unstable as was thought. The new study, which will be published online Nov. 18 in Nature, showed that what seemed to be changes in iPS cells' genetic makeup — presumed to be inflicted either in the course of their generation from adult cells or during ...

Young children who attend daycare on a regular basis are 50% more likely to be overweight compared to those who stayed at home with their parents, according to a study by researchers at the University of Montreal and the CHU Sainte-Justine Hospital Research Centre. "We found that children whose primary care arrangement between 1.5 and 4 years was in daycare-center or with an extended family member were around 50% more likely to be overweight or obese between the ages of 4-10 years compared to those cared for at home by their parents," said Dr. Marie-Claude Geoffroy, who ...

Decreased kidney function is associated with decreased cognitive functioning in areas such as global cognitive ability, abstract reasoning and verbal memory, according to a study led by Temple University. This is the first study describing change in multiple domains of cognitive functioning in order to determine which specific abilities are most affected in individuals with impaired renal function. Researchers from Temple, University of Maine and University of Maryland examined longitudinal data, five years apart, from 590 people. They wanted to see how much kidney function ...

A drug commonly prescribed to help patients sleep in hospitals has been associated with an increased risk of falls, according to a study published in the Journal of Hospital Medicine. U.S. sleep specialists from the Mayo Clinic found that the fall rate among the 4,962 patients who took zolpidem during their hospital stay was more than four times as high as the 11,358 who did not take the drug. They also found that the risk posed by the drug was greater than the risks posed by factors such as age, cognitive impairment, delirium or insomnia, regardless of the dosage used. "Ensuring ...

PHOENIX, Ariz. — A program at Mayo Clinic using telemedicine technology is showing promise for patients with concussions in rural Arizona. A case study published in the December 2012 issue of Telemedicine and e-Health validates "teleconcussion" as a useful means to assess concussed patients. In the case study, doctors at Mayo Clinic in Arizona conducted a live audio-video evaluation of a 15-year-old soccer player in Show Low, Ariz., who received a concussion during a game. The teleconcussion evaluation, believed to be the first in the state to use telemedicine for concussions, ...

UNIVERSITY OF CALIFORNIA, BERKELEY'S HAAS SCHOOL OF BUSINESS – As a corporate responsibility consultant, Kellie McElhaney publicly criticized Apple's recent appointment of another man to an already all-male executive team. McElhaney's new research goes one step further, indicating that the number of women on a corporate board correlates with a firm's sustainability performance. "While not studied in this paper, the cases of strong ESG performance leading to improved financial and more women in leadership leading to better financial performance has been well documented," ...

Time marches relentlessly forward for you and me; watch a movie in reverse, and you'll quickly see something is amiss. But from the point of view of a single, isolated particle, the passage of time looks the same in either direction. For instance, a movie of two particles scattering off of each other would look just as sensible in reverse – a concept known as time reversal symmetry. Now the BaBar experiment at the Department of Energy's (DOE) SLAC National Accelerator Laboratory has made the first direct observation of a long-theorized exception to this rule. Digging ...

According to the World Health Organization, COPD was the fifth leading cause of death worldwide in 2002 and is estimated to be the third leading cause by 2030 [WHO, 2010]. Are you a current or ex-smoker are suffering from a new or increased shortness of breath, cough, or congestion? If have COPD, Bronchitis, Emphysema or suffer from these symptoms this trial may fit for you. Chronic obstructive pulmonary disease (COPD) has been defined as a preventable and treatable disease with some significant extra-pulmonary effects that may contribute to the severity in individual ...

myASDF (www.myASDF.org), a national organization that provides direct support for children living with autism, has helped make life better for Ryan McGrath and his family. Ryan was diagnosed with an autism spectrum disorder when he was very young, and has since required specialized care to assist him in developing the necessary skills typically acquired by children in the natural course of social interaction and learning. The incidence of autism has been steadily growing in the United States, as the Centers for Disease Control now report that one out of every 88 ...

Josh Silvers, the founder of Wicked Catch (and http://www.wickedcatchgear.com), is a 26 year old Florida native. He has been a graphic designer for 7 years and grew up near the Tampa Bay area where he acquired a passion for fishing because of the easy access he has had to these great fresh and saltwater Florida fisheries. When asked how Wicked Catch got started, Josh stated "Wicked Catch was brought to reality through a single vision I had in 2009, which was to one day combine my graphic design career with my passion for fishing and form an apparel company to create ...

What's the best way to attract customers to your business? Until recently, the standard answer was first, rank well on Google. Second, rank well on Google. A distant third, consider other promotion platforms as a supplement. Business owners could spend a bit of effort on a website, twiddle with keywords, link exchanges, articles, and a blog, then watch the ranks, clicks, and sales grow. At least, that was the idea. Those standard steps are now a sure way to attract the wrong kind of search engine attention -- and get banned from the ranch. Many businesses that previously ...

Eneset Group's premium website SEO Blasts recently announced the achievement of a new milestone by signing up its 500th customer. SEO Blasts is an online search engine optimization management service provider based in Australia with a global clientele. Recently, it has announced a restructuring of their prices on SEO packages in a bid to become the biggest SEO services re-seller in Australia, as announced by their newly appointed CEO Egor Pervuninski. "Our immediate goal for 2013 is to become the biggest SEO services re-seller in Australia", Mr. Pervuninski ...

After a successful LA screening at the LA Femme Film Festival and sell-out Arizona premier, inspirational film, Sacred Journey of the Heart continues for its fourth week at Harkins Camelview Theatre in Scottsdale. A new version of the inspirational film has been released and has proven to be a great success. Digital downloads and DVD will be available soon along with workshops open to the public. According to Prince "Audience members have been so gracious They have greeted me warmly after seeing my film and are thanking me for providing this healing forum for them. ...