Basic and translational research on cancer, and development of new cancer therapeutics, has focused on different aspects of cancer cellular function. One area of focus is the life and death of a cancer cell. Apoptosis, also known as programmed cell death, is a fundamental process of cells including cancer cells. The signal transduction pathways of apoptosis involve many different proteins and their interactions with each other. Protein-protein interactions involved in these apoptotic signals, like those in many other biological processes, are often determined or influenced ...

An international team of astronomers has identified for the first time a thick stellar disc in the Andromeda galaxy, the nearest large spiral galaxy to our own Milky Way. The discovery of the thick disc, a major result from a five-year investigation, will help astronomers better understand the processes involved in the formation and evolution of large spiral galaxies like ours, according to the team, which includes UCLA research astronomer Michael Rich and colleagues from Europe and Australia. Using the Keck Telescope in Hawaii, the astronomers analyzed the velocities ...

HOUSTON - An essential protein for normal stem cell renewal also promotes the growth of breast cancer stem cells when it's overproduced in those cells, researchers at The University of Texas MD Anderson Cancer Center report in the February edition of Cancer Cell. In mouse and lab experiments, the team also discovered that two drugs block the cascade of molecular events that they describe in the paper, thwarting formation of breast tumor-initiating cells. "Overexpression of the EZH2 protein has been linked to breast cancer progression, but the molecular details of that ...

AMES, Iowa – Automobiles, military vehicles, even large-scale power generating facilities may someday operate far more efficiently thanks to a new alloy developed at the U.S. Department of Energy's Ames Laboratory. A team of researchers at the Lab that is jointly funded by the DOE Office of Basic Energy Sciences, Division of Materials Sciences and Engineering and the Defense Advanced Research Projects Agency, achieved a 25 percent improvement in the ability of a key material to convert heat into electrical energy. "What happened here has not happened anywhere else," ...

Infrared data from NASA's AIRS instrument revealed that the low level center of Cyclone Bingiza was still over land in western Madagascar this morning, but the bulk of its rainfall was over the Mozambique Channel. When NASA's Aqua satellite flew over Madagascar this morning, Feb. 15 at 11:11 UTC (6:11 a.m. EST), the Atmospheric Infrared Sounder (AIRS) instrument read the temperatures of the cold thunderstorm cloud tops in Cyclone Bingiza. Most of the strongest thunderstorms were north and west of the center of circulation already over the Mozambique Channel, while Bingiza's ...

Australia is getting hit with two "tropical fists" as NASA satellites watch two low pressure areas develop near the Northern Territory and Western Australia. System 99S is currently strengthening near Darwin, Australia and another low pressure area called System 97S is strengthening near Western Australia. System 97S was located about 210 nautical miles north-northwest of Learmonth, Western Australia, at 1800 UTC (1 p.m. EST), Feb. 15. It was centered near 19.2 South and 112.1 East. That puts the center of System 97S well to the northwest of Exmouth. System 97S is forecast ...

NASA's Aqua satellite captured a low pressure area known as System 99S that appears to be strengthening very close to Darwin, Australia. Aqua satellite data indicated that the strongest thunderstorms were over the Timor Sea on Feb. 15. System 99S is a threat to Australia's Northern Territory because on Feb. 15 it was centered only 20 miles (32 km) south of Darwin, Australia, near 12.7 degrees South latitude and 130.7 degrees East longitude. The Joint Typhoon Warning Center gives System 99S a good chance for development in the next 24 hours, and NASA satellite imagery ...

SCOTTSDALE, Ariz. — Feb. 16, 2011 — Whole genome sequencing — spelling out a person's entire DNA genetic code — has moved one step closer to being a medical option for direct patient care. Physicians and researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) successfully completed sequencing both a single patients normal and cancer cells – a tour de force of more than 6 billion DNA chemical bases. While the whole genomes of several individuals or their cancers have been sequenced in recent years, this is believed to be among the ...

