One of our genes is apolipoprotein E (APOE), which often appears with a variation which nobody would want to have: APOEε4, the main genetic risk factor for sporadic Alzheimer's disease (the most common form in which this disorder manifests itself and which is caused by a combination of hereditary and environmental factors). It is estimated that at least 40% of the sporadic patients affected by this disease are carriers of APOEε4, but this also means that much more still remains to be studied. The researcher at the University of the Basque Country (UPV/EHU) Xabier ...

How sildenafil, the active ingredient in Viagra, can alleviate heart problems is reported by Bochum's researchers in cooperation with colleagues from the Mayo Clinic in Rochester (Minnesota) in the journal Circulation. They studied dogs with diastolic heart failure, a condition in which the heart chamber does not sufficiently fill with blood. The scientists showed that sildenafil makes stiffened cardiac walls more elastic again. The drug activates an enzyme that causes the giant protein titin in the myocardial cells to relax. "We have developed a therapy in an animal model ...

Some illnesses such as lung and stomach cancer or liver diseases which, due to the difficulty of diagnosis, have symptoms that are often confused with routine disorders. Therefore, in most cases, the disease is only detected at an advanced stage. New methods for early detection are being investigated as an urgent need. Tecnalia, through the Interreg project Medisen, is contributing to develop biosensors capable of detecting the presence of tumour markers of lung cancer in exhaled breath. This is possible because of the changes produced within the organism of an ill person, ...

Every year for Christmas, the North American Air Defence Command NORAD posts an animation on their website, in which the exact flight path of Santa Claus' sled led by reindeer Rudolf is precisely located (http://www.noradsanta.org/en/). The path of navigation satellites, however, has to be determined much more accurately than Santa's flight path, when precise ground positioning is required. GPS is the best known system of this kind, the European system Galileo is planned to be decidedly more accurate. On 10 December, seven weeks after the start of the first two Galileo ...

A mysterious line where two millipede species meet has been mapped in northwest Tasmania, Australia. Both species are common in their respective ranges, but the two millipedes cross very little into each other's territory. The 'mixing zone' where they meet is about 230 km long and less than 100 m wide where carefully studied. The mapping was done over a two-year period by Dr Bob Mesibov, who is a millipede specialist and a research associate at the Queen Victoria Museum and Art Gallery in Launceston, Tasmania. His results have been published in the open access journal ...

If all the UK's discarded wrapping paper and Christmas cards were collected and fermented, they could make enough biofuel to run a double-decker bus to the moon and back more than 20 times, according to the researchers behind a new scientific study. The study, by scientists at Imperial College London, demonstrates that industrial quantities of waste paper could be turned into high grade biofuel, to power motor vehicles, by fermenting the paper using microorganisms. The researchers hope that biofuels made from waste paper could ultimately provide one alternative to fossil ...

LEXINGTON, Ky. (Dec. 23, 2011) — The University of Kentucky Markey Cancer Center breast oncologist Dr. Suleiman Massarweh and his research team presented findings from their studies on relapse of breast cancer at the San Antonio Breast Cancer Symposium this month. The two studies aimed to characterize further risk factors for presentation with metastatic disease or risk of early metastatic relapse after initial therapy. Data for each study was collected from 1,089 patients at the UK Markey Cancer Center between January 2007 and May 2011. The studies showed that patients ...

Friday, December 23, 2011, Cleveland: Cleveland Clinic researchers have discovered three genes that increase the risk of thyroid cancer, which is has the largest incidence increase in cancers among both men and women. Research led by Charis Eng, M.D., Ph.D., Chair and founding Director of the Genomic Medicine Institute of Cleveland Clinic's Lerner Research Institute, included nearly 3,000 patients with Cowden syndrome (CS) or CS-like disease, which is related to an increased risk of breast and thyroid cancer. Mutations in the PTEN gene are the foundation of Cowden ...

That cartoon scary face – wide eyes, ready to run – may have helped our primate ancestors survive in a dangerous wild, according to the authors of an article published in Current Directions in Psychological Science, a journal of the Association for Psychological Science. The authors present a way that fear and other facial expressions might have evolved and then come to signal a person's feelings to the people around him. The basic idea, according to Azim F. Shariff of the University of Oregon, is that the specific facial expressions associated with each particular emotion ...

When an international collaboration of physicists came up with a result that punched a hole in Einstein's theory of special relativity and couldn't find any mistakes in their work, they asked the world to take a second look at their experiment. Responding to the call was Ramanath Cowsik, PhD, professor of physics in Arts & Sciences and director of the McDonnell Center for the Space Sciences at Washington University in St. Louis. Online and in the December 24 issue of Physical Review Letters, Cowsik and his collaborators put their finger on what appears to be an insurmountable ...

PROVIDENCE, R.I. [Brown University] — To track what they can't see, pilots look to the green glow of the radar screen. Now biologists monitoring gene expression, individual variation, and disease have a glowing green indicator of their own: Brown University biologists have developed a "radar" for tracking ADAR, a crucial enzyme for editing RNA in the nervous system. The advance gives scientists a way to view when and where ADAR is active in a living animal and how much of it is operating. In experiments in fruit flies described in the journal Nature Methods, the researchers ...

A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine. Prof. Irit Sagi of the Biological Regulation Department and her research group have spent years looking for ways to home in on and block members of the ...

Lightning fast and yet highly sensitive: HHblits is a new software tool for protein research which promises to significantly improve the functional analysis of proteins. A team of computational biologists led by Dr. Johannes Söding of LMU's Genzentrum has developed a new sequence search method to identify proteins with similar sequences in databases that is faster and can discover twice as many evolutionarily related proteins as previous methods. From the functional and structural properties of the identified proteins conclusions can then be drawn on the properties of ...

This release is available in Spanish. Barcelona, 23rd of December 2011.- For the first time, it has been discovered that neutrophils exist in the spleen without there being an infection. This important finding made by the research group on the Biology of B Cells of IMIM (Hospital del Mar Research Institute) in collaboration with researchers from Mount Sinai in New York, has also made it possible to determine that these neutrophils have an immunoregulating role. Neutrophils are the so-called cleaning cells, since they are the first cells to migrate to a place ...

COLUMBUS, Ohio – The quality of the emotional relationship between a mother and her young child could affect the potential for that child to be obese during adolescence, a new study suggests. Researchers analyzed national data detailing relationship characteristics between mothers and their children during their toddler years. The lower the quality of the relationship in terms of the child's emotional security and the mother's sensitivity, the higher the risk that a child would be obese at age 15 years, according to the analysis. Among those toddlers who had the lowest-quality ...

An advisory from two leading allergists, Robert Wood of the Johns Hopkins Children's Center and Scott Sicherer of Mt. Sinai Hospital in New York, urges clinicians to use caution when ordering allergy tests and to avoid making a diagnosis based solely on test results. In an article, published in the January issue of Pediatrics, the researchers warn that blood tests, an increasingly popular diagnostic tool in recent years, and skin-prick testing, an older weapon in the allergist's arsenal, should never be used as standalone diagnostic strategies. These tests, Sicherer ...

Cold Spring Harbor, N.Y. – The secret to pushing tomato plants to produce more fruit might not lie in an extra dose of Miracle-Gro. Instead, new research from Cold Spring Harbor Laboratory (CSHL) suggests that an increase in fruit yield might be achieved by manipulating a molecular timer or so-called "maturation clock" that determines the number of branches that make flowers, called inflorescences. "We have found that a delay in this clock causes more branching to occur in the inflorescences, which in turn results in more flowers and ultimately, more fruits," says CSHL ...

PROVIDENCE, R.I. -- History often seems to happen in waves – fashion and musical tastes turn over every decade and empires give way to new ones over centuries. A similar pattern characterizes the last 65 million years of natural history in North America, where a novel quantitative analysis has identified six distinct, consecutive waves of mammal species diversity, or "evolutionary faunas." What force of history determined the destiny of these groupings? The numbers say it was typically climate change. "Although we've always known in a general way that mammals respond ...

The 2007 Cosco Busan disaster, which spilled 54,000 gallons of oil into the San Francisco Bay, had an unexpectedly lethal impact on embryonic fish, devastating a commercially and ecologically important species for nearly two years, reports a new study by the University of California, Davis, and the National Oceanic and Atmospheric Administration. The study, to be published the week of Dec. 26 in the early edition of the journal Proceedings of the National Academy of Sciences, suggests that even small oil spills can have a large impact on marine life, and that common chemical ...

Internet marketing is an important component in the marketing strategy of every business, including dentists. Having a top ranking website is quite essential for bringing in new customers. That is why Avital Web, a top SEO company in Los Angeles, is now offering free dental SEO packages to qualified dentists to help them improve the ranking of their websites. Competition Fierce for Dental Practices The family dentistry office barely exists anymore. Between teeth whitening and dental implants, impressive new Invisalign technology and other cosmetic dental practices, ...

Saline, an 11 year old Kenyan girl received the first of three surgeries last week. Saline had been rejected from all major charities due to the complexity of her facial deformity. She was born with a cleft lip and palate and then infected with NOMA disease. NOMA is a flesh eating disease caused by malnutrition, poor sanitation and dehydration. Estimates show 80-90% die from the disease. Click here to see YouTube video. Dr. Leon Klempner founded Coolsmiles Orthodontics in 1978 with offices in Medford and Port Jefferson, NY. In addition to treating local patients with ...

An estimated 10 to 15 percent of the healthcare market is currently utilizing a real-time location system (RTLS) solution. Some providers may initially view RTLS as a specialty investment that is only helpful at certain types of organizations. However, the KLAS "Real-Time Location Systems (RTLS) 2011: Maximizing the ROI" study finds that 95 percent of responding organizations (ranging from facilities with 25 beds to large IDNs with thousands of beds) that use RTLS cite operational efficiency gains. Over 150 organizations shared their RTLS experiences--outlining ...

Next are excited to launch the latest schoolwear additions to their upcoming children's collection. From girls' and boys' coats right down to underwear essentials, the new arrivals include beautifully made long-lasting pieces brimming with great quality and value for money. Children from 3-16 years can go back to school in style with playground friendly fabrics which look good too. Features include stain-resistant Teflon finished skirts, shorts and trousers and non-iron school shirts. There are also adjustable waistbands throughout the range with options for slim fit ...

Infuze Mobile, Inc. today announced it has launched its new mobile app, JobChangeAlert for LinkedIn on the Appstore. JobChangeAlert will send a daily push notification to a user's iPhone or iPad with a list of LinkedIn connections in their network that have changed their jobs. "We all have hundreds if not thousands of LinkedIn contacts and it is very difficult to keep track of who is doing what," said Bharath Natarajan, CEO and co-Founder, Infuze Mobile. "JobChangeAlert will help solve this problem and will enable increased engagement with the user's professional ...

December 22nd, 2011, Modesto, Ca - College graduates face the sobering reality of entering the real working world, but one company hopes to make that foray into full-time employment a little easier. My Resume Manager is now offering following services: Federal Resume Writing Military Resume Writing Executive Resume Writing Entry and Mid Level Resumes Resumes for Professionals The company has recently unveiled college graduate resume writing. For just over one-hundred dollars, the service will create a complete, powerful and professionally written resume that will ...