Cold Spring Harbor, NY -- The story of the double helix's discovery has a few new twists. A new primary source -- a never-before-read stack of letters to and from Francis Crick, and other historical materials dating from the years 1950-76 -- has been uncovered by two professors at the Watson School of Biological Sciences at Cold Spring Harbor Laboratory (CSHL). The letters both confirm and extend current knowledge of the circumstances surrounding the epoch-making discovery of DNA's elegant double-helical structure, for which Crick, James D. Watson (now CSHL's chancellor ...

### Grants from the National Institutes of Health and the Food and Drug Administration supported the immunotherapy study. Grants from the National Cancer Institute, part of the National Institutes of Health, supported the study of intermediate-risk neuroblastoma. Both studies were conducted through the Children’s Oncology Group. “Anti-GD2 Antibody with GM-CSF, Interleukin-2 and Isotretinoin for Neuroblastoma,” and “Outcome after Reduced Chemotherapy for Intermediate Risk Neuroblastoma,” New England Journal of Medicine, Sept. 30, 2010. About The Children’s Hospital ...

EDITOR'S NOTE: Images to accompany this story are available at http://www.news.wisc.edu/newsphotos/river-crisis.html END ...

Multiple environmental stressors, such as agricultural runoff, pollution and invasive species, threaten rivers that serve 80 percent of the world's population, around 5 billion people, according to researchers from The City College (CCNY) of The City University of New York (CUNY), University of Wisconsin and seven other institutions. These same stressors endanger the biodiversity of 65 percent of the world's river habitats and put thousands of aquatic wildlife species at risk. The findings, reported in the September 30 issue of Nature, come from the first global-scale ...

HOUSTON -- (Sept. 29, 2010) -- A Rice University-led team of physicists is reporting the first success in a three-year effort to build a precision simulator for superconductors using a grid of intersecting laser beams and ultracold atomic gas. The research appears this week in the journal Nature. Using lithium atoms cooled to within a few billionths of a degree of absolute zero and loaded into optical tubes, the researchers created a precise analog of a one-dimensional superconducting wire. Because the atoms in the experiment are so cold, they behave according to the ...

CHAPEL HILL – An international team of researchers, including a number from the University of North Carolina at Chapel Hill schools of medicine and public health, have discovered hundreds of genes that influence human height. Their findings confirm that the combination of a large number of genes in any given individual, rather than a simple "tall" gene or "short" gene, helps to determine a person's stature. It also points the way to future studies exploring how these genes combine into biological pathways to impact human growth. "While we haven't explained all of the ...

EDITOR'S NOTE: An image and video are available at http://www.news.wisc.edu/newsphotos/macaque-mirror.html The study, with several videos of the monkeys, appears in today's PLoS One, at http://dx.plos.org/10.1371/journal.pone.0012865 END ...

New discoveries about the immune defenses of rare HIV patients who produce antibodies that prevent infection suggest a novel direction for designing new vaccines. Researchers at Rockefeller University and colleagues have now made two fundamental discoveries about the so called broadly neutralizing anti-HIV antibodies, which effectively keep the virus at bay. By detailing the molecular workings of a proven immune response, the researchers hope their work will ultimately enable them to similarly arm those who are not equipped with this exceptional immunological firepower. ...

Close relatives of women diagnosed with breast cancer before the age of 35 years are at an increased risk of developing other cancers, according to a University of Melbourne study, published in the British Journal of Cancer today. Professor John Hopper, Director of Research from the Centre for Molecular, Environmental, Genetic and Analytic Epidemiology at the University of Melbourne, Australia, a lead investigator in the study, said these are surprising and novel findings which could be pointing to the existence of a new cancer genetic syndrome. "The results suggest ...

A high protein diet during development primes the body to react unhealthily to future food binges. A study on juvenile rats, published in BioMed Central's open access journal Nutrition and Metabolism, suggests that lasting changes result from altering the composition of the first solid food that is consumed throughout growth into early adulthood. Raylene Reimer worked with a team of researchers from the University of Calgary, Canada, to carry out the weaning experiments in 18 litters of rats. Six litters were placed on each of three diets: high prebiotic fiber, high ...

SANTA CRUZ, CA--A team of planet hunters led by astronomers at the University of California, Santa Cruz, and the Carnegie Institution of Washington has announced the discovery of an Earth-sized planet (three times the mass of Earth) orbiting a nearby star at a distance that places it squarely in the middle of the star's "habitable zone," where liquid water could exist on the planet's surface. If confirmed, this would be the most Earth-like exoplanet yet discovered and the first strong case for a potentially habitable one. To astronomers, a "potentially habitable" planet ...

Boston, Mass. -- An international collaboration of more than 200 institutions, led by researchers at Children's Hospital Boston, the Broad Institute, and a half-dozen other institutions in Europe and North America, has identified hundreds of genetic variants that together account for about 10 percent of the inherited variation of height among people. Known as the GIANT (Genetic Investigation of ANthropometric Traits) Consortium, the collaboration pooled data from more than 180,000 individuals, including millions of genetic results from each of 46 separate studies in the ...

Washington, D.C. Astronomers have found a new, potentially habitable Earth-sized planet. It is one of two new planets discovered around the star Gliese 581, some 20 light years away. The planet, Gliese 581g, is located in a "habitable zone"—a distance from the star where the planet receives just the right amount of stellar energy to maintain liquid water at or near the planet's surface. The 11- year study, published in the Astrophysical Journal and posted online at arXiv.org, suggests that the fraction of stars in the Milky Way harboring potentially habitable planets could ...

CHICAGO --- A phase II clinical trial of the first new type of drug for musculoskeletal pain since aspirin shows that it significantly reduces knee pain in osteoarthritis, the most common osteoarthritis pain, according to new research from Northwestern Medicine. However, phase III trials of that drug, tanezumab, have been placed on clinical hold after 16 out of several thousand participants in the new trial developed progressively worsening arthritis and bone changes that required total joint replacements. "The bottom line is this is a very effective drug for relieving ...

September 29, 2010 ─ (BRONX, NY) ─ A seemingly simple inherited trait – height – springs from hundreds of genetic causes, according to an international team of scientists. Robert Kaplan, Ph.D., professor of epidemiology & population health at Albert Einstein College of Medicine of Yeshiva University, is co-author of a paper on the group's findings published in the September 29 online edition of Nature. The study identified hundreds of gene variants in at least 180 locations that influence adult height. These results prove that with internet technology it ...

New Haven, Conn.—The rules that govern the world of the very small, quantum mechanics, are known for being bizarre. One of the strangest tenets is something called quantum entanglement, in which two or more objects (such as particles of light, called photons) become inextricably linked, so that measuring certain properties of one object reveals information about the other(s), even if they are separated by thousands of miles. Einstein found the consequences of entanglement so unpalatable he famously dubbed it "spooky action at a distance." Now a team led by Yale researchers ...

(SACRAMENTO, Calif.) — Just months after a pharmaceutical company halted studies of tanezumab, a drug used in reducing pain and improving function in people with moderate-to-severe osteoarthritis of the knee, the results of a small, phase II clinical trial found only a few minor side effects and substantial improvement in patient conditions. The results of the 16-week study are published in the Sept. 30 issue of The New England Journal of Medicine. Other, longer-term studies have indicated that tanezumab may accelerate osteoarthritis, and the company that manufactures the ...

Research published today provides the first direct evidence that attention-deficit/hyperactivity disorder (ADHD) is a genetic condition. Scientists at Cardiff University found that children with ADHD were more likely to have small segments of their DNA duplicated or missing than other children. The study also found significant overlap between these segments, known as copy number variants (CNVs), and genetic variants implicated in autism and schizophrenia, proving strong evidence that ADHD is a neurodevelopmental disorder – in other words, that the brains of children ...

A particularly aggressive childhood cancer can be fought successfully with far less chemotherapy than previously believed, avoiding harmful side effects caused by cancer drugs. The 96 percent survival rate found in an eight-year clinical trial at the University of California, San Francisco, stands to change the approach toward fighting intermediate-risk – stage three and stage four – neuroblastoma. Neuroblastoma attacks the network of cells that control the body's response to stress, known as the sympathetic nervous system, and affects 650 children in the United States ...

Many researchers have studied the relationship between the increase in sales of new antidepressants in recent decades and a simultaneous decline in the suicide rate. In a study based on figures from the Nordic countries, researchers at the Norwegian Institute of Public Health found no evidence that increased sales of the new medicines could be linked to a lower suicide rate. The researchers also did not find any relationship between reduced sales of the older and more toxic antidepressants and a reduction in suicide rates. The suicide rate has been declining since the ...

Severe sepsis, a disease characterised by a sudden drop in blood pressure and progressive organ dysfunction following infection, remains one of the most common causes of mortality in intensive care units worldwide. Even under the best possible medical conditions, mortality rates range between 30 and 70%. A research team from the Instituto Gulbenkian de Ciência, Portugal, led by Miguel Soares, found that free heme, released from red blood cells during infection, is the cause of organ failure, leading to the lethal outcome of severe sepsis. Moreover this team found that the ...

The key to the stability of any building is its foundation, but it is difficult to test some building sites in advance – such as those on the moon. New research from North Carolina State University is helping resolve the problem by using computer models that can utilize a small sample of soil to answer fundamental questions about how soil at a building site will interact with foundations. "If you are going to build a large structure, you have to run a lot of tests on the building site to learn how the soil will behave in relation to the building's foundation," says Dr. ...

Athens, Ga. – A new University of Georgia study suggests that mothers who consume a diet high in trans fats double the likelihood that their infants will have high levels of body fat. Researchers, whose results appear in the early online edition of the European Journal of Clinical Nutrition, found that infants whose mothers consumed more than 4.5 grams of trans fats per day while breastfeeding were twice as likely to have high percentages of body fat, or adiposity, than infants whose mothers consumed less than 4.5 grams per day of trans fats. The researchers investigated ...

In an advance that may give brewers powerful new ability to engineer the flavor and aroma of beer — the world's favorite alcoholic beverage — scientists are publishing the most comprehensive deciphering of the beer's "proteome" ever reported. Their report on the proteome (the set of proteins that make beer "beer") appears in ACS' monthly Journal of Proteome Research. Pier Giorgio Righetti and colleagues say they were inspired to do the research by a popular Belgian story, Les Maîtres de l'Orge (The Brew Masters), which chronicles the fortunes of a family of brewers over ...

Traces of crude oil that linger on the shores of Alaska's Prince William Sound after the Exxon Valdez oil spill remain highly biodegradable, despite almost 20 years of weathering and decomposition, scientists are reporting in a new study. Their findings, which appear in ACS' semi-monthly journal Environmental Science & Technology, suggest a simple approach for further cleaning up remaining traces of the Exxon Valdez spill — the largest in U.S. waters until the 2010 Deepwater Horizon episode. Albert D. Venosa and colleagues note that bacteria, evaporation, sunlight, and ...