New York, NY [February 17, 2025]—Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier. The findings, in mouse models and isolated human brain tissue, were published in the February 17 online issue of Nature Materials [10.1038/s41563-024-02114-5]. They demonstrate the potential of this technology to pave the way for ...

In September 2018, a wildfire burned nearly two thousand hectares of shrubland on the Pichu Pichu volcano, an ecologically significant area in the Peruvian Andes. Unlike Mediterranean ecosystems, where vegetation has evolved strategies to withstand fire, the volcanic soils of Arequipa—one of the driest regions in the world—are not adapted to wildfire disturbances. A Miguel Hernández University of Elche (UMH) research team collected and analyzed soil samples from the burned area at 3,700 meters above sea level to understand how these fragile ecosystems ...

These include those linked to body image, fatherhood and sexual relationships. His latest book - Current Issues Facing Men and Boys – also argues that men struggle to negotiate harmful notions of masculinity and are not included in conversations around gender. Current Issues Facing Men and Boys urges the public, policymakers, practitioners and other key stakeholders to explore and support policies and practices that promote male wellbeing. This book comes as the UK government announces plans for the country's first men's health strategy, aiming ...

For teens who may be self-conscious about issues such as acne scarring or discolored teeth, non-surgical cosmetic procedures are an increasingly popular way to address their concerns. And some parents are supportive of this decision, a national poll suggests, with a sixth saying teenagers should be allowed to receive these types of aesthetic treatments for any reason as long as they have parental approval. But half of parents only support teens getting non-surgical cosmetic procedures if there’s a valid reason –  and their beliefs about which reasons count as valid differ –  according to ...

This September, recipients of the Abel Prize, ACM A.M. Turing Award, ACM Prize in Computing, Fields Medal, IMU Abacus Medal and the Nevanlinna Prize are invited to gather in Heidelberg to meet with 200 young researchers from all over the world at the 12th Heidelberg Laureate Forum (HLF). In order to reach a broader, more diverse and international audience, the Heidelberg Laureate Forum Foundation (HLFF) encourages journalists to cover the event and affords them the chance to interact with the preeminent scientists of mathematics and computer science. The 12th HLF will take ...

The evolutionary roots of human dominance and aggression remain central to social and political behaviour, and without conscious intervention these primal survival drives will continue to fuel inequality and division. These are the arguments of a medical professor who, as global conflicts rise and democracies face growing challenges, says understanding how dominance and tribal instincts fuel division is more critical than ever. In A New Approach to Human Social Evolution, Professor Jorge A. Colombo MD, PhD explores neuroscience, anthropology, and behavioural science to provide a new perspective on human social evolution. He argues that fundamental behavioural drives ...

A rare discovery of a nearly complete skull in the Egyptian desert has led scientists to the “dream” revelation of a new 30-million-year-old species of the ancient apex predatory carnivore, Hyaenodonta. Bearing sharp teeth and powerful jaw muscles, suggesting a strong bite, the newly-identified ‘Bastetodon’ was a leopard-sized “fearsome” mammal. It would have been at the top of all carnivores and the food chain when our own monkey-like ancestors were evolving. Findings, published in the peer-reviewed Journal of Vertebrate Paleontology, detail ...

University of Leeds news Embargoed until 05:01 GMT, 17 February Reintroducing wolves to the Scottish Highlands could lead to an expansion of native woodland which could take in and store one million tonnes of CO2 annually, according to a new study led by researchers at the University of Leeds. The team modelled the potential impact that wolves could have in four areas classified as Scottish Wild Land, where the eating of tree saplings by growing red deer populations is suppressing natural regeneration of trees and woodland. They used a predator–prey model to ...

ROCKVILLE, MD – In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that damage brain cells. The process of proteins spontaneously clumping is called protein aggregation and researchers have developed novel methods to generate aggregate-specific antibodies as specific probes or modulators of the aggregation process. This new method overcomes significant challenges in characterizing these complex and often transient protein structures. The work will be presented at the 69th Biophysical ...