Nearly 35 percent of all the imaging costs ordered for 2,068 orthopaedic patient encounters in Pennsylvania were ordered for defensive purposes, according to a new study presented today at the 2011 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). For many years now, some physicians have ordered specific diagnostic procedures that are of little or no benefit to a patient, largely to protect themselves from a lawsuit. Until now, however, efforts to actually measure defensive medicine practices have been limited primarily to surveys sent to physicians. ...

There are three things women usually do when trying to get their ex boyfriend back, but those actions will only succeed in persuading them to run in the opposite direction. The comprehensive multimedia program by Brian Bold, "The Ex Back System," helps women avoid those pitfalls and points them in the right direction to avoiding the Valentine's Day Hangover Blues! "Women make three mistakes when a relationship breaks up," said Bold. "They act desperate, they tell their ex that this time will be different, and they constantly try to contact their ex. Instead of bringing ...

A relatively new treatment is available for difficult back pain, low back pain and neck pain in Atlanta. It is called spinal decompression. It is somewhat like traction, but more sophisticated in its engineering. The reason it usually helps patients is based on a simple, factual premise- as we age, our spines get more compressed. Eventually, this can cause pain and disability. This new spinal decompression treatment is the most effective way we have had to reverse this process. Reversing spinal compression is the most direct way to treat pain and disability that arises ...

Ann Brizolis, Southern California's top specialist in Rancho Santa Fe real Estate for sale partnered with Laguna Beach based Virtual Results to provide state-of-the-art IDX technology on her easy-to-use website last week. Designed to help Rancho Santa Fe home buyers improve their ability to research and find homes in record time, this website features innovative online technology sets Brizolis' team apart as they seek to improve and enhance the home buying experience for each and every client. "At ranchosantaferealestatefinder.com we try hard to give our clients the ...

BattleNoidz is an arcade-style fun-for-all with a unique mix of side-scrolling action and strategy! People wishing to download the app can visit http://www.pixeltactics.com or go directly to the itunes app store: (opens up itunes) For iPhone 4 http://itunes.apple.com/us/app/battlenoidz-for-iphone-4/id419246257?mt=8 For iPad http://itunes.apple.com/us/app/battlenoidz-hd/id418759445?mt=8# BattleNoidz Features: Different missions offer diverse gameplay, from search and rescue to all-out shoot 'em up! Different types of enemies, and every type of on-screen ...

ComplianceBridge, Inc., a provider of web-based policy and procedure management software announced today a new website for its web-based solution TotalCompliance and a blog delivering tips and best practices for managing policy and procedure documents. Website: http://www.compliancebridge.com Blog: http://blog.compliancebridge.com/ TotalCompliance is a cost-effective policy and procedure management software solution that enables organizations of any size to improve efficiency and compliance through automated publication, distribution, and tracking of policies, procedures ...

XBOSoft, a fast growing software quality assurance services company, announced today that Pracplay has chosen XBOSoft for functionality and UI testing of products built on Pracplay's TradeLink open source trading platform. TradeLink provides a free and open platform to quickly build, test and trade strategies and trading applications, while their value-added commercial products accelerate tradelink adoption and promote integration with 3rd party platforms. Pracplay, with its expanding range of feature rich open-source trading solutions, and growing demand, needed a reliable ...

Our Mission at Charity Promoter is to raise money and awareness for charities and nonprofits across the world. Our program is founded on the premise that people are both generous and selfish...at the same time. Americans enjoy to give, however they also like to gain personal benefit. Our program promotes both...check out the "How It Works" page at http://www.CharityPromoter.com. The basic idea of Charity Promoter is to allow people like you to donate to charities, while having an opportunity to be rewarded for doing so. For every donation you make to a featured charity ...

Motivational speaker and best-selling author Joe Roberts encouraged and inspired the administrators and members of Toastmasters District 21 last week with his inspirational "Skid Row CEO" presentation. The event took place at the Jim Pattison Pavilion in the Vancouver General Hospital in Vancouver, British Columbia, Canada on Saturday February 5th, 2011. Roberts' presentation "From Skid Row to" highlighted his unique "rags to riches" personal life story, which inspired his audience of young speakers to overcome adversity and use their speaking abilities to become leaders ...

In a market where real estate presented 2010's biggest challenge, North Star Yacht Club celebrated a very good year. Forty-two residences in the 12-story twin high rises were sold during 2010, making North Star Yacht Club Fort Myers' top selling luxury waterfront condominium community. More than 50 percent occupied, a vibrant atmosphere has evolved with active owner residents participating in various clubs, classes and on site amenities. Located along the Caloosahatchee River with a panoramic view of downtown Fort Myers from southern facing terraces, North Star Yacht ...

Dr. Marcus Williams join host Annalisa Adams-Qualtiere, President of Altruistic Leadership & Ed Harris, Leadership Consultant to discuss his leadership journey & the importance of good health. Wednesday, May 11, 9am PST—Dr Williams will share with the listening audience of Altruistic Leadership his career journey, successes, trials, triumphs, and tripping points. During this 45-minute segment, we will discuss the importance of owning your career. Callers are welcome to join the conversation during the show by calling (917) 889-3394. The LIVE, Internet talk-radio show ...

Many cleaning companies have tried to develop efficient vacuum systems using advanced filtration. Others have focused on earth friendly and chemical free products. The missing link has been combining the two methods in a single cleaning regiment that offers superior sanitation using only safe and environmentally conscience products. The president of Ways Cleaning states "We are excited to launch our new 'Green Clean' program. We seamlessly combine pet safe cleaning products, ultra high end air filtration and cutting edge mechanical dirt and debris removal. The end result ...

Renowned interior designer James Magni received highest honors when Michael S. Smith chose his Jewel Coffee Table for use in the White House renovation. Moreover, Architectural Digest's March 2011 edition features Magni's table in a high-end Manhattan apartment with luxurious interior designs also by Michael S. Smith. Magni's modern furniture line, The Magni Home Collection, can be found at MagniHomeCollection.com. The Jewel Coffee Table captures Magni's modern furniture style. A contemporary piece from the Magni's Home Collection, the featured piece is a satin finished ...

The Oasis Park Hotel, the budget friendly business hotel in Manila,recently announced that the hotel will undergo renovations to enhance their facilities and provide high quality service to its guests. The renovation of the Oasis Park Hotel will start on February 14, 2011. During the renovation period, the hotel will be closed for approximately 2 weeks until renovations are completed. The newly refurbished Oasis Park Hotel will be back to business on March 1,2011 . Among the areas that will be renovated include the newly-designed lobby to give guests a more intimate ...

A new website Withholding-tax-refund.com aims to help non-resident alien workers in the US obtain the tax refunds to which they are entitled, even if they have already left the country. Foreigners working under the J-1 visa program typically have taxes withheld by the IRS, but do not earn enough to owe any taxes at the end of the year. However many of these workers are entitled to receive anywhere from $200 up to $500 dollars per year in tax refunds yet they often fail to claim their refunds, either because they do not understand sufficiently US tax law and therefore ...

The 7 day retreat, called 7 Days + 7 Chakras focuses on integration of mind, body and soul through specialized process created by founder and director Nicholas Pratley. June 20-26, 2011 is the first of a series of transformational retreats offered by Intruessence.com. Participants will be guided through various modalities including yoga, sacred breathwork, reiki, sound/energy healing, chi-gung, chiga , mediation and sacred ceremonies. Nicholas Pratley has been practicing the healing arts for over 10 years. His Award-Winning classes and private sessions facilitate healing ...

SunPods announced today that the Company received a Letter of Intent to utilize the SunPods SOILS (Solar Operational Landfill System) for a closed municipal landfill project. Project Navigator, Ltd. (PNL) via its solar power projects development group, PVNavigator (PVN), has entered into a lease option agreement with the County of San Bernardino to begin the site evaluation to develop a 2 MW photovoltaic (PV) solar facility on their closed Big Bear Sanitary landfill located in Big Bear, CA. PNL chose SunPods solar technology as the go to approach in their original proposal ...