Finnish researchers found a new mechanism inhibiting the spread and growth of cancer found in motile cells It has long been held that cells use different mechanisms for regulating migration and growth. This conception was proven false by research scientists Anja Mai and Stefan Veltel from the research team of Professor Johanna Ivaska. Their findings on aggressively spreading breast cancer cells revealed – completely contrary to previous expectations – that a single cell protein (p120RasGAP) acts as an important inhibitor of both cell migration and growth. Cancer cells ...

A University of Michigan Health System-led team of researchers has found a biomarker they believe can help rapidly identify one of the most serious complications in patients with leukemia, lymphoma and other blood disorders who have received a transplant of new, blood-forming cells. Known as a hematopoietic stem cell transplant, these patients receive bone marrow or peripheral blood stem cells from a matched donor who is either a family member or an unrelated volunteer. The most common fatal complication of this type of transplant is graft-versus-host disease (GVHD), ...

In a summer with unprecedented weather events, from tornados, floods, fires and hurricanes, researchers at the University of Pennsylvania School of Nursing found that physiological changes associated with aging and the presence of chronic illness make older adults more susceptible to illness or injury, even death, during a disaster. Investigators followed 17 long-term care residents, with a mean age of 86, who were evacuated for five days due to a severe summer storm and were relocated to different facilities with different care providers and physical surroundings. The ...

Lithium-ion batteries are applied widely, but their storage capacity is limited. In the future, battery systems of enhanced energy density will be needed for mobile applications in particular. Such batteries can store more energy at reduced weight. For this reason, KIT researchers are also conducting research into alternative systems. A completely new concept for secondary batteries based on metal fluorides was developed by Dr. Maximilian Fichtner, Head of the Energy Storage Systems Group, and Dr. Munnangi Anji Reddy at the KIT Institute of Nanotechnology (INT). Metal ...

For those suffering a stroke, effective early treatment is critical in order to avoid long term complications or even death. But, stroke is commonly thought of as a condition only affecting older patients. According to a study presented at the American Stroke Association's International Stroke Conference, this misperception often leads to misdiagnosis when stroke victims seek medical attention in an emergency room setting. Nearly One in Seven Young Stroke Sufferers Misdiagnosed It is true that the typical stroke victim is at least 55 years old. However, research shows ...

Research led by St. Jude Children's Research Hospital scientists advances a strategy for taming the side effects and enhancing the therapeutic benefits of steroids and other medications that work by disrupting the activity of certain hormones. The approach relies on a small molecule developed at St. Jude. In this study, scientists showed that a compound known as SJ-AK selectively blocked the activity of genes in a cell signaling pathway regulated by thyroid hormone. Investigators showed that SJ-AK also affected cells growing in the laboratory, reducing cell proliferation ...

In a report to be published soon in EPJE¹, researchers from the National University of the South in Bahía Blanca, Argentina studied the condition for model cavity and tunnel structures resembling the binding sites of proteins to stay dry without losing their ability to react, a prerequisite for proteins to establish stable interactions with other proteins in water. E.P. Schulz and colleagues used models of nanometric-scale hydrophobic cavities and tunnels to understand the influence of geometry on the ability of those structures to stay dry in solution. The authors ...

The University of Pittsburgh Medical Center (UPMC) is known as a leading American health care provider. Yet, despite UPMC's high ranking in hospital rating publications, serious medical errors can and do occur in its facilities. In early 2011, Michael Yocabet received a kidney from longtime girlfriend Christina Mecannic in an operation performed at UPMC Presbyterian. Although the surgery was completed without incident, it was later discovered that the donated kidney was infected with hepatitis C, which was passed to Yocabet. As a result, UPMC's living kidney donor transplant ...

Athens, Ga. – A commonly prescribed blood pressure-lowering medication appears to kick start recovery in the unaffected brain hemisphere after a stroke by boosting blood vessel growth, a new University of Georgia study has found. The discovery, based on a study using rats and published recently in the online journal PLoS ONE, occurred only because the team, led by Susan Fagan, professor of clinical and administrative pharmacy at the UGA College of Pharmacy, struck a new path in stroke research by examining the healthy side of brain after the stroke occurred. "I'm ...

Reconstructive surgical approaches can help delay endoprosthetic joint replacement in patients with osteoarthritis. Henning Madry and coauthors introduce such procedures in the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2011; 108[40]: 669-77). Articular cartilage defects often develop subsequent to injury or osteoarthritis. The authors in their article provide an overview of currently available medical and surgical therapeutic options. Medical therapy aims to preserve articular function for as long as possible and to delay surgical intervention. ...

WORCESTER, Mass. — A team of researchers at the University of Massachusetts Medical School, Harvard Medical School, Stanford University and the Prince Felipe Research Centre in Spain have deciphered the complete three-dimensional structure of the bacterium Caulobacter crescentus's chromosome. Analysis of the resulting structure —published this week in Molecular Cell — has revealed new insights into the function of genetic sequences responsible for the shape and structure of this genome. Scientists know that the three-dimensional shape of a cell's chromosome plays a role ...

New research reveals how we make decisions. Birds choosing between berry bushes and investors trading stocks are faced with the same fundamental challenge - making optimal choices in an environment featuring varying costs and benefits. A neuroeconomics study from the Montreal Neurological Institute and Hospital – The Neuro, McGill University, shows that the brain employs two separate regions and two distinct processes in valuing 'stimuli' i.e. 'goods' (for example, berry bushes), as opposed to valuing the 'actions,' needed to obtain the desired option (for example flight ...

