WASHINGTON, D.C. – Three organizations representing America's research universities today launched a website that aims to inform policymakers and the public of the impact that the upcoming budget sequester would have on federal funding for university research. The organizations – the Association of American Universities (AAU), the Association of Public and Land-grant Universities (APLU) and The Science Coalition (TSC) – urge Congressional leaders and the President to act quickly to develop a comprehensive, balanced solution to America's fiscal crisis that avoids steep cuts ...

Injured patients were less likely to die in the hospital if they had alcohol in their blood, according to a study from the University of Illinois at Chicago School of Public Health -- and the more alcohol, the more likely they were to survive. "This study is not encouraging people to drink," cautions UIC injury epidemiologist Lee Friedman, author of the study, which will be published in the December issue of the journal Alcohol and is now online. That's because alcohol intoxication -- even minor inebriation -- is associated with an increased risk of being injured, he ...

KANSAS CITY, MO—Changes in how DNA interacts with histones—the proteins that package DNA—regulate many fundamental cell activities from stem cells maturing into a specific body cell type or blood cells becoming leukemic. These interactions are governed by a biochemical tug of war between repressors and activators, which chemically modify histones signaling them to clamp down tighter on DNA or move aside and allow a gene to be expressed. In the November 19, 2012, online edition of the journal Genes & Development, researchers at the Stowers Institute for Medical Research ...

It has been 25 years since the identification of two proteins that facilitate communication between nerve cells – a significant achievement that revealed a group of related proteins. In recognition of this advancement, the Journal of Biological Chemistry has published a series of articles that assess what we know about each family member in this group and where that research is headed. This superfamily was recognized in 1987 with the discoveries of the genes that encode two of its members, the GABAA and glycine receptors, and of the similarity of these proteins to the ...

PROVIDENCE, R.I. – Most people are faced with embarrassment or humiliation at some point in their lives. Maybe they get nervous before a big presentation to the bosses at work. Maybe they get a bit anxious thinking about approaching an attractive stranger at a party. But where is the line between normal shyness and social anxiety disorder? Rhode Island Hospital researcher Kristy L. Dalrymple, Ph.D., of the department of psychiatry, explores the variances between the two, and discusses the differing beliefs of over, and under-, diagnosis of social anxiety disorder (SAD) ...

JACKSONVILLE, Fla. — A novel test that measures proteins from nerve damage that are deposited in blood and spinal fluid reveals the rate of progression of amyotrophic lateral sclerosis (ALS) in patients, according to researchers from Mayo Clinic's campus in Florida, Emory University and the University of Florida. Their study, which appears online in the Journal of Neurology, Neurosurgery & Psychiatry, suggests this test, if perfected, could help physicians and researchers identify those patients at most risk for rapid progression. These patients could then be offered ...

EAST LANSING, Mich. — Support for gay marriage is growing in Michigan, mirroring changing attitudes in many parts of the United States, according to Michigan State University's State of the State Survey. A recent survey found that 56 percent of the state's residents support gay marriage while 39 percent oppose it. Two years ago, 48 percent supported gay marriage and 51 percent were opposed. "Support for gay marriage has increased in recent years, in Michigan and across the country," said Charles Ballard, MSU economics professor and director of the State of the State ...

Akron, Ohio, Nov. 19, 2012 —Working in the lab for the last few years, three generations of University of Akron polymer scientists say their mutual and passionate curiosity about science has led to their discovery of a first-of-its-kind, easily adaptable biocompatible polymer structure able to fight infection, filter water and perform a host of other functions. Darrell Reneker, 82, distinguished professor of polymer science; Matthew Becker, 37, associate professor of polymer science; and 25-year-old graduate student Jukuan Zheng developed what they call a one-size-fits-all ...

Philadelphia, Pa. (November 19, 2012) – Limits on duty hours for residents in training haven't increased the safety of one common brain operation, concludes a study in the November issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Hospitals that train neurosurgery residents have had an uptick in complication rates since the work-hour limits were introduced, according to the study led by Drs. Anand I. Rughani, of the University of Toronto, and Travis ...

Philadelphia, Pa. (November 19, 2012) – Portable bed rails marketed to "make any bed safer" actually increase the risk of injury and death, according to an article in the November 15 issue of Biomedical Safety & Standards (BS&S). A newsletter for medical device safety professionals, BS&S is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Two consumer watchdog groups have requested the Federal Trade Commission (FTC) to order one manufacturer to stop making false advertising claims regarding the safety of its portable bed rail. A front-page ...

Hydrogen, the lightest element, can easily dissolve and migrate within metals to make these otherwise ductile materials brittle and substantially more prone to failures. Since the phenomenon was discovered in 1875, hydrogen embrittlement has been a persistent problem for the design of structural materials in various industries, from battleships to aircraft and nuclear reactors. Despite decades of research, experts have yet to fully understand the physics underlying the problem or to develop a rigorous model for predicting when, where and how hydrogen embrittlement will ...

"Our analysis shows that the Norse in Greenland ate lots of food from the sea, especially seals," says Jan Heinemeier, Institute of Physics and Astronomy, Aarhus University. "Even though the Norse are traditionally thought of as farmers, they adapted quickly to the Arctic environment and the unique hunting opportunities. During the period they were in Greenland, the Norse ate gradually more seals. By the 14th century, seals made up between 50 and 80 per cent of their diet." The Danish and Canadian researchers are studying the 80 Norse skeletons kept at the University ...

