SALT LAKE CITY, March 19, 2012—Researchers from Huntsman Cancer Institute (HCI) at the University of Utah report they have discovered a method to identify cancer-causing rearrangements of genetic material called chromosomal translocations quickly, accurately, and inexpensively. A description of the method and the research results appear online in this month's issue of the EMBO Molecular Medicine journal. Many cancers result from chromosomal translocations in tumor cells. Hundreds of cancer-causing translocations have been discovered, but current methods for detecting ...

CHICAGO --- A genetic pathway previously known for its role in embryonic development and cancer has been identified as a target for systemic sclerosis, or scleroderma, therapy. The finding, discovered by a cross-disciplinary team led by John Varga, MD, John and Nancy Hughes Distinguished Professor of Rheumatology at Northwestern University Feinberg School of Medicine, was recently published in the journal Arthritis & Rheumatism. "We showed, for the first time, that the Wnt signaling pathway is abnormally activated in scleroderma patients," said Varga, who is also a physician ...

HOUSTON - Identification of a non-traditional pathway for spiriting a cancer-promoting protein into the cell nucleus points to a possible combination therapy for esophageal cancer and indicates a mechanism of resistance for new drugs that attack the Hedgehog pathway. A team of researchers at The University of Texas MD Anderson Cancer Center reports in the March 20 Cancer Cell that the mTOR molecular pathway promotes the activity of the Gli1 protein in esophageal cancer development and progression. "The Hedgehog pathway is the established, or canonical, pathway for activating ...

VIDEO: A movie was created using infrared and visible data from NOAA's GOES-13 satellite from March 17 to March 19 at 1740 UTC (1:40 p.m. EST).The GOES satellite animation shows convection... Click here for more information. Infrared and microwave satellite imagery from NASA have been providing forecasters at the National Weather Service valuable data on weather system that has potential to bring severe weather to the south central U.S. over the next several days. A large ...

Retro College Cuts, the only manufacturer in the world of throwback college basketball game shorts, announced the debut of their line of 1979 Final Four Michigan State Spartans and Indiana State Sycamores vintage bottoms. These one of a kind throwback game shorts are cut in modern lengths with quality fabric that delivers a true game weight feel for the most discerning of passionate college basketball fans. "Smart concept, solid product -- a company to keep an eye on." said Paul Lukas, apparel industry expert and owner of Uni-Watch.com. "How come nobody ...

With the Easter holidays around the corner and many families planning long car trips, car hire price comparator Carrentals.co.uk can help Mums and Dads out with a range of useful hints to make journeys easier. Gareth Robinson, Managing Director of Carrentals.co.uk, says: "It's well known that kids can get very bored on long car rides, so we're happy to help people out. By sticking to the tips we recommend parents can make sure that they enjoy rather more manageable drives!" Top Tips from Carrentals.co.uk Plan Ahead - Planning is essential - make lists ...

Philadelphia, PA, March 20, 2012 – The Canadian Journal of Cardiology has published a focused update to the Canadian Cardiovascular Society's atrial fibrillation guidelines. Atrial fibrillation is the most common cardiac arrhythmia and is a significant cause of stroke, illness in general, and death. It is, for example, the leading cause of stroke in the elderly. The past year has seen important changes in the drugs available to treat atrial fibrillation and in our understanding of their indications and complications. These changes will strongly affect how doctors treat ...

Two judo fighters face off, one in a white judogi (the traditional judo uniform) and one in blue. They reach for each other's shoulders and lock arms, in what looks like an awkward dance, before the fighter in blue throws his opponent head-over-feet onto the mat. Judo and mixed martial arts have become increasingly popular over the past few years and scientists have taken note. The two fighters were actually filmed as part of a science experiment that demonstrates how researchers can quantify exactly how the athletes are spending their energy. The video will be published ...

