PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

MSK Research Highlights, May 24, 2024

MSK Research Highlights, May 24, 2024
2024-05-24
(Press-News.org) New research from Memorial Sloan Kettering Cancer Center (MSK) investigates a promising approach against diabetic retinopathy and finds patients with early-onset colorectal cancer likely don’t need more frequent surveillance colonoscopies.

Anti-ceramide immunotherapy promising against diabetic retinopathy, animal studies suggest Diabetic retinopathy is a condition that affects blood vessels in people with diabetes and can cause blindness. Now a new study from a team at MSK, Michigan State University, and the University of Oklahoma Health Sciences Center shows that diabetic retinopathy can be considered a “ceramidopathy” — which can be reversed with anti-ceramide immunotherapy. The group — overseen by Richard Kolesnick, MD, of the Sloan Kettering Institute, and Julia Busik, PhD, of the University of Oklahoma — found that in patients with advanced diabetic retinopathy, there is an imbalance of ceramides in the eye. Too much of these lipids leads to inflammation and cell death in the blood vessels of the eye. Moreover, the researchers showed in animal models that antibodies that act against ceramides can protect against diabetic retinopathy. Their findings suggest that targeting ceramides could be a potential treatment for diabetic retinopathy, both in the disease’s early stages to prevent progression and in more advanced stages. in Cell Metabolism.

Early-onset colorectal cancer patients don’t need more frequent surveillance colonoscopies A new study led by MSK gastroenterologist Robin Mendelsohn, MD, suggests that early-onset colorectal patients, who are diagnosed before age 50, do not require more frequent surveillance colonoscopies compared with older average-onset colorectal patients. The study included 612 early-onset patients and 647 average-onset patients, and found the younger group had a 29% lower risk of developing advanced neoplasms from the time of initial surgery to first surveillance colonoscopy — which was 12.6 months for both cohorts. Subsequent colonoscopies also showed a lower risk.

This study is believed to be the largest of its kind for early-onset patients, for whom there currently aren’t colonoscopy guidelines. The results support the idea that young patients can follow the same surveillance guidelines as older patients.  “The incidence of early onset colorectal cancer is rising,” Dr. Mendelsohn notes. “This study suggests this younger patient group does not need more aggressive surveillance, which would benefit them by reducing costs and disruptions to life and the risks posed by unneeded exams.” in Clinical Gastroenterology and Hepatology. 

END

[Attachments] See images for this press release:
MSK Research Highlights, May 24, 2024

ELSE PRESS RELEASES FROM THIS DATE:

ASCO: Large precision oncology study identifies differences in prostate cancer genomics among a racially and ethnically diverse cohort of U.S. veterans

2024-05-24
FINDINGS A new study led by a UCLA-VA collaborative team looking at the landscape of genomic alterations in more than 5,000 veterans with metastatic prostate cancer uncovered differences in the genomic makeup of cancer cells that were associated with race and ethnicity.  Although the team found that a similar set of cancer-related genes were altered in both non-Hispanic Black and non-Hispanic white veterans, the frequencies that these alterations were observed at varied significantly ...

ASCO: Combination therapy significantly improves outcomes for patients with metastatic colorectal cancer

2024-05-24
FINDINGS A study led by UCLA Health Jonsson Comprehensive Cancer Center researchers found that using a combination of experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard chemotherapy treatment when compared to those who received the targeted therapy regorafenib alone. The median progression-free survival, which is the amount of time during and after treatment when the cancer does not worsen or progress, with the combination treatment was 6.2 months compared to 2.1 months for those ...

Euclid space mission releases first scientific results and new images of the cosmos

Euclid space mission releases first scientific results and new images of the cosmos
2024-05-24
European space mission Euclid has released early scientific papers based on observations made by the space telescope, along with five new astronomical images of the Universe, as the project sets about unravelling the secrets of the cosmos. The new images are part of Euclid’s Early Release Observations (EROs) and accompany the mission’s first scientific data and 10 forthcoming science papers. Their publication comes less than a year after the space telescope’s launch and some six months after it returned its first full-colour ...

Sociodemographic heterogeneity in the associations of social isolation with mortality

2024-05-24
About The Study: Social isolation was associated with increased risks of all-cause, cardiovascular diseases, and malignant neoplasm mortality, with associations varying across populations. This study fills an important gap in research on social isolation, emphasizing its varied associations across demographic and socioeconomic groups.  Corresponding Author: To contact the corresponding author, Atsushi Nakagomi, M.D., Ph.D., email anakagomi0211@gmail.com. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.13132) Editor’s Note: Please ...

COVID-19 admission rates and changes in care quality in us hospitals

2024-05-24
About The Study: In this cross-sectional study, COVID-19 surges were associated with declines in hospital quality, highlighting the importance of identifying and implementing strategies to maintain care quality during periods of high hospital use.  Corresponding Author: To contact the corresponding author, Giacomo Meille, Ph.D., email giacomo.meille@ahrq.hhs.gov. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.13127) Editor’s Note: Please see the article for additional information, ...

Preterm and early-term delivery after heat waves in 50 US metropolitan areas

2024-05-24
About The Study: Preterm and early-term birth rates increased after heat waves, particularly among socioeconomically disadvantaged subgroups in this cohort study. Extreme heat events have implications for perinatal health.  Corresponding Author: To contact the corresponding author, Lyndsey A. Darrow, Ph.D., email ldarrow@unr.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.12055) Editor’s Note: Please see the article for additional information, including other authors, author contributions and ...

Research spotlight: Virtual scribes reduced physicians’ time spent on electronic health records

Research spotlight: Virtual scribes reduced physicians’ time spent on electronic health records
2024-05-24
Lisa Rotenstein, MD, of the Department of Medicine at Brigham and Women’s Hospital, is the lead author of a new study published in JAMA Network Open, “Virtual Scribes and Physician Time Spent on Electronic Health Records.” What question were you investigating? We sought to understand the impact of virtual scribes (human scribes who are not physically present in the exam room with the physician and patient) on how physicians spend their time and which characteristics are associated with physicians responding best to scribes. What methods or approach did you use? We studied the experiences of 144 physicians across specialties treating patients ...

Duke-NUS researchers develop new light-controlled ‘off switch’ for brain cells

Duke-NUS researchers develop new light-controlled ‘off switch’ for brain cells
2024-05-24
Researchers from Duke-NUS Medical School have found that a new class of light-sensitive proteins are capable of turning off brain cells with light, offering scientists an unprecedentedly effective tool to investigate brain function. The study, recently published in Nature Communications, opens exciting new opportunities to apply optogenetics to investigate the brain activity underlying neurodegenerative and psychiatric disorders such as Parkinson’s disease and depression. Optogenetics is a technique where specific cells are bioengineered to include light-sensitive proteins that act as switches, allowing ...

Liver lesions at risk of transformation into hepatocellular carcinoma in cirrhotic patients

Liver lesions at risk of transformation into hepatocellular carcinoma in cirrhotic patients
2024-05-24
Hepatocellular carcinoma (HCC) represents a significant global health burden as one of the most common malignancies in individuals with chronic liver disease or cirrhosis. This malignancy evolves through a multistep process, beginning with dysplastic nodules (DNs) and early HCC, progressing to overt HCC. Recent advancements in liver imaging, particularly the use of hepatocyte-specific contrast agents, have enhanced the detection of these precursor lesions, known as borderline hepatic nodules. These nodules, especially those hypointense in the hepatobiliary phase (HBP) without arterial phase hyperenhancement (APHE), present ...

Update on the STING signaling pathway in developing nonalcoholic fatty liver disease

Update on the STING signaling pathway in developing nonalcoholic fatty liver disease
2024-05-24
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, affecting about 25% of the global population due to the increasing rates of obesity and metabolic syndrome. NAFLD encompasses a spectrum of liver conditions ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite its prevalence, there are limited effective treatment options available. Inflammation driven by metabolic disturbances is a key factor in the development and progression of ...

LAST 30 PRESS RELEASES:

Discovery of spontaneous inflow and outflow states of high-temperature plasma by energetic ions

Tax the rich, say a majority of adults across 17 G20 countries surveyed

Semaglutide leads to greater weight loss in women than men with HF, improves HF symptoms in both sexes

12.5, the 1st Impact Factor of COMMTR released!

Circadian clock impact on cluster headaches funded by $2.4M NIH grant for UTHealth Houston research

Study identifies first drug therapy for sleep apnea

How old is your bone marrow?

Boosting biodiversity without hurting local economies

ChatGPT is biased against resumes with credentials that imply a disability — but it can improve

Simple test for flu could improve diagnosis and surveillance

UT Health San Antonio researcher awarded five-year, $2.53 million NIH grant to study alcohol-assisted liver disease

Giving pre-med students hands-on clinical training

CAMH research suggests potential targets for prevention and early identification of psychotic disorders

Mapping the heart to prevent damage caused by a heart attack

Study challenges popular idea that Easter islanders committed ‘ecocide’

Chilling discovery: Study reveals evolution of human cold and menthol sensing protein, offering hope for future non-addictive pain therapies.

Elena Beccalli, new rector of Università Cattolica del Sacro Cuore, takes office on 1st July

Pacific Northwest Research Institute uncovers hidden DNA mechanisms of rare genetic diseases

Empowering older adults: Wearable tech made easier with personalized support

Pennington Biomedical researchers partner on award-winning Long Covid study

Cooling ‘blood oranges’ could make them even healthier – a bonus for consumers

Body image and overall health found important to the sexual health of older gay men, according to new studies

Lab-grown muscles reveal mysteries of rare muscle diseases

Primary hepatic angiosarcoma: Treatment options for a rare tumor

Research finds causal evidence tying cerebral small-vessel disease to Alzheimer’s, dementia

Navigating the Pyrocene: Recent Cell Press papers on managing fire risk

Restoring the Great Salt Lake would have environmental justice as well as ecological benefits

Cannabis, tobacco use, and COVID-19 outcomes

A 5:2 intermittent fasting meal replacement diet and glycemic control for adults with diabetes

Scientists document self-propelling oxygen decline in the oceans

[Press-News.org] MSK Research Highlights, May 24, 2024