SCOTTSDALE, Ariz. — A new cancer drug combination demonstrated significant improvement in overall survival of late-stage pancreatic cancer patients compared to those receiving standard treatment, according to results of a Phase III clinical trial led by physicians from Scottsdale Healthcare's Virginia G. Cancer Center Clinical Trials, a partnership with the Translational Genomics Research Institute (TGen). Physicians at the Virginia G. Piper Cancer Center at Scottsdale Healthcare were first to design a clinical trial to determine the safety, tolerability and effectiveness ...

Countless studies demonstrate the virtues of complete smoking cessation, including a lowered risk of disease, increased life expectancy, and an improved quality of life. But health professionals acknowledge that quitting altogether can be a long and difficult road, and only a small percentage succeed. Every day, doctors are confronted with patients who either cannot or will not quit, says Vicki Myers, a researcher at Tel Aviv University's Sackler Faculty of Medicine. To address this reality, Myers and her fellow researchers, Dr. Yariv Gerber and Prof. Uri Goldbourt of ...

TORONTO, ON – Astrophysicists at the University of Toronto and other institutions across the United States, Europe and Asia have discovered a 'super-Jupiter' around the massive star Kappa Andromedae. The object, which could represent the first new observed exoplanet system in almost four years, has a mass at least 13 times that of Jupiter and an orbit somewhat larger than Neptune's. The host star around which the planet orbits has a mass 2.5 times that of the Sun, making it the highest mass star to ever host a directly observed planet. The star can be seen with the naked ...

AUSTIN, Texas — "Zero- tolerance" policies that rely heavily on suspensions and expulsions hinder teens who have been arrested from completing high school or pursuing a college degree, according to a new study from The University of Texas at Austin. In Chicago, 25,000 male adolescents are arrested each year. One quarter of these arrests occurred in school, according to the Chicago Police Department. The stigma of a public arrest can haunt an individual for years — ultimately stunting academic achievement and transition into adulthood, says David Kirk, associate professor ...

The structure and processes of United Nations climate negotiations are "antiquated", unfair and obstruct attempts to reach agreements, according to research published today. The findings come ahead of the 18th UN Climate Change Summit, which starts in Doha on November 26. The study, led by Dr Heike Schroeder from the University of East Anglia (UEA) and the Tyndall Centre for Climate Change Research, argues that the consensus-based decision making used by the United Nations Framework Convention on Climate Change (UNFCCC) stifles progress and contributes to negotiating ...

When a paralyzed person imagines moving a limb, cells in the part of the brain that controls movement still activate as if trying to make the immobile limb work again. Despite neurological injury or disease that has severed the pathway between brain and muscle, the region where the signals originate remains intact and functional. In recent years, neuroscientists and neuroengineers working in prosthetics have begun to develop brain-implantable sensors that can measure signals from individual neurons, and after passing those signals through a mathematical decode algorithm, ...

By fabricating graphene structures atop nanometer-scale "steps" etched into silicon carbide, researchers have for the first time created a substantial electronic bandgap in the material suitable for room-temperature electronics. Use of nanoscale topography to control the properties of graphene could facilitate fabrication of transistors and other devices, potentially opening the door for developing all-carbon integrated circuits. Researchers have measured a bandgap of approximately 0.5 electron-volts in 1.4-nanometer bent sections of graphene nanoribbons. The development ...

New nanoparticle tricks and resets immune system in mice with MS First MS approach that doesn't suppress immune system Clinical trial for MS patients shows why nanoparticle is best option Nanoparticle now being tested in Type 1 diabetes and asthma CHICAGO --- In a breakthrough for nanotechnology and multiple sclerosis, a biodegradable nanoparticle turns out to be the perfect vehicle to stealthily deliver an antigen that tricks the immune system into stopping its attack on myelin and halt a model of relapsing remitting multiple sclerosis (MS) in mice, according ...

Reporters, please see "For news media only" box at the end of the release for embargoed sound bites of researchers. In a mouse model of multiple sclerosis (MS), researchers funded by the National Institutes of Health have developed innovative technology to selectively inhibit the part of the immune system responsible for attacking myelin—the insulating material that encases nerve fibers and facilitates electrical communication between brain cells. Autoimmune disorders occur when T-cells—a type of white blood cell within the immune system—mistake the body's own tissues ...

(SACRAMENTO, Calif.) -- An international team of geneticists, pediatricians, surgeons and epidemiologists from 23 institutions across three continents has identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis ― premature closure of the bony plates of the skull. "We have discovered two genetic factors that are strongly associated with the most common form of premature closure of the skull," said Simeon Boyadjiev, professor of pediatrics and genetics, principal investigator for the study and leader of the International ...

The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening, according to Yale School of Medicine researchers. Published in the Nov. 18 issue of Nature, the study paves the way for assessing the extent of gene variation, and for better understanding human development and disease. "We found that humans are made up of a mosaic of cells with different genomes," ...

STANFORD, Calif. — Whether you are an apple tree or an antelope, survival depends on using your energy efficiently. In a difficult or dangerous situation, the key question is whether exerting effort — sending out roots in search of nutrients in a drought or running at top speed from a predator — will be worth the energy. In a paper to be published online Nov. 18 in Nature, Karl Deisseroth, MD, PhD, a professor of bioengineering and of psychiatry and behavioral sciences at Stanford University, and postdoctoral scholar Melissa Warden, PhD, describe how they have isolated ...

STANFORD, Calif. — Stanford University School of Medicine scientists have demonstrated, in a study conducted jointly with researchers at Yale University, that induced-pluripotent stem cells — the embryonic-stem-cell lookalikes whose discovery a few years ago won this year's Nobel Prize in medicine — are not as genetically unstable as was thought. The new study, which will be published online Nov. 18 in Nature, showed that what seemed to be changes in iPS cells' genetic makeup — presumed to be inflicted either in the course of their generation from adult cells or during ...