A motorcyclist was killed on Interstate 88 in Warrenville, Illinois, on his way to Chicago, when he was thrown from his bike and hit by a passing truck. At the time, Nicholas Linton was riding with a group of other cyclists on his way to Chicago when he lost control, swerved, and was thrown from his bike. The accident is still under investigation; eye witness statements give conflicting reasons for the cyclist's loss of control. On I-80, another motorcycle rider was thrown from his bike after hitting a bump in the road produced by recent road construction. The rider ...

"Picture yourself hiking through the woods or walking across a lawn," says Elizabeth Haswell, PhD, assistant professor of biology in Arts & Sciences at Washington University in St. Louis. "Now ask yourself: Do the bushes know that someone is brushing past them? Does the grass know that it is being crushed underfoot? Of course, plants don't think thoughts, but they do respond to being touched in a number of ways." "It's clear," Haswell says, "that plants can respond to physical stimuli, such as gravity or touch. Roots grow down, a 'sensitive plant' folds its leaves, and ...

Sexual harassment in the workplace has long been illegal. Title VII of the Civil Rights Act of1964 classifies sexual harassment as discrimination. The specific definition is "unwelcome verbal, visual, or physical conduct of a sexual nature that is severe or pervasive and affects working conditions or creates a hostile work environment." The EEOC, the federal agency responsible for policing discrimination in the workplace notes the following: Sexual harassment can occur in a variety of circumstances, including but not limited to the following: - The victim ...

The court uses a complex set of factors when determining a New Jersey child support award. Child support, intended to provide for the care, maintenance and education of a child, can be a hotly contested issue. In some cases, parents try to manipulate the system in an effort to receive more or pay less. While it is important to make sure that the court has all the facts when considering child support, it is also important to remember why child support exists in the first place -- to support minor children after divorce or when parents never married. The court evaluates ...

Consumers who tell little white lies to avoid confrontation might find themselves rewarding the people who inconvenienced them, according to a new study in the Journal of Consumer Research. "Most consumers have told an inquiring server that their cold meal is fine, a hairdresser that they like their unexpected 'new look,' or a friend that his/her too-snug jeans look great," write authors Jennifer J. Argo (University of Alberta) and Baba Shiv (Stanford University). But according to the researchers, white lies have negative repercussions for the people who tell them. In ...

Consumers who feel powerless will choose larger size food portions in an attempt to gain status, according to a new study in the Journal of Consumer Research. But there is hope for convincing them that a Big Gulp won't translate to higher ranking. "An ongoing trend in food consumption is consumers' tendency to eat more and more," write authors David Dubois (HEC Paris), Derek D. Rucker, and Adam D. Galinsky (both Northwestern University). "Even more worrisome, the increase in food consumption is particularly prevalent among vulnerable populations such as lower socioeconomic ...

Consumers need a little help when it comes to imagining using products, according to a new study in the Journal of Consumer Research. Sometimes that means orienting an advertisement toward a dominant hand or helping them picture using the product (like putting a spoon in a soup advertisement). "Across four studies we show that by simply orienting a product toward one's dominant (vs. non-dominant hand) in a visual advertisement leads to increases in imagined product use," write authors Ryan S. Elder (Brigham Young University) and Aradhna Krishna (University of Michigan). The ...

Consumers are more likely to choose products when marketers withhold some favorable information until late in the choice process, according to the Journal of Consumer Research. But marketers need to walk a fine line to disclose information at just the right time. "Conventional wisdom suggests that when seeking to persuade consumers to buy certain products, sellers ought to always 'put their best foot forward' by providing as much favorable information about these products as possible once they have consumers' attention," write authors Xin Ge (University of Northern British ...

The tornado that touched down in Joplin, Missouri earlier this year reminds us just how devastating natural disasters can be. This deadly tornado not only destroyed countless homes, but also decimated a number of Joplin businesses in the process. In a statement to CBS News, Rob O'Brian, president of the Joplin Area Chamber of Commerce, estimated that as many as 300 businesses were lost due to the tornado - affecting as many as 4,000 jobs. Many of the area's largest employers, including national chains and large businesses, have pledged to rebuild. Even small, local ...

People whose basic needs are met get more life satisfaction when they are more connected to others and when they experience greater autonomy, according to a new study in the Journal of Consumer Research. But those who live in dire conditions have little hope of achieving such satisfaction. "About three-fourths of the planet's population lives in nations with less than ideal material conditions, defined by low levels of marketplace abundance and lack of bargaining power necessary to access this abundance," write authors Kelly D. Martin (Colorado State University) and Ronald ...

When consumers share their thoughts about products or experiences, their opinions can intensify, according to a new study in the Journal of Consumer Research. But it depends on whether they're talking about something sensory or practical. "Consumers constantly share stories with others about products and services through word of mouth (WOM)," writes author Sarah G. Moore (University of Alberta). "How does sharing WOM change storytellers' feelings about their own experiences? Does sharing stories make consumers like the experience more or less than before? Moore asks. In ...

Despite the proliferation of social networks, many Americans feel alone and isolated. According to a new study in the Journal of Consumer Research, lonely individuals behave differently in the marketplace than people with strong social networks. "Despite the popularity of Wi-Fi technologies and social networks such as Facebook, Americans are more socially isolated than two decades ago," write authors Jing Wang (University of Iowa), Rui (Juliet) Zhu (University of British Columbia), and Baba Shiv (Stanford University). According to the authors, in 2004 almost twenty five ...

It costs 8 percent more on average than it did two years ago for Washington residents to make ends meet, according to a new report from a University of Washington research group. A single parent with one preschooler and one school-age child living in Seattle needs an annual income of $56,904 – up 13 percent from $50,268 two years ago – to meet the family's most basic requirements, according to the Self-Sufficiency Standard for Washington State 2011 released today. A similar family living in Spokane County needs $41,750, up 8 percent from $38,562 two years ago. "Even ...