Driving is a privilege that should not be taken lightly. If someone loses a driver's license for a period of time due to some offense, it is important to know that continuing to drive can lead to severe consequences. It is illegal in New York to drive when your driver's license has been suspended, revoked or withdrawn by the Department of Motor Vehicles. A driver who does so can be cited for an offense called Aggravated Unlicensed Operation (AUO). The least serious level of AUO is the third degree, which applies when there are no other AUO offenses on the driver's record ...

Cameleon Software (Paris: CAM), the leader in product configurator, quotes, proposals and eCommerce software, today announced that a leading global provider of information management and electronic commerce systems for the financial services industry has chosen to implement Cameleon CPQ, beginning in the U.S. market. With Cameleon CPQ, this market leader aims to improve productivity, win rates and overall customer satisfaction. The customer offers a broad range of products and services that can be configured in myriad ways. The resulting sales proposals can span thousands ...

WASHINGTON – A supportive supervisor can keep employees in certain hazardous jobs from being absent even when co-workers think it's all right to miss work, according to new research published by the American Psychological Association. Researchers explored factors that can influence employee absenteeism and found that a job's level of risk and peer pressure were both negligible compared to the influence of the employee's supervisor. Having peers who think it's OK to miss a lot of work days influenced employees to miss more work only when the employees felt their supervisors ...

Since that time, TB researchers have assembled a significant pipeline of vaccine candidates and assessed them in clinical trials. However, to transform the field and help make licensure of new vaccines a reality, the editorial co-authors stress, scientists must investigate remaining fundamental questions, including the following: Why does infection with the TB bacterium cause active disease in some people but not others? Why does the current licensed TB vaccine, Bacille Calmette-Guérin, protect children more effectively than adults? What ...

Corcentric, a leading provider of Accounts Payable automation solutions, today announced they will be hosting a new Webinar for AP professionals titled "5 Habits of Highly Successful Accounts Payable Departments." This Webinar will take place on Thursday, March 22, 2012 at 2:00 PM ET/11:00 AM PT. This Webinar will feature Rob DeVincent, Vice President of Product Marketing for Corcentric, who will discuss which actions leading AP departments are taking to position their organizations for success. The following topics will be covered during the Webinar: - ...

We at MyVoucherCodes.co.uk love Friends (and, let's be honest, who doesn't?) The day that Joey, Rachel and the gang bid their final farewells to Central Perk was a sad day indeed. Whilst watching countless re-runs the other day, we got to thinking; even though the sitcom is no more, Sky customers in reality are never more than a few channels away from their favourite Friends stars. In its 10-series run, the show had more famous pals drop by as guest stars than a party at Elton John's house. So we got to thinking some more; even though the show is no more, can we ever ...

HostPapa 100% Green Web Hosting today announced it has become an authorized reseller of the Google Apps for Business suite of communication and collaboration tools. HostPapa offers its customers Google Apps expert consultation, setup and deployment, training, and around-the-clock support services. "HostPapa Support Services for Google Apps will help customers take full advantage of this powerful cloud office suite, by offering HostPapa's enhanced customer support and other service options," says Sylvain Patry, Senior Vice-President of Business Development ...

Brick Marketing has released an updated version of its popular SEO checklist guide. The original SEO whitepaper checklist guide was released in 2011 and received thousands of downloads. The updated version for 2012 includes information about recent changes to the industry that affect an SEO campaign. The Brick Marketing SEO checklist guide breaks the SEO process down into two phases which each include a number of steps. The first phase includes Pre-SEO tips, site structure recommendations, SEO best practice guidelines, SEO content writing advice, an outline of keyword ...

Being at the forefront of the online pawn shop industry since its launch in the middle of 2011, PawnUp.com has been accepting a wide range of valuables either for purchase or for collateral for a secured loan. Almost every month PawnUp.com has been extending the list of the items they accept, and, today, they revealed some facts about the types of items that their customers are using most often for a pawn loan or to simply sell. The list of items that PawnUp.com's customers use (and usually get the most money for) is topped with luxury watches. Next on the list is jewelry: ...

