Philadelphia, PA, August 8, 2011 – Researchers have gained a new understanding of the way in which growing tumors are fed and how this growth can be slowed via angiogenesis inhibitors that eliminate the blood supply to tumors. This represents a step forward towards developing new anti-cancer drug therapies. The results of this study have been published today in the September issue of The American Journal of Pathology. "The central role of capillary sprouting in tumor vascularization makes it an attractive target for anticancer therapy. Our observations suggest, however, ...

Philadelphia, PA, August 8, 2011 – Researchers have demonstrated the feasibility of focused fetal gene expression analysis of target genes found in amniotic fluid using Standardized NanoArray PCR (SNAP) technology. This analysis could be used to monitor fetal development, enabling clinicians to determine very early in pregnancy whether fetal organ systems are developing normally. The study appears today in the September issue of The Journal of Molecular Diagnostics. Using a previously developed SNAP gene panel as proof of concept, investigators from the Floating Hospital ...

Two new studies have found that smokers who tend to take their first cigarette soon after they wake up in the morning may have a higher risk of developing lung and head and neck cancers than smokers who refrain from lighting up right away. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the results may help identify smokers who have an especially high risk of developing cancer and would benefit from targeted smoking interventions to reduce their risk. Cigarette smoking increases one's likelihood of developing various types of ...

A new technique that stimulates heart muscle cells with low-energy light raises the possibility of a future light-controlled pacemaker, researchers reported in Circulation: Arrhythmia & Electrophysiology, a journal of the American Heart Association. "Electronic cardiac pacemakers and defibrillators are well established and successful technologies, but they are not without problems, including the breakage of metal leads, limited battery life and interference from strong magnetic fields," said Emilia Entcheva, Ph.D., senior author of the study and associate professor of ...

Siblings of those who have been hospitalized with potentially lethal blood clots in the legs or pelvis are more likely to also suffer the disorder than those with healthy siblings, according to research published in Circulation: Journal of the American Heart Association. The Swedish study is the first to show a direct correlation between venous thromboembolism (VTE) and family risk in a nationwide setting, sorted by age and gender. VTE consists of deep vein thrombosis (DVT), which typically involves blood clots that form in the deep veins of the leg or pelvis, and ...

An undergraduate student has overcome a major hurdle in the development of invisibility cloaks by adding an optical device into their design that not only remains invisible itself, but also has the ability to slow down light. The optical device, known as an 'invisible sphere', would slow down all of the light that approaches a potential cloak, meaning that the light rays would not need to be accelerated around the cloaked objects at great speeds ― a requirement that has limited invisibility cloaks to work only in a specified region of the visible spectrum. This ...

The development of drugs for brain-related conditions is not an efficient process; only 8% of candidate drugs that enter clinical trials gain FDA approval. A key reason for this low success rate is a lack of preclinical tests that accurately predict drug efficacy and detect unwanted side effects. But now, Jeremy Nathans and colleagues, at Johns Hopkins University School of Medicine, Baltimore, have developed a new preclinical approach that they hope can be used alongside current strategies to guide more efficient drug development for brain-related conditions. In the study, ...

EDITOR'S PICK: Drug development in the blink of an eye The development of drugs for brain-related conditions is not an efficient process; only 8% of candidate drugs that enter clinical trials gain FDA approval. A key reason for this low success rate is a lack of preclinical tests that accurately predict drug efficacy and detect unwanted side effects. But now, Jeremy Nathans and colleagues, at Johns Hopkins University School of Medicine, Baltimore, have developed a new preclinical approach that they hope can be used alongside current strategies to guide more efficient ...

Parents often ask their doctors for advice on toilet training young children, and a new article in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/site/embargo/cmaj110830.pdf summarizes current approaches and evidence to help physicians respond to these queries. "Toilet training is felt to be a natural process that occurs with development, yet very little scientific information is available for physicians who care for children," writes Dr. Darcie Kiddoo, Divisions of Pediatric Surgery and Urology, University of Alberta, Edmonton, ...

SAN FRANCISCO, CA—August 8, 2011—A scientist at the Gladstone Institutes has discovered how gene regulation can make hearts beat out of sync, offering new hope for the millions who suffer from a potentially fatal heart condition. In a paper being published this week in the online Early Edition of the Proceedings of the National Academy of Sciences, Gladstone Investigator Benoit G. Bruneau, PhD announces the identity of the molecular regulator that uses electrical impulses to synchronize each heartbeat. Abnormalities in heartbeat synchronization, called heart arrhythmias, ...

COLUMBUS, Ohio – An early phase multiple myeloma trial has unexpectedly revealed that the drug lenalidomide interacts with another protein in cells that affect its dose level in the body, say researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) who conducted the study. Lenalidomide is an anti-inflammatory drug, and more than 390 clinical trials have been initiated to study its activity in a number of cancers and other diseases. The study found that lenalidomide ...

Many people use herbal medicines believing them to be safe simply because they are 'natural'. However many of these products have potentially dangerous interactions with other drugs and can have similar side effects to conventional drugs. New research published in BioMed Central's open access journal BMC Medicine reveals that many over-the-counter herbal products do not contain any of the key information required for safe use. Despite their wholesome image, many herbal products have adverse effects and a third of users are completely unaware of any risks. Researchers ...