ROCKVILLE, MD – Marcel P. Goldschen-Ohm, of the University of Texas at Austin, USA will be honored as the recipient of the Biophysical Journal Paper of the Year-Early Career Investigator Award at the 69th Annual Meeting of the Biophysical Society, held February 15-19 in Los Angeles, California. This award recognizes the work of outstanding early career investigators in biophysics. The winning paper is titled “GABAA Receptor Subunit M2-M3 Linkers Have Asymmetric Roles in Pore Gating and Diazepam Modulation.” The paper was published in Volume 123, Issue 14 of Biophysical Journal. GABAA receptors mediate inhibitory synaptic signaling ...

ROCKVILLE, MD – Phytoplankton, tiny plant-like organisms in the ocean, are incredibly important for life on Earth. They're a major food source for many sea creatures and produce almost half the oxygen we breathe.  They also help control the climate by soaking up a lot of carbon dioxide, a gas that contributes to global warming. Scientists want to learn more about how these phytoplankton use sunlight to make energy and oxygen, which can be useful in the context of environmental monitoring during ...

ROCKVILLE, MD – The Apennine brown bear, also known as the Marsican brown bear (Ursus arctos marsicanus), is a unique and critically endangered subspecies of brown bear found only in the remote and rugged Apennine Mountains of central Italy. A new study by the Italian Endemixit project (endemixit.com) reveals a potentially critical genetic flaw in the endangered Apennine brown bear population of Italy, offering insights that could help boost conservation efforts. The work will be presented at the 69th Biophysical Society Annual Meeting, to be held February 15 - 19, 2025 in Los Angeles. This distinct population has been isolated for centuries, evolving unique physical ...

ROCKVILLE, MD – Brain inflammation, while a crucial part of the body's immune response, takes on a detrimental role in Alzheimer's disease. Unlike the acute, short-lived inflammation that combats infection, the inflammation associated with Alzheimer's becomes chronic and persistent. Scientists have been trying to understand why this happens.  New research reveals key differences in how the brain's immune system responds to the disease compared to a bacterial infection. The work will be presented at the 69th ...

ROCKVILLE, MD – In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can modulate the heartbeat. This research opens new avenues for understanding heart function and potentially for developing novel treatments for heart failure. While taste receptors are traditionally associated with the tongue and our ability to perceive flavors, recent studies ...

ROCKVILLE, MD – Viruses, like those that cause COVID-19 or HIV, are formidable opponents once they invade our bodies. Antiviral treatments strive to block a virus or halt its replication. However, viruses are dynamic—constantly evolving and changing shape, which can make designing antiviral treatments a challenge. But new research utilizes an innovative computational modeling approach to capture the complex and diverse shapes that viral proteins can adopt. The work will be presented at the 69th Biophysical Society Annual Meeting, to be held February 15 - 19, 2025 in Los Angeles. This new approach, implemented in the open-source Integrative Modeling Platform ...

ROCKVILLE, MD – When scientists develop new molecules—whether for the purposes of agriculture, species control, or life-savings drugs—it’s important to know exactly what its targets are. Thoroughly understanding a molecule's interactions, both intended and unintended, is crucial for ensuring its safety and efficacy. A cone snail toxin known to affect both insects and fish inspired Weizmann Institute scientists to develop a new way of finding molecular targets. By combining artificial intelligence with traditional ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have developed a way to treat ageing-related muscular atrophy using regenerative medicine. Conventional methods to implant myoblasts, precursors to muscle fiber, required prior scarring for the new cells to graft properly. By adding extracellular matrix (ECM) fluid into the implant, the team successfully grafted myoblasts onto healthy muscle in mice. Their technique opens the way for using implantation to treat unscarred muscle atrophied by ageing.   Age-related muscular atrophy in skeletal muscle can have a devastating impact on people’s quality ...