The websites are designed to assist people from Canada and the UK who bought vacation homes or investment properties in the United States during the real estate boom and who are now facing the prospect of losing those properties to nefarious lending and/or foreclosure practices. "Since June of 2011, MFI-Miami has had a 300% increase in the number of emails and phone calls from people in these two countries inquiring on how to navigate the lending and foreclosure process in places like Florida, Michigan and New York," explained MFI-Miami President Steve Dibert, ...

Los Gatos Research (LGR), the leader in precision trace gas and isotope analyzers, has introduced the world's first instrument to simultaneously and continuously provide all three stable isotope ratios (delta-13C, delta-17O, and delta-18O) for CO2, directly from ambient air samples with no pre-concentration required. With data sampling rates as fast as 10 Hz, the Triple Isotope CO2 Analyzer provides a real-time and field-portable alternative to traditional, lab-bound isotope ratio mass spectrometry (IRMS). And unlike competitive instruments that use first-generation CRDS ...

On the heels of a standing room only album-release show held at Portland's premier jazz club Jimmy Mak's, Naomi LaViolette prepares for the iTunes launch of her self-titled debut album, set for March 13, 2012. The album finds an acoustic niche between the worlds of folk singer-songwriter and jazz soulstress with ten original songs and fresh arrangements of George Gershwin's "Our Love Is Here to Stay" and Joni Mitchell's "Both Sides Now". Oregon Music News wrote, "LaViolette takes a classical jazz core and braids it together with lightly poppy ...

The Dallas SEO Company, i-rank-u.com, launches "Link and Breathe" effective immediately. The i-rank-u company owner/founder, David M Daniels, hatched the idea in February 2012 and it will become effective March 18, 2012. David saw a need to raise awareness and money for the Cystic Fibrosis Foundation in light of the exciting news from Vertex Pharmaceuticals regarding the success of VX-770 in FDA stage 3 testing. "After the FDA approved the Vertex VX-770 in late January of this year, I saw a way to help people with Cystic Fibrosis by donating money ...

Go Sun Smart is a research study sponsored by San Diego State University. The purpose of the project is to educate vacationing Americans about comprehensive sun safety techniques and skin cancer prevention. The study is funded by the National Cancer Institute, and has the potential to reach a significant portion of the US population when they are most vulnerable to skin damage from the sun. Sun Threadz will join the Go Sun Smart project in the fight against skin cancer. Employees of the project will be outfitted in sun safe attire and will visit the resorts and interface ...

Bulldog Marketing and Sales, located in New York City, now has a blog to help pet businesses succeed, from start ups to the established pet brands. John Cullen, Pet Marketing Expert, will share tips, economy related discussions on the pet industry, getting your pet product into the big box stores, online advertising techniques, and the effectiveness of traditional print ads. Interested customers can view the blog at http://www.BulldogMS.com/blog-page/. "The pet marketing industry moves really quickly," said John Cullen, owner of Bulldog Marketing and Sales. ...

Summit Legal Publishing is pleased to announce the release of "Ohio Felony Sentencing, 2012 Update." Ohio Felony Sentencing, 2012 Update, contains the text of Amended Substitute House Bill 86, as signed by the Governor, along with relevant analysis by the Ohio Legislative Service Commission. Am.Sub. H.B. 86, effective September 30, 2011, sets forth the most significant changes to Ohio's criminal and prison law in over a decade. Noteworthy amendments were made to theft threshold, drug penalty, probation, reentry plan, juvenile and numerous other criminal statutes. Ohio ...

Thunderbull Entertainment is a developer of innovative and great games primarily designed for iPhone and iPad. Our team consists of well-qualified, young and creative people who ensure that every Thunderbull game is eye-catching and provides everyone with a lot of fun. We have recently released a new game The Death Zone - compatible with iPad, available to download on iTunes. The game is full of action and fighting - and will definitely not bore the most demanding gamers: A great plague erupted in a small coastal city in the United States, the dead rising to serve some ...