Many herbal remedies available over-the-counter in pharmacies and health food shops are still lacking important information needed for safe use, according to University of Leeds researchers. In April this year, a new EU law came into force regulating the sale of traditional herbal medicines, such as St John's wort and Echinacea. These products must now contain clear information on possible side effects, how they could interact with other prescribed medicines and whether people with existing illnesses should take them or not. They are clearly marked with the THR logo showing ...

Researchers at the Yerkes National Primate Research Center have shown chimpanzees have a significant bias for prosocial behavior. This, the study authors report, is in contrast to previous studies that positioned chimpanzees as reluctant altruists and led to the widely held belief that human altruism evolved in the last six million years only after humans split from apes. The current study findings are available in the online edition of Proceedings of the National Academy of Sciences. According to Yerkes researchers Victoria Horner, PhD, Frans de Waal, PhD, and their ...

PITTSBURGH, Aug. 8 – Researchers at the University of Pittsburgh School of Dental Medicine are piecing together the process of tooth enamel biomineralization, which could lead to novel nanoscale approaches to developing biomaterials. The findings are reported online this week in the Proceedings of the National Academy of Sciences. Dental enamel is the most mineralized tissue in the body and combines high hardness with resilience, said Elia Beniash, Ph.D., associate professor of oral biology, Pitt School of Dental Medicine. Those properties are the result of its unique ...

One decade after receiving implants that stimulate areas of their brains, patients with Parkinson's disease (PD) appear to sustain improvement in motor function, although part of the initial benefit wore off mainly because of progressive loss of benefit in other functions, according to a report published Online First by Archives of Neurology, one of the JAMA/Archives journals. According to background information in the article, several previous clinical studies have shown deep brain stimulation of the subthalamic nucleus (STN-DBS) for PD to be effective and safe. Studies ...

Los Angeles, CA (DATE) The gender composition of those responsible for candidate recruitment plays a crucial role in either encouraging or discouraging women candidates to run for office, according to a recent study in Political Research Quarterly (PRQ) published by SAGE on behalf of the Western Political Science Association. "Researchers Christine Cheng and Margit Tavits looked at "party gatekeepers" (local party presidents) from the five major political parties in the 2004 and 2006 Canadian national elections. Unlike the US, the nomination of party candidates for the ...

Older patients with lower rates of left ventricular ejection fraction (a measure of how well the left ventricle of the heart pumps with each contraction) appear more likely than younger patients to have significantly reduced verbal memory function, according to a report in the August issue of Archives of Neurology, one of the JAMA/Archives journals. Three decades ago, researchers began investigating the association of heart failure with cognitive decline, according to background information in the article. Thirty to 80 percent of patients with heart failure may experience ...

In patients with acute myocardial infarction (heart attack), blood loss from greater use of phlebotomy (blood drawn for diagnostic testing) appears to be independently associated with the development of hospital-acquired anemia (HAA), according to a report published Online First by Archives of Internal Medicine, one of the JAMA/Archives journals. The article is part of the journal's Less Is More series. Anemia (low red blood cell count or low hemoglobin level) is associated with greater mortality and worse health status in patients with AMI, whether the condition is chronic ...

A new risk assessment model may help predict development of advanced age-related macular degeneration, according to a report published Online First by Archives of Ophthalmology, one of the JAMA/Archives journals. Age-related macular degeneration (AMD) is a leading cause of blindness in the United States and the Western world, according to background information in the article. "As progress in designing better preventive measures and earlier treatment options accelerates and new gene associations are identified that add to currently known risk factors, the desirability ...

In patients with glaucoma, frequent visual field testing may be associated with earlier detection of the condition's progression, according to a report published Online First by Archives of Ophthalmology, one of the JAMA/Archives journals. According to background information in the article, visual field testing is one of the main ways of monitoring patients with glaucoma for progression. "Estimating rates of progression can help identify patients who are progressing at a faster pace and are therefore at serious risk of developing visual disability during their lifetime," ...

Soy isoflavone tablets do not appear to be associated with a reduction in bone loss or menopausal symptoms in women within the first five years of menopause, according to a report in the August 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. The beginning stages of menopause are often accompanied by rapid bone loss, hot flashes, vaginal dryness and sleep disturbances among other symptoms, according to background information in the article. "Estrogen therapy with or without progesterone prevents most of these changes. However, as a result of ...

Patient demand for care from safety-net providers (such as community health centers and public hospitals) in Massachusetts has increased, even though the number of patients with health insurance also increased following the state's passage of health care reform, according to a report in the August 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. The article is part of the journal's Health Care Reform series. According to background information in the article, a disproportionate share of patients who do not have health insurance obtain care ...

Some vaccines are once-in-a-lifetime; others need a booster shot or two to maintain their potency. And then there's the flu vaccine, which only lasts a year. Strains of influenza virus change so much from year-to-year that new vaccines must be developed annually to target the strains of virus that are most likely to cause illness. But Howard Hughes Medical Institute (HHMI) scientists have now discovered a human antibody that recognizes many different flu strains. Understanding more about this antibody may help scientists design a longer-lasting vaccine against the influenza ...

Washington, D.C.—Meteorites hold a record of the chemicals that existed in the early Solar System and that may have been a crucial source of the organic compounds that gave rise to life on Earth. Since the 1960s, scientists have been trying to find proof that nucleobases, the building blocks of our genetic material, came to Earth on meteorites. New research, published next week in the Proceedings of the National Academy of Sciences, indicates that certain nucleobases do reach the Earth from extraterrestrial sources, by way of certain meteorites, and in greater diversity ...