Three innovative design techniques substantially enhance wireless transmitter performance and can boost power efficiency and elevate data rates concurrently, as reported by the researchers from Science Tokyo, Japan. This effectively aligns with the growing demand for speed and efficiency, accelerating the widespread deployment of wireless devices. This enables synergistic operation of wireless electronic devices and better quality of modern life.   Background: Integrating artificial intelligence (AI) into everyday life requires the interconnectedness of all electronic devices via a technology called the Internet of Things (IoT). The rapid expansion of the IoT market has ...

The clownfish-anemone living arrangement is one of the most widely recognized examples of symbiosis. Researchers have made a breakthrough in understanding how anemonefish can live safely among sea anemones without being stung by their venomous tentacles, solving a century-long mystery.   Scientists at the Okinawa Institute of Science and Technology (OIST) and their international collaborators have discovered that anemonefish have evolved to maintain very low levels of sialic acid in their skin mucus to avoid triggering the release of nematocysts (stinging cells) in ...

Sotagliflozin, a drug recently approved by the Food and Drug Administration to treat type 2 diabetes and kidney disease with additional cardiovascular risk factors, can significantly reduce heart attack and stroke among these patients, according to results from an international clinical trial led by a Mount Sinai researcher. Sotagliflozin is a sodium-glucose cotransporter (SGLT) inhibitor. It blocks the function of two proteins, known as SGLT1 and SGLT2, which move glucose and sodium across cell membranes and help control blood sugar levels. Other SGLT2 inhibitors do not as significantly block SGLT1. The study, published ...

PROVIDENCE, R.I. [Brown University] — Scientists discovered years ago that the hypothalamus — which helps to manage body temperature, hunger, sex drive, sleep and more — includes neurons that express the protein opsin 3 (OPN3). Far less clear, however, was what this light-sensing protein does so deep inside the brain. A study published in PNAS suggests that OPN3 plays an important role in regulating food consumption.  “Our results uncover a mechanism by which the nonvisual opsin ...

 New blood test could improve Alzheimer’s Disease diagnosis, research finds Up to half of all people living with Alzheimer’s Disease in Ireland remain undiagnosed. Now, a new blood test may have the potential to transform patient care, allowing for better diagnosis, earlier interventions and more targeted treatments. Researchers at Trinity College Dublin, the Tallaght Institute of Memory and Cognition and St James’s Hospital, Dublin are exploring the ability of a new blood test, plasma p-tau217, to detect Alzheimer’s Disease (AD). This test could potentially replace the current diagnostic method, a lumbar puncture/spinal tap (which ...

Cal Poly Assistant Professor Joni Roberts has been chosen, with two additional university faculty members, as the first Cal Poly Faculty Excellence Award honorees. The inaugural Faculty Excellence Award — an honor recognizing outstanding contributions in teaching, research and service — is administered by the Office of the Provost and funded by generous donor contributions. The award reflects Cal Poly’s commitment to academic excellence and its Learn by Doing philosophy.  The ...

A new Colorado State University study of the interior U.S. West has found that tree ranges are generally contracting in response to climate change but not expanding into cooler, wetter climates – suggesting that forests are not regenerating fast enough to keep pace with climate change, wildfire, insects and disease.  As the climate becomes too warm for trees in certain places, tree ranges have been expected to shift toward more ideal conditions. The study analyzed national forest inventory data for more than 25,000 plots in ...

From punch card-operated looms in the 1800s to modern cellphones, if an object has an “on” and an “off” state, it can be used to store information. In a computer laptop, the binary ones and zeroes are transistors either running at low or high voltage. On a compact disc, the one is a spot where a tiny indented “pit” turns to a flat “land” or vice versa, while a zero is when there’s no change. Historically, the size of the object making the “ones” and “zeroes” has put a limit on the size of the storage device. But now, University of Chicago Pritzker School of Molecular ...