Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
Gold is not necessarily precious—at least not as a coating on atomic force microscope (AFM) probes.
JILA researchers found that removing an AFM probe's gold coating—until now considered helpful—greatly improved force measurements performed in a liquid, the medium favored for biophysical studies such as stretching DNA or unfolding proteins. As described in Nano Letters,* stripping the gold from the diving-board-shaped probe, or cantilever, with a brief chemical bath improved the precision and stability of force measurements about 10-fold. The advance is expected to